EP1551973A4 - NOVEL GDF-9 AND GDF-9B (BMP-15) SEQUENCES INTENDED TO MODIFY OVARIAN FUNCTION AND OVULATION SPEED IN MAMMALS - Google Patents

NOVEL GDF-9 AND GDF-9B (BMP-15) SEQUENCES INTENDED TO MODIFY OVARIAN FUNCTION AND OVULATION SPEED IN MAMMALS

Info

Publication number
EP1551973A4
EP1551973A4 EP03723538A EP03723538A EP1551973A4 EP 1551973 A4 EP1551973 A4 EP 1551973A4 EP 03723538 A EP03723538 A EP 03723538A EP 03723538 A EP03723538 A EP 03723538A EP 1551973 A4 EP1551973 A4 EP 1551973A4
Authority
EP
European Patent Office
Prior art keywords
gdf
ovulation
bmp
mammals
modify
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03723538A
Other languages
German (de)
French (fr)
Other versions
EP1551973A1 (en
Inventor
George H Davis
Susan M Galloway
Scott M Gregan
James P Hanrahan
Jennifer L Juengel
Kenneth P Mcnatty
Philippe Mulsant
Richard Powell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanrahan James Patrick
MULSANT, PHILIPPE
National University of Ireland Galway NUI
New Zealand Institute for Bioeconomy Science Ltd
Original Assignee
National University of Ireland Galway NUI
National University of Ireland
Ovita Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University of Ireland Galway NUI, National University of Ireland, Ovita Ltd filed Critical National University of Ireland Galway NUI
Publication of EP1551973A1 publication Critical patent/EP1551973A1/en
Publication of EP1551973A4 publication Critical patent/EP1551973A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP03723538A 2002-05-30 2003-05-30 NOVEL GDF-9 AND GDF-9B (BMP-15) SEQUENCES INTENDED TO MODIFY OVARIAN FUNCTION AND OVULATION SPEED IN MAMMALS Withdrawn EP1551973A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NZ51933002A NZ519330A (en) 2002-05-30 2002-05-30 New sequences for altering mammalian ovarian function and ovulation rate
NZ51933002 2002-05-30
PCT/NZ2003/000109 WO2003102199A1 (en) 2002-05-30 2003-05-30 New gdf-9 and gdf-9b (bmp-15) sequences for altering mammalian ovarian function and ovulation rate

Publications (2)

Publication Number Publication Date
EP1551973A1 EP1551973A1 (en) 2005-07-13
EP1551973A4 true EP1551973A4 (en) 2006-06-07

Family

ID=29707820

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03723538A Withdrawn EP1551973A4 (en) 2002-05-30 2003-05-30 NOVEL GDF-9 AND GDF-9B (BMP-15) SEQUENCES INTENDED TO MODIFY OVARIAN FUNCTION AND OVULATION SPEED IN MAMMALS

Country Status (7)

Country Link
EP (1) EP1551973A4 (en)
JP (1) JP2006510345A (en)
AU (1) AU2003235525B2 (en)
BR (1) BR0311465A (en)
CA (1) CA2490051A1 (en)
NZ (1) NZ519330A (en)
WO (1) WO2003102199A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0518900A2 (en) * 2004-12-02 2008-12-16 Agres Ltd ovulation modulation
JP2008521891A (en) * 2004-12-02 2008-06-26 アグリサーチ・リミテッド Regulation of ovulation
WO2006130022A1 (en) * 2005-05-30 2006-12-07 Agresearch Limited Modulation of ovulation by agonists and antagonists of bmprii
ATE487800T1 (en) * 2005-09-13 2010-11-15 Neocodex S L METHOD FOR IN VITRO DETECTION OF A PRESIDENCY TO DEVELOP CHANGES IN OVARIAN FUNCTION
ES2338960B1 (en) * 2007-11-23 2011-04-19 Carnes Oviaragon S.C.L. PROCEDURE FOR IMPROVING PRODUCTIVITY IN SHEEP.
BRPI0706173C1 (en) * 2007-11-23 2011-02-22 Brasil Pesquisa Agropec method for mass identification of animals with increased prolificacy
WO2014018404A1 (en) * 2012-07-21 2014-01-30 Baylor College Of Medicine Gdf9:bmp15 heterodimers for enhancing fertility
CN104774836A (en) * 2015-04-15 2015-07-15 兰州大学 Polygene pyramiding early-breeding method for raising litter size of sheep
EP3577457A4 (en) * 2017-02-01 2021-01-20 Robert Bruce Gilchrist GROWTH FACTORS SECRETED BY GAMETEN
CN112601756A (en) * 2018-05-09 2021-04-02 莫拿什大学 Agent and method for enhancing fertility
CN116649285A (en) * 2023-05-12 2023-08-29 上海市老年医学中心 Construction method and application of a mouse model of premature ovarian insufficiency

