EP1866951A4 - FLOW-TIME AND MULTI-REFLECTIVE MASS SPECTROMETER HAVING ISOCHRONE CURVED ION INTERFACE - Google Patents
FLOW-TIME AND MULTI-REFLECTIVE MASS SPECTROMETER HAVING ISOCHRONE CURVED ION INTERFACEInfo
- Publication number
- EP1866951A4 EP1866951A4 EP06748558A EP06748558A EP1866951A4 EP 1866951 A4 EP1866951 A4 EP 1866951A4 EP 06748558 A EP06748558 A EP 06748558A EP 06748558 A EP06748558 A EP 06748558A EP 1866951 A4 EP1866951 A4 EP 1866951A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- isochrone
- flow
- time
- mass spectrometer
- curved ion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
- H01J49/408—Time-of-flight spectrometers with multiple changes of direction, e.g. by using electric or magnetic sectors, closed-loop time-of-flight
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0004—Imaging particle spectrometry
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
- H01J49/406—Time-of-flight spectrometers with multiple reflections
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/44—Energy spectrometers, e.g. alpha-, beta-spectrometers
- H01J49/46—Static spectrometers
- H01J49/48—Static spectrometers using electrostatic analysers, e.g. cylindrical sector, Wien filter
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66406205P | 2005-03-22 | 2005-03-22 | |
| PCT/US2006/010437 WO2006102430A2 (en) | 2005-03-22 | 2006-03-22 | Multi-reflecting time-of-flight mass spectrometer with isochronous curved ion interface |
| US11/277,181 US7326925B2 (en) | 2005-03-22 | 2006-03-22 | Multi-reflecting time-of-flight mass spectrometer with isochronous curved ion interface |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP1866951A2 EP1866951A2 (en) | 2007-12-19 |
| EP1866951A4 true EP1866951A4 (en) | 2010-12-08 |
| EP1866951B1 EP1866951B1 (en) | 2018-01-17 |
Family
ID=37024584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP06748558.1A Expired - Lifetime EP1866951B1 (en) | 2005-03-22 | 2006-03-22 | Multi-reflecting time-of-flight mass spectrometer with isochronous curved ion interface |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7326925B2 (en) |
| EP (1) | EP1866951B1 (en) |
| JP (1) | JP5357538B2 (en) |
| CN (1) | CN101171660B (en) |
| WO (1) | WO2006102430A2 (en) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006228435A (en) * | 2005-02-15 | 2006-08-31 | Shimadzu Corp | Time-of-flight mass spectrometer |
| GB2434484B (en) | 2005-06-03 | 2010-11-03 | Thermo Finnigan Llc | Improvements in an electrostatic trap |
| CN107833823B (en) * | 2005-10-11 | 2021-09-17 | 莱克公司 | Multiple reflection time-of-flight mass spectrometer with orthogonal acceleration |
| GB0605089D0 (en) * | 2006-03-14 | 2006-04-26 | Micromass Ltd | Mass spectrometer |
| GB0607542D0 (en) * | 2006-04-13 | 2006-05-24 | Thermo Finnigan Llc | Mass spectrometer |
| US7501621B2 (en) * | 2006-07-12 | 2009-03-10 | Leco Corporation | Data acquisition system for a spectrometer using an adaptive threshold |
| GB0620398D0 (en) * | 2006-10-13 | 2006-11-22 | Shimadzu Corp | Multi-reflecting time-of-flight mass analyser and a time-of-flight mass spectrometer including the time-of-flight mass analyser |
| GB0620963D0 (en) * | 2006-10-20 | 2006-11-29 | Thermo Finnigan Llc | Multi-channel detection |
| GB0624677D0 (en) * | 2006-12-11 | 2007-01-17 | Shimadzu Corp | A co-axial time-of-flight mass spectrometer |
