EP1539997A4 - High-throughput assay of hematopoietic stem and progenitor cell proliferation - Google Patents

High-throughput assay of hematopoietic stem and progenitor cell proliferation

Info

Publication number
EP1539997A4
EP1539997A4 EP03793209A EP03793209A EP1539997A4 EP 1539997 A4 EP1539997 A4 EP 1539997A4 EP 03793209 A EP03793209 A EP 03793209A EP 03793209 A EP03793209 A EP 03793209A EP 1539997 A4 EP1539997 A4 EP 1539997A4
Authority
EP
European Patent Office
Prior art keywords
cell proliferation
hematopoietic stem
progenitor cell
throughput assay
throughput
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03793209A
Other languages
German (de)
French (fr)
Other versions
EP1539997A2 (en
Inventor
Ivan N Rich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rich Ivan N
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1539997A2 publication Critical patent/EP1539997A2/en
Publication of EP1539997A4 publication Critical patent/EP1539997A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP03793209A 2002-08-21 2003-08-21 High-throughput assay of hematopoietic stem and progenitor cell proliferation Withdrawn EP1539997A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40497202P 2002-08-21 2002-08-21
US404972P 2002-08-21
PCT/US2003/026167 WO2004018996A2 (en) 2002-08-21 2003-08-21 High-throughput assay of hematopoietic stem and progenitor cell proliferation

Publications (2)

Publication Number Publication Date
EP1539997A2 EP1539997A2 (en) 2005-06-15
EP1539997A4 true EP1539997A4 (en) 2007-04-25

Family

ID=31946791

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03793209A Withdrawn EP1539997A4 (en) 2002-08-21 2003-08-21 High-throughput assay of hematopoietic stem and progenitor cell proliferation

Country Status (4)

