EP2212694A4 - METHODS OF IDENTIFYING ANTAGONISTS OF THE SAFE NMDA RECEPTOR - Google Patents

METHODS OF IDENTIFYING ANTAGONISTS OF THE SAFE NMDA RECEPTOR

Info

Publication number: EP2212694A4
Authority: EP; European Patent Office
Prior art keywords: methods; nmda receptor; identifying antagonists; safe; safe nmda
Prior art date: 2007-11-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP08847388A

Other languages

German (de)

French (fr)

Other versions

EP2212694A2 (en

Inventor

Raymond J Dingledine

Stephen F Traynelis

Dennis C Liotta

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Emory University

Original Assignee

Emory University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-11-06

Filing date

2008-11-06

Publication date

2011-10-12

2008-11-06 Application filed by Emory University filed Critical Emory University

2010-08-04 Publication of EP2212694A2 publication Critical patent/EP2212694A2/en

2011-10-12 Publication of EP2212694A4 publication Critical patent/EP2212694A4/en

Status Withdrawn legal-status Critical Current

Links

102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 title 1
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2842—Pain, e.g. neuropathic pain, psychogenic pain
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2857—Seizure disorders; Epilepsy
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Pathology (AREA)
Biotechnology (AREA)
Cell Biology (AREA)
General Physics & Mathematics (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Analytical Chemistry (AREA)
Food Science & Technology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Inorganic Chemistry (AREA)
Toxicology (AREA)
Tropical Medicine & Parasitology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EP08847388A 2007-11-06 2008-11-06 METHODS OF IDENTIFYING ANTAGONISTS OF THE SAFE NMDA RECEPTOR Withdrawn EP2212694A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US98592207P	2007-11-06	2007-11-06
US98592407P	2007-11-06	2007-11-06
PCT/US2008/082660 WO2009061935A2 (en)	2007-11-06	2008-11-06	Methods of identifying safe nmda receptor antagonists

Publications (2)

Publication Number	Publication Date
EP2212694A2 EP2212694A2 (en)	2010-08-04
EP2212694A4 true EP2212694A4 (en)	2011-10-12

Family

ID=40626437

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP08847388A Withdrawn EP2212694A4 (en)	2007-11-06	2008-11-06	METHODS OF IDENTIFYING ANTAGONISTS OF THE SAFE NMDA RECEPTOR

Country Status (12)

Country	Link
EP (1)	EP2212694A4 (en)
JP (1)	JP2011503013A (en)
KR (1)	KR20100100858A (en)
CN (1)	CN101918832A (en)
AU (1)	AU2008323877A1 (en)
BR (1)	BRPI0820406A2 (en)
CA (1)	CA2704475A1 (en)
EA (1)	EA201070571A1 (en)
IL (1)	IL205432A0 (en)
MX (1)	MX2010004971A (en)
WO (1)	WO2009061935A2 (en)
ZA (1)	ZA201003724B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2014159960A (en) *	2011-06-08	2014-09-04	Astellas Pharma Inc	Automatic measurement method for spontaneous pain action of chronic pain model animal
JP2018521007A (en) *	2015-05-22	2018-08-02	ヴィスタゲンセラピューティクス、インコーポレイテッド	Therapeutic use of L-4-chlorokynurenine
US10583171B2 (en)	2015-11-30	2020-03-10	INSERM (Institut National de la Santé et de la Recherche Médicale)	NMDAR antagonists for the treatment of diseases associated with angiogenesis
CN111960514A (en) *	2020-08-28	2020-11-20	浙江浙能技术研究院有限公司	A kind of electrodialysis intelligent control system and method for desulfurization wastewater concentration
CA3230601A1 (en)	2021-09-02	2023-03-09	Dennis Liotta	Glun2b-subunit selective antagonists of the n-methyl-d-aspartate receptors with enhanced potency at acidic ph

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006023957A1 (en) *	2004-08-23	2006-03-02	Emory University	Improved selection of-ph dependent compounds for in vivo therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7375136B2 (en) *	2001-03-08	2008-05-20	Emory University	pH-dependent NMDA receptor antagonists
KR20030063765A (en) *	2002-01-24	2003-07-31	엘지전자 주식회사	Objective Lens for Pick Up System
UY27939A1 (en) *	2002-08-21	2004-03-31	Glaxo Group Ltd	COMPOUNDS
WO2005061536A1 (en) *	2003-12-16	2005-07-07	Aventis Pharmaceuticals Inc.	Secreted neural apoptosis inhibiting proteins