| GB0624679D0 (en) * | 2006-12-11 | 2007-01-17 | Shimadzu Corp | A time-of-flight mass spectrometer and a method of analysing ions in a time-of-flight mass spectrometer |
| CN101632148B (en) * | 2007-02-23 | 2013-03-20 | 杨百翰大学 | Coaxial hybrid radio frequency ion trap mass analyzer |
| JP4883176B2 (en) * | 2007-05-09 | 2012-02-22 | 株式会社島津製作所 | Charged particle analyzer |
| GB0712252D0 (en) * | 2007-06-22 | 2007-08-01 | Shimadzu Corp | A multi-reflecting ion optical device |
| DE102007048618B4 (en) * | 2007-10-10 | 2011-12-22 | Bruker Daltonik Gmbh | Purified daughter ion spectra from MALDI ionization |
| GB2455977A (en) * | 2007-12-21 | 2009-07-01 | Thermo Fisher Scient | Multi-reflectron time-of-flight mass spectrometer |
| JP2009194639A (en) * | 2008-02-14 | 2009-08-27 | Panasonic Corp | Communication device |
| WO2010001439A1 (en) * | 2008-07-03 | 2010-01-07 | 株式会社島津製作所 | Mass spectroscope |
| CN102131563B (en) | 2008-07-16 | 2015-01-07 | 莱克公司 | Quasiplanar Multiple Reflection Time-of-Flight Mass Spectrometer |
| WO2010041296A1 (en) * | 2008-10-09 | 2010-04-15 | 株式会社島津製作所 | Mass spectrometer |
| GB2470600B (en) * | 2009-05-29 | 2012-06-13 | Thermo Fisher Scient Bremen | Charged particle analysers and methods of separating charged particles |
| GB2470599B (en) * | 2009-05-29 | 2014-04-02 | Thermo Fisher Scient Bremen | Charged particle analysers and methods of separating charged particles |
| GB2476964A (en) | 2010-01-15 | 2011-07-20 | Anatoly Verenchikov | Electrostatic trap mass spectrometer |
| GB2478300A (en) * | 2010-03-02 | 2011-09-07 | Anatoly Verenchikov | A planar multi-reflection time-of-flight mass spectrometer |
| GB2480660B (en) | 2010-05-27 | 2012-07-11 | Thermo Fisher Scient Bremen | Mass spectrometry detector system and method of detection |
| EP2595174B8 (en) * | 2010-06-08 | 2019-01-16 | Micromass UK Limited | Mass spectrometer comprising two Time of Flight analysers for analysing both positive and negative ions |
| WO2012005561A2 (en) * | 2010-07-09 | 2012-01-12 | Saparqaliyev Aldan Asanovich | Mass spectrometry method and device for implementing same |
| GB201021840D0 (en) * | 2010-12-23 | 2011-02-02 | Micromass Ltd | Improved space focus time of flight mass spectrometer |
| GB201103361D0 (en) * | 2011-02-28 | 2011-04-13 | Shimadzu Corp | Mass analyser and method of mass analysis |
| GB2495127B (en) * | 2011-09-30 | 2016-10-19 | Thermo Fisher Scient (Bremen) Gmbh | Method and apparatus for mass spectrometry |
| GB201118279D0 (en) * | 2011-10-21 | 2011-12-07 | Shimadzu Corp | Mass analyser, mass spectrometer and associated methods |
| CN103907171B (en) * | 2011-10-28 | 2017-05-17 | 莱克公司 | Electrostatic ion mirrors |
| US9111715B2 (en) * | 2011-11-08 | 2015-08-18 | Fei Company | Charged particle energy filter |
| CN102568976B (en) * | 2011-12-14 | 2014-07-09 | 深圳市盛喜路科技有限公司 | Manufacturing method of secondary reflector |
| GB201201403D0 (en) | 2012-01-27 | 2012-03-14 | Thermo Fisher Scient Bremen | Multi-reflection mass spectrometer |
| GB201201405D0 (en) | 2012-01-27 | 2012-03-14 | Thermo Fisher Scient Bremen | Multi-reflection mass spectrometer |
| WO2013138326A2 (en) | 2012-03-12 | 2013-09-19 | Leco Corporation | Selective analyte detection and quantitation in mass spectrometry using multiplication of high resolution signal channels |
