EP1185286A4 - MU O-CONOPEPTIDE AND THEIR USE AS A LOCAL ANESTHETIC - Google Patents

MU O-CONOPEPTIDE AND THEIR USE AS A LOCAL ANESTHETIC

Info

Publication number
EP1185286A4
EP1185286A4 EP00939692A EP00939692A EP1185286A4 EP 1185286 A4 EP1185286 A4 EP 1185286A4 EP 00939692 A EP00939692 A EP 00939692A EP 00939692 A EP00939692 A EP 00939692A EP 1185286 A4 EP1185286 A4 EP 1185286A4
Authority
EP
European Patent Office
Prior art keywords
conopeptide
local anesthetic
anesthetic
local
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00939692A
Other languages
German (de)
French (fr)
Other versions
EP1185286A1 (en
Inventor
Baldomero M Olivera
J Michael Mcintosh
R Tyler Mccabe
James E Garrett
Richard T Layer
John D Wagstaff
Robert M Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cognetix Inc
University of Utah Research Foundation Inc
Original Assignee
Cognetix Inc
University of Utah Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cognetix Inc, University of Utah Research Foundation Inc filed Critical Cognetix Inc
Publication of EP1185286A1 publication Critical patent/EP1185286A1/en
Publication of EP1185286A4 publication Critical patent/EP1185286A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP00939692A 1999-06-10 2000-06-09 MU O-CONOPEPTIDE AND THEIR USE AS A LOCAL ANESTHETIC Withdrawn EP1185286A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13850799P 1999-06-10 1999-06-10
US138507P 1999-06-10
PCT/US2000/015779 WO2000076532A1 (en) 1999-06-10 2000-06-09 νO-CONOPEPTIDES AND THEIR USE AS LOCAL ANESTHETICS

Publications (2)

Publication Number Publication Date
EP1185286A1 EP1185286A1 (en) 2002-03-13
EP1185286A4 true EP1185286A4 (en) 2004-09-08

Family

ID=22482336

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00939692A Withdrawn EP1185286A4 (en) 1999-06-10 2000-06-09 MU O-CONOPEPTIDE AND THEIR USE AS A LOCAL ANESTHETIC

Country Status (5)

Country Link
EP (1) EP1185286A4 (en)
JP (1) JP2003501109A (en)
AU (1) AU5474200A (en)
CA (1) CA2376357A1 (en)
WO (1) WO2000076532A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2396529A1 (en) 1999-12-30 2001-07-12 University Of Utah Research Foundation O-superfamily conotoxin peptides
GB0011202D0 (en) * 2000-05-09 2000-06-28 Kci Licensing Inc Abdominal wound dressing
WO2002007756A1 (en) * 2000-07-20 2002-01-31 Cognetix, Inc. MuO-CONOPEPTIDES AND THEIR USE AS LOCAL ANESTHETICS
WO2002007678A2 (en) * 2000-07-21 2002-01-31 University Of Utah Research Foundation Mu-conopeptides
CA2661014A1 (en) * 2006-08-17 2008-02-21 Eribis Pharmaceuticals Ab Cardioprotective compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719264A (en) * 1994-10-07 1998-02-17 Univ. Of Utah Research Foundation Conotoxin peptides
FR2785613A1 (en) * 1998-11-10 2000-05-12 Commissariat Energie Atomique New conotoxin, useful for treating neurodegenerative disorders, e.g. multiple sclerosis, have selective presynaptic action on neuronal sodium channels

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2216751A1 (en) * 1995-04-17 1996-10-24 Doju Yoshikami Conotoxin peptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719264A (en) * 1994-10-07 1998-02-17 Univ. Of Utah Research Foundation Conotoxin peptides
FR2785613A1 (en) * 1998-11-10 2000-05-12 Commissariat Energie Atomique New conotoxin, useful for treating neurodegenerative disorders, e.g. multiple sclerosis, have selective presynaptic action on neuronal sodium channels

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAI-SONG L ET AL: "CONOPEPTIDES FROM CONUS STRIATUS AND CONUS TEXTILE BY CDNA CLONING", PEPTIDES, ELMSFORD, US, vol. 20, 1999, pages 1139 - 1144, XP002939062, ISSN: 0196-9781 *
FAINZILBER M ET AL: "NEW SODIUM CHANNEL-BLOCKING CONOTOXINS ALSO AFFECT CALCIUM CURRENTSIN LYMNAEA NEURONS", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 34, no. 16, 25 April 1995 (1995-04-25), pages 5364 - 5371, XP002061899, ISSN: 0006-2960 *
See also references of WO0076532A1 *
TERLAU HEINRICH ET AL: "Mu-O-conotoxin MrVIA inhibits mammalian sodium channels, but not through site I", JOURNAL OF NEUROPHYSIOLOGY (BETHESDA), vol. 76, no. 3, 1996, pages 1423 - 1429, XP009034053, ISSN: 0022-3077 *

Also Published As

Publication number Publication date
EP1185286A1 (en) 2002-03-13
AU5474200A (en) 2001-01-02
JP2003501109A (en) 2003-01-14
CA2376357A1 (en) 2000-12-21
WO2000076532A1 (en) 2000-12-21

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