2008
- 2008-11-06 WO PCT/US2008/082660 patent/WO2009061935A2/en not_active Ceased
- 2008-11-06 AU AU2008323877A patent/AU2008323877A1/en not_active Abandoned
- 2008-11-06 CN CN2008801240927A patent/CN101918832A/en active Pending
- 2008-11-06 JP JP2010532343A patent/JP2011503013A/en active Pending
- 2008-11-06 KR KR1020107012419A patent/KR20100100858A/en not_active Withdrawn
- 2008-11-06 BR BRPI0820406-3A patent/BRPI0820406A2/en not_active IP Right Cessation
- 2008-11-06 MX MX2010004971A patent/MX2010004971A/en active IP Right Grant
- 2008-11-06 EP EP08847388A patent/EP2212694A4/en not_active Withdrawn
- 2008-11-06 CA CA2704475A patent/CA2704475A1/en not_active Abandoned
- 2008-11-06 EA EA201070571A patent/EA201070571A1/en unknown
2010
- 2010-04-29 IL IL205432A patent/IL205432A0/en unknown
- 2010-05-25 ZA ZA2010/03724A patent/ZA201003724B/en unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006023957A1 (en) *	2004-08-23	2006-03-02	Emory University	Improved selection of-ph dependent compounds for in vivo therapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MOTT D D ET AL: "Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition.", NATURE NEUROSCIENCE DEC 1998 LNKD- PUBMED:10196581, vol. 1, no. 8, December 1998 (1998-12-01), pages 659 - 667, XP002657901, ISSN: 1097-6256 *
TAKIZAWA S ET AL: "THE EFFECTS OF A COMPETITIVE NMDA RECEPTOR ANTAGONIST CGS-19755 ON CEREBRAL BLOOD FLOW AND PH IN FOCAL ISCHEMIA", JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, vol. 11, no. 5, 1991, pages 786 - 793, XP002657900, ISSN: 0271-678X *

Also Published As

Publication number	Publication date
MX2010004971A (en)	2010-07-28
WO2009061935A2 (en)	2009-05-14
KR20100100858A (en)	2010-09-15
AU2008323877A1 (en)	2009-05-14
ZA201003724B (en)	2013-10-30
CN101918832A (en)	2010-12-15
WO2009061935A3 (en)	2009-08-20
IL205432A0 (en)	2010-12-30
EP2212694A2 (en)	2010-08-04
CA2704475A1 (en)	2009-05-14
JP2011503013A (en)	2011-01-27
EA201070571A1 (en)	2010-12-30
BRPI0820406A2 (en)	2015-05-19

Legal Events

Date	Code	Title	Description
2010-07-02	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2010-08-04	17P	Request for examination filed	Effective date: 20100604
2010-08-04	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
2010-08-04	AX	Request for extension of the european patent	Extension state: AL BA MK RS
2010-08-25	RIN1	Information on inventor provided before grant (corrected)	Inventor name: DINGLEDINE, RAYMOND, J. Inventor name: LIOTTA, DENNIS, C. Inventor name: TRAYNELIS, STEPHEN, F.
2011-05-20	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1146314 Country of ref document: HK
2011-10-05	RIC1	Information provided on ipc code assigned before grant	Ipc: G01N 33/15 20060101ALI20110901BHEP Ipc: G01N 33/84 20060101ALI20110901BHEP Ipc: G01N 33/50 20060101ALI20110901BHEP Ipc: G01N 33/48 20060101AFI20110901BHEP Ipc: G01N 31/22 20060101ALI20110901BHEP Ipc: G01N 31/20 20060101ALI20110901BHEP
2011-10-12	A4	Supplementary search report drawn up and despatched	Effective date: 20110912
2012-08-15	DAX	Request for extension of the european patent (deleted)
2013-01-23	17Q	First examination report despatched	Effective date: 20130107
2013-09-27	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2013-10-30	18D	Application deemed to be withdrawn	Effective date: 20130518
2017-06-02	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1146314 Country of ref document: HK

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