| JP2015515733A (en) * | 2012-04-26 | 2015-05-28 | レコ コーポレイションLeco Corporation | Electron impact ion source with fast response. |
| CN104508792B (en) | 2012-06-18 | 2017-01-18 | 莱克公司 | Tandem time-of-flight mass spectrometry using non-uniform sampling |
| KZ27187A4 (en) * | 2012-11-07 | 2013-07-15 | Nekommercheskoe Aktsionernoe Obschestvo Almatinsky Universitetenergetiki I Svyazi | Multiple reflection time-of-flight mass analyzer |
| CN105009251B (en) * | 2013-03-14 | 2017-12-22 | 莱克公司 | Multiple reflection mass spectrograph |
| DE102014104451B4 (en) * | 2014-03-28 | 2018-11-15 | Krohne Messtechnik Gmbh | mass spectrometry |
| DE112015001566B4 (en) * | 2014-03-31 | 2024-01-25 | Leco Corporation | Multiple reflection and time-of-flight mass spectrometer with axially pulsed converter |
| US10416131B2 (en) | 2014-03-31 | 2019-09-17 | Leco Corporation | GC-TOF MS with improved detection limit |
| WO2016028132A1 (en) * | 2014-08-20 | 2016-02-25 | Некоммерческое Акционерное Общество "Алматинский Университет Энергетики И Связи" | Multiple reflection time-of-flight mass spectrometer |
| US9767984B2 (en) * | 2014-09-30 | 2017-09-19 | Fei Company | Chicane blanker assemblies for charged particle beam systems and methods of using the same |
| JP5946881B2 (en) * | 2014-10-02 | 2016-07-06 | レコ コーポレイションLeco Corporation | Quasi-planar multiple reflection time-of-flight mass spectrometer |
| DE112014007095B4 (en) * | 2014-10-23 | 2021-02-18 | Leco Corporation | Multi-reflective time-of-flight analyzer |
| GB201507363D0 (en) * | 2015-04-30 | 2015-06-17 | Micromass Uk Ltd And Leco Corp | Multi-reflecting TOF mass spectrometer |
| GB2541383B (en) * | 2015-08-14 | 2018-12-12 | Thermo Fisher Scient Bremen Gmbh | Mirror lens for directing an ion beam |
| GB2543036A (en) | 2015-10-01 | 2017-04-12 | Shimadzu Corp | Time of flight mass spectrometer |
| GB201520130D0 (en) * | 2015-11-16 | 2015-12-30 | Micromass Uk Ltd And Leco Corp | Imaging mass spectrometer |
| GB201520134D0 (en) * | 2015-11-16 | 2015-12-30 | Micromass Uk Ltd And Leco Corp | Imaging mass spectrometer |
| GB201520540D0 (en) | 2015-11-23 | 2016-01-06 | Micromass Uk Ltd And Leco Corp | Improved ion mirror and ion-optical lens for imaging |
| CN105789019B (en) * | 2016-05-23 | 2017-08-01 | 安图实验仪器(郑州)有限公司 | Delayed ion extraction module suitable for time of-flight mass spectrometer |
| CN106169411B (en) * | 2016-07-13 | 2018-03-27 | 中国计量科学研究院 | New type series-parallel connected mass spectrometric apparatus system and its parameter adjusting method and application method |
| GB201613988D0 (en) | 2016-08-16 | 2016-09-28 | Micromass Uk Ltd And Leco Corp | Mass analyser having extended flight path |
| CN106338506A (en) * | 2016-08-29 | 2017-01-18 | 钢研纳克检测技术有限公司 | Bi-directional observation light path structure applied to ICP spectrograph |
| GB2555609B (en) * | 2016-11-04 | 2019-06-12 | Thermo Fisher Scient Bremen Gmbh | Multi-reflection mass spectrometer with deceleration stage |
| WO2018183201A1 (en) * | 2017-03-27 | 2018-10-04 | Leco Corporation | Multi-reflecting time-of-flight mass spectrometer |
| GB2567794B (en) | 2017-05-05 | 2023-03-08 | Micromass Ltd | Multi-reflecting time-of-flight mass spectrometers |
| GB2563571B (en) | 2017-05-26 | 2023-05-24 | Micromass Ltd | Time of flight mass analyser with spatial focussing |
