EP1194768A4 - METHODS FOR PEPTIDE CARTOGRAPHY OF POLYPEPTIDES, PROFILING OF PROFILES, AND BIOINFORMATIC DATABASE SYSTEM - Google Patents
METHODS FOR PEPTIDE CARTOGRAPHY OF POLYPEPTIDES, PROFILING OF PROFILES, AND BIOINFORMATIC DATABASE SYSTEMInfo
- Publication number
- EP1194768A4 EP1194768A4 EP00923511A EP00923511A EP1194768A4 EP 1194768 A4 EP1194768 A4 EP 1194768A4 EP 00923511 A EP00923511 A EP 00923511A EP 00923511 A EP00923511 A EP 00923511A EP 1194768 A4 EP1194768 A4 EP 1194768A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cartography
- profiling
- polypeptides
- peptide
- profiles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
- G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44773—Multi-stage electrophoresis, e.g. two-dimensional electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44782—Apparatus specially adapted therefor of a plurality of samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44795—Isoelectric focusing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10180277A EP2293056A3 (en) | 1999-04-20 | 2000-04-19 | A method for analysing a metabolic pathway |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13023899P | 1999-04-20 | 1999-04-20 | |
| US130238P | 1999-04-20 | ||
| US513907 | 2000-02-25 | ||
| US09/513,395 US6379971B1 (en) | 1998-02-24 | 2000-02-25 | Methods for sequencing proteins |
| US09/513,907 US6677114B1 (en) | 1999-04-20 | 2000-02-25 | Polypeptide fingerprinting methods and bioinformatics database system |
| US513395 | 2000-02-25 | ||
| US513486 | 2000-02-25 | ||
| US09/513,486 US6537432B1 (en) | 1998-02-24 | 2000-02-25 | Protein separation via multidimensional electrophoresis |
| PCT/US2000/010504 WO2000063683A1 (en) | 1999-04-20 | 2000-04-19 | Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1194768A1 EP1194768A1 (en) | 2002-04-10 |
| EP1194768A4 true EP1194768A4 (en) | 2008-03-26 |
Family
ID=27494844
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP00923511A Withdrawn EP1194768A4 (en) | 1999-04-20 | 2000-04-19 | METHODS FOR PEPTIDE CARTOGRAPHY OF POLYPEPTIDES, PROFILING OF PROFILES, AND BIOINFORMATIC DATABASE SYSTEM |
| EP10180277A Withdrawn EP2293056A3 (en) | 1999-04-20 | 2000-04-19 | A method for analysing a metabolic pathway |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP10180277A Withdrawn EP2293056A3 (en) | 1999-04-20 | 2000-04-19 | A method for analysing a metabolic pathway |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP1194768A4 (en) |
| JP (2) | JP4723725B2 (en) |
| AU (2) | AU774662B2 (en) |
| CA (1) | CA2370749A1 (en) |
| IL (1) | IL146093A0 (en) |
| WO (1) | WO2000063683A1 (en) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2298181C (en) | 2000-02-02 | 2006-09-19 | Dayan Burke Goodnough | Non-targeted complex sample analysis |
| US20040209251A1 (en) | 2000-10-19 | 2004-10-21 | Schneider Luke V | Methods for determining protein and peptide terminal sequences |
| DE10123711A1 (en) * | 2001-05-15 | 2003-02-27 | Wolfgang Altmeyer | Procedure for determining the origin of biological materials |
| US6800449B1 (en) | 2001-07-13 | 2004-10-05 | Syngenta Participations Ag | High throughput functional proteomics |
| JP4873801B2 (en) * | 2001-08-10 | 2012-02-08 | サントリーホールディングス株式会社 | Structural analysis method for organic compounds |
| WO2003061479A1 (en) | 2001-10-24 | 2003-07-31 | The Regents Of The University Of California | Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water |
| ATE412906T1 (en) | 2002-02-12 | 2008-11-15 | Univ California | NON-INVASIVE MEASUREMENT OF BIOSYNTHESIS AND DEGRADATION RATES OF BIOLOGICAL MOLECULES THAT ARE IMPASSIBLE TO DIRECT SAMPLING OR NOT EASILY ACCESSIBLE BY INCORPORATING A LABEL INTO METABOLIC DERIVATIVES AND CATABOLIC PRODUCTS |
