EP1578996A4 - COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING TUMORS - Google Patents

COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING TUMORS

Info

Publication number
EP1578996A4
EP1578996A4 EP03813488A EP03813488A EP1578996A4 EP 1578996 A4 EP1578996 A4 EP 1578996A4 EP 03813488 A EP03813488 A EP 03813488A EP 03813488 A EP03813488 A EP 03813488A EP 1578996 A4 EP1578996 A4 EP 1578996A4
Authority
EP
European Patent Office
Prior art keywords
diagnosing
compositions
methods
treating tumors
tumors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03813488A
Other languages
German (de)
French (fr)
Other versions
EP1578996A2 (en
Inventor
Thomas D Wu
Yan Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of EP1578996A2 publication Critical patent/EP1578996A2/en
Publication of EP1578996A4 publication Critical patent/EP1578996A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP03813488A 2002-10-18 2003-10-15 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING TUMORS Withdrawn EP1578996A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41898802P 2002-10-18 2002-10-18
US418988P 2002-10-18
PCT/US2003/029126 WO2004060270A2 (en) 2002-10-18 2003-10-15 Compositions and methods for the diagnosis and treatment of tumor

Publications (2)

Publication Number Publication Date
EP1578996A2 EP1578996A2 (en) 2005-09-28
EP1578996A4 true EP1578996A4 (en) 2007-12-19

Family

ID=32712943

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03813488A Withdrawn EP1578996A4 (en) 2002-10-18 2003-10-15 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING TUMORS

Country Status (5)

Country Link
EP (1) EP1578996A4 (en)
JP (1) JP2006516192A (en)
AU (1) AU2003303144A1 (en)
CA (1) CA2503043A1 (en)
WO (1) WO2004060270A2 (en)