| US11211238B2 (en) | 2017-08-06 | 2021-12-28 | Micromass Uk Limited | Multi-pass mass spectrometer |
| EP3662501A1 (en) | 2017-08-06 | 2020-06-10 | Micromass UK Limited | Ion mirror for multi-reflecting mass spectrometers |
| US11081332B2 (en) | 2017-08-06 | 2021-08-03 | Micromass Uk Limited | Ion guide within pulsed converters |
| US11817303B2 (en) | 2017-08-06 | 2023-11-14 | Micromass Uk Limited | Accelerator for multi-pass mass spectrometers |
| EP3662503A1 (en) | 2017-08-06 | 2020-06-10 | Micromass UK Limited | Ion injection into multi-pass mass spectrometers |
| US11295944B2 (en) | 2017-08-06 | 2022-04-05 | Micromass Uk Limited | Printed circuit ion mirror with compensation |
| WO2019030473A1 (en) | 2017-08-06 | 2019-02-14 | Anatoly Verenchikov | Fields for multi-reflecting tof ms |
| CN109841495B (en) * | 2017-11-27 | 2020-08-28 | 中国科学院大连化学物理研究所 | A Multiple Reflection Time-of-Flight Mass Spectrometry with Full Spectral Information Preservation |
| GB201806507D0 (en) | 2018-04-20 | 2018-06-06 | Verenchikov Anatoly | Gridless ion mirrors with smooth fields |
| GB201807605D0 (en) | 2018-05-10 | 2018-06-27 | Micromass Ltd | Multi-reflecting time of flight mass analyser |
| GB201807626D0 (en) * | 2018-05-10 | 2018-06-27 | Micromass Ltd | Multi-reflecting time of flight mass analyser |
| GB201808530D0 (en) | 2018-05-24 | 2018-07-11 | Verenchikov Anatoly | TOF MS detection system with improved dynamic range |
| GB201810573D0 (en) * | 2018-06-28 | 2018-08-15 | Verenchikov Anatoly | Multi-pass mass spectrometer with improved duty cycle |
| GB2580089B (en) | 2018-12-21 | 2021-03-03 | Thermo Fisher Scient Bremen Gmbh | Multi-reflection mass spectrometer |
| GB201901411D0 (en) | 2019-02-01 | 2019-03-20 | Micromass Ltd | Electrode assembly for mass spectrometer |
| GB201903779D0 (en) | 2019-03-20 | 2019-05-01 | Micromass Ltd | Multiplexed time of flight mass spectrometer |
| EP3983808A4 (en) | 2019-06-14 | 2023-05-24 | Shanghai Polaris Biology Co., Ltd. | SYSTEMS AND METHODS FOR SINGLE PARTICLE ANALYSIS |
| GB2585876A (en) * | 2019-07-19 | 2021-01-27 | Shimadzu Corp | Mass analyser |
| EP4012748B1 (en) * | 2019-09-18 | 2025-04-23 | Non-Profit Joint Stock Company "Almaty University of Power Engineering and Telecommunications" named after Gumarbek Daukeyev | Time-of-flight mass spectrometer |
| WO2021131140A1 (en) * | 2019-12-24 | 2021-07-01 | 株式会社島津製作所 | Multi-turn time-of-flight mass spectrometer |
| GB2635290B (en) * | 2020-09-03 | 2025-07-30 | HGSG Ltd | Mass spectrometer and method |
| JP7556333B2 (en) * | 2020-12-15 | 2024-09-26 | 株式会社島津製作所 | Time-of-flight mass spectrometer |
| CN113223919B (en) * | 2021-03-31 | 2023-05-30 | 杭州谱育科技发展有限公司 | Annular TOF mass analyzer and its working method |
| GB202110152D0 (en) * | 2021-07-14 | 2021-08-25 | Micromass Ltd | Mass or mobility spectrometer having high sampling duty cycle |
| GB202312458D0 (en) * | 2023-08-15 | 2023-09-27 | Thermo Fisher Scient Bremen Gmbh | Multi-reflection mass spectrometer |
| DE102024126836A1 (en) | 2024-09-17 | 2026-03-19 | Spectro Analytical Instruments Gmbh | Ion-optical component |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037586A (en) * | 1998-06-18 | 2000-03-14 | Universite Laval | Apparatus and method for separating pulsed ions by mass as said pulsed ions are guided along a course |