| AU2003219275B2 (en) * | 2002-03-07 | 2008-01-24 | Cambridge Enterprise Ltd | SCD fingerprints |
| EP1361438A1 (en) * | 2002-05-10 | 2003-11-12 | Proteome Factory AG | Solid-phase assisted spectroscopic and spectrometric analysis of complex peptide mixes |
| ATE381018T1 (en) * | 2002-05-10 | 2007-12-15 | Proteome Factory Ag | SOLID PHASE ASSISTED SPECTROSCOPIC AND SPECTROMETRIC ANALYSIS OF COMPLEX BIOPOLYMER MIXTURES |
| US20060094057A1 (en) | 2002-07-30 | 2006-05-04 | Maro K. Hellerstein | Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry |
| JP4610337B2 (en) | 2002-09-13 | 2011-01-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Method for measuring reverse cholesterol transport rate in vivo as an indicator of anti-atherogenesis |
| WO2004034049A1 (en) * | 2002-10-09 | 2004-04-22 | Waters Investments Limited | Methods and apparatus for identifying compounds in a sample |
| WO2004042360A2 (en) | 2002-11-04 | 2004-05-21 | The Regents Of The Univeristy Of California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
| US7425700B2 (en) | 2003-05-22 | 2008-09-16 | Stults John T | Systems and methods for discovery and analysis of markers |
| US20040236603A1 (en) * | 2003-05-22 | 2004-11-25 | Biospect, Inc. | System of analyzing complex mixtures of biological and other fluids to identify biological state information |
| AU2003238288A1 (en) | 2003-06-19 | 2005-02-04 | Everest Biomedical Instruments | Breath end-tidal gas monitor |
| US7262020B2 (en) | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
| US20050202406A1 (en) | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
| JP2007514173A (en) * | 2003-12-15 | 2007-05-31 | ユニバーシティ オブ ペンシルベニア | Method and apparatus for performing a reaction on a target plate for MALDI mass spectrometry |
| US8510054B2 (en) * | 2004-02-05 | 2013-08-13 | Ajinomoto Co., Inc. | Intracellular metabolic flux analysis method using substrate labeled with isotope |
| TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
| US20050201937A1 (en) * | 2004-03-11 | 2005-09-15 | The Regents Of The University Of California | Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients |
| KR100611313B1 (en) * | 2004-06-30 | 2006-08-10 | 고려대학교 산학협력단 | N-terminal substitution of polypeptide, amino acid sequencing and quantification method in polypeptide |
| JP4512745B2 (en) * | 2004-10-29 | 2010-07-28 | 独立行政法人産業技術総合研究所 | Cell separation and identification apparatus and method |
| JP2008064459A (en) * | 2004-12-24 | 2008-03-21 | Univ Kurume | Quantitative determination of pigment epithelium-derived factor |
| JP2006308523A (en) * | 2005-05-02 | 2006-11-09 | Ebara Corp | Method for coating inside of microchannel for microchip for electrophoresis, and coated microchip for electrophoresis prepared by the method |
| JP5038311B2 (en) | 2005-09-12 | 2012-10-03 | フェノメノーム ディスカバリーズ インク | Method for diagnosing colorectal cancer and ovarian cancer by measuring vitamin E-related metabolites |
| JP2007163423A (en) * | 2005-12-16 | 2007-06-28 | Ajinomoto Co Inc | Amino acid analysis method by mass spectrometer |
| US8626449B2 (en) | 2006-10-17 | 2014-01-07 | The Regents Of The University Of California | Biological cell sorting and characterization using aerosol mass spectrometry |
| WO2008059568A1 (en) * | 2006-11-15 | 2008-05-22 | Shimadzu Corporation | Method of analyzing mass spectrometric data and apparatus therefor |
| FR2936316B1 (en) * | 2008-09-25 | 2015-05-01 | Etat Francais Dga | DEVICE FOR SELECTIVE PRECONCENTRATION / DETECTION OF CHARGED ANALYTES CONTAINED IN AN ELECTROLYTE AND ASSOCIATED METHOD. |
| CA2794248C (en) * | 2010-03-24 | 2018-02-20 | Glendon John Parker | Methods for conducting genetic analysis using protein polymorphisms |
