EP1150701A4 - Homing pro-apoptotic conjugates and methods of using same - Google Patents

Homing pro-apoptotic conjugates and methods of using same

Info

Publication number: EP1150701A4
Authority: EP; European Patent Office
Prior art keywords: methods; same; homing pro; apoptotic conjugates; apoptotic
Prior art date: 1999-01-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

EP00911617A

Other languages

German (de)

French (fr)

Other versions

EP1150701A2 (en

Inventor

H Michael Ellerby

Dale E Bredesen

Renata Pasqualini

Erkki I Ruoslahti

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanford Burnham Prebys Medical Discovery Institute

Original Assignee

Sanford Burnham Prebys Medical Discovery Institute

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-22

Filing date

2000-01-21

Publication date

2003-03-26

2000-01-21 Application filed by Sanford Burnham Prebys Medical Discovery Institute filed Critical Sanford Burnham Prebys Medical Discovery Institute

2001-11-07 Publication of EP1150701A2 publication Critical patent/EP1150701A2/en

2003-03-26 Publication of EP1150701A4 publication Critical patent/EP1150701A4/en

Status Ceased legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP00911617A 1999-01-22 2000-01-21 Homing pro-apoptotic conjugates and methods of using same Ceased EP1150701A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US23590299A	1999-01-22	1999-01-22
US235902		1999-01-22
PCT/US2000/001602 WO2000042973A2 (en)	1999-01-22	2000-01-21	Homing pro-apoptotic conjugates and methods of using same

Publications (2)

Publication Number	Publication Date
EP1150701A2 EP1150701A2 (en)	2001-11-07
EP1150701A4 true EP1150701A4 (en)	2003-03-26

Family

ID=22887331

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP00911617A Ceased EP1150701A4 (en)	1999-01-22	2000-01-21	Homing pro-apoptotic conjugates and methods of using same

Country Status (5)

Country	Link
EP (1)	EP1150701A4 (en)
JP (1)	JP4531267B2 (en)
AU (1)	AU770381B2 (en)
CA (1)	CA2359633A1 (en)
WO (1)	WO2000042973A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2003520808A (en) *	2000-01-21	2003-07-08	ザバーナムインスティチュート	Chimeric prostate homing peptide with pro-apoptotic activity
JP2003522183A (en) *	2000-02-02	2003-07-22	トランジェーヌ、ソシエテ、アノニム	Targeting peptide
CA2421872A1 (en)	2000-09-11	2002-03-14	Institut Pasteur	Mechanism of mitochondrial membrane permeabilization by hiv-1 vpr, mimetics of vpr and methods of screening active molecules having the ability to alter and/or prevent and/or mimic the interaction of vpr with ant
US20030077826A1 (en) *	2001-02-02	2003-04-24	Lena Edelman	Chimeric molecules containing a module able to target specific cells and a module regulating the apoptogenic function of the permeability transition pore complex (PTPC)
US8507445B2 (en)	2001-09-07	2013-08-13	Board Of Regents, The University Of Texas System	Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
US7671010B2 (en) *	2002-08-30	2010-03-02	The Board Of Regents Of The University Of Texas System	Compositions and methods of use of targeting peptides for diagnosis and therapy of human cancer
US7192921B2 (en)	2001-11-08	2007-03-20	The Burnham Institute	Peptides that home to tumor lymphatic vasculature and methods of using same
ATE419861T1 (en) *	2001-11-08	2009-01-15	Burnham Inst	HOMING PEPTIDES FOR LYMPH VESSEL TUMOR AND THEIR USE
EP1346729A1 (en) *	2002-03-19	2003-09-24	Cardiovascular Research Institute Maastricht	Targeting of myocardial angiogenesis through CD13/APN
WO2004007557A2 (en) *	2002-07-12	2004-01-22	Novo Nordisk A/S	Tf antagonist
CA2519826A1 (en)	2003-03-24	2004-10-07	Nippon Medical School Foundation	Cell death-inducing fusion gene specifically acting on cancer and product thereof
GB0312309D0 (en) *	2003-05-29	2003-07-02	Gaslini Children S Hospital G	Targeted liposome
US7598341B2 (en)	2003-10-31	2009-10-06	Burnham Institue For Medical Research	Molecules that selectively home to vasculature of premalignant or malignant lesions of the pancreas and other organs
CA2594927A1 (en) *	2004-03-31	2005-10-13	Buck Institute	Hunter-killer peptides and methods of use
CN102558334B (en) *	2004-09-07	2016-08-03	伯纳姆研究院	Selectivity anchors to the peptide in heart vasculature and related conjugates and method
AU2006320327A1 (en) *	2005-12-01	2007-06-07	Duke University	Compounds and methods for inhibiting apoptosis
FI121959B (en) *	2008-05-09	2011-06-30	Pirjo Laakkonen	Peptide seeking for brain tumors
EP2414389A1 (en) *	2009-04-01	2012-02-08	Schmidt-Wolf, Ingo	Tumor targeting peptides, therapeutic and diagnostic compositions comprising the peptides
JP2013525285A (en) *	2010-04-08	2013-06-20	サンフォード−バーナムメディカルリサーチインスティテュート	Methods and compositions for enhancing delivery of compounds
WO2016172515A1 (en)	2015-04-23	2016-10-27	Sanford Burnham Prebys Medical Discovery Institute	Targeted delivery system and methods of use therefor
KR101741594B1 (en) *	2015-06-30	2017-05-30	경북대학교 산학협력단	Pharmaceutical composition comprising fusion peptide targeting cancer cells and tumor associated macrophages for treating cancer and inhibiting metastasis
WO2017124147A1 (en) *	2016-01-19	2017-07-27	The University Of Western Australia	Novel biomolecule conjugates and uses therefor
US11180535B1 (en)	2016-12-07	2021-11-23	David Gordon Bermudes	Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11021529B2 (en)	2017-03-03	2021-06-01	Massachusetts Institute Of Technology	Antimicrobial constructs and uses thereof
CN108314741B (en) *	2018-03-22	2021-08-03	中国人民解放军第四军医大学	A kind of tumor blood vessel targeting anticancer peptide NKL-DOTA and preparation method thereof
EP4139327A4 (en) *	2020-04-22	2024-10-02	Oncovolution, LLC	PEPTIDE-PLATINUM COMPLEXES AND METHODS OF USE THEREOF
CN112830975B (en) *	2021-02-02	2023-03-10	西南交通大学	Pro-apoptotic bicyclic polypeptide with stable α-helical conformation, preparation method and application

