EP1549616A4 - ORGANIC ACID SALT OF AMLODIPINE - Google Patents

ORGANIC ACID SALT OF AMLODIPINE

Info

Publication number
EP1549616A4
EP1549616A4 EP03771480A EP03771480A EP1549616A4 EP 1549616 A4 EP1549616 A4 EP 1549616A4 EP 03771480 A EP03771480 A EP 03771480A EP 03771480 A EP03771480 A EP 03771480A EP 1549616 A4 EP1549616 A4 EP 1549616A4
Authority
EP
European Patent Office
Prior art keywords
amlodipine
organic acid
acid salt
salt
organic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03771480A
Other languages
German (de)
French (fr)
Other versions
EP1549616A1 (en
Inventor
Seong-Hwan Cho
Yong-Sik Youn
Yun-Taek Jung
Choong-Sil Park
Hyuk-Koo Lee
Kwang-Hyeg Lee
Eun-Ju Jeong
Young-Hoon Kim
Jun-Hee Cheon
Hae-Tak Jin
Sung-Hak Lee
Sung-Hak Jung
Dong-Kwon Lim
Kyu-Jeong Yeon
Yun-Cheul Kim
Kyung-Mi Park
Hyun-Suk Kang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CJ Corp
Original Assignee
CJ Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CJ Corp filed Critical CJ Corp
Publication of EP1549616A1 publication Critical patent/EP1549616A1/en
Publication of EP1549616A4 publication Critical patent/EP1549616A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
EP03771480A 2002-07-30 2003-07-30 ORGANIC ACID SALT OF AMLODIPINE Withdrawn EP1549616A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR2002044856 2002-07-30
KR1020020044856A KR20040011751A (en) 2002-07-30 2002-07-30 An organic acid salt of amlodipine
PCT/KR2003/001522 WO2004011432A1 (en) 2002-07-30 2003-07-30 Organic acid salt of amlodipine

Publications (2)

Publication Number Publication Date
EP1549616A1 EP1549616A1 (en) 2005-07-06
EP1549616A4 true EP1549616A4 (en) 2006-10-18

Family

ID=31185754

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03771480A Withdrawn EP1549616A4 (en) 2002-07-30 2003-07-30 ORGANIC ACID SALT OF AMLODIPINE

Country Status (8)

Country Link
EP (1) EP1549616A4 (en)
JP (1) JP2005538103A (en)
KR (1) KR20040011751A (en)
CN (1) CN1678583A (en)
AU (1) AU2003247208A1 (en)
BR (1) BR0313076A (en)
MX (1) MXPA05001241A (en)
WO (1) WO2004011432A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100913791B1 (en) * 2006-07-21 2009-08-26 한미약품 주식회사 (S)-(-)-amlodipine camsylate or a hydrate thereof and a pharmaceutical composition containing the same
KR100821688B1 (en) 2006-08-10 2008-04-11 (주)유케이케미팜 Method for isolating stereoisomers of amlodipine rasemide, hydrophilic drugs and preparation methods thereof
ES2607806T5 (en) 2010-02-12 2024-10-07 Pfizer Salts and polymorphs of 8-fluoro-2-{4-[(methylamino}methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
CN101972254B (en) * 2010-09-28 2012-05-30 石药集团欧意药业有限公司 Solid preparation of levamlodipine or pharmaceutically acceptable salt thereof and preparation method thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (en) * 1982-03-11 1991-12-09 Pfizer CHANGES FOR THE PREPARATION FOR THE PREPARATION OF 2-Amino-CO-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-4-Methyl-2-D-Hydroxy
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
GB8710493D0 (en) * 1987-05-02 1987-06-03 Pfizer Ltd Dihydropyridines
US6057344A (en) * 1991-11-26 2000-05-02 Sepracor, Inc. Methods for treating hypertension, and angina using optically pure (-) amlodipine
KR100452491B1 (en) * 2001-03-29 2004-10-12 한미약품 주식회사 A novel crystalline amlodipine camsylate and a preparing method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOSEFSSON M ET AL: "Chiral ion-pair chromatographic separation of two dihydropyridines with camphorsulfonic acids on porous graphitic carbon", 28 October 1994, JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, PAGE(S) 23-27, ISSN: 0021-9673, XP004174362 *

