EP1753423A4 - BENZO-UREES WITH ANTIDIABETIC ACTIVITY - Google Patents

BENZO-UREES WITH ANTIDIABETIC ACTIVITY

Info

Publication number: EP1753423A4
Authority: EP; European Patent Office
Prior art keywords: urees; benzo; antidiabetic activity; antidiabetic; activity
Prior art date: 2004-05-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP05812065A

Other languages

German (de)

French (fr)

Other versions

EP1753423A2 (en

Inventor

Weiguo Liu

Harold B Wood

Fiona Wai-Yu Lau-Phua

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-28

Filing date

2005-05-26

Publication date

2009-10-21

2005-05-26 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

2007-02-21 Publication of EP1753423A2 publication Critical patent/EP1753423A2/en

2009-10-21 Publication of EP1753423A4 publication Critical patent/EP1753423A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP05812065A 2004-05-28 2005-05-26 BENZO-UREES WITH ANTIDIABETIC ACTIVITY Withdrawn EP1753423A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57514404P	2004-05-28	2004-05-28
PCT/US2005/018721 WO2006022954A2 (en)	2004-05-28	2005-05-26	Benzoureas having anti-diabetic activity

Publications (2)

Publication Number	Publication Date
EP1753423A2 EP1753423A2 (en)	2007-02-21
EP1753423A4 true EP1753423A4 (en)	2009-10-21

Family

ID=35967997

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP05812065A Withdrawn EP1753423A4 (en)	2004-05-28	2005-05-26	BENZO-UREES WITH ANTIDIABETIC ACTIVITY

Country Status (6)

Country	Link
EP (1)	EP1753423A4 (en)
JP (1)	JP2008501027A (en)
CN (1)	CN101076334A (en)
AU (1)	AU2005278099A1 (en)
CA (1)	CA2565803A1 (en)
WO (1)	WO2006022954A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102006014685A1 (en)	2006-03-28	2007-10-04	Sanofi-Aventis	Imidazo-pyridin-2-one derivatives as inhibitors of lipases and phospholiphases
PT2100604E (en) *	2008-03-10	2012-07-24	Nestec Sa	Medium chain dicarboxylic acids and their derivates and metabolic disorders
RU2636483C2 (en) *	2012-09-21	2017-11-23	Реоксин Дискавериз Груп, Инк.	Cell for liquid electrolysis
JP7607799B2 (en) *	2021-04-27	2024-12-27	メッドシャインディスカバリーインコーポレイテッド	Derivatives of six-membered aromatic heterourea rings and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5624935A (en) *	1994-04-11	1997-04-29	Sankyo Company, Limited	Heterocyclic compounds having anti-diabetic activity and their use
WO2004019869A2 (en) *	2002-08-29	2004-03-11	Merck & Co., Inc.	Indoles having anti-diabetic activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6653478B2 (en) *	2000-10-27	2003-11-25	Ortho-Mcneil Pharmaceutical, Inc.	Substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide Y modulators

2005
- 2005-05-26 JP JP2007515386A patent/JP2008501027A/en not_active Withdrawn
- 2005-05-26 WO PCT/US2005/018721 patent/WO2006022954A2/en not_active Ceased
- 2005-05-26 CN CNA2005800171945A patent/CN101076334A/en active Pending
- 2005-05-26 CA CA002565803A patent/CA2565803A1/en not_active Abandoned
- 2005-05-26 AU AU2005278099A patent/AU2005278099A1/en not_active Abandoned
- 2005-05-26 EP EP05812065A patent/EP1753423A4/en not_active Withdrawn

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5624935A (en) *	1994-04-11	1997-04-29	Sankyo Company, Limited	Heterocyclic compounds having anti-diabetic activity and their use
WO2004019869A2 (en) *	2002-08-29	2004-03-11	Merck & Co., Inc.	Indoles having anti-diabetic activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BRAJ B. LOHRAY ET AL: "Novel euglycemic and hypolipidemic agents. 1", JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, no. 10, 1998, pages 1619 - 1630, XP002149048, ISSN: 0022-2623 *

Also Published As

Publication number	Publication date
WO2006022954A3 (en)	2006-10-12
AU2005278099A1 (en)	2006-03-02
CN101076334A (en)	2007-11-21
EP1753423A2 (en)	2007-02-21
WO2006022954A2 (en)	2006-03-02
JP2008501027A (en)	2008-01-17
CA2565803A1 (en)	2006-03-02

Legal Events

Date	Code	Title	Description
2007-01-19	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2007-02-21	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
2007-02-21	AX	Request for extension of the european patent	Extension state: AL BA HR LV MK YU
2007-05-30	17P	Request for examination filed	Effective date: 20070412
2007-05-30	RAX	Requested extension states of the european patent have changed	Extension state: LV Payment date: 20070412
2007-05-30	RBV	Designated contracting states (corrected)	Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
2007-09-05	RAX	Requested extension states of the european patent have changed	Extension state: LV Payment date: 20070412
2009-10-21	A4	Supplementary search report drawn up and despatched	Effective date: 20090923
2009-10-21	RIC1	Information provided on ipc code assigned before grant	Ipc: A61P 3/10 20060101ALI20090917BHEP Ipc: A61K 31/428 20060101ALI20090917BHEP Ipc: A61K 31/42 20060101ALI20090917BHEP Ipc: C07D 417/14 20060101ALI20090917BHEP Ipc: C07D 413/10 20060101ALI20090917BHEP Ipc: C07D 413/14 20060101AFI20090917BHEP
2010-03-10	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: MERCK SHARP & DOHME CORP.
2010-05-14	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2010-06-16	18D	Application deemed to be withdrawn	Effective date: 20091223

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