EP1680079A4 - Rapidly disintegrating films for delivery of pharmaceutical or cosmetic agents - Google Patents
Rapidly disintegrating films for delivery of pharmaceutical or cosmetic agentsInfo
- Publication number
- EP1680079A4 EP1680079A4 EP04796241A EP04796241A EP1680079A4 EP 1680079 A4 EP1680079 A4 EP 1680079A4 EP 04796241 A EP04796241 A EP 04796241A EP 04796241 A EP04796241 A EP 04796241A EP 1680079 A4 EP1680079 A4 EP 1680079A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pharmaceutical
- delivery
- cosmetic agents
- rapidly disintegrating
- disintegrating films
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000002537 cosmetic Substances 0.000 title 1
- 239000008177 pharmaceutical agent Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Organic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51354703P | 2003-10-24 | 2003-10-24 | |
| PCT/US2004/035208 WO2005039499A2 (en) | 2003-10-24 | 2004-10-22 | Rapidly disintegrating film |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1680079A2 EP1680079A2 (en) | 2006-07-19 |
| EP1680079A4 true EP1680079A4 (en) | 2008-01-02 |
Family
ID=34520112
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP04796239.4A Expired - Lifetime EP1695094B1 (en) | 2003-10-24 | 2004-10-22 | Disintegratable films for diagnostic devices |
| EP04796241A Ceased EP1680079A4 (en) | 2003-10-24 | 2004-10-22 | Rapidly disintegrating films for delivery of pharmaceutical or cosmetic agents |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP04796239.4A Expired - Lifetime EP1695094B1 (en) | 2003-10-24 | 2004-10-22 | Disintegratable films for diagnostic devices |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US7470397B2 (en) |
| EP (2) | EP1695094B1 (en) |
| JP (2) | JP4838723B2 (en) |
| AU (2) | AU2004284080B2 (en) |
| CA (2) | CA2543350C (en) |
| DK (1) | DK1695094T3 (en) |
| ES (1) | ES2426990T3 (en) |
| WO (2) | WO2005039499A2 (en) |
Families Citing this family (211)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7666337B2 (en) * | 2002-04-11 | 2010-02-23 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
| US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
| US20060039958A1 (en) * | 2003-05-28 | 2006-02-23 | Monosolrx, Llc. | Multi-layer films having uniform content |
| US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
| US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US7425292B2 (en) * | 2001-10-12 | 2008-09-16 | Monosol Rx, Llc | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
| US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
| US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
| US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
| US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
| US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
| US8663687B2 (en) * | 2001-10-12 | 2014-03-04 | Monosol Rx, Llc | Film compositions for delivery of actives |
| US8017150B2 (en) * | 2002-04-11 | 2011-09-13 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
| EP1542903B1 (en) * | 2002-07-22 | 2015-05-20 | MonoSolRX, LLC | Packaging and dispensing of rapid dissolve dosage form |
| WO2005039499A2 (en) | 2003-10-24 | 2005-05-06 | Adhesives Research, Inc. | Rapidly disintegrating film |
| US9248146B2 (en) * | 2003-10-24 | 2016-02-02 | Adhesives Research, Inc. | Dissolvable adhesive films for delivery of pharmaceutical or cosmetic agents |
| ITMI20032087A1 (en) | 2003-10-27 | 2005-04-28 | Pharmafilm S R L | SELF-SUPPORTING FILMS FOR PHARMACEUTICAL AND FOOD USE. |
| US9267167B2 (en) | 2004-06-28 | 2016-02-23 | Becton, Dickinson And Company | Dissolvable films and methods including the same |
| DK1859330T3 (en) | 2005-01-28 | 2012-10-15 | Univ Duke | DEVICES AND METHODS OF HANDLING SMALL DROPS ON A PRINTED CIRCUIT CARD |
| CN101287845B (en) | 2005-05-11 | 2012-07-18 | 先进液体逻辑公司 | Method and device for conducting biochemical or chemical reactions at multiple temperatures |
| DE102005033943A1 (en) * | 2005-07-20 | 2007-02-22 | Hexal Ag | Non-spitting, oral, fast-disintegrating film for a neuroleptic |
| DE102005058569B4 (en) * | 2005-12-08 | 2010-07-15 | Lts Lohmann Therapie-Systeme Ag | Foam wafer with polyvinyl alcohol-polyethylene glycol graft copolymer |
| CN101346135A (en) * | 2005-12-27 | 2009-01-14 | 莫诺索尔克斯有限公司 | pH adjusted membranes for active agent delivery |
| US20070192182A1 (en) * | 2006-02-10 | 2007-08-16 | Tovin Monaco | Method of delivering coupons using customer data |
| US20070192183A1 (en) * | 2006-02-10 | 2007-08-16 | Tovin Monaco | System and architecture for providing retail buying options to consumer using customer data |
| US20070192438A1 (en) * | 2006-02-10 | 2007-08-16 | Esmond Goei | System and method for on-demand delivery of media products |