Country Link
EP (1) EP1539997A4 (en)
AU (1) AU2003258319B2 (en)
CA (1) CA2496251A1 (en)
WO (1) WO2004018996A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7989178B2 (en) 2001-01-29 2011-08-02 Hemogenix, Inc. Colony assay miniaturization with enumeration output
EP1364197B1 (en) 2001-01-29 2010-04-14 Ivan N. Rich ATP-based assay for the determination of the proliferation status of hematopoietic stem and progenitor cells
US7666615B2 (en) 2001-01-29 2010-02-23 Hemogenix, Inc. High-throughput assay of hematopoietic stem and progenitor cell proliferation
US7354730B2 (en) 2002-01-29 2008-04-08 Hemogenix, Inc. High-throughput assay of hematopoietic stem and progenitor cell proliferation
CN103827667B (en) * 2011-09-13 2016-07-13 巴斯夫欧洲公司 Tools and Methods for Assessing Hematopoietic Toxicity
EP4417210A1 (en) * 2017-03-15 2024-08-21 Orca Biosystems, Inc. Compositions and methods for hematopoietic stem cell transplants
WO2021013669A1 (en) * 2019-07-24 2021-01-28 Miltenyi Biotec B.V. & Co. KG Assay for identifing colony-forming cells
CN115927169B (en) * 2022-10-11 2023-08-11 再造再生医学科技(杭州)有限公司 For amplification of CD34 + Culture medium for hematopoietic stem cells and in vitro amplification of CD34 + Methods of hematopoietic stem cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998021313A1 (en) * 1996-11-08 1998-05-22 Otsuka Pharmaceutical Co., Ltd. Method for culturing hematopoietic stem cells
WO2003004995A2 (en) * 2001-01-29 2003-01-16 Rich Ivan N High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283179A (en) * 1990-09-10 1994-02-01 Promega Corporation Luciferase assay method
US5733541A (en) * 1995-04-21 1998-03-31 The Regent Of The University Of Michigan Hematopoietic cells: compositions and methods
US5854010A (en) * 1997-03-10 1998-12-29 Denison; Michael S. Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin and TCDD-like compounds and novel recombinant cell line useful therefor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998021313A1 (en) * 1996-11-08 1998-05-22 Otsuka Pharmaceutical Co., Ltd. Method for culturing hematopoietic stem cells
WO2003004995A2 (en) * 2001-01-29 2003-01-16 Rich Ivan N High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
BALLMAIER M ET AL: "C-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, US, vol. 97, no. 1, 2001, pages 139 - 146, XP002980535, ISSN: 0006-4971 *
BRADLEY T R ET AL: "THE EFFECT OF OXYGEN TENSION ON HAEMOPOIETIC AND FIBROBLAST CELL PROLIFERATION IN VITRO", JOURNAL OF CELLULAR PHYSIOLOGY, LISS, NEW YORK, NY, US, vol. 97, no. 3 PT 2 SUPPL1, December 1978 (1978-12-01), pages 517 - 522, XP009080296, ISSN: 0021-9541 *
BULANOVA E G ET AL: "Bioluminescent assay for human lymphocyte blast transformation", IMMUNOLOGY LETTERS, vol. 46, no. 1-2, 1995, pages 153 - 155, XP009048894, ISSN: 0165-2478 *
CROUCH S P M ET AL: "THE USE OF ATP BIOLUMINESCENCE AS A MEASURE OF CELL PROLIFERATION AND CYTOTOXICITY", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 160, no. 1, 1993, pages 81 - 88, XP002059949, ISSN: 0022-1759 *
DATABASE WPI Week 1998, Derwent World Patents Index; AN 1998-297920, XP002424190, "Culture method kit haematopoietic stem cell culture cell adhesive culture vessel presence stem cell growth factor" *
FUJISAKI T ET AL: "Rapid differentiation of a rare subset of adult human lin(-)CD34(-)CD38(-) cells stimulated by multiple growth factors in vitro.", BLOOD 15 SEP 1999, vol. 94, no. 6, 15 September 1999 (1999-09-15), pages 1926 - 1932, XP002424141, ISSN: 0006-4971 *
GABBIANELLI M ET AL: "Multi-level effects of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors.", BLOOD 1 SEP 1995, vol. 86, no. 5, 1 September 1995 (1995-09-01), pages 1661 - 1670, XP002424142, ISSN: 0006-4971 *
KATAYAMA YOSHIO ET AL: "Replating potential of colony-forming units of granulocytes/macrophages (CFU-GM) expanded ex vivo by stem cell factor, interleukin (IL)-3, IL-6, granulocyte colony-stimulating factor, erythropoietin with or without thrombopoietin", INTERNATIONAL JOURNAL OF HEMATOLOGY, vol. 68, no. 2, August 1998 (1998-08-01), pages 157 - 168, XP009048892, ISSN: 0925-5710 *
LEMOLI ROBERTO M ET AL: "Interleukin-9 stimulates the proliferation of human myeloid leukemic cells", BLOOD, vol. 87, no. 9, 1996, pages 3852 - 3859, ISSN: 0006-4971 *
RICH I N ET AL: "THE EFFECT OF REDUCED OXYGEN TENSION ON COLONY FORMATION OF ERYTHROPOIETIC CELLS IN VITRO", BRITISH JOURNAL OF HAEMATOLOGY, OXFORD, GB, vol. 52, no. 4, December 1982 (1982-12-01), pages 579 - 588, XP009080297, ISSN: 0007-1048 *
RICH IVAN N ET AL: "HALO - A Multifunctional Colony-Forming-Based Assay Platform for Drug Development and Basic and Clinical Research.", BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), & 44TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY; PHILADELPHIA, PA, USA; DECEMBER 06-10, 2002, pages Abstract No. 2434, XP009048843, ISSN: 0006-4971 *
SHIOHARA MASAAKI ET AL: "24-Oxo metabolites of vitamin D3 analogues: Disassociation of their prominent antileukemic effects from their lack of calcium modulation", CANCER RESEARCH, vol. 61, no. 8, 15 April 2001 (2001-04-15), pages 3361 - 3368, ISSN: 0008-5472 *
SOTTONG P R ET AL: "Measurement of T-lymphocyte responses in whole-blood cultures using newly synthesized DNA and ATP.", CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY. MAR 2000, vol. 7, no. 2, March 2000 (2000-03-01), pages 307 - 311, XP002331295, ISSN: 1071-412X *

Also Published As

Publication number Publication date
WO2004018996A2 (en) 2004-03-04
AU2003258319A1 (en) 2004-03-11
EP1539997A2 (en) 2005-06-15
AU2003258319B2 (en) 2009-09-17
CA2496251A1 (en) 2004-03-04
WO2004018996A3 (en) 2004-06-10

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