EP2211903A4 - ANTI-CLL-1 ANTIBODIES - Google Patents

ANTI-CLL-1 ANTIBODIES

Info

Publication number
EP2211903A4
EP2211903A4 EP08840487A EP08840487A EP2211903A4 EP 2211903 A4 EP2211903 A4 EP 2211903A4 EP 08840487 A EP08840487 A EP 08840487A EP 08840487 A EP08840487 A EP 08840487A EP 2211903 A4 EP2211903 A4 EP 2211903A4
Authority
EP
European Patent Office
Prior art keywords
cll
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08840487A
Other languages
German (de)
French (fr)
Other versions
EP2211903A1 (en
Inventor
Arie Abo
Wouter Korver
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nuvelo Inc
Original Assignee
Nuvelo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuvelo Inc filed Critical Nuvelo Inc
Publication of EP2211903A1 publication Critical patent/EP2211903A1/en
Publication of EP2211903A4 publication Critical patent/EP2211903A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP08840487A 2007-10-17 2008-10-03 ANTI-CLL-1 ANTIBODIES Withdrawn EP2211903A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98056707P 2007-10-17 2007-10-17
PCT/US2008/078702 WO2009051974A1 (en) 2007-10-17 2008-10-03 Antibodes to cll-1

Publications (2)

Publication Number Publication Date
EP2211903A1 EP2211903A1 (en) 2010-08-04
EP2211903A4 true EP2211903A4 (en) 2011-07-06

Family

ID=40567735

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08840487A Withdrawn EP2211903A4 (en) 2007-10-17 2008-10-03 ANTI-CLL-1 ANTIBODIES

Country Status (3)

Country Link
US (1) US8536310B2 (en)
EP (1) EP2211903A4 (en)
WO (1) WO2009051974A1 (en)

Families Citing this family (53)

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USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
DK2314629T4 (en) 2002-07-18 2023-02-06 Merus Nv RECOMBINANT PRODUCTION OF MIXTURES OF ANTIBODIES
EP2220247A4 (en) 2007-11-16 2011-10-26 Nuvelo Inc ANTIBODIES DIRECTED AGAINST LRP6
WO2011091181A1 (en) 2010-01-20 2011-07-28 Tolerx, Inc. Immunoregulation by anti-ilt5 antibodies and ilt5-binding antibody fragments
CA2787783A1 (en) * 2010-01-20 2011-07-28 Tolerx, Inc. Anti-ilt5 antibodies and ilt5-binding antibody fragments
SMT202600080T1 (en) 2010-02-08 2026-03-09 Regeneron Pharma Common light chain mouse
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
PH12012502193A1 (en) 2010-05-06 2021-08-09 Novartis Ag Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies
EP2566892B1 (en) 2010-05-06 2017-12-20 Novartis AG Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (lrp6) antibodies
HUE047278T2 (en) 2011-08-05 2020-04-28 Regeneron Pharma Humanized universal light chain mice
ES2666856T3 (en) 2011-11-04 2018-05-08 Novartis Ag Protein 6 related to low density lipoproteins (LRP6) - half-life extender constructs
US9248181B2 (en) 2012-04-20 2016-02-02 Merus B.V. Methods and means for the production of Ig-like molecules
US9163090B2 (en) 2012-05-07 2015-10-20 Cellerant Therapeutics, Inc. Antibodies specific for CLL-1
HUE042040T2 (en) * 2012-09-27 2019-06-28 Merus Nv Bispecific IGG antibodies as T-cell switches
CN105283201B (en) * 2013-03-14 2019-08-02 斯克利普斯研究所 Targeting agent antibody conjugates and uses thereof
WO2015093949A2 (en) 2013-12-17 2015-06-25 Aimm Therapeutics B.V. Means and methods for counteracting myeloproliferative or lymphoproliferative disorders
JP6771385B2 (en) 2014-02-28 2020-10-21 メルス ナムローゼ フェンノートシャップ Bispecific antibody and pharmaceutical composition
WO2015130173A1 (en) 2014-02-28 2015-09-03 Merus B.V. Antibody that binds erbb-2 and erbb-3
CA3124228C (en) 2014-03-21 2024-05-14 Regeneron Pharmaceuticals, Inc. Non-human animals that make single domain binding proteins
BR112017001183A2 (en) 2014-07-21 2017-11-28 Novartis Ag cancer treatment using humanized anti-bcma chimeric antigen receptor
SG10201913782UA (en) 2014-07-21 2020-03-30 Novartis Ag Treatment of cancer using a cll-1 chimeric antigen receptor
MA40579A (en) * 2014-09-12 2016-03-17 Genentech Inc ANTI-CLL-1 ANTIBODIES AND IMMUNOCONJUGATES
BR112017013981A2 (en) * 2015-01-26 2018-01-02 Cellectis anti-cll1-specific chimeric single-chain antigen receptors (sccars) for cancer immunotherapy
CA2979702A1 (en) 2015-03-19 2016-09-22 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
WO2016168769A1 (en) * 2015-04-15 2016-10-20 The California Institute For Biomedical Research Chimeric receptor t cell switches for her2
US10501545B2 (en) 2015-06-16 2019-12-10 Genentech, Inc. Anti-CLL-1 antibodies and methods of use
US9914777B2 (en) 2015-07-10 2018-03-13 Merus N.V. Human CD3 binding antibody
MX389194B (en) 2015-10-06 2025-03-20 Univ Minnesota THERAPEUTIC COMPOUNDS AND METHODS.
SMT202100230T1 (en) 2015-10-23 2021-07-12 Fundacio Inst De Recerca Biomedica Irb Barcelona Binding molecules that inhibit cancer growth
KR102891788B1 (en) 2016-02-04 2025-11-26 더 스크립스 리서치 인스티튜트 Humanized anti-CD3 antibodies, conjugates and uses thereof
CA3019650C (en) * 2016-04-01 2023-07-25 Kite Pharma, Inc. Chimeric receptors and methods of use thereof
ES2891578T3 (en) 2016-04-01 2022-01-28 Kite Pharma Inc Chimeric antigen and T cell receptors and methods of use
TWI795133B (en) 2016-04-01 2023-03-01 美商凱特製藥公司 Bcma binding molecules and uses thereof
US20190307799A1 (en) 2016-09-23 2019-10-10 The Regents Of The University Of Michigan Engineered lymphocytes
EP4649966A3 (en) 2016-12-01 2026-02-18 Regeneron Pharmaceuticals, Inc. Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging
IL269656B2 (en) 2017-03-31 2024-06-01 Merus Nv Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment of cells that have an nrg1 fusion gene
JP7296891B2 (en) 2017-05-17 2023-06-23 メルス ナムローゼ フェンノートシャップ Combining ErbB-2/ErbB-3 bispecific antibodies with endocrine therapy for breast cancer
SG11202001050PA (en) 2017-08-09 2020-03-30 Merus Nv Antibodies that bind egfr and cmet
TWI890660B (en) 2018-06-13 2025-07-21 瑞士商諾華公司 Bcma chimeric antigen receptors and uses thereof
GB201813178D0 (en) 2018-08-13 2018-09-26 Autolus Ltd Cell
JP2022505921A (en) * 2018-10-26 2022-01-14 カファ セラピューティクス リミテッド Antibodies targeting CLL1 and their applications
WO2020113063A1 (en) * 2018-11-30 2020-06-04 Aleta Biotherapeutics Inc. Single domain antibodies against cll-1
WO2020210719A1 (en) 2019-04-10 2020-10-15 Elevatebio Management, Inc. Flt3-specific chimeric antigen receptors and methods of using the same
JP7489407B2 (en) 2019-05-21 2024-05-23 ノバルティス アーゲー CD19 binding molecules and uses thereof
AU2020338011A1 (en) 2019-08-28 2022-03-10 Vor Biopharma Inc. Compositions and methods for CLL1 modification
US20240117053A1 (en) * 2019-10-17 2024-04-11 Regents Of The University Of Minnesota Clec12a antibody fragment sequences and methods
US20220396628A1 (en) * 2019-10-23 2022-12-15 Kite Pharma, Inc. Anti-idiotypic antigen binding molecules and methods of use thereof
WO2022047168A1 (en) 2020-08-28 2022-03-03 Vor Biopharma Inc. Compositions and methods for cll1 modification
CN113234169B (en) 2020-12-11 2022-11-01 广州百暨基因科技有限公司 Targeting CLL1 chimeric antigen receptor and its application
CN113045658B (en) 2020-12-11 2021-12-24 广州百暨基因科技有限公司 anti-CLL1 antibodies and uses thereof
GB202209920D0 (en) 2022-07-06 2022-08-17 Autolus Ltd Cell
WO2025076048A1 (en) * 2023-10-02 2025-04-10 Fred Hutchinson Cancer Center Anti-cd90 antibodies, binding fragments, and uses thereof

