EP2035005A4 - Therapy using cytokine inhibitors - Google Patents
Therapy using cytokine inhibitorsInfo
- Publication number
- EP2035005A4 EP2035005A4 EP07798190A EP07798190A EP2035005A4 EP 2035005 A4 EP2035005 A4 EP 2035005A4 EP 07798190 A EP07798190 A EP 07798190A EP 07798190 A EP07798190 A EP 07798190A EP 2035005 A4 EP2035005 A4 EP 2035005A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- therapy
- cytokine inhibitors
- cytokine
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000004127 Cytokines Human genes 0.000 title 1
- 108090000695 Cytokines Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81226806P | 2006-06-09 | 2006-06-09 | |
| US83307806P | 2006-07-24 | 2006-07-24 | |
| US83527006P | 2006-08-03 | 2006-08-03 | |
| PCT/US2007/070547 WO2007146712A2 (en) | 2006-06-09 | 2007-06-06 | Therapy using cytokine inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2035005A2 EP2035005A2 (en) | 2009-03-18 |
| EP2035005A4 true EP2035005A4 (en) | 2011-07-06 |
Family
ID=38832677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP07798190A Withdrawn EP2035005A4 (en) | 2006-06-09 | 2007-06-06 | Therapy using cytokine inhibitors |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2035005A4 (en) |
| AR (1) | AR061273A1 (en) |
| AU (1) | AU2007257959A1 (en) |
| CA (1) | CA2691214A1 (en) |
| CL (1) | CL2007001670A1 (en) |
| PE (1) | PE20080935A1 (en) |
| TW (1) | TW200814998A (en) |
| WO (1) | WO2007146712A2 (en) |
Families Citing this family (81)
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| CA2641880C (en) | 2006-02-10 | 2014-09-09 | Summit Corporation Plc | Treatment of duchenne muscular dystrophy |
| US7989459B2 (en) | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
| US7919490B2 (en) | 2006-10-04 | 2011-04-05 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| US7902187B2 (en) | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
| TW200837064A (en) | 2006-10-04 | 2008-09-16 | Pharmacopeia Inc | 8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US7902248B2 (en) | 2006-12-14 | 2011-03-08 | Hoffmann-La Roche Inc. | Oxime glucokinase activators |
| US8440832B2 (en) * | 2007-07-13 | 2013-05-14 | Board Of Regents, The University Of Texas System | Heterocyclic modulators of cannabinoid receptors |
| CA2685540C (en) | 2007-08-03 | 2018-10-16 | Graham Michael Wynne | Drug combinations for the treatment of duchenne muscular dystrophy |
| CN102099036B (en) | 2008-06-03 | 2015-05-27 | 英特芒尼公司 | Compounds and methods for treating inflammatory and fibrotic disorders |
| WO2010053861A2 (en) * | 2008-11-07 | 2010-05-14 | H. Lundbeck A/S | Biologically active amides |
| WO2010141932A1 (en) | 2009-06-05 | 2010-12-09 | Link Medicine Corporation | Aminopyrrolidinone derivatives and uses thereof |
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| EP2633857B1 (en) * | 2009-12-23 | 2015-08-12 | ratiopharm GmbH | Solid pharmaceutical dosage form of ticagrelor and acetylsalicylic acid |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| CN102918034B (en) | 2010-03-30 | 2015-06-03 | 维颂公司 | Polysubstituted aromatic compounds as inhibitors of thrombin |
| ES2608474T3 (en) | 2010-04-22 | 2017-04-11 | Vertex Pharmaceuticals Incorporated | Production process of indole compounds cycloalkylcarboxamido |
| AR081331A1 (en) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | AMINO- PYRIMIDINES COMPOSITIONS OF THE SAME AND METHODS FOR THE USE OF THE SAME |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| AR081626A1 (en) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | AMINO-PYRIDAZINIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME TO TREAT CARDIAC AND SKELETIC MUSCULAR DISORDERS |
| US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
| DE202012012955U1 (en) | 2011-10-21 | 2014-07-14 | Abbvie Inc. | A combination of at least two direct-acting antiviral agents (DAAs) for use in the treatment of HCV |
| EP2583677A3 (en) | 2011-10-21 | 2013-07-03 | Abbvie Inc. | Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon. |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| AR092742A1 (en) | 2012-10-02 | 2015-04-29 | Intermune Inc | ANTIFIBROTIC PYRIDINONES |
| LT2968297T (en) | 2013-03-15 | 2019-01-10 | Verseon Corporation | Multisubstituted aromatic compounds as serine protease inhibitors |
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| ES2885181T3 (en) | 2014-04-15 | 2021-12-13 | Vertex Pharma | Pharmaceutical compositions for the treatment of diseases mediated by the transmembrane conductance regulator of cystic fibrosis |
| CN106687445A (en) | 2014-09-17 | 2017-05-17 | 维颂公司 | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
| EP3230279A1 (en) | 2014-12-10 | 2017-10-18 | Massachusetts Institute of Technology | Fused 1,3-azole derivatives useful for the treatment of proliferative diseases |
| RU2017131562A (en) | 2015-02-27 | 2019-03-27 | Версеон Корпорейшн | SUBSTITUTED PYRAZOLIC COMPOUNDS AS SERINE PROTEASES INHIBITORS |
| EP3307273B1 (en) * | 2015-06-12 | 2020-12-09 | University of Greenwich | Triazine derivatives as interferon-gamma inhibitors |
| WO2017070089A1 (en) | 2015-10-19 | 2017-04-27 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
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| KR20180107261A (en) | 2016-02-16 | 2018-10-01 | 메사추세츠 인스티튜트 오브 테크놀로지 | MAX binders as Myc modifiers and their uses |
| EA201892448A1 (en) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | ALKYN-CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND RELATED APPLICATION METHODS |
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| ES2866883T3 (en) | 2016-06-08 | 2021-10-20 | Support Venture Gmbh | Pharmaceutical combinations for the treatment of cancer |
