EP2187893A4 - SMALL BORONOUS MOLECULES AS ANTI-INFLAMMATORY ACTIVE SUBSTANCES - Google Patents

SMALL BORONOUS MOLECULES AS ANTI-INFLAMMATORY ACTIVE SUBSTANCES

Info

Publication number
EP2187893A4
EP2187893A4 EP09700012A EP09700012A EP2187893A4 EP 2187893 A4 EP2187893 A4 EP 2187893A4 EP 09700012 A EP09700012 A EP 09700012A EP 09700012 A EP09700012 A EP 09700012A EP 2187893 A4 EP2187893 A4 EP 2187893A4
Authority
EP
European Patent Office
Prior art keywords
boronous
molecules
small
active substances
inflammatory active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09700012A
Other languages
German (de)
French (fr)
Other versions
EP2187893A2 (en
Inventor
Tsutomu Akama
Yong-Kang Zhang
Charles Z Ding
Jacob J Plattner
Kirk R Maples
Yvonne Freund
Virginia Sanders
Yi Xia
Stephen J Baker
James A Niemann
Xiaosong Lu
Marcelo Sales
Rashmi Sharma
Rajeshwar Singh
Robert Jacobs
Daitao Chen
Michael Richard Kevin Alley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anacor Pharmaceuticals LLC
Original Assignee
Anacor Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anacor Pharmaceuticals LLC filed Critical Anacor Pharmaceuticals LLC
Priority to EP12178640.4A priority Critical patent/EP2564857B1/en
Priority to EP17158536.7A priority patent/EP3246034A1/en
Publication of EP2187893A2 publication Critical patent/EP2187893A2/en
Publication of EP2187893A4 publication Critical patent/EP2187893A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP09700012A 2008-03-06 2009-03-05 SMALL BORONOUS MOLECULES AS ANTI-INFLAMMATORY ACTIVE SUBSTANCES Withdrawn EP2187893A4 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP12178640.4A EP2564857B1 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
EP17158536.7A EP3246034A1 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US3437108P 2008-03-06 2008-03-06
US5263708P 2008-05-12 2008-05-12
US9440608P 2008-09-04 2008-09-04
US10599008P 2008-10-16 2008-10-16
US11090308P 2008-11-03 2008-11-03
US14370009P 2009-01-09 2009-01-09
US14873109P 2009-01-30 2009-01-30
PCT/US2009/036250 WO2009111676A2 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP12178640.4A Division EP2564857B1 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents
EP17158536.7A Division EP3246034A1 (en) 2008-03-06 2009-03-05 Boron-containing small molecules as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
EP2187893A2 EP2187893A2 (en) 2010-05-26
EP2187893A4 true EP2187893A4 (en) 2012-02-22

Family

ID=41056660

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09700012A Withdrawn EP2187893A4 (en) 2008-03-06 2009-03-05 SMALL BORONOUS MOLECULES AS ANTI-INFLAMMATORY ACTIVE SUBSTANCES

Country Status (2)