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030617A (en) * 1993-01-12 2000-02-29 The Johns Hopkins University School Of Medicine Use of growth differentiation factor-9 (GDF-9) to inhibit oocyte maturation
EP1181041A2 (en) * 1999-04-30 2002-02-27 Curis, Inc. Morphogen-induced enhancement of fertility
NZ500844A (en) * 2000-05-05 2003-06-30 Agres Ltd Nucleotide sequences (mutated GDF-9B polypeptides) involved in increasing and decreasing mammalian ovulation rate
NZ502796A (en) * 2000-06-15 2003-02-28 Agres Ltd Nucleotide and amino acid sequences of oocyte factors related to GDF-9B or GDF-9

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BODENSTEINER K J ET AL: "Molecular cloning of the ovine growth/differentiation factor-9 gene and expression of growth/differentiation factor-9 in ovine and bovine ovaries", BIOLOGY OF REPRODUCTION, SOCIETY FOR THE STUDY OF REPRODUCTION, CHAMPAIGN, IL, US, vol. 60, no. 2, February 1999 (1999-02-01), pages 381 - 386, XP002192638, ISSN: 0006-3363 *
DATABASE EMBL [online] 4 August 1998 (1998-08-04), "Ovis aries growth differentiation factor-9 gene, complete cds.", XP002358265, retrieved from EBI accession no. EM_PRO:AF078545 Database accession no. AF078545 *
GALLOWAY SUSAN M ET AL: "Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner", NATURE GENETICS, NATURE AMERICA, NEW YORK, US, vol. 25, no. 3, July 2000 (2000-07-01), pages 279 - 283, XP002188991, ISSN: 1061-4036 *
HANRAHAN J P: "Evidence for single gene effects on ovulation rate in the Cambridge and Beclare breeds", [INRA COLLOQUIA; MAJOR GENES FOR REPRODUCTION IN SHEEP] INRA (INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE) {A}, 147 RUE DE L'UNIVERSITE, 75007 PARIS, FRANCE SERIES : COLLOQUES DE L'INRA (ISSN 0293-1915), 1991, & 2ND INTERNATIONAL WORKSHOP; TOULOUSE, FRANCE; JULY 16-18, 1990, pages 93 - 102, XP008056997, ISSN: 2-7380-0337-0 *
HANRAHAN JAMES P ET AL: "Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries).", BIOLOGY OF REPRODUCTION, vol. 70, no. 4, April 2004 (2004-04-01), pages 900 - 909, XP008056979, ISSN: 0006-3363 *
See also references of WO03102199A1 *

Also Published As

Publication number Publication date
WO2003102199A1 (en) 2003-12-11
BR0311465A (en) 2005-04-05
AU2003235525B2 (en) 2008-09-11
JP2006510345A (en) 2006-03-30
EP1551973A1 (en) 2005-07-13
NZ519330A (en) 2004-12-24
CA2490051A1 (en) 2003-12-11
AU2003235525A1 (en) 2003-12-19

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20041222

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: NATIONAL UNIVERSITY OF IRELAND, GALWAY

Owner name: MULSANT, PHILIPPE

Owner name: HANRAHAN, JAMES PATRICK

Owner name: OVITA LIMITED

A4 Supplementary search report drawn up and despatched

Effective date: 20060504

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: NATIONAL UNIVERSITY OF IRELAND, GALWAY

Owner name: MULSANT, PHILIPPE

Owner name: HANRAHAN, JAMES PATRICK

Owner name: AGRESEARCH LIMITED

17Q First examination report despatched

Effective date: 20070719

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20071130