| HUE060256T2 (en) | 2016-06-20 | 2023-02-28 | Incyte Corp | Heterocyclic compounds as immunomodulators |
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| WO2018044783A1 (en) | 2016-08-29 | 2018-03-08 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| JP6883653B2 (en) | 2016-12-20 | 2021-06-09 | アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag | Amino-triazolopyridine compounds and their use in the treatment of cancer |
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| US11242327B2 (en) * | 2017-05-15 | 2022-02-08 | Recurium Ip Holdings, Llc | Analgesic compounds |
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| BR112020006677A2 (en) | 2017-10-05 | 2020-10-06 | Fulcrum Therapeutics, Inc. | use of p38 inhibitors to reduce dux4 expression |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
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| KR20250161056A (en) * | 2018-09-13 | 2025-11-14 | 에이리온 테라퓨틱스, 인코포레이티드 | Uses of plasminogen activator inhibitor 1(pai-1) inhibitors |
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| TW202112767A (en) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
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| JP7665593B2 (en) | 2019-08-09 | 2025-04-21 | インサイト・コーポレイション | Salts of PD-1/PD-L1 inhibitors |
| PE20221038A1 (en) | 2019-09-30 | 2022-06-17 | Incyte Corp | PYRIDO[3,2-D] PYRIMIDINE COMPOUNDS AS IMMUNOMODULATORS |
| WO2021092240A1 (en) * | 2019-11-05 | 2021-05-14 | Dermira, Inc. | Mrgprx2 antagonists for the treatment of inflammatory disorders |
| CA3160131A1 (en) | 2019-11-11 | 2021-05-20 | Incyte Corporation | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
| JP7665619B2 (en) | 2019-12-04 | 2025-04-21 | イドルシア・ファーマシューティカルズ・リミテッド | Combination of an azetidine LPA1 receptor antagonist with pirfenidone and/or nintedanib for use in the treatment of fibrotic diseases |
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| CR20230230A (en) | 2020-11-06 | 2023-07-27 | Incyte Corp | PROCESS FOR MAKING A PD-1/PDL1 INHIBITOR AND SALTS AND CRYSTALLINE FORMS THEREOF |
| TW202233615A (en) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | Crystalline form of a pd-1/pd-l1 inhibitor |
| WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
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| SMT202500481T1 (en) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
| KR20250010152A (en) | 2022-02-14 | 2025-01-20 | 액센트 테라퓨틱스, 인크. | Inhibitors of RNA helicase DHX9 and uses thereof |
| WO2024059220A2 (en) * | 2022-09-15 | 2024-03-21 | Vanderbilt University | 6,5 southwestern core compounds as mglu5 negative allosteric modulators and methods of making and using the same |
| CN118496159B (en) * | 2024-07-18 | 2024-09-24 | 广州医科大学附属市八医院 | Application of compound in preparation of medicine with liver fibrosis preventing and/or treating effect |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030008868A1 (en) * | 2001-05-16 | 2003-01-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
| WO2005023761A2 (en) * | 2003-09-11 | 2005-03-17 | Kemia, Inc. | Cytokine inhibitors |
-
2007
- 2007-06-06 CA CA2691214A patent/CA2691214A1/en not_active Abandoned
- 2007-06-06 AU AU2007257959A patent/AU2007257959A1/en not_active Abandoned
- 2007-06-06 WO PCT/US2007/070547 patent/WO2007146712A2/en not_active Ceased
- 2007-06-06 EP EP07798190A patent/EP2035005A4/en not_active Withdrawn
- 2007-06-08 PE PE2007000714A patent/PE20080935A1/en not_active Application Discontinuation
- 2007-06-08 CL CL2007001670A patent/CL2007001670A1/en unknown
- 2007-06-08 TW TW096120764A patent/TW200814998A/en unknown
- 2007-06-08 AR ARP070102483A patent/AR061273A1/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030008868A1 (en) * | 2001-05-16 | 2003-01-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
| WO2005023761A2 (en) * | 2003-09-11 | 2005-03-17 | Kemia, Inc. | Cytokine inhibitors |
| US20100273797A1 (en) * | 2003-09-11 | 2010-10-28 | Itherx Pharmaceuticals, Inc. | Alpha-ketoamides and derivatives thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007146712A2 (en) | 2007-12-21 |
| CA2691214A1 (en) | 2007-12-21 |
| CL2007001670A1 (en) | 2008-01-18 |
| PE20080935A1 (en) | 2008-08-02 |
| AR061273A1 (en) | 2008-08-13 |
| EP2035005A2 (en) | 2009-03-18 |
| TW200814998A (en) | 2008-04-01 |
| WO2007146712A3 (en) | 2008-11-27 |
| AU2007257959A1 (en) | 2007-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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| 17P | Request for examination filed |
Effective date: 20090108 |
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| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR |
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| AX | Request for extension of the european patent |
Extension state: AL BA HR MK RS |
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| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SHUSTER, LEWIS, J. Inventor name: PRYOR, KENT Inventor name: MILLER, STEPHEN Inventor name: LARSON, CHRISTOPHER, J. Inventor name: KING, BERNARD Inventor name: HEPBURN, BONNIE Inventor name: GROVE, CARRIE, GAIL Inventor name: ERNST, JUSTIN Inventor name: DELAET, NANCY G., J. Inventor name: CROWLEY, CONSTANCE, A. |
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| DAX | Request for extension of the european patent (deleted) | ||
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20110607 |
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| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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| 18D | Application deemed to be withdrawn |
Effective date: 20120105 |