EP1570073A4 - Detection of molecular interaction by reactivation of an auto-inhibited responder (rair) - Google Patents

Detection of molecular interaction by reactivation of an auto-inhibited responder (rair)

Info

Publication number: EP1570073A4
Authority: EP; European Patent Office
Prior art keywords: rair; reactivation; auto; detection; molecular interaction
Prior art date: 2002-02-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP03713528A

Other languages

German (de)

French (fr)

Other versions

EP1570073A2 (en

Inventor

Robert R Balint

Jeng-Horng Her

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Humanigen Inc

Original Assignee

Kalobios Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-14

Filing date

2003-02-14

Publication date

2006-01-18

2002-02-14 Priority claimed from US10/076,845 external-priority patent/US20030157579A1/en

2002-07-29 Priority claimed from US10/208,730 external-priority patent/US7335478B2/en

2003-02-14 Application filed by Kalobios Inc filed Critical Kalobios Inc

2005-09-07 Publication of EP1570073A2 publication Critical patent/EP1570073A2/en

2006-01-18 Publication of EP1570073A4 publication Critical patent/EP1570073A4/en

Status Withdrawn legal-status Critical Current

Links

238000001514 detection method Methods 0.000 title 1
230000004001 molecular interaction Effects 0.000 title 1
230000007420 reactivation Effects 0.000 title 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Organic Chemistry (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Food Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Cell Biology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP03713528A 2002-02-14 2003-02-14 Detection of molecular interaction by reactivation of an auto-inhibited responder (rair) Withdrawn EP1570073A4 (en)

Applications Claiming Priority (11)

Application Number	Priority Date	Filing Date	Title
US10/076,845 US20030157579A1 (en)	2002-02-14	2002-02-14	Molecular sensors activated by disinhibition
US37380202P	2002-04-18	2002-04-18
US37376502P	2002-04-18	2002-04-18
US373765P		2002-04-18
US373802P		2002-04-18
US37971802P	2002-05-10	2002-05-10
US379718P		2002-05-10
US208730		2002-07-29
US10/208,730 US7335478B2 (en)	2002-04-18	2002-07-29	Reactivation-based molecular interaction sensors
PCT/US2003/004925 WO2003068945A2 (en)	2002-02-14	2003-02-14	Detection of molecular interaction by reactivation of an auto-inhibited responder (rair)
US76845		2008-06-30

Publications (2)

Publication Number	Publication Date
EP1570073A2 EP1570073A2 (en)	2005-09-07
EP1570073A4 true EP1570073A4 (en)	2006-01-18

Family

ID=27739444

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP03713528A Withdrawn EP1570073A4 (en)	2002-02-14	2003-02-14	Detection of molecular interaction by reactivation of an auto-inhibited responder (rair)

Country Status (3)

Country	Link
EP (1)	EP1570073A4 (en)
AU (1)	AU2003217575A1 (en)
WO (1)	WO2003068945A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20140178895A1 (en) *	2011-03-23	2014-06-26	Saurabh Rajendra Nirantar	Recombinant protein biosensors and a method for detecting the presence of an analyte molecule
US20170315114A1 (en) *	2014-10-27	2017-11-02	The University Of Queensland	Bimolecular autoinhibited biosensor
EP3541935A4 (en) *	2016-11-16	2020-09-16	Universal Biosensors, Pty. Ltd.	Cleavage event transduction methods and products

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6342345B1 (en) *	1997-04-02	2002-01-29	The Board Of Trustees Of The Leland Stanford Junior University	Detection of molecular interactions by reporter subunit complementation

2003
- 2003-02-14 EP EP03713528A patent/EP1570073A4/en not_active Withdrawn
- 2003-02-14 WO PCT/US2003/004925 patent/WO2003068945A2/en not_active Ceased
- 2003-02-14 AU AU2003217575A patent/AU2003217575A1/en not_active Abandoned

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WEHRMAN T ET AL: "Protein-protein interactions monitored in mammalian cells via complementation of beta-lactamase enzyme fragments", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 99, no. 6, 19 March 2002 (2002-03-19), pages 3469 - 3474, XP002254024, ISSN: 0027-8424 *

Also Published As

Publication number	Publication date
AU2003217575A8 (en)	2003-09-04
WO2003068945A2 (en)	2003-08-21
WO2003068945A3 (en)	2005-07-14
EP1570073A2 (en)	2005-09-07
AU2003217575A1 (en)	2003-09-04

Legal Events

Date	Code	Title	Description
2005-07-22	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2005-09-07	17P	Request for examination filed	Effective date: 20040914
2005-09-07	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR
2005-09-07	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO
2006-01-18	A4	Supplementary search report drawn up and despatched	Effective date: 20051201
2007-04-11	17Q	First examination report despatched	Effective date: 20070307
2009-08-26	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: KALOBIOS PHARMACEUTICALS, INC.
2010-04-23	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2011-02-04	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2011-03-09	18D	Application deemed to be withdrawn	Effective date: 20100914

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