EP1187934A4 - CELL-BASED ASSAY FOR SCREENING COX-2 INHIBITORS - Google Patents

CELL-BASED ASSAY FOR SCREENING COX-2 INHIBITORS

Info

Publication number
EP1187934A4
EP1187934A4 EP00941446A EP00941446A EP1187934A4 EP 1187934 A4 EP1187934 A4 EP 1187934A4 EP 00941446 A EP00941446 A EP 00941446A EP 00941446 A EP00941446 A EP 00941446A EP 1187934 A4 EP1187934 A4 EP 1187934A4
Authority
EP
European Patent Office
Prior art keywords
cox
inhibitors
screening
cell
based assay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00941446A
Other languages
German (de)
French (fr)
Other versions
EP1187934A1 (en
Inventor
E Premkumar Reddy
M V Ramana Reddy
N Dhanasekaran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temple Univ School of Medicine
Original Assignee
Temple Univ School of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Temple Univ School of Medicine filed Critical Temple Univ School of Medicine
Publication of EP1187934A1 publication Critical patent/EP1187934A1/en
Publication of EP1187934A4 publication Critical patent/EP1187934A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/88—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving prostaglandins or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP00941446A 1999-06-16 2000-06-15 CELL-BASED ASSAY FOR SCREENING COX-2 INHIBITORS Withdrawn EP1187934A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13956999P 1999-06-16 1999-06-16
US139569P 1999-06-16
PCT/US2000/016486 WO2000077245A1 (en) 1999-06-16 2000-06-15 Cell-based assay for screening cox-2 inhibitors

Publications (2)

Publication Number Publication Date
EP1187934A1 EP1187934A1 (en) 2002-03-20
EP1187934A4 true EP1187934A4 (en) 2002-07-31

Family

ID=22487303

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00941446A Withdrawn EP1187934A4 (en) 1999-06-16 2000-06-15 CELL-BASED ASSAY FOR SCREENING COX-2 INHIBITORS

Country Status (4)

Country Link
EP (1) EP1187934A4 (en)
AU (1) AU5615200A (en)
CA (1) CA2374676A1 (en)
WO (1) WO2000077245A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2690188C2 (en) * 2017-05-26 2019-05-31 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" New multitarget preparation for treating diseases in mammals

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014977A1 (en) * 1992-12-22 1994-07-07 Merck Frosst Canada Inc. HUMAN CYCLOOXYGENASE-2cDNA AND ASSAY FOR EVALUATING INHIBITION OF CYCLOOXYGENASE-2
AT402732B (en) * 1996-02-16 1997-08-25 Nycomed Austria Gmbh Use of the human megakaryocytic cell line dami for identifying and determining substances for inhibiting the enzymatic activity of the enzyme cyclooxygenase-1
AT402936B (en) * 1996-05-29 1997-09-25 Nycomed Austria Gmbh Use of a human cell line for identifying and determining substances for inhibiting the induction of the expression of the cyclooxygenase-2 gene

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014977A1 (en) * 1992-12-22 1994-07-07 Merck Frosst Canada Inc. HUMAN CYCLOOXYGENASE-2cDNA AND ASSAY FOR EVALUATING INHIBITION OF CYCLOOXYGENASE-2
AT402732B (en) * 1996-02-16 1997-08-25 Nycomed Austria Gmbh Use of the human megakaryocytic cell line dami for identifying and determining substances for inhibiting the enzymatic activity of the enzyme cyclooxygenase-1
AT402936B (en) * 1996-05-29 1997-09-25 Nycomed Austria Gmbh Use of a human cell line for identifying and determining substances for inhibiting the induction of the expression of the cyclooxygenase-2 gene

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MC DERMOTT JONATHAN M ET AL: "Oncogenic mutant of Galpha12 stimulates cell proliferation through cycloxygenase-2 signaling pathway.", ONCOGENE, vol. 18, no. 51, 2 December 1999 (1999-12-02), pages 7185 - 7189, XP001071176, ISSN: 0950-9232 *
See also references of WO0077245A1 *

Also Published As

Publication number Publication date
AU5615200A (en) 2001-01-02
WO2000077245A9 (en) 2002-06-20
EP1187934A1 (en) 2002-03-20
CA2374676A1 (en) 2000-12-21
WO2000077245A1 (en) 2000-12-21

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