| GB201019337D0 (en) * | 2010-11-16 | 2010-12-29 | Micromass Ltd | Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis |
| WO2013036885A1 (en) | 2011-09-08 | 2013-03-14 | The Regents Of The University Of California | Metabolic flux measurement, imaging and microscopy |
| ES2668678T3 (en) | 2011-12-07 | 2018-05-21 | Glaxosmithkline Llc | Procedure for determining total body skeletal muscle mass |
| RU2014129561A (en) | 2011-12-21 | 2016-02-10 | Кэпниа, Инк. | EXHAUST GAS COLLECTION AND ANALYSIS WITH CORRECTION FOR RESPIRATORY FREQUENCY |
| EP2841927B1 (en) * | 2012-04-27 | 2018-01-17 | Bio-rad Laboratories, Inc. | Stain-free protein quantification and normalization |
| RU2015133209A (en) | 2013-01-08 | 2017-02-15 | Кэпниа, Инк. | SELECTING A RESPIRATORY CYCLE FOR ANALYSIS |
| JP5977269B2 (en) | 2013-01-22 | 2016-08-24 | アークレイ株式会社 | Sample analysis method and solution used therefor |
| EP2956058A4 (en) | 2013-02-12 | 2016-11-02 | Capnia Inc | Sampling and storage registry device for breath gas analysis |
| US9134319B2 (en) | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
| RU2016111654A (en) | 2013-08-30 | 2017-10-05 | Кэпниа, Инк. | CARBON GAS MEASUREMENT SYSTEM IN NEWBORNS |
| JP6281349B2 (en) * | 2014-03-19 | 2018-02-21 | 株式会社島津製作所 | Method for preparing a peptide mixture sample for mass spectrometry |
| WO2016033382A1 (en) | 2014-08-27 | 2016-03-03 | Capnia, Inc. | Methods for immune globulin administration |
| US10618050B2 (en) | 2015-03-09 | 2020-04-14 | Panasonic Intellectual Property Management Co., Ltd. | Microfluidic device for reducing fluctuation in the solution feeding rate of a reaction solution |
| WO2016183222A1 (en) * | 2015-05-12 | 2016-11-17 | Regeneron Pharmaceuticals, Inc. | Multimeric protein purity determination |
| WO2017163413A1 (en) * | 2016-03-25 | 2017-09-28 | 科健化学株式会社 | Hollow-column liquid chromatography system and substance separation using said system |
| DE102017130322B4 (en) | 2017-12-18 | 2022-09-22 | Jana Heise | Method and kit for the specific detection of diagnostically relevant proteins in biological samples |
| CA3126712A1 (en) * | 2019-01-31 | 2020-08-06 | Regeneron Pharmaceuticals, Inc. | Native microfluidic ce-ms analysis of antibody charge heterogeneity |
| KR20240137114A (en) | 2019-08-05 | 2024-09-19 | 시어 인코퍼레이티드 | Systems and methods for sample preparation, data generation, and protein corona analysis |
| US20220328134A1 (en) | 2021-03-31 | 2022-10-13 | PrognomIQ, Inc. | Multi-omic assessment |
| CN121726086A (en) * | 2021-03-31 | 2026-03-24 | 普罗科技有限公司 | Multiple study assessment |
| CN113433200A (en) * | 2021-06-16 | 2021-09-24 | 华南农业大学 | Method for identifying cross-linked polymer by electrospray mass spectrometry technology |
| CN114935609A (en) * | 2021-06-17 | 2022-08-23 | 上海阿趣生物科技有限公司 | High-throughput target detection method for biological sample polyamine and related metabolites |
| US12387508B2 (en) | 2021-09-10 | 2025-08-12 | PrognomIQ, Inc. | Direct classification of raw biomolecule measurement data |
| AU2022341187A1 (en) | 2021-09-13 | 2024-03-21 | PrognomIQ, Inc. | Enhanced detection and quantitation of biomolecules |
| CN115097038B (en) * | 2022-06-22 | 2023-08-01 | 山东国仓健生物科技有限公司 | Screening and identifying method and application of metabolite related to soybean phytophthora resistance |
| US12563037B2 (en) * | 2022-07-29 | 2026-02-24 | Arkose Labs Holdings, Inc. | Security monitoring utilizing device signature detection |
| CN116735754A (en) * | 2023-08-04 | 2023-09-12 | 北京大学现代农业研究院 | A high-resolution liquid mass spectrometry analysis method and application of amino acid metabolites |
| WO2025085658A1 (en) * | 2023-10-17 | 2025-04-24 | Northeastern University | System and method for proteomic analysis of limited samples |
