EP2175865A4 - Controlled release interferon drug products and treatment of hcv infection using same - Google Patents

Controlled release interferon drug products and treatment of hcv infection using same

Info

Publication number
EP2175865A4
EP2175865A4 EP08782397A EP08782397A EP2175865A4 EP 2175865 A4 EP2175865 A4 EP 2175865A4 EP 08782397 A EP08782397 A EP 08782397A EP 08782397 A EP08782397 A EP 08782397A EP 2175865 A4 EP2175865 A4 EP 2175865A4
Authority
EP
European Patent Office
Prior art keywords
treatment
same
controlled release
hcv infection
drug products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08782397A
Other languages
German (de)
French (fr)
Other versions
EP2175865A2 (en
Inventor
David Gelvin Spencer Jr
John Elliot Humphries
Leede Leonardus Gerardus Jozef De
Rudolf Verrijk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biolex Therapeutics Inc
Original Assignee
Biolex Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolex Therapeutics Inc filed Critical Biolex Therapeutics Inc
Publication of EP2175865A2 publication Critical patent/EP2175865A2/en
Publication of EP2175865A4 publication Critical patent/EP2175865A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EP08782397A 2007-07-25 2008-07-25 Controlled release interferon drug products and treatment of hcv infection using same Withdrawn EP2175865A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95187907P 2007-07-25 2007-07-25
US95214007P 2007-07-26 2007-07-26
US97833007P 2007-10-08 2007-10-08
US98552607P 2007-11-05 2007-11-05
PCT/US2008/071191 WO2009015336A2 (en) 2007-07-25 2008-07-25 Controlled release interferon drug products and treatment of hcv infection using same

Publications (2)

Publication Number Publication Date
EP2175865A2 EP2175865A2 (en) 2010-04-21
EP2175865A4 true EP2175865A4 (en) 2012-01-11

Family

ID=40282165

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08782397A Withdrawn EP2175865A4 (en) 2007-07-25 2008-07-25 Controlled release interferon drug products and treatment of hcv infection using same

Country Status (11)

Country Link
US (1) US8137661B2 (en)
EP (1) EP2175865A4 (en)
JP (1) JP2010534681A (en)
KR (1) KR20100056479A (en)
CN (1) CN101820887A (en)
AU (1) AU2008279087A1 (en)
BR (1) BRPI0814363A2 (en)
CA (1) CA2694440A1 (en)
MX (1) MX2010000965A (en)
WO (1) WO2009015336A2 (en)
ZA (1) ZA201000681B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI480272B (en) * 2008-10-09 2015-04-11 Anadys Pharmaceuticals Inc Method for inhibiting hepatitis C virus by a combination of 5,6-dihydro-1H-pyridin-2-one and one or more other antiviral compounds
WO2012066581A1 (en) 2010-11-19 2012-05-24 Venus Remedies Limited Novel conjugates for targeted drug delivery
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
CA2811203C (en) 2011-10-21 2015-05-05 Abbvie Inc. Methods for treating hcv
CN104023726A (en) 2011-10-21 2014-09-03 艾伯维公司 Combination therapy with one or more DAAs used to treat HCV (eg, with ABT-072 or ABT-333)
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US20140363396A1 (en) * 2012-02-01 2014-12-11 Kadmon Pharmaceuticals Llc Once daily treatment of hepatitis c with ribavirin and taribavirin
WO2013168179A2 (en) * 2012-04-03 2013-11-14 Rubicon Research Private Limited Controlled release pharmaceutical formulations of antiviral agents
JP7129703B2 (en) 2016-04-28 2022-09-02 エモリー ユニバーシティー Alkyne-Containing Nucleotide and Nucleoside Therapeutic Compositions and Uses Associated Therewith
AU2020312735A1 (en) * 2019-07-18 2021-12-16 Enyo Pharma Method for decreasing adverse-effects of interferon
WO2021211659A2 (en) * 2020-04-14 2021-10-21 Amerimmune, Llc Treatment for diseases caused by rna viruses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1679065A1 (en) * 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410697B1 (en) 1979-04-20 2002-06-25 Schering Corporation Process for purifying human leukocyte interferon
US6835557B1 (en) 1980-01-08 2004-12-28 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human interferon-like polypeptides
US6610830B1 (en) 1980-07-01 2003-08-26 Hoffman-La Roche Inc. Microbial production of mature human leukocyte interferons
US4749576A (en) 1984-05-10 1988-06-07 Ciba-Geigy Corporation Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
US6387365B1 (en) 1995-05-19 2002-05-14 Schering Corporation Combination therapy for chronic hepatitis C infection
ES2214551T3 (en) 1995-11-02 2004-09-16 Schering Corporation CONTINUOUS INFUSION THERAPY OF CITOCINES AT LOW DOSE.
US5980948A (en) 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
TR200001021T2 (en) 1997-07-18 2000-09-21 Infimed Inc. Biodegradable macromers for controlled release of active substances.
ATE206618T1 (en) 1997-09-21 2001-10-15 Schering Corp COMBINATION THERAPY FOR REMOVAL OF DETECTED HCV RNA IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION
US6472373B1 (en) 1997-09-21 2002-10-29 Schering Corporation Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection
US6172046B1 (en) 1997-09-21 2001-01-09 Schering Corporation Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection
TWI277424B (en) 1998-05-15 2007-04-01 Schering Corp Combination therapy for eradicating detectable NCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
US20030206928A1 (en) 1999-04-07 2003-11-06 Pertti Tormala Bioactive, bioabsorbable surgical polyethylene glycol and polybutylene terephtalate copolymer composites and devices
US6465425B1 (en) 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US7959910B2 (en) 2000-07-31 2011-06-14 Biolex Therapeutics, Inc. C-terminally truncated interferon alpha variants
NZ523912A (en) 2000-07-31 2005-03-24 Biolex Inc Expression of biologically active polypeptides in duckweed
GB0018968D0 (en) 2000-08-02 2000-09-20 Pfizer Ltd Particulate composition
US7208167B2 (en) * 2000-08-07 2007-04-24 Sciclone Pharmaceuticals, Inc. Treatment of hepatitis C with thymosin and peptide combination therapy
AU2002343681B2 (en) 2001-11-12 2006-07-06 Alkermes Controlled Therapeutics, Inc. Biocompatible polymer blends and uses thereof
ATE435870T1 (en) 2003-01-28 2009-07-15 Academisch Ziekenhuis Leiden PEPTIDE INHIBITORS OF TOXINS DERIVED FROM LL-37
US20050269364A1 (en) 2004-04-30 2005-12-08 Gibson Rayce D Inflatable seal for bin discharge system
EP1621205A1 (en) 2004-07-28 2006-02-01 OctoPlus Technologies B.V. Antimicrobial peptides derived from CAP18
US20070021434A1 (en) 2005-06-24 2007-01-25 Migenix Inc. Non-nucleoside anti-hepacivirus agents and uses thereof
AP2907A (en) * 2006-01-09 2014-05-31 Romark Lab Lc Viral hepatitis treatment