| US20070190013A1 (en) * | 2006-02-13 | 2007-08-16 | Yeli Zhang | Film and film-forming compositions |
| BRPI0709382A2 (en) * | 2006-03-16 | 2011-07-12 | Novartis Ag | solid dosage form containing a masked flavoring active agent |
| US9476856B2 (en) | 2006-04-13 | 2016-10-25 | Advanced Liquid Logic, Inc. | Droplet-based affinity assays |
| US20140193807A1 (en) | 2006-04-18 | 2014-07-10 | Advanced Liquid Logic, Inc. | Bead manipulation techniques |
| US10078078B2 (en) | 2006-04-18 | 2018-09-18 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US7439014B2 (en) * | 2006-04-18 | 2008-10-21 | Advanced Liquid Logic, Inc. | Droplet-based surface modification and washing |
| US7901947B2 (en) * | 2006-04-18 | 2011-03-08 | Advanced Liquid Logic, Inc. | Droplet-based particle sorting |
| US8716015B2 (en) * | 2006-04-18 | 2014-05-06 | Advanced Liquid Logic, Inc. | Manipulation of cells on a droplet actuator |
| WO2007123908A2 (en) | 2006-04-18 | 2007-11-01 | Advanced Liquid Logic, Inc. | Droplet-based multiwell operations |
| US8980198B2 (en) * | 2006-04-18 | 2015-03-17 | Advanced Liquid Logic, Inc. | Filler fluids for droplet operations |
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| US8637324B2 (en) | 2006-04-18 | 2014-01-28 | Advanced Liquid Logic, Inc. | Bead incubation and washing on a droplet actuator |
| US8809068B2 (en) | 2006-04-18 | 2014-08-19 | Advanced Liquid Logic, Inc. | Manipulation of beads in droplets and methods for manipulating droplets |
| US8389297B2 (en) | 2006-04-18 | 2013-03-05 | Duke University | Droplet-based affinity assay device and system |
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| WO2011084703A2 (en) | 2009-12-21 | 2011-07-14 | Advanced Liquid Logic, Inc. | Enzyme assays on a droplet actuator |
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| ES2453379T3 (en) * | 2007-04-25 | 2014-04-07 | 3M Innovative Properties Company | Supported reagents, methods and devices |
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| US8951732B2 (en) | 2007-06-22 | 2015-02-10 | Advanced Liquid Logic, Inc. | Droplet-based nucleic acid amplification in a temperature gradient |
| EP2170247A2 (en) * | 2007-06-29 | 2010-04-07 | Union Carbide Chemicals & Plastics Technology LLC | Personal care dissolvable films |
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- 2004-10-22 ES ES04796239T patent/ES2426990T3/en not_active Expired - Lifetime
- 2004-10-22 JP JP2006536865A patent/JP4838723B2/en not_active Expired - Fee Related
- 2004-10-22 AU AU2004284080A patent/AU2004284080B2/en not_active Ceased
- 2004-10-22 EP EP04796239.4A patent/EP1695094B1/en not_active Expired - Lifetime
- 2004-10-22 EP EP04796241A patent/EP1680079A4/en not_active Ceased
- 2004-10-22 US US10/970,383 patent/US7470397B2/en active Active
- 2004-10-22 US US10/970,391 patent/US20050118217A1/en not_active Abandoned
- 2004-10-22 DK DK04796239.4T patent/DK1695094T3/en active
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- 2004-10-22 JP JP2006536864A patent/JP4563393B2/en not_active Expired - Fee Related
- 2004-10-22 CA CA2543350A patent/CA2543350C/en not_active Expired - Lifetime
- 2004-10-22 CA CA2543324A patent/CA2543324C/en not_active Expired - Lifetime
- 2004-10-22 AU AU2004283721A patent/AU2004283721B2/en not_active Ceased
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2008
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2012
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Also Published As
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| US9937123B2 (en) | 2018-04-10 |
| JP2007509172A (en) | 2007-04-12 |
| EP1680079A2 (en) | 2006-07-19 |
| US20050118217A1 (en) | 2005-06-02 |
| US7470397B2 (en) | 2008-12-30 |
| US9585961B2 (en) | 2017-03-07 |
| WO2005039499A2 (en) | 2005-05-06 |
| US7727466B2 (en) | 2010-06-01 |
| WO2005039499A3 (en) | 2005-10-06 |
| WO2005040228A3 (en) | 2006-03-09 |
| CA2543350A1 (en) | 2005-05-06 |
| JP2007514135A (en) | 2007-05-31 |
| EP1695094A4 (en) | 2008-01-02 |
| US20130095156A1 (en) | 2013-04-18 |
| AU2004283721A1 (en) | 2005-05-06 |
| WO2005040228A2 (en) | 2005-05-06 |
| AU2004284080B2 (en) | 2008-10-02 |
| CA2543324C (en) | 2011-02-01 |
| EP1695094A2 (en) | 2006-08-30 |
| AU2004283721B2 (en) | 2009-08-13 |
| JP4838723B2 (en) | 2011-12-14 |
| AU2004284080A1 (en) | 2005-05-06 |
| DK1695094T3 (en) | 2013-09-16 |
| CA2543350C (en) | 2011-04-26 |
| US20080299005A1 (en) | 2008-12-04 |
| EP1695094B1 (en) | 2013-06-19 |
| US20170128358A1 (en) | 2017-05-11 |
| ES2426990T3 (en) | 2013-10-28 |
| JP4563393B2 (en) | 2010-10-13 |
| US20090142850A1 (en) | 2009-06-04 |
| CA2543324A1 (en) | 2005-05-06 |
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