| CN117169317B (en) * | 2023-10-30 | 2024-01-19 | 内蒙古蒙牛乳业(集团)股份有限公司 | Alpha-s 1 casein phosphorylation degree detection method, sample buffer solution and application thereof |
| WO2025179149A1 (en) * | 2024-02-22 | 2025-08-28 | Toby, Inc. | Training and use of machine-learning models for predicting biological conditions using volatile organic compounds |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0653631A2 (en) * | 1993-11-11 | 1995-05-17 | Ciba-Geigy Ag | Apparatus and method for the electrophoretical separation of mixtures of fluid substances |
| WO1996033405A1 (en) * | 1995-04-17 | 1996-10-24 | Mayo Foundation For Medical Education And Research | Sample preprocessor |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4351760A (en) | 1979-09-07 | 1982-09-28 | Syva Company | Novel alkyl substituted fluorescent compounds and polyamino acid conjugates |
| US4656133A (en) | 1983-09-29 | 1987-04-07 | Board Of Regents, University Of Texas System | Method for enzymatic synthesis of isotopically labeled carbohydrates |
| JPH0828934B2 (en) | 1984-07-31 | 1996-03-21 | 株式会社東芝 | Protection control device |
| US4830010A (en) | 1986-04-04 | 1989-05-16 | Marshall Barry J | Methods for the diagnosis of gastrointestinal disorders |
| US4842701A (en) * | 1987-04-06 | 1989-06-27 | Battelle Memorial Institute | Combined electrophoretic-separation and electrospray method and system |
| US4994165A (en) * | 1989-02-16 | 1991-02-19 | Cornell Research Foundation, Inc. | Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry |
| US5059702A (en) * | 1989-09-29 | 1991-10-22 | The United States Of America As Represented By The Secretary Of The Navy | 124 Sn-labelled tetra-n-butyltin and tri-n-butyltin bromide |
| US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
| US5935401A (en) | 1996-09-18 | 1999-08-10 | Aclara Biosciences | Surface modified electrophoretic chambers |
| US5858188A (en) | 1990-02-28 | 1999-01-12 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
| US5133844A (en) | 1990-03-15 | 1992-07-28 | United States Department Of Energy | Method of electric field flow fractionation wherein the polarity of the electric field is periodically reversed |
| SE9002480D0 (en) | 1990-07-23 | 1990-07-23 | Hans Lilja | ASSAY OF FREE AND COMPLEXED PROSTATE-SPECIFIC ANTIGEN |
| US5295261A (en) | 1990-07-27 | 1994-03-15 | Pacific Bell Corporation | Hybrid database structure linking navigational fields having a hierarchial database structure to informational fields having a relational database structure |
| US5534440A (en) | 1991-02-22 | 1996-07-09 | Biomedical Research Centre Limited | Compounds and methods for sequencing amino acids |
| WO1992021138A1 (en) * | 1991-05-21 | 1992-11-26 | Analytica Of Brandford, Inc. | Method and apparatus for improving electrospray ionization of solute species |
| JP2844503B2 (en) | 1991-11-20 | 1999-01-06 | 東京瓦斯株式会社 | Gas measurement device |
| US5140993A (en) | 1991-12-27 | 1992-08-25 | Baylor College Of Medicine | Device for collecting a breath sample |
| US5317156A (en) | 1992-01-29 | 1994-05-31 | Sri International | Diagnostic tests using near-infrared laser absorption spectroscopy |
| US5338686A (en) * | 1992-04-29 | 1994-08-16 | Hellerstein Marc K | Method for measuring in vivo synthesis of biopolymers |
| CA2140891A1 (en) * | 1992-07-24 | 1994-02-03 | David C. Parmelee | Peptides useful as internal standards for microsequencing and methods for their use |
| JP3509100B2 (en) | 1993-01-21 | 2004-03-22 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Method for measuring toxicity of compound utilizing mammalian stress promoter and diagnostic kit |
| US5439803A (en) | 1993-08-13 | 1995-08-08 | The Regents Of The University Of Michigan | Isotope and assay for glycolysis and the pentose phosphate pathway |
