EP1793846A4 - Compositions and methods comprising vitamin b12 and an impdh inhibitor for treating viral, inflammatory and proliferative diseases - Google Patents

Compositions and methods comprising vitamin b12 and an impdh inhibitor for treating viral, inflammatory and proliferative diseases

Info

Publication number: EP1793846A4
Authority: EP; European Patent Office
Prior art keywords: vitamin; inflammatory; compositions; methods; proliferative diseases
Prior art date: 2004-07-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP05770301A

Other languages

German (de)

French (fr)

Other versions

EP1793846A1 (en

Inventor

Antonio Cruz

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Transition Therapeutics Inc

Original Assignee

Transition Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-07-26

Filing date

2005-07-26

Publication date

2008-03-26

2005-07-26 Application filed by Transition Therapeutics Inc filed Critical Transition Therapeutics Inc

2007-06-13 Publication of EP1793846A1 publication Critical patent/EP1793846A1/en

2008-03-26 Publication of EP1793846A4 publication Critical patent/EP1793846A4/en

Status Withdrawn legal-status Critical Current

Links

101150088003 IMPDH gene Proteins 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
230000002757 inflammatory effect Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
239000000203 mixture Substances 0.000 title 1
230000002062 proliferating effect Effects 0.000 title 1
230000003612 virological effect Effects 0.000 title 1
RMRCNWBMXRMIRW-WYVZQNDMSA-L vitamin b12 Chemical compound N([C@@H]([C@@]1(C)[C@@](C)(CC(N)=O)[C@H](CCC(N)=O)\C(N1[Co+]C#N)=C(/C)\C1=N\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NCC(C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO RMRCNWBMXRMIRW-WYVZQNDMSA-L 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Zoology (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP05770301A 2004-07-26 2005-07-26 Compositions and methods comprising vitamin b12 and an impdh inhibitor for treating viral, inflammatory and proliferative diseases Withdrawn EP1793846A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US59134604P	2004-07-26	2004-07-26
PCT/CA2005/001163 WO2006010256A1 (en)	2004-07-26	2005-07-26	Compositions and methods comprising vitamin b12 and an impdh inhibitor for treating viral, inflammatory and proliferative diseases

Publications (2)

Publication Number	Publication Date
EP1793846A1 EP1793846A1 (en)	2007-06-13
EP1793846A4 true EP1793846A4 (en)	2008-03-26

Family

ID=35785872

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP05770301A Withdrawn EP1793846A4 (en)	2004-07-26	2005-07-26	Compositions and methods comprising vitamin b12 and an impdh inhibitor for treating viral, inflammatory and proliferative diseases

Country Status (2)

Country	Link
EP (1)	EP1793846A4 (en)
WO (1)	WO2006010256A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101242857A (en) *	2005-08-15	2008-08-13	弗·哈夫曼-拉罗切有限公司	PEG-IFNa and ribavirin for HBV treatment
EA014669B1 (en) *	2009-06-08	2010-12-30	Общество С Ограниченной Ответственностью "Научно-Производственный Центр Белагроген"	Interferon-based formulation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2004536819A (en) *	2001-06-11	2004-12-09	トランジション・セラピューティックス・インコーポレーテッド	Combination therapy with vitamin B12 and therapeutics for the treatment of viral, proliferative and inflammatory diseases
AU2003249659A1 (en) *	2002-05-31	2003-12-19	Schering Corporation	Combination therapy for rna virus infections involving ribavirin and impdh inhibitors

2005
- 2005-07-26 WO PCT/CA2005/001163 patent/WO2006010256A1/en not_active Ceased
- 2005-07-26 EP EP05770301A patent/EP1793846A4/en not_active Withdrawn

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1992, DEHARA K ET AL: "Herpes zoster of the right cervical region associated with right facial nerve palsy and hoarseness", XP002468626, Database accession no. EMB-1992294464 *
JAPANESE JOURNAL OF ANESTHESIOLOGY 1992 JAPAN, vol. 41, no. 8, 1992, pages 1322 - 1326, ISSN: 0021-4892 *
OHYA K ET AL: "Neurogenic bladder associated with herpes zoster: A case report", NISHINIHON JOURNAL OF UROLOGY 1995 JAPAN, vol. 57, no. 3, 1995, pages 287 - 288, XP009095672, ISSN: 0029-0726 *
See also references of WO2006010256A1 *

Also Published As

Publication number	Publication date
EP1793846A1 (en)	2007-06-13
WO2006010256A1 (en)	2006-02-02

Legal Events

Date	Code	Title	Description
2007-05-11	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2007-06-13	17P	Request for examination filed	Effective date: 20070226
2007-06-13	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
2007-10-31	DAX	Request for extension of the european patent (deleted)
2008-03-26	A4	Supplementary search report drawn up and despatched	Effective date: 20080227
2008-08-01	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2008-09-03	18D	Application deemed to be withdrawn	Effective date: 20071216

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