Citations (2)

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WO2000044788A1 (en) * 1999-01-28 2000-08-03 Idec Pharmaceuticals Corporation Production of tetravalent antibodies
US20060177451A1 (en) * 2003-06-25 2006-08-10 Crucell Holland B.V. Binding molecules for the treatment of myeloid cell malignancies

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TWI335821B (en) * 2002-12-16 2011-01-11 Genentech Inc Immunoglobulin variants and uses thereof
JP2006517970A (en) * 2003-02-14 2006-08-03 ユニバーシティ オブ サザン カリフォルニア Compositions and methods for cancer immunotherapy
TW200823237A (en) 2006-08-28 2008-06-01 Nuvelo Inc Antibodies to NTB-A
CN103396486A (en) * 2006-10-12 2013-11-20 中外制药株式会社 Diagnosis and treatment of cancer using anti-EREG antibody
US20100291108A1 (en) 2007-10-16 2010-11-18 Arie Abo Antibodies to irem-1
EP2220247A4 (en) 2007-11-16 2011-10-26 Nuvelo Inc ANTIBODIES DIRECTED AGAINST LRP6

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044788A1 (en) * 1999-01-28 2000-08-03 Idec Pharmaceuticals Corporation Production of tetravalent antibodies
US20060177451A1 (en) * 2003-06-25 2006-08-10 Crucell Holland B.V. Binding molecules for the treatment of myeloid cell malignancies

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAKKER ALEXANDER B H ET AL: "C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia.", CANCER RESEARCH 15 NOV 2004 LNKD- PUBMED:15548716, vol. 64, no. 22, 15 November 2004 (2004-11-15), pages 8443 - 8450, XP002632478, ISSN: 0008-5472 *
MARSHALL ANDREW S J ET AL: "Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US, vol. 279, no. 15, 9 April 2004 (2004-04-09), pages 14792 - 14802, XP002305616, ISSN: 0021-9258, DOI: 10.1074/JBC.M313127200 *
See also references of WO2009051974A1 *
VAN RHENEN ANNA ET AL: "The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells.", BLOOD 1 OCT 2007 LNKD- PUBMED:17609428, vol. 110, no. 7, 1 October 2007 (2007-10-01), pages 2659 - 2666, XP002632479, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
US20100285037A1 (en) 2010-11-11
US8536310B2 (en) 2013-09-17
EP2211903A1 (en) 2010-08-04
WO2009051974A1 (en) 2009-04-23

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