| JPH0793370A (en) | 1993-09-27 | 1995-04-07 | Hitachi Device Eng Co Ltd | Gene database search system |
| US5599677A (en) | 1993-12-29 | 1997-02-04 | Abbott Laboratories | Immunoassays for prostate specific antigen |
| US5542419A (en) | 1994-02-28 | 1996-08-06 | Boston University | Noninvasive method to detect gastric Helicobacter pylori |
| US5538897A (en) | 1994-03-14 | 1996-07-23 | University Of Washington | Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases |
| DE4415480C2 (en) * | 1994-05-02 | 1999-09-02 | Bruker Daltonik Gmbh | Device and method for the mass spectrometric analysis of substance mixtures by coupling capillary electrophoretic separation (CE) with electrospray ionization (ESI) |
| US5856082A (en) * | 1994-08-31 | 1999-01-05 | University Of British Columbia | Devices and methods for characterizing proteins and peptides |
| DE4433384C2 (en) * | 1994-09-09 | 1996-12-19 | Ufz Leipzighalle Gmbh | Ecotoxicological metabolism test with stable isotopes |
| US5628328A (en) * | 1995-04-25 | 1997-05-13 | Iowa State University Research Foundation | Method for measuring muscle mass |
| US6004770A (en) * | 1995-06-07 | 1999-12-21 | Arizona State University Board Of Regents | Sample presentation apparatus for mass spectrometry |
| US5872010A (en) * | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
| US5710007A (en) | 1995-09-29 | 1998-01-20 | Luderer; Albert A. | Methods for diagnosing prostatic adenocarcinoma |
| JPH10291955A (en) * | 1997-04-22 | 1998-11-04 | Sagami Chem Res Center | 13c-labeled docosahexaenoic acid and its production |
| US5800784A (en) | 1996-07-09 | 1998-09-01 | Horn; Marcus J. | Chemical sample treatment system and cassette, and methods for effecting multistep treatment process |
| US6023659A (en) | 1996-10-10 | 2000-02-08 | Incyte Pharmaceuticals, Inc. | Database system employing protein function hierarchies for viewing biomolecular sequence data |
| US5953727A (en) | 1996-10-10 | 1999-09-14 | Incyte Pharmaceuticals, Inc. | Project-based full-length biomolecular sequence database |
| US5966712A (en) | 1996-12-12 | 1999-10-12 | Incyte Pharmaceuticals, Inc. | Database and system for storing, comparing and displaying genomic information |
| WO1998036095A1 (en) * | 1997-02-14 | 1998-08-20 | George Washington University | An assay for the measurement of dna synthesis rates |
| US5976336A (en) | 1997-04-25 | 1999-11-02 | Caliper Technologies Corp. | Microfluidic devices incorporating improved channel geometries |
| US5910403A (en) | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
| US5926818A (en) | 1997-06-30 | 1999-07-20 | International Business Machines Corporation | Relational database implementation of a multi-dimensional database |
| JP3862366B2 (en) * | 1997-07-01 | 2006-12-27 | 東京瓦斯株式会社 | Liver function diagnostic agent |
| US6001231A (en) | 1997-07-15 | 1999-12-14 | Caliper Technologies Corp. | Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems |
| US5876675A (en) | 1997-08-05 | 1999-03-02 | Caliper Technologies Corp. | Microfluidic devices and systems |
| US5924995A (en) | 1997-11-10 | 1999-07-20 | Meretek Diagnostics | Non-invasive method for the functional assessment of infants and children with an inherited metabolic disorder |
-
2000
- 2000-04-19 WO PCT/US2000/010504 patent/WO2000063683A1/en not_active Ceased
- 2000-04-19 AU AU43624/00A patent/AU774662B2/en not_active Ceased
- 2000-04-19 JP JP2000612736A patent/JP4723725B2/en not_active Expired - Fee Related
- 2000-04-19 CA CA002370749A patent/CA2370749A1/en not_active Abandoned
- 2000-04-19 IL IL14609300A patent/IL146093A0/en not_active IP Right Cessation
- 2000-04-19 EP EP00923511A patent/EP1194768A4/en not_active Withdrawn