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1679065A1 (en) * 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BEZEMER J M ET AL: "Microspheres for protein delivery prepared from amphiphilic multiblock copolymers - 1. Influence of preparation techniques on particle characteristics and protein delivery", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 67, no. 2-3, 1 July 2000 (2000-07-01), pages 233 - 248, XP004199172, ISSN: 0168-3659, DOI: 10.1016/S0168-3659(00)00213-3 *
BEZEMER J M ET AL: "Microspheres for protein delivery prepared from amphiphilic multiblock copolymers - 2. Modulation of release rate", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 67, no. 2-3, 1 July 2000 (2000-07-01), pages 249 - 260, XP004199173, ISSN: 0168-3659, DOI: 10.1016/S0168-3659(00)00212-1 *

Also Published As

Publication number Publication date
CA2694440A1 (en) 2009-01-29
WO2009015336A3 (en) 2009-03-19
EP2175865A2 (en) 2010-04-21
US20090068280A1 (en) 2009-03-12
CN101820887A (en) 2010-09-01
WO2009015336A2 (en) 2009-01-29
AU2008279087A1 (en) 2009-01-29
BRPI0814363A2 (en) 2015-01-27
ZA201000681B (en) 2013-07-31
JP2010534681A (en) 2010-11-11
US8137661B2 (en) 2012-03-20
MX2010000965A (en) 2010-03-09
KR20100056479A (en) 2010-05-27

Similar Documents

Publication Publication Date Title
ZA201000681B (en) Controlled release interferon drug products and treatment of hcv infection using same
IL207575A0 (en) Vaccine for prevention and treatment of hiv infection
AP3069A (en) Thienopyridine derivatives for the treatment and prvention of dengue virus infection
AP2009005070A0 (en) Antiviral drugs for treatment or prevention of dengue infection
ZA200807507B (en) Antiviral drugs for treatment of arenavirus infection
IL213861A0 (en) Cyclosporine derivative for use in the treatment of hcv and hiv infection
ZA201001585B (en) Spiropyrrolidines and their use against hcv and hiv infection
ZA200803493B (en) Methods and pharmaceutical compositions for the treatment and prevention of hepatitis C infection
AP2707A (en) Antiviral drugs for treatment of arenavirus infection
IL200116A0 (en) Compounds and pharmaceutical compositions for the treatment of viral infections
ZA201109187B (en) Treatment and prevention of dengue virus infections
ZA201100176B (en) Compounds and pharmaceutical compositions for the treatment of viral infections
ZA200807506B (en) Antiviral drugs for treatment of arenavirus infection
ZA201403852B (en) Substituted benzylamine compounds, their use in medicine, and in particular the treatment of hepatitis c virus (hcv) infection
IL225861A (en) Derivatives of indazole-3-carboxamide and use thereof in the manufacture of medicaments for the treatment of hepatitis c virus (hcv) infection
GB2445651B (en) Well treatment products and methods of using them
IL201376A0 (en) Products for prophylaxis and /or treatment of viral diseases and method of making and using same
IL185637A (en) Apparatus for treatment and prevention of infectious disease
PL2106401T3 (en) Derivatives of pyrrolopyridine-2-carboxamids, preparation thereof and therapeutic application thereof
HK1142835A (en) Controlled release interferon drug products and treatment of hcv infection using same
GB0815179D0 (en) Medication and treatment for infection
ZA201202070B (en) Treatment and prevention of hiv infection
PL383271A1 (en) Pharmaceutical composition useful in treatment of virus diseases
PL383272A1 (en) Pharmaceutical composition useful in treatment of virus diseases
ZA201103320B (en) Pharmaceutical composition for therapeutic or prophylactic treatment of bacterial infections and associated diseases

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20100212

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA MK RS

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1142835

Country of ref document: HK

A4 Supplementary search report drawn up and despatched

Effective date: 20111212

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 31/14 20060101ALI20111206BHEP

Ipc: A61K 38/21 20060101ALI20111206BHEP

Ipc: A61K 9/14 20060101ALI20111206BHEP

Ipc: A61K 31/74 20060101AFI20111206BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20140201

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1142835

Country of ref document: HK