Also Published As

Publication number Publication date
JP2005538103A (en) 2005-12-15
KR20040011751A (en) 2004-02-11
WO2004011432A1 (en) 2004-02-05
BR0313076A (en) 2005-06-28
EP1549616A1 (en) 2005-07-06
MXPA05001241A (en) 2005-06-08
CN1678583A (en) 2005-10-05
AU2003247208A1 (en) 2004-02-16

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20050301

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20060915

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 9/12 20060101ALI20060911BHEP

Ipc: A61K 31/4422 20060101ALI20060911BHEP

Ipc: C07D 211/86 20060101ALI20060911BHEP

Ipc: C07D 211/90 20060101AFI20060911BHEP

RIN1 Information on inventor provided before grant (corrected)

Inventor name: KANG, HYUN-SUK,102-1307, SEOCHO HYUNDAI APT

Inventor name: PARK, KYUNG-MI,110-506, HANGANG HYUNDAI APT

Inventor name: KIM, YUN-CHEUL,202368-2 BULKWANG 3-DONG

Inventor name: YEON, KYU-JEONG,126-801, YEONWONMAUL SAMHOBY APT

Inventor name: LIM, DONG-KWON,201-1804, CCACHIMAUL

Inventor name: JUNG, SUNG-HAK,47-402, JOOGONG APT

Inventor name: LEE, SUNG-HAK,103-1004, HYUNDAI APT

Inventor name: JIN, HAE-TAK,105-1406, HYUNDAI APT

Inventor name: CHEON, JUN-HEE,149-904, HWANGGOLMAUL

Inventor name: KIM, YOUNG-HOON,108-309, HYUNDAI APT

Inventor name: JEONG, EUN-JU,101-1102, MOCKHWA APT

Inventor name: LEE, KWANG-HYEG,702-402, MOCKRYUNMAUL HWASEONG-V

Inventor name: LEE, HYUK-KOO,101-902, LIFE APT

Inventor name: PARK, CHOONG-SIL,D-203, HEIGHTS VILLA

Inventor name: JUNG, YUN-TAEK,102-902, HALLA APT

Inventor name: YOUN, YONG-SIK,105-104 BYCOKSAN APARTMENT

Inventor name: CHO, SEONG-HWAN,721-602, HYUNDAI APT

RIN1 Information on inventor provided before grant (corrected)

Inventor name: KANG, HYUN-SUK,102-1307, SEOCHO HYUNDAI APT

Inventor name: PARK, KYUNG-MI,110-506, HANGANG HYUNDAI APT

Inventor name: KIM, YUN-CHEUL,202368-2 BULKWANG 3-DONG

Inventor name: YEON, KYU-JEONG,126-801, YEONWONMAUL SAMHOBY APT

Inventor name: LIM, DONG-KWON,201-1804, CCACHIMAUL

Inventor name: JUNG, SUNG-HAK,47-402, JOOGONG APT

Inventor name: LEE, SUNG-HAK,103-1004, HYUNDAI APT

Inventor name: JIN, HAE-TAK,105-1406, HYUNDAI APT

Inventor name: CHEON, JUN-HEE,149-904, HWANGGOLMAUL

Inventor name: KIM, YOUNG-HOON,108-309, HYUNDAI APT

Inventor name: JEONG, EUN-JU,101-1102, MOCKHWA APT

Inventor name: LEE, KWANG-HYEG,702-402, MOCKRYUNMAUL HWASEONG-V

Inventor name: LEE, HYUK-KOO,101-902, LIFE APT

Inventor name: PARK, CHOONG-SIL,D-203, HEIGHTS VILLA

Inventor name: JUNG, YUN-TAEK,102-902, HALLA APT

Inventor name: YOUN, YONG-SIK,105-104 BYCOKSAN APARTMENT

Inventor name: CHO, SEONG-HWAN,721-602, HYUNDAI APT

17Q First examination report despatched

Effective date: 20071114

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20080326