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WO2003065006A2 (en) * 2002-01-31 2003-08-07 Millennium Pharmaceuticals, Inc. Methods and compositions for treating cancer
AU2003226131A1 (en) 2002-03-28 2003-10-13 Bristol-Myers Squibb Company Novel human cell surface protein with immunoglobulin folds, bgs-19
WO2003091402A2 (en) * 2002-04-23 2003-11-06 University Of Georgia Research Foundation, Inc. N-ACETYLGLUCOSAMINYLTRANSFERASE Vb CODING SEQUENCE, RECOMBINANT CELLS AND METHODS
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
JP2005230011A (en) * 2004-02-20 2005-09-02 Samsung Electronics Co Ltd Breast cancer-related protein, gene encoding the same, and protein and diagnostic method for breast cancer using the gene
EP2319925B1 (en) 2004-08-16 2018-07-25 Quark Pharmaceuticals, Inc. Therapeutic uses of inhibitors of RTP801
GB0422211D0 (en) * 2004-10-06 2004-11-03 Randox Lab Ltd Method
US20080145369A1 (en) * 2004-10-13 2008-06-19 Ginette Serrero Autocrine Growth Factor Receptors and Methods
JP2007008844A (en) * 2005-06-29 2007-01-18 Nippon Flour Mills Co Ltd Monoclonal antibody specifically reacting with septin 2 protein, hybridoma producing the same, cancer detection method and cancer detection kit
NL2000439C2 (en) 2006-01-20 2009-03-16 Quark Biotech Therapeutic applications of inhibitors of RTP801.
US20070237713A1 (en) 2006-04-04 2007-10-11 Fan Rong A PCan065 Antibody Compositions and Methods of Use
WO2008054534A2 (en) 2006-05-11 2008-05-08 Quark Pharmaceuticals, Inc. Screening systems utilizing rtp801
CN103424541B (en) * 2006-05-18 2018-01-30 分子压型学会股份有限公司 It is determined that the system and method intervened for the personalized medicine of symptom
WO2007141796A2 (en) 2006-06-09 2007-12-13 Quark Pharmaceuticals, Inc. Therapeutic uses of inhibitors of rtp801l
US7872119B2 (en) 2007-02-26 2011-01-18 Quark Pharmaceuticals, Inc. Inhibitors of RTP801 and their use in disease treatment
WO2008148072A2 (en) * 2007-05-24 2008-12-04 The Brigham And Women's Hospital, Inc. Disease-associated genetic variations and methods for obtaining and using same
US8614311B2 (en) 2007-12-12 2013-12-24 Quark Pharmaceuticals, Inc. RTP801L siRNA compounds and methods of use thereof
EP2334790A1 (en) * 2008-08-27 2011-06-22 Oncotherapy Science, Inc. Pancreatic cancer related gene ttll4
SMT202300421T1 (en) 2009-02-20 2024-01-10 Astellas Pharma Inc Methods and compositions for diagnosis and treatment of cancer
DK3305813T3 (en) 2009-11-11 2020-04-20 Astellas Pharma Inc ANTIBODIES SPECIFIC TO CLAUDIN 6 (CLDN6)
WO2011150400A1 (en) * 2010-05-28 2011-12-01 New York Blood Center, Inc. Nuclear scaffold protein stip/tfip11 target for cancer therapy
EP2404936A1 (en) 2010-07-06 2012-01-11 Ganymed Pharmaceuticals AG Cancer therapy using CLDN6 target-directed antibodies in vivo
ES2989943T3 (en) 2011-05-13 2024-11-28 Astellas Pharma Inc Antibodies for the treatment of cancer expressing Claudin 6
DK2928921T3 (en) 2012-12-05 2021-04-19 Novartis Ag COMPOSITIONS AND PROCEDURES FOR ANTIBODIES TARGETED EPO
EP3388834B1 (en) * 2013-03-15 2020-04-15 Translate Bio, Inc. Synergistic enhancement of the delivery of nucleic acids via blended formulations
WO2015014376A1 (en) 2013-07-31 2015-02-05 Biontech Ag Diagnosis and therapy of cancer involving cancer stem cells
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN107922975B (en) 2015-08-12 2022-06-28 诺华股份有限公司 Methods of treating eye disorders
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
MX2019014027A (en) 2017-05-24 2020-08-03 Thoeris Gmbh Use of glutamine synthetase for treating hyperammonemia.
US12274733B2 (en) 2018-09-28 2025-04-15 President And Fellows Of Harvard College Cellular reprogramming to reverse aging and promote organ and tissue regeneration
IL281470B2 (en) 2018-09-28 2025-08-01 Harvard College Cell reprogramming to reverse aging and promote organ and tissue regeneration
JP7766904B2 (en) * 2021-06-04 2025-11-11 地方独立行政法人東京都健康長寿医療センター Pharmaceutical composition for treating prostate cancer
US12252518B2 (en) 2023-01-06 2025-03-18 Life Biosciences, Inc. Methods of treating non-arteritic anterior ischemic optic neuropathy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2420140A1 (en) * 2000-08-24 2002-02-28 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
KR20040014392A (en) * 2000-08-24 2004-02-14 제넨테크, 인크. Compositions and Methods for the Diagnosis and Treatment of Tumor
AU8678501A (en) * 2000-08-24 2002-03-04 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL/GENBANK/DDBJ 13 June 2001 (2001-06-13), STRAUSBERG, R.L. ET AL: "Homo sapiens papillary renal cell carcinoma", XP002446467, retrieved from EBI Database accession no. BC010450 *
WETERMAN MARIAN A J ET AL: "Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1) (p11;q21)-positive papillary renal cell carcinomas", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 93, no. 26, 1996, pages 15294 - 15298, XP002446464, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
EP1578996A2 (en) 2005-09-28
WO2004060270A8 (en) 2005-07-14
WO2004060270A2 (en) 2004-07-22
AU2003303144A1 (en) 2004-07-29
CA2503043A1 (en) 2004-07-22
JP2006516192A (en) 2006-06-29

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Inventor name: ZHOU, YAN

Inventor name: WU, THOMAS, D.

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Owner name: GENENTECH, INC.

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