- 2000-04-19 EP EP10180277A patent/EP2293056A3/en not_active Withdrawn
-
2004
- 2004-09-30 AU AU2004216642A patent/AU2004216642B2/en not_active Ceased
-
2010
- 2010-06-04 JP JP2010128894A patent/JP2010249831A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0653631A2 (en) * | 1993-11-11 | 1995-05-17 | Ciba-Geigy Ag | Apparatus and method for the electrophoretical separation of mixtures of fluid substances |
| WO1996033405A1 (en) * | 1995-04-17 | 1996-10-24 | Mayo Foundation For Medical Education And Research | Sample preprocessor |
Non-Patent Citations (3)
| Title |
|---|
| FIGEYS D ET AL: "PROTEIN IDENTIFICATION BY SOLID PHASE MICROEXTRACTION-CAPILLARY ZONE ELECTROPHORESIS-MICROELECTROSPRAY-TANDEM MASS SPECTROMETRY", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 14, no. 11, 1996, pages 1579 - 1583, XP001041771, ISSN: 0733-222X * |
| MANN M ET AL: "ERROR-TOLERANT IDENTIFICATION OF PEPTIDES IN SEQUENCE DATABASES BY PEPTIDE SEQUENCE TAGS", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 66, no. 24, 15 December 1994 (1994-12-15), pages 4390 - 4399, XP000573399, ISSN: 0003-2700 * |
| See also references of WO0063683A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000063683A1 (en) | 2000-10-26 |
| EP2293056A2 (en) | 2011-03-09 |
| JP2010249831A (en) | 2010-11-04 |
| AU774662B2 (en) | 2004-07-01 |
| JP2003529044A (en) | 2003-09-30 |
| EP2293056A3 (en) | 2011-06-29 |
| AU2004216642B2 (en) | 2007-05-10 |
| AU4362400A (en) | 2000-11-02 |
| AU2004216642A1 (en) | 2004-10-28 |
| IL146093A0 (en) | 2002-07-25 |
| EP1194768A1 (en) | 2002-04-10 |
| CA2370749A1 (en) | 2000-10-26 |
| JP4723725B2 (en) | 2011-07-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK114797A (en) | Pharmaceuticals for intranasal administration | |
| DE60230406D1 (en) | SYSTEM FOR MEASURING CHROMATIZATION COORDINATES | |
| PL360589A1 (en) | System for local gel administration | |
| FI973360A0 (en) | New dipeptide amidines as thrombin inhibitors | |
| DE69819244D1 (en) | Refrigerant cycle system | |
| CY2013005I2 (en) | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | |
| NO990944L (en) | Controlled-release tablet of alfuzosin hydrochloride | |
| DE69806599D1 (en) | MULTIPLE-FLASHPOINT EXPANSION SYSTEM | |
| IS6079A (en) | System and method for performing in 3D virtualisation and study | |
| EP1221690A4 (en) | DATA DISTRIBUTION SYSTEM | |
| EP1208472A4 (en) | SYSTEM AND METHOD FOR VISUALIZING DATA | |
| NO20006319L (en) | Therapeutic biaryl derivatives | |
| EP1542506A4 (en) | PLATE HOLDER AND SEMICONDUCTOR PRODUCTION SYSTEM | |
| DE10328828A8 (en) | surveying system | |
| DE69724789D1 (en) | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSIN KINASE INHIBITORS | |
| DE60037697D1 (en) | surveying system | |
| ATE322491T1 (en) | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | |
| NO20002273D0 (en) | Procedure for estimating bias for a tracking system | |
| DE69819672D1 (en) | Acoustic location measurement system | |
| EE200300150A (en) | Computer system operation method for performing discrete substructure analysis | |
| DK2295968T3 (en) | Pyrogenicity test for use in automated immunoassay systems | |
| DE50306333D1 (en) | CLEANING SYSTEM WITH BASE STATION | |
| EP0837872A4 (en) | CYTOTOXICITY-BASED GENETIC SELECTION SYSTEM (TOXSEL) | |
| FR2783124B1 (en) | DATA SUPPORT SYSTEM | |
| NO20002149D0 (en) | Procedure for reducing mammalian addiction |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20011029 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20080226 |
|
| 17Q | First examination report despatched |
Effective date: 20080623 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
| 18W | Application withdrawn |
Effective date: 20101108 |