EP1448580A4 - Inhibition, induite par adn d'interference, de l'expression genique d'un antigene nucleaire de proliferation cellulaire (pcna) a l'aide d'un acide nucleique a interference courte (sina) - Google Patents

Inhibition, induite par adn d'interference, de l'expression genique d'un antigene nucleaire de proliferation cellulaire (pcna) a l'aide d'un acide nucleique a interference courte (sina)

Info

Publication number: EP1448580A4
Authority: EP; European Patent Office
Prior art keywords: interference; sina; pcna; nucleic acid; gene expression
Prior art date: 2002-02-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP03716055A

Other languages

German (de)

English (en)

Other versions

EP1448580A2 (fr

Inventor

James Mcswiggen

Bharat Chowrira

Leonid Beigelman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sirna Therapeutics Inc

Original Assignee

Sirna Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-20

Filing date

2003-02-18

Publication date

2005-07-20

2003-02-18 Application filed by Sirna Therapeutics Inc filed Critical Sirna Therapeutics Inc

2004-08-25 Publication of EP1448580A2 publication Critical patent/EP1448580A2/fr

2005-07-20 Publication of EP1448580A4 publication Critical patent/EP1448580A4/fr

Status Withdrawn legal-status Critical Current

Links

108050006400 Cyclin Proteins 0.000 title 1
108010051791 Nuclear Antigens Proteins 0.000 title 1
102000019040 Nuclear Antigens Human genes 0.000 title 1
102000009339 Proliferating Cell Nuclear Antigen Human genes 0.000 title 1
230000004663 cell proliferation Effects 0.000 title 1
230000014509 gene expression Effects 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
108020004707 nucleic acids Proteins 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 title 1
102000039446 nucleic acids Human genes 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/332—Abasic residue
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP03716055A 2002-02-20 2003-02-18 Inhibition, induite par adn d'interference, de l'expression genique d'un antigene nucleaire de proliferation cellulaire (pcna) a l'aide d'un acide nucleique a interference courte (sina) Withdrawn EP1448580A4 (fr)

Applications Claiming Priority (17)

Application Number	Priority Date	Filing Date	Title
US35858002P	2002-02-20	2002-02-20
US358580P		2002-02-20
US36312402P	2002-03-11	2002-03-11
US363124P		2002-03-11
US38678202P	2002-06-06	2002-06-06
US386782P		2002-06-06
US40678402P	2002-08-29	2002-08-29
US406784P		2002-08-29
US40837802P	2002-09-05	2002-09-05
US408378P		2002-09-05
US40929302P	2002-09-09	2002-09-09
US409293P		2002-09-09
US40978502P	2002-09-11	2002-09-11
US409785P		2002-09-11
US44012903P	2003-01-15	2003-01-15
US440129P		2003-01-15
PCT/US2003/004738 WO2003070896A2 (fr)	2002-02-20	2003-02-18	Inhibition, induite par adn d'interference, de l'expression genique d'un antigene nucleaire de proliferation cellulaire (pcna) a l'aide d'un acide nucleique a interference courte (sina)

Publications (2)

Publication Number	Publication Date
EP1448580A2 EP1448580A2 (fr)	2004-08-25
EP1448580A4 true EP1448580A4 (fr)	2005-07-20

Family

ID=27761719

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP03716055A Withdrawn EP1448580A4 (fr)	2002-02-20	2003-02-18	Inhibition, induite par adn d'interference, de l'expression genique d'un antigene nucleaire de proliferation cellulaire (pcna) a l'aide d'un acide nucleique a interference courte (sina)

Country Status (3)

