EP1929003A4 - Reactifs de detection de phosporylation proteinique dans des voies de signalisation de carcinome - Google Patents

Reactifs de detection de phosporylation proteinique dans des voies de signalisation de carcinome

Info

Publication number
EP1929003A4
EP1929003A4 EP06814000A EP06814000A EP1929003A4 EP 1929003 A4 EP1929003 A4 EP 1929003A4 EP 06814000 A EP06814000 A EP 06814000A EP 06814000 A EP06814000 A EP 06814000A EP 1929003 A4 EP1929003 A4 EP 1929003A4
Authority
EP
European Patent Office
Prior art keywords
reagents
detection
signaling pathways
protein phosphorylation
carcinoma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06814000A
Other languages
German (de)
English (en)
Other versions
EP1929003A2 (fr
Inventor
Roberto Polakiewicz
Kimberly Lee
Charles Farnsworth
Ailan Guo
Klarisa Rikova
Yu Li
Albrecht Moritz
Erik Spek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Signaling Technology Inc
Original Assignee
Cell Signaling Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Signaling Technology Inc filed Critical Cell Signaling Technology Inc
Priority to EP10151010A priority Critical patent/EP2182057A1/fr
Publication of EP1929003A2 publication Critical patent/EP1929003A2/fr
Publication of EP1929003A4 publication Critical patent/EP1929003A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008Peptides; Proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP06814000A 2005-08-31 2006-08-31 Reactifs de detection de phosporylation proteinique dans des voies de signalisation de carcinome Withdrawn EP1929003A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10151010A EP2182057A1 (fr) 2005-08-31 2006-08-31 Anticorps contre tyrosine phosphorylée pour la détection de la phosphorylation de protéines dans des voies signalant un carcinome

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71304105P 2005-08-31 2005-08-31
PCT/US2006/033991 WO2007027867A2 (fr) 2005-08-31 2006-08-31 Reactifs de detection de phosporylation proteinique dans des voies de signalisation de carcinome

Publications (2)

Publication Number Publication Date
EP1929003A2 EP1929003A2 (fr) 2008-06-11
EP1929003A4 true EP1929003A4 (fr) 2009-04-29

Family

ID=37809500

Family Applications (2)

Application Number Title Priority Date Filing Date
EP06814000A Withdrawn EP1929003A4 (fr) 2005-08-31 2006-08-31 Reactifs de detection de phosporylation proteinique dans des voies de signalisation de carcinome
EP10151010A Withdrawn EP2182057A1 (fr) 2005-08-31 2006-08-31 Anticorps contre tyrosine phosphorylée pour la détection de la phosphorylation de protéines dans des voies signalant un carcinome

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP10151010A Withdrawn EP2182057A1 (fr) 2005-08-31 2006-08-31 Anticorps contre tyrosine phosphorylée pour la détection de la phosphorylation de protéines dans des voies signalant un carcinome

Country Status (2)

Country Link
EP (2) EP1929003A4 (fr)
WO (1) WO2007027867A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
DE102004024617A1 (de) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
EP1790664A1 (fr) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Anticorps monoclonaux contre claudin-18 pour le traitement du cancer
WO2008030543A2 (fr) * 2006-09-08 2008-03-13 Cell Signaling Technology, Inc. Sites de phosphorylation de tyrosine, sérine et thréonine
EP1983002A3 (fr) * 2007-04-19 2009-03-11 Peter Hornbeck Sites de phosphorylation à tyrosine et anticorps spécifiques
CA2729219A1 (fr) 2008-06-23 2010-01-21 Perkinelmer Health Sciences, Inc. Substrats de kinases
ES2670651T3 (es) 2011-10-04 2018-05-31 Expression Pathology, Inc. Ensayo de SRM/MRM para determinar la proteína ERBB-4 del receptor de tirosina-proteína quinasa (HER4)
WO2013167153A1 (fr) * 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Anticorps utiles dans le diagnostic du cancer
WO2013174404A1 (fr) 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer
WO2014075788A1 (fr) 2012-11-13 2014-05-22 Biontech Ag Agents de traitement de maladies cancéreuses exprimant claudine
WO2014127785A1 (fr) 2013-02-20 2014-08-28 Ganymed Pharmaceuticals Ag Polythérapie impliquant des anticorps dirigés contre la claudine 18,2 pour le traitement du cancer
WO2014146672A1 (fr) 2013-03-18 2014-09-25 Ganymed Pharmaceuticals Ag Thérapie comprenant des anticorps dirigés contre cldn 18.2 pour le traitement du cancer
WO2022103990A1 (fr) * 2020-11-12 2022-05-19 Phosfish Llc Procédés de modification de résidus de tyrosine phosphorylés ou sulfatés de polypeptides
WO2025224609A1 (fr) * 2024-04-23 2025-10-30 Seqirus Inc. Dosage de potentiel

