EP1148878A4 - 1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES USEFUL AS RADIODIAGNOSTIC AGENTS AND THE USE THEREOF IN DETERMINING HYPOXIA AND TUMOR RADIOR RESISTANCE - Google Patents

1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES USEFUL AS RADIODIAGNOSTIC AGENTS AND THE USE THEREOF IN DETERMINING HYPOXIA AND TUMOR RADIOR RESISTANCE

Info

Publication number
EP1148878A4
EP1148878A4 EP00908353A EP00908353A EP1148878A4 EP 1148878 A4 EP1148878 A4 EP 1148878A4 EP 00908353 A EP00908353 A EP 00908353A EP 00908353 A EP00908353 A EP 00908353A EP 1148878 A4 EP1148878 A4 EP 1148878A4
Authority
EP
European Patent Office
Prior art keywords
radior
tumor
resistance
derivatives useful
radiodiagnostic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00908353A
Other languages
German (de)
French (fr)
Other versions
EP1148878A1 (en
Inventor
Donald J Chapman
Richard F Schneider
Edward L Engelhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fox Chase Cancer Center
Original Assignee
Fox Chase Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fox Chase Cancer Center filed Critical Fox Chase Cancer Center
Publication of EP1148878A1 publication Critical patent/EP1148878A1/en
Publication of EP1148878A4 publication Critical patent/EP1148878A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP00908353A 1999-01-26 2000-01-26 1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES USEFUL AS RADIODIAGNOSTIC AGENTS AND THE USE THEREOF IN DETERMINING HYPOXIA AND TUMOR RADIOR RESISTANCE Withdrawn EP1148878A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11725399P 1999-01-26 1999-01-26
US117253P 1999-01-26
PCT/US2000/001754 WO2000043004A1 (en) 1999-01-26 2000-01-26 1,4,8,11-tetraazacyclotetradecane derivatives as radiodiganostic agents and their use in determining hypoxia and radioresistance of tumors

Publications (2)

Publication Number Publication Date
EP1148878A1 EP1148878A1 (en) 2001-10-31
EP1148878A4 true EP1148878A4 (en) 2003-04-02

Family

ID=22371814

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00908353A Withdrawn EP1148878A4 (en) 1999-01-26 2000-01-26 1,4,8,11-TETRAAZACYCLOTETRADECANE DERIVATIVES USEFUL AS RADIODIAGNOSTIC AGENTS AND THE USE THEREOF IN DETERMINING HYPOXIA AND TUMOR RADIOR RESISTANCE

Country Status (3)

Country Link
EP (1) EP1148878A4 (en)
CA (1) CA2361115A1 (en)
WO (1) WO2000043004A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004509967A (en) 2000-09-25 2004-04-02 ザ、プロクター、エンド、ギャンブル、カンパニー Metal complexes for use in medical and therapeutic applications
WO2005087275A2 (en) * 2004-03-11 2005-09-22 Board Of Regents, The University Of Texas System Metal radiolabeled pet imaging agents
US7842278B2 (en) * 2006-10-27 2010-11-30 Natural Pharmacia International, Inc. Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
WO2008119036A2 (en) 2007-03-27 2008-10-02 Radiomedix Inc. Compositions for targeted imaging and therapy
CN101486708B (en) * 2009-02-27 2012-08-29 北京师范大学 4-nitro glyoxaline compound, preparation and use thereof
CN101486707B (en) * 2009-02-27 2012-08-29 北京师范大学 2-methyl-5-nitro glyoxaline compound, preparation and use thereof
WO2012027727A2 (en) * 2010-08-26 2012-03-01 Kunyuan Cui Lipomacrocycles and uses thereof
DK2721045T3 (en) 2011-06-20 2017-07-24 Radiomedix Inc COMPOSITIONS, METHODS OF SYNTHESIS AND USE OF CARBOHYDRATE TARGETED AGENTS
CN111372940A (en) * 2017-09-19 2020-07-03 阿尔伯塔大学理事会 Bioreduction-activated compounds, prodrugs thereof, radiopharmaceuticals, compositions and their use in multimodal therapeutic control of hypoxic diseases including cancer
CN111356698B (en) * 2017-09-19 2025-02-25 威奇生物科技公司 Markers, conjugates, compositions and methods for imaging, mapping and treating hypoxia
WO2022178840A1 (en) * 2021-02-26 2022-09-01 Seecure Taiwan Co. , Ltd. Thiopurine-based compound, composition, method of preparation and applications

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2654102B1 (en) * 1989-11-09 1992-01-10 Air Liquide PROCESS FOR THE SYNTHESIS OF CYCLIC POLYAZOT DERIVATIVES.
JP2885944B2 (en) * 1991-02-01 1999-04-26 富士写真フイルム株式会社 Amine compound having heterocyclic group
US5708022A (en) * 1994-10-28 1998-01-13 Procept, Inc. Method for inhibiting immune response
GB9511357D0 (en) * 1995-06-06 1995-08-02 Johnson Matthey Plc Improved antiviral compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO0043004A1 *

Also Published As

Publication number Publication date
EP1148878A1 (en) 2001-10-31
WO2000043004A1 (en) 2000-07-27
CA2361115A1 (en) 2000-07-27

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