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5789542A (en) *	1994-04-22	1998-08-04	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Amphipathic peptides
US5773292A (en) *	1995-06-05	1998-06-30	Cornell University	Antibodies binding portions, and probes recognizing an antigen of prostate epithelial cells but not antigens circulating in the blood
EP0938505B1 (en) *	1996-05-31	2002-03-06	Health Research, Inc.	Anti-endoglin monoclonal antibodies and their use in anti-angiogenesis therapy
WO1998010795A2 (en) *	1996-09-10	1998-03-19	The Burnham Institute	Tumor homing molecules, conjugates derived therefrom, and methods of using same
ATE407943T1 (en) *	1998-03-13	2008-09-15	Burnham Inst	TARGETING CONNECTIONS FOR VARIOUS ORGANS AND TISSUES

2000
- 2000-01-21 EP EP00911617A patent/EP1150701A4/en not_active Ceased
- 2000-01-21 AU AU33486/00A patent/AU770381B2/en not_active Ceased
- 2000-01-21 WO PCT/US2000/001602 patent/WO2000042973A2/en not_active Ceased
- 2000-01-21 JP JP2000594432A patent/JP4531267B2/en not_active Expired - Fee Related
- 2000-01-21 CA CA002359633A patent/CA2359633A1/en not_active Abandoned

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JAVADPOUR MARYAM M ET AL: "De novo antimicrobial peptides with low mammalian cell toxicity.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, no. 16, 1996, pages 3107 - 3113, XP002228388, ISSN: 0022-2623 *
See also references of WO0042973A3 *

Also Published As

Publication number	Publication date
JP4531267B2 (en)	2010-08-25
CA2359633A1 (en)	2000-07-27
WO2000042973A3 (en)	2000-09-28
WO2000042973A2 (en)	2000-07-27
EP1150701A2 (en)	2001-11-07
JP2002535258A (en)	2002-10-22
AU770381B2 (en)	2004-02-19
AU3348600A (en)	2000-08-07

Legal Events

Date	Code	Title	Description
2001-09-21	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2001-11-07	17P	Request for examination filed	Effective date: 20010806
2001-11-07	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2001-11-14	RIN1	Information on inventor provided before grant (corrected)	Inventor name: PASQUALINI, RENATA Inventor name: RUOSLAHTI, ERKKI, I. Inventor name: ELLERBY, H., MICHAEL Inventor name: BREDESEN, DALE, E.
2001-11-28	RIN1	Information on inventor provided before grant (corrected)	Inventor name: RUOSLAHTI, ERKKI, I. Inventor name: PASQUALINI, RENATA Inventor name: ELLERBY, H., MICHAEL Inventor name: BREDESEN, DALE, E.
2002-03-13	RIN1	Information on inventor provided before grant (corrected)	Inventor name: BREDESEN, DALE, E. Inventor name: ELLERBY, H., MICHAEL Inventor name: PASQUALINI, RENATA Inventor name: RUOSLAHTI, ERKKI, I.
2003-03-19	RIC1	Information provided on ipc code assigned before grant	Ipc: 7A 61K 39/00 B Ipc: 7A 61K 38/00 A Ipc: 7C 07K 5/00 B Ipc: 7C 07K 4/00 B Ipc: 7C 07K 2/00 B Ipc: 7C 07K 17/00 B Ipc: 7C 07K 14/00 B Ipc: 7A 61K 47/48 B Ipc: 7A 61K 39/02 B Ipc: 7A 61K 38/04 B Ipc: 7C 07K 16/00 B
2003-03-26	A4	Supplementary search report drawn up and despatched	Effective date: 20030206
2004-08-04	17Q	First examination report despatched	Effective date: 20040617
2006-11-24	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED
2006-12-27	18R	Application refused	Effective date: 20060820
2007-08-08	RIN1	Information on inventor provided before grant (corrected)	Inventor name: BREDESEN, DALE, E. Inventor name: PASQUALINI, RENATA Inventor name: RUOSLAHTI, ERKKI, I. Inventor name: ELLERBY, H., MICHAEL

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