EP1781627A4 - METHODS FOR PREPARING IRBESARTAN AND ASSOCIATED INTERMEDIATES - Google Patents

METHODS FOR PREPARING IRBESARTAN AND ASSOCIATED INTERMEDIATES

Info

Publication number
EP1781627A4
EP1781627A4 EP05791492A EP05791492A EP1781627A4 EP 1781627 A4 EP1781627 A4 EP 1781627A4 EP 05791492 A EP05791492 A EP 05791492A EP 05791492 A EP05791492 A EP 05791492A EP 1781627 A4 EP1781627 A4 EP 1781627A4
Authority
EP
European Patent Office
Prior art keywords
methods
associated intermediates
preparing irbesartan
irbesartan
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP05791492A
Other languages
German (de)
French (fr)
Other versions
EP1781627A2 (en
EP1781627B1 (en
Inventor
Edgar I Miranda
Cornelis Vlaar
Jingyang Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of EP1781627A2 publication Critical patent/EP1781627A2/en
Publication of EP1781627A4 publication Critical patent/EP1781627A4/en
Application granted granted Critical
Publication of EP1781627B1 publication Critical patent/EP1781627B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
EP05791492A 2004-08-23 2005-08-23 A method for preparing irbesartan and intermediates thereof Expired - Lifetime EP1781627B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60360604P 2004-08-23 2004-08-23
PCT/US2005/029879 WO2006023889A2 (en) 2004-08-23 2005-08-23 A method for preparing irbesartan and intermediates thereof

Publications (3)

Publication Number Publication Date
EP1781627A2 EP1781627A2 (en) 2007-05-09
EP1781627A4 true EP1781627A4 (en) 2009-09-02
EP1781627B1 EP1781627B1 (en) 2010-11-17

Family

ID=35968277

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05791492A Expired - Lifetime EP1781627B1 (en) 2004-08-23 2005-08-23 A method for preparing irbesartan and intermediates thereof

Country Status (20)

Country Link
US (2) US7211676B2 (en)
EP (1) EP1781627B1 (en)
JP (1) JP5203703B2 (en)
KR (1) KR101252309B1 (en)
CN (1) CN101006064B (en)
AR (1) AR050709A1 (en)
AT (1) ATE488508T1 (en)
AU (1) AU2005277162B2 (en)
BR (1) BRPI0514584A (en)
CA (2) CA2578409A1 (en)
DE (1) DE602005024819D1 (en)
ES (1) ES2357393T3 (en)
IL (1) IL181464A (en)
MX (1) MX2007002030A (en)
NO (1) NO20071254L (en)
PE (1) PE20060650A1 (en)
RU (1) RU2388753C2 (en)
TW (1) TWI346108B (en)
WO (1) WO2006023889A2 (en)
ZA (1) ZA200701363B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1918288A1 (en) 2006-11-02 2008-05-07 Cadila Pharmaceuticals Limited A novel and improved process for the preparation of Irbesartan, an angiotensin-II receptor antagonist for the treatment of hypertension
GB0700993D0 (en) * 2007-01-18 2007-02-28 Rainbow Engineering Services Novel compounds
CN101657442A (en) * 2007-03-06 2010-02-24 阿克塔维什集团Ptc公司 Improved process for preparing irbesartan
SI22488A (en) * 2007-04-24 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Crystal 1-(cyclohexyloxycarbonyloxy)ethyl 1-((2'-cyanobiphenyl-4-yl)methyl)-ethoxy-1h-benz(d)imidazol-7-carboxyn
HUP0900788A2 (en) * 2009-12-16 2011-11-28 Sanofi Aventis Process for producing 4-bromomethyl-biphenyl derivatives
US8841458B2 (en) * 2010-03-12 2014-09-23 Nippon Soda Co., Ltd. Compound containing pyridine ring and method for producing halogenated picoline derivative and tetrazolyloxime derivative
CN102807564A (en) * 2012-08-30 2012-12-05 珠海润都制药股份有限公司 Preparation method of irbesartan
CN102898420B (en) * 2012-09-10 2014-10-29 珠海保税区丽珠合成制药有限公司 Synthetic route and preparation method of irbesartan
CN103497178B (en) * 2013-09-27 2015-04-08 中国药科大学 Irbesartan and repaglinide co-amorphous substance
CN104744303B (en) * 2015-02-15 2017-06-23 北京欣奕华科技有限公司 Bromomethylbiphenyls of 2 R 4 ' and preparation method thereof
CN108164434A (en) * 2017-12-27 2018-06-15 安徽太主科技发展有限公司 A kind of preparation method of inexpensive 4 '-bromomethyl -2- cyanobiphenyls
US11655220B2 (en) 2020-10-22 2023-05-23 Hetero Labs Limited Process for the preparation of angiotensin II receptor blockers