| GB2403063A (en) * | 2003-06-21 | 2004-12-22 | Anatoli Nicolai Verentchikov | Time of flight mass spectrometer employing a plurality of lenses focussing an ion beam in shift direction |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4072862A (en) * | 1975-07-22 | 1978-02-07 | Mamyrin Boris Alexandrovich | Time-of-flight mass spectrometer |
| CA1307859C (en) * | 1988-12-12 | 1992-09-22 | Donald James Douglas | Mass spectrometer and method with improved ion transmission |
| SU1725289A1 (en) | 1989-07-20 | 1992-04-07 | Институт Ядерной Физики Ан Казсср | Time-of-flight mass spectrometer with multiple reflection |
| JPH08254504A (en) * | 1994-11-29 | 1996-10-01 | Zellweger Luwa Ag | Method and apparatus for recording the properties of a stretched object |
| US5654544A (en) * | 1995-08-10 | 1997-08-05 | Analytica Of Branford | Mass resolution by angular alignment of the ion detector conversion surface in time-of-flight mass spectrometers with electrostatic steering deflectors |
| US5847385A (en) * | 1996-08-09 | 1998-12-08 | Analytica Of Branford, Inc. | Mass resolution by angular alignment of the ion detector conversion surface in time-of-flight mass spectrometers with electrostatic steering deflectors |
| JP4848528B2 (en) * | 2000-12-28 | 2011-12-28 | 株式会社Ihi | Ion mass separation method and apparatus, and ion doping apparatus |
| US6888130B1 (en) * | 2002-05-30 | 2005-05-03 | Marc Gonin | Electrostatic ion trap mass spectrometers |
| US7196324B2 (en) * | 2002-07-16 | 2007-03-27 | Leco Corporation | Tandem time of flight mass spectrometer and method of use |
| GB2390935A (en) * | 2002-07-16 | 2004-01-21 | Anatoli Nicolai Verentchikov | Time-nested mass analysis using a TOF-TOF tandem mass spectrometer |
| JP2006500757A (en) * | 2002-09-24 | 2006-01-05 | サイファージェン バイオシステムズ インコーポレイテッド | Electric sector time-of-flight tandem mass spectrometer |
| JP2006228435A (en) * | 2005-02-15 | 2006-08-31 | Shimadzu Corp | Time-of-flight mass spectrometer |
-
2006
- 2006-03-22 JP JP2008503137A patent/JP5357538B2/en not_active Expired - Lifetime
- 2006-03-22 EP EP06748558.1A patent/EP1866951B1/en not_active Expired - Lifetime
- 2006-03-22 US US11/277,181 patent/US7326925B2/en active Active
- 2006-03-22 WO PCT/US2006/010437 patent/WO2006102430A2/en not_active Ceased
- 2006-03-22 CN CN2006800153674A patent/CN101171660B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037586A (en) * | 1998-06-18 | 2000-03-14 | Universite Laval | Apparatus and method for separating pulsed ions by mass as said pulsed ions are guided along a course |
| GB2403063A (en) * | 2003-06-21 | 2004-12-22 | Anatoli Nicolai Verentchikov | Time of flight mass spectrometer employing a plurality of lenses focussing an ion beam in shift direction |
Non-Patent Citations (1)
| Title |
|---|
| See also references of WO2006102430A2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101171660A (en) | 2008-04-30 |
| EP1866951B1 (en) | 2018-01-17 |
| CN101171660B (en) | 2010-09-29 |
| WO2006102430A2 (en) | 2006-09-28 |
| JP5357538B2 (en) | 2013-12-04 |
| US20060214100A1 (en) | 2006-09-28 |
| JP2008535164A (en) | 2008-08-28 |
| US7326925B2 (en) | 2008-02-05 |
| WO2006102430A3 (en) | 2007-12-06 |
| EP1866951A2 (en) | 2007-12-19 |
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