EP1929003A4 - Reactifs de detection de phosporylation proteinique dans des voies de signalisation de carcinome - Google Patents
Reactifs de detection de phosporylation proteinique dans des voies de signalisation de carcinomeInfo
- Publication number
- EP1929003A4 EP1929003A4 EP06814000A EP06814000A EP1929003A4 EP 1929003 A4 EP1929003 A4 EP 1929003A4 EP 06814000 A EP06814000 A EP 06814000A EP 06814000 A EP06814000 A EP 06814000A EP 1929003 A4 EP1929003 A4 EP 1929003A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- reagents
- detection
- signaling pathways
- protein phosphorylation
- carcinoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10151010A EP2182057A1 (fr) | 2005-08-31 | 2006-08-31 | Anticorps contre tyrosine phosphorylée pour la détection de la phosphorylation de protéines dans des voies signalant un carcinome |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71304105P | 2005-08-31 | 2005-08-31 | |
| PCT/US2006/033991 WO2007027867A2 (fr) | 2005-08-31 | 2006-08-31 | Reactifs de detection de phosporylation proteinique dans des voies de signalisation de carcinome |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1929003A2 EP1929003A2 (fr) | 2008-06-11 |
| EP1929003A4 true EP1929003A4 (fr) | 2009-04-29 |
Family
ID=37809500
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP06814000A Withdrawn EP1929003A4 (fr) | 2005-08-31 | 2006-08-31 | Reactifs de detection de phosporylation proteinique dans des voies de signalisation de carcinome |
| EP10151010A Withdrawn EP2182057A1 (fr) | 2005-08-31 | 2006-08-31 | Anticorps contre tyrosine phosphorylée pour la détection de la phosphorylation de protéines dans des voies signalant un carcinome |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP10151010A Withdrawn EP2182057A1 (fr) | 2005-08-31 | 2006-08-31 | Anticorps contre tyrosine phosphorylée pour la détection de la phosphorylation de protéines dans des voies signalant un carcinome |
Country Status (2)
| Country | Link |
|---|---|
| EP (2) | EP1929003A4 (fr) |
| WO (1) | WO2007027867A2 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| DE102004024617A1 (de) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| EP1790664A1 (fr) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Anticorps monoclonaux contre claudin-18 pour le traitement du cancer |
| WO2008030543A2 (fr) * | 2006-09-08 | 2008-03-13 | Cell Signaling Technology, Inc. | Sites de phosphorylation de tyrosine, sérine et thréonine |
| EP1983002A3 (fr) * | 2007-04-19 | 2009-03-11 | Peter Hornbeck | Sites de phosphorylation à tyrosine et anticorps spécifiques |
| CA2729219A1 (fr) | 2008-06-23 | 2010-01-21 | Perkinelmer Health Sciences, Inc. | Substrats de kinases |
| ES2670651T3 (es) | 2011-10-04 | 2018-05-31 | Expression Pathology, Inc. | Ensayo de SRM/MRM para determinar la proteína ERBB-4 del receptor de tirosina-proteína quinasa (HER4) |
| WO2013167153A1 (fr) * | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Anticorps utiles dans le diagnostic du cancer |
| WO2013174404A1 (fr) | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer |
| WO2014075788A1 (fr) | 2012-11-13 | 2014-05-22 | Biontech Ag | Agents de traitement de maladies cancéreuses exprimant claudine |
| WO2014127785A1 (fr) | 2013-02-20 | 2014-08-28 | Ganymed Pharmaceuticals Ag | Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer |
| WO2014146672A1 (fr) | 2013-03-18 | 2014-09-25 | Ganymed Pharmaceuticals Ag | Thérapie comprenant des anticorps dirigés contre cldn 18.2 pour le traitement du cancer |
| WO2022103990A1 (fr) * | 2020-11-12 | 2022-05-19 | Phosfish Llc | Procédés de modification de résidus de tyrosine phosphorylés ou sulfatés de polypeptides |