Country	Link
EP (1)	EP1448580A4 (fr)
AU (1)	AU2003219781A1 (fr)
WO (1)	WO2003070896A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050148530A1 (en)	2002-02-20	2005-07-07	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
WO2005078097A2 (fr)	2004-02-10	2005-08-25	Sirna Therapeutics, Inc.	Inhibition induite par l'interference arn de l'expression genetique, a l'aide d'un acide nucleique interferant court multifonctionnel (sina multifonctionnel)
US9994853B2 (en)	2001-05-18	2018-06-12	Sirna Therapeutics, Inc.	Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US7517864B2 (en)	2001-05-18	2009-04-14	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US9181551B2 (en)	2002-02-20	2015-11-10	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9657294B2 (en)	2002-02-20	2017-05-23	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
WO2005045035A2 (fr) *	2003-10-23	2005-05-19	Sirna Therapeutics, Inc.	Inhibition mediee par interference arn de l'expression genique de nogo et du recepteur nogo au moyen d'un petit acide nucleique interferent (sina)
US10508277B2 (en)	2004-05-24	2019-12-17	Sirna Therapeutics, Inc.	Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
WO2008109372A2 (fr) *	2007-03-02	2008-09-12	Mdrna, Inc.	Composés d'acide nucléique permettant d'inhiber l'expression de gène pdgf et utilisations de ceux-ci
WO2011113942A2 (fr) *	2010-03-18	2011-09-22	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Procédé pour la prédiction de la sensibilité à une chimiothérapie
WO2012027206A1 (fr)	2010-08-24	2012-03-01	Merck Sharp & Dohme Corp.	Agents à base d'arni à un seul brin contenant une séquence intercalaire interne ne correspondant pas à un acide nucléique
WO2012058210A1 (fr)	2010-10-29	2012-05-03	Merck Sharp & Dohme Corp.	INHIBITION FACILITÉE PAR L'INTERFÉRENCE D'ARN DE L'EXPRESSION D'UN GÈNE AU MOYEN D'ACIDES NUCLÉIQUES INTERFÉRENTS COURTS (siNA)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001083740A2 (fr) *	2000-05-04	2001-11-08	Avi Biopharma, Inc.	Composition anti-sens a region d'epissage et methode associee

2003
- 2003-02-18 WO PCT/US2003/004738 patent/WO2003070896A2/fr not_active Ceased
- 2003-02-18 AU AU2003219781A patent/AU2003219781A1/en not_active Abandoned
- 2003-02-18 EP EP03716055A patent/EP1448580A4/fr not_active Withdrawn

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001083740A2 (fr) *	2000-05-04	2001-11-08	Avi Biopharma, Inc.	Composition anti-sens a region d'epissage et methode associee

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BASS B L: "RNA interference: the short answer", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 411, 24 May 2001 (2001-05-24), pages 428 - 429, XP002239989, ISSN: 0028-0836 *
ELBASHIR SAYDA M ET AL: "RNA interference is mediated by 21- and 22-nucleotide RNAs", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, NEW YORK, US, vol. 15, no. 2, 15 January 2001 (2001-01-15), pages 188 - 200, XP002204651, ISSN: 0890-9369 *
JASKULSKI D ET AL: "INHIBITION OF CELLULAR PROLIFERATION BY ANTISENSE OLIGODEOXYNUCLEOTIDES TO PCNA CYCLIN", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 240, 10 June 1988 (1988-06-10), pages 1544 - 1546, XP002039132, ISSN: 0036-8075 *

Also Published As

Publication number	Publication date
AU2003219781A8 (en)	2003-09-09
WO2003070896A3 (fr)	2004-03-04
AU2003219781A1 (en)	2003-09-09
WO2003070896A2 (fr)	2003-08-28
EP1448580A2 (fr)	2004-08-25

Legal Events

Date	Code	Title	Description
2004-07-10	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2004-08-25	17P	Request for examination filed	Effective date: 20040429
2004-08-25	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR
2004-08-25	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO
2005-07-20	A4	Supplementary search report drawn up and despatched	Effective date: 20050603
2005-07-20	RIC1	Information provided on ipc code assigned before grant	Ipc: 7C 07H 21/04 B Ipc: 7C 07H 21/02 B Ipc: 7C 12N 15/63 B Ipc: 7C 12P 19/34 B Ipc: 7C 12Q 1/68 A
2009-01-23	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2009-02-25	18D	Application deemed to be withdrawn	Effective date: 20080902

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