EP2170064A4 - ANTAGONISTS 6,5-PYRROLOPIPERIDINE OF TACHYKININ RECEPTORS - Google Patents

ANTAGONISTS 6,5-PYRROLOPIPERIDINE OF TACHYKININ RECEPTORS

Info

Publication number
EP2170064A4
EP2170064A4 EP08771300A EP08771300A EP2170064A4 EP 2170064 A4 EP2170064 A4 EP 2170064A4 EP 08771300 A EP08771300 A EP 08771300A EP 08771300 A EP08771300 A EP 08771300A EP 2170064 A4 EP2170064 A4 EP 2170064A4
Authority
EP
European Patent Office
Prior art keywords
pyrrolopiperidine
antagonists
tachykinin receptors
tachykinin
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08771300A
Other languages
German (de)
French (fr)
Other versions
EP2170064A1 (en
Inventor
Jianming Bao
Robert J Devita
Huagang Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Merck Sharp & Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp & Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp & Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Publication of EP2170064A1 publication Critical patent/EP2170064A1/en
Publication of EP2170064A4 publication Critical patent/EP2170064A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP08771300A 2007-06-22 2008-06-18 ANTAGONISTS 6,5-PYRROLOPIPERIDINE OF TACHYKININ RECEPTORS Withdrawn EP2170064A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93686407P 2007-06-22 2007-06-22
PCT/US2008/067270 WO2009002770A1 (en) 2007-06-22 2008-06-18 6.5-pyrrolopiperidine tachykinin receptor antagonists

Publications (2)

Publication Number Publication Date
EP2170064A1 EP2170064A1 (en) 2010-04-07
EP2170064A4 true EP2170064A4 (en) 2010-08-04

Family

ID=40185984

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08771300A Withdrawn EP2170064A4 (en) 2007-06-22 2008-06-18 ANTAGONISTS 6,5-PYRROLOPIPERIDINE OF TACHYKININ RECEPTORS

Country Status (5)

Country Link
EP (1) EP2170064A4 (en)
JP (1) JP2010530874A (en)
AU (1) AU2008268667A1 (en)
CA (1) CA2690737A1 (en)
WO (1) WO2009002770A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101074202B1 (en) * 2007-01-18 2011-10-14 에스케이종합화학 주식회사 Ethylene tetramerization catalyst systems and method for preparing 1-octene using the same
PT2501234T (en) * 2009-11-20 2017-12-13 Tonix Pharma Holdings Ltd METHODS AND COMPOSITIONS FOR THE TREATMENT OF SYMPTOMS ASSOCIATED WITH POST-TRAUMATIC STRESS DISORDERS USING CICLOBENZAPRINA
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US11998516B2 (en) 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
EP2817312B1 (en) * 2012-02-22 2016-02-17 Leo Pharma A/S Novel neurokinin 1 receptor antagonist compounds
AR092211A1 (en) * 2012-09-24 2015-04-08 Merck Patent Ges Mit Beschränkter Haftung HYDROPIRROLOPIRROL DERIVATIVES
MY196014A (en) 2013-03-15 2023-03-06 Tonix Pharmaceuticals Inc Eutectic Formulations of Cyclobenzaprine Hydrochloride and Amitriptyline Hydrochloride
WO2015024203A1 (en) * 2013-08-20 2015-02-26 Leo Pharma A/S Novel neurokinin 1 receptor antagonist compounds ii
SG10201902203VA (en) 2014-09-18 2019-04-29 Tonix Pharma Holdings Ltd Eutectic formulations of cyclobenzaprine hydrochloride
BR112020011345A2 (en) 2017-12-11 2020-11-17 Tonix Pharma Holdings Limited cyclobenzaprine treatment for agitation, psychosis and cognitive decline in dementia and neurodegenerative conditions
RU2020131446A (en) 2018-02-26 2022-03-28 Оспедале Сан Раффаэле С.Р.Л. NK-1 ANTAGONISTS FOR USE IN THE TREATMENT OF EYE PAIN
EP4117673A1 (en) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Treatment of stem cell deficiency

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004110996A1 (en) * 2003-06-19 2004-12-23 Pfizer Products Inc. Nk1 antagonist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0203020D0 (en) * 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
US7652058B2 (en) * 2004-12-14 2010-01-26 Merck Sharp & Dohme Corp. Octahydropyrano[3,4-C]pyrrole tachykinin receptor antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004110996A1 (en) * 2003-06-19 2004-12-23 Pfizer Products Inc. Nk1 antagonist

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2009002770A1 *

Also Published As

Publication number Publication date
EP2170064A1 (en) 2010-04-07
AU2008268667A1 (en) 2008-12-31
CA2690737A1 (en) 2008-12-31
WO2009002770A1 (en) 2008-12-31
JP2010530874A (en) 2010-09-16

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Ipc: A61P 25/24 20060101ALI20100701BHEP

Ipc: A61P 25/22 20060101ALI20100701BHEP

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Ipc: A61P 13/00 20060101ALI20100701BHEP

Ipc: A61K 31/437 20060101ALI20100701BHEP

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