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007133702A2 (fr) * 2006-05-12 2007-11-22 Cell Signaling Technology, Inc. Réactifs pour la détection des chemins de signalisation de l'acétylation des protéines

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4474893A (en) 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4659678A (en) 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4727022A (en) 1984-03-14 1988-02-23 Syntex (U.S.A.) Inc. Methods for modulating ligand-receptor interactions and their application
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5675063A (en) 1995-02-28 1997-10-07 Loyola University Of Chicago Immortalized rabbit hybridoma fusion partner
US7198896B2 (en) 1998-09-04 2007-04-03 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
ATE508361T1 (de) 2001-08-14 2011-05-15 Harvard College Absolute quantifizierung von proteinen und modifizierten formen davon mittels mehrstufiger massenspektrometrie
JP2003088388A (ja) * 2001-09-14 2003-03-25 Herikkusu Kenkyusho:Kk 新規な全長cDNA
US20050187147A1 (en) * 2003-09-22 2005-08-25 Newman Michael J. Compositions and methods for increasing drug efficiency

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007133702A2 (fr) * 2006-05-12 2007-11-22 Cell Signaling Technology, Inc. Réactifs pour la détection des chemins de signalisation de l'acétylation des protéines

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALBERTA J A ET AL: "Generation and utilization of phosphorylation state-specific antibodies to investigate signaling pathways.", CURRENT PROTOCOLS IN NEUROSCIENCE / EDITORIAL BOARD, JACQUELINE N. CRAWLEY ... [ET AL.] MAY 2001, vol. Chapter 3, May 2001 (2001-05-01), pages Unit 3.14, XP002518938, ISSN: 1934-8576 *
MANDELL J W: "Phosphorylation state-specific antibodies: applications in investigative and diagnostic pathology", AMERICAN JOURNAL OF PATHOLOGY, AMERICAN SOCIETY FOR INVESTIGATIVE PATHOLOGY, US, vol. 163, no. 5, 1 November 2003 (2003-11-01), pages 1687 - 1698, XP003017035, ISSN: 0002-9440 *
OGAWA R ET AL: "INCREASE OF PHOSPHOTYROSINE-CONTAINING PROTEINS IN HUMAN CARCINOMAS", JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 76, no. 11, 1 January 1985 (1985-01-01), pages 1049 - 1055, XP009113485, ISSN: 0910-5050 *
PULFORD KAREN ET AL: "Immunohistochemical screening for oncogenic tyrosine kinase activation", JOURNAL OF PATHOLOGY, vol. 187, no. 5, April 1999 (1999-04-01), pages 588 - 593, XP002518937, ISSN: 0022-3417 *

Also Published As

Publication number Publication date
WO2007027867A3 (fr) 2007-12-21
EP1929003A2 (fr) 2008-06-11
WO2007027867A2 (fr) 2007-03-08
EP2182057A1 (fr) 2010-05-05

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: SPEK, ERIK

Inventor name: MORITZ, ALBRECHT

Inventor name: LI, YU

Inventor name: RIKOVA, KLARISA

Inventor name: GUO, AILAN

Inventor name: FARNSWORTH, CHARLES

Inventor name: LEE, KIMBERLY

Inventor name: POLAKIEWICZ, ROBERTO

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