| WO2025224609A1 (fr) * | 2024-04-23 | 2025-10-30 | Seqirus Inc. | Dosage de potentiel |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007133702A2 (fr) * | 2006-05-12 | 2007-11-22 | Cell Signaling Technology, Inc. | Réactifs pour la détection des chemins de signalisation de l'acétylation des protéines |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| US4659678A (en) | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4727022A (en) | 1984-03-14 | 1988-02-23 | Syntex (U.S.A.) Inc. | Methods for modulating ligand-receptor interactions and their application |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5675063A (en) | 1995-02-28 | 1997-10-07 | Loyola University Of Chicago | Immortalized rabbit hybridoma fusion partner |
| US7198896B2 (en) | 1998-09-04 | 2007-04-03 | Cell Signaling Technology, Inc. | Immunoaffinity isolation of modified peptides from complex mixtures |
| ATE508361T1 (de) | 2001-08-14 | 2011-05-15 | Harvard College | Absolute quantifizierung von proteinen und modifizierten formen davon mittels mehrstufiger massenspektrometrie |
| JP2003088388A (ja) * | 2001-09-14 | 2003-03-25 | Herikkusu Kenkyusho:Kk | 新規な全長cDNA |
| US20050187147A1 (en) * | 2003-09-22 | 2005-08-25 | Newman Michael J. | Compositions and methods for increasing drug efficiency |
-
2006
- 2006-08-31 EP EP06814000A patent/EP1929003A4/fr not_active Withdrawn
- 2006-08-31 WO PCT/US2006/033991 patent/WO2007027867A2/fr not_active Ceased
- 2006-08-31 EP EP10151010A patent/EP2182057A1/fr not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007133702A2 (fr) * | 2006-05-12 | 2007-11-22 | Cell Signaling Technology, Inc. | Réactifs pour la détection des chemins de signalisation de l'acétylation des protéines |
Non-Patent Citations (4)
| Title |
|---|
| ALBERTA J A ET AL: "Generation and utilization of phosphorylation state-specific antibodies to investigate signaling pathways.", CURRENT PROTOCOLS IN NEUROSCIENCE / EDITORIAL BOARD, JACQUELINE N. CRAWLEY ... [ET AL.] MAY 2001, vol. Chapter 3, May 2001 (2001-05-01), pages Unit 3.14, XP002518938, ISSN: 1934-8576 * |
| MANDELL J W: "Phosphorylation state-specific antibodies: applications in investigative and diagnostic pathology", AMERICAN JOURNAL OF PATHOLOGY, AMERICAN SOCIETY FOR INVESTIGATIVE PATHOLOGY, US, vol. 163, no. 5, 1 November 2003 (2003-11-01), pages 1687 - 1698, XP003017035, ISSN: 0002-9440 * |
| OGAWA R ET AL: "INCREASE OF PHOSPHOTYROSINE-CONTAINING PROTEINS IN HUMAN CARCINOMAS", JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 76, no. 11, 1 January 1985 (1985-01-01), pages 1049 - 1055, XP009113485, ISSN: 0910-5050 * |
| PULFORD KAREN ET AL: "Immunohistochemical screening for oncogenic tyrosine kinase activation", JOURNAL OF PATHOLOGY, vol. 187, no. 5, April 1999 (1999-04-01), pages 588 - 593, XP002518937, ISSN: 0022-3417 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007027867A3 (fr) | 2007-12-21 |
| EP1929003A2 (fr) | 2008-06-11 |
| WO2007027867A2 (fr) | 2007-03-08 |
| EP2182057A1 (fr) | 2010-05-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20080320 |
|
| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
| AX | Request for extension of the european patent |
Extension state: AL BA HR MK RS |
|
| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SPEK, ERIK Inventor name: MORITZ, ALBRECHT Inventor name: LI, YU Inventor name: RIKOVA, KLARISA Inventor name: GUO, AILAN Inventor name: FARNSWORTH, CHARLES Inventor name: LEE, KIMBERLY Inventor name: POLAKIEWICZ, ROBERTO |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20090330 |
|
| 17Q | First examination report despatched |
Effective date: 20090708 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20100119 |