Country Link
EP (1) EP2187893A4 (en)
WO (1) WO2009111676A2 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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US7767657B2 (en) 2005-02-16 2010-08-03 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
ES2872962T3 (en) 2005-02-16 2021-11-03 Anacor Pharmaceuticals Inc Boronophthalides for therapeutic use
RU2642628C2 (en) 2006-02-16 2018-01-25 Анакор Фармасьютикалз, Инк. Boron-containing small molecules as anti-inflammatory agents
EP3246034A1 (en) 2008-03-06 2017-11-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-inflammatory agents
WO2010027975A1 (en) 2008-09-04 2010-03-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US8461336B2 (en) 2008-09-04 2013-06-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US9493489B2 (en) 2008-10-15 2016-11-15 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agents
SG172040A1 (en) 2008-12-17 2011-07-28 Anacor Pharmaceuticals Inc Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol
EP2458995A1 (en) 2009-07-28 2012-06-06 Anacor Pharmaceuticals, Inc. Trisubstituted boron-containing molecules
AP4039A (en) 2009-08-14 2017-02-28 Daitao Chen Boron-containing small molecules as antiprotozoal agents
US20110207701A1 (en) 2009-08-19 2011-08-25 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011049971A1 (en) 2009-10-20 2011-04-28 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
US8461134B2 (en) 2009-11-11 2013-06-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2011063293A1 (en) * 2009-11-20 2011-05-26 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antihelminth agents
US8716478B2 (en) * 2010-01-27 2014-05-06 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2011116348A1 (en) 2010-03-19 2011-09-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agent
DK2613788T3 (en) 2010-09-07 2017-08-07 Anacor Pharmaceuticals Inc BENZOXABOROLD DERIVATIVES FOR TREATMENT OF BACTERIA INFECTIONS
US8927593B2 (en) 2011-08-19 2015-01-06 Glaxo Group Limited Benzofuran compounds for the treatment of hepatitis C virus infections
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
AR094666A1 (en) 2013-01-30 2015-08-19 Dow Agrosciences Llc USE OF BENZOXABOROLAS AS VOLATILE ANTIMICROBIAL AGENTS IN MEATS, PLANTS OR PLANT PARTS
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US8669207B1 (en) 2013-01-30 2014-03-11 Dow Agrosciences, Llc. Compounds and compositions
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
CN106459097A (en) 2014-07-01 2017-02-22 第三共株式会社 Tricyclic benzoxaboroles as antibacterial agents
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
WO2017093857A1 (en) 2015-11-30 2017-06-08 Anacor Pharmaceuticals, Inc. Topical pharmaceutical formulations for treating inflammatory-related conditions
WO2017155879A1 (en) 2016-03-07 2017-09-14 Agrofresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
US11447506B2 (en) 2016-05-09 2022-09-20 Anacor Pharmaceuticals, Inc. Crystal forms of crisaborole in free form and preparation method and use thereof
WO2017203514A1 (en) * 2016-05-26 2017-11-30 Perrigo Api Ltd Polymorphs of crisaborole and production processes therefor
US10961261B2 (en) 2017-03-01 2021-03-30 Anacor Pharmaceuticals, Inc. Oxaborole analogs and uses thereof
US10981939B2 (en) 2017-05-12 2021-04-20 Biophore India Pharmaceuticals Pvt. Ltd. Process for the preparation of 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl) oxy] benzonitrile (Crisaborole)
US10865217B2 (en) 2017-05-23 2020-12-15 Msn Laboratories Private Limited, R & D Center Process for the preparation of 5-(4-cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and polymorphs thereof
MX2020005464A (en) 2017-11-30 2020-12-03 Boragen Inc Benzoxaborole compounds and formulations thereof.
EP3836938A4 (en) 2018-08-18 2022-05-11 Boragen, Inc. SOLID FORMS OF SUBSTITUTED BENZOXABOROLE AND RELATED COMPOSITIONS
KR102576125B1 (en) 2018-10-05 2023-09-08 화이자 인코포레이티드 Boron-containing PDE4 inhibitors
US12240855B2 (en) 2019-03-06 2025-03-04 Daiichi Sankyo Company, Limited Pyrrolopyrazole derivative
CN112174989B (en) * 2019-07-02 2023-06-20 江西同和药业股份有限公司 A kind of preparation method of crisborole
WO2022043936A1 (en) 2020-08-31 2022-03-03 Pfizer Inc. Methods of protecting rna
CA3264513A1 (en) * 2022-08-18 2024-02-22 Mitodicure Gmbh Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance
CN116239498B (en) * 2023-05-11 2023-07-21 北京元延医药科技股份有限公司 The method for preparing crisborole intermediate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060234981A1 (en) * 2005-02-16 2006-10-19 Anacor Pharmaceuticals Boron-containing small molecules

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596985B2 (en) * 2000-02-22 2003-07-22 Rioch Company, Ltd. Multi-beam scanning device, multi-beam scanning method, light source device, and image forming apparatus
US20060251689A1 (en) * 2005-03-30 2006-11-09 Astion Development A/S Treatment or prevention of pruritus
RU2642628C2 (en) * 2006-02-16 2018-01-25 Анакор Фармасьютикалз, Инк. Boron-containing small molecules as anti-inflammatory agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060234981A1 (en) * 2005-02-16 2006-10-19 Anacor Pharmaceuticals Boron-containing small molecules

Also Published As

Publication number Publication date
WO2009111676A3 (en) 2010-04-01
WO2009111676A8 (en) 2010-09-30
EP2187893A2 (en) 2010-05-26
WO2009111676A2 (en) 2009-09-11

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: ALLEY, MICHAEL RICHARD KEVIN

Inventor name: CHEN, DAITAO

Inventor name: JACOBS, ROBERT

Inventor name: SINGH, RAJESHWAR

Inventor name: SHARMA, RASHMI

Inventor name: SALES, MARCELO

Inventor name: LU, XIAOSONG

Inventor name: NIEMANN, JAMES A.

Inventor name: BAKER, STEPHEN J.

Inventor name: XIA, YI

Inventor name: SANDERS, VIRGINIA

Inventor name: FREUND, YVONNE

Inventor name: MAPLES, KIRK R.

Inventor name: PLATTNER, JACOB J.

Inventor name: DING, CHARLES Z.

Inventor name: ZHANG, YONG-KANG

Inventor name: AKAMA, TSUTOMU

A4 Supplementary search report drawn up and despatched

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