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991014679A1 (en) * 1990-03-20 1991-10-03 Sanofi Heterocyclic n-substituted derivatives, their preparation and thepharmaceutical compositions containing them
US5541209A (en) * 1994-08-22 1996-07-30 Bristol-Myers Squibb Company Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative
WO1999038847A1 (en) * 1998-01-30 1999-08-05 Bristol-Myers Squibb Company Method for preparing n-substituted heterocyclic derivatives using a phase-transfer catalyst
WO1999067236A1 (en) * 1998-06-24 1999-12-29 Sanofi-Synthelabo Novel form of irbesartan, methods for obtaining said form and pharmaceutical compositions containing same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3340595A1 (en) * 1983-11-10 1985-05-23 Hoechst Ag, 6230 Frankfurt IMIDAZOLINONES, METHOD FOR THEIR PRODUCTION AND THEIR USE IN PLANT PROTECTION
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2725987B1 (en) * 1994-10-19 1997-01-10 Sanofi Sa PROCESS FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE IN TWO CRYSTALLINE FORMS AND NOVEL CRYSTALLINE FORM THEREOF
US5994348A (en) * 1995-06-07 1999-11-30 Sanofi Pharmaceutical compositions containing irbesartan
JP3003030B2 (en) * 1997-05-26 2000-01-24 武田薬品工業株式会社 Method for producing aminobenzene compounds
FR2766821A1 (en) 1997-07-29 1999-02-05 Sanofi Sa 1,3-OXAZOLINYL-BIPHENYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS SYNTHESIS INTERMEDIATES
CN100418962C (en) * 2002-10-28 2008-09-17 南京长澳医药科技有限公司 Technique for synthesizing Irbesartan
WO2004065383A2 (en) * 2003-01-16 2004-08-05 Teva Pharmaceutical Industries Ltd. Novel synthesis of irbesartan

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991014679A1 (en) * 1990-03-20 1991-10-03 Sanofi Heterocyclic n-substituted derivatives, their preparation and thepharmaceutical compositions containing them
US5541209A (en) * 1994-08-22 1996-07-30 Bristol-Myers Squibb Company Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative
WO1999038847A1 (en) * 1998-01-30 1999-08-05 Bristol-Myers Squibb Company Method for preparing n-substituted heterocyclic derivatives using a phase-transfer catalyst
WO1999067236A1 (en) * 1998-06-24 1999-12-29 Sanofi-Synthelabo Novel form of irbesartan, methods for obtaining said form and pharmaceutical compositions containing same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C. A. BERNHART ET AL.: "A New Series of Imidazolones: Highly Specific and Potent Nonpeptide AT(1) Angiotensin II Receptor Antagonists", J. MED. CHEM., vol. 36, no. 22, 1993, pages 3371 - 3380, XP002534964 *

Also Published As

Publication number Publication date
AR050709A1 (en) 2006-11-15
WO2006023889A2 (en) 2006-03-02
IL181464A (en) 2011-08-31
EP1781627A2 (en) 2007-05-09
HK1098157A1 (en) 2007-07-13
ATE488508T1 (en) 2010-12-15
AU2005277162B2 (en) 2010-12-16
RU2388753C2 (en) 2010-05-10
MX2007002030A (en) 2007-03-28
TWI346108B (en) 2011-08-01
NO20071254L (en) 2007-03-22
CA2754633A1 (en) 2006-03-02
EP1781627B1 (en) 2010-11-17
KR101252309B1 (en) 2013-04-08
TW200619205A (en) 2006-06-16
BRPI0514584A (en) 2008-06-17
CN101006064A (en) 2007-07-25
RU2007109330A (en) 2008-09-27
KR20070045275A (en) 2007-05-02
US20060041147A1 (en) 2006-02-23
PE20060650A1 (en) 2006-07-09
ES2357393T3 (en) 2011-04-26
DE602005024819D1 (en) 2010-12-30
US7365208B2 (en) 2008-04-29
JP2008510819A (en) 2008-04-10
JP5203703B2 (en) 2013-06-05
CA2578409A1 (en) 2006-03-02
US20070167634A1 (en) 2007-07-19
AU2005277162A1 (en) 2006-03-02
WO2006023889A3 (en) 2006-09-08
CN101006064B (en) 2011-01-26
ZA200701363B (en) 2008-06-25
US7211676B2 (en) 2007-05-01
IL181464A0 (en) 2007-07-04

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