EP2255009A4 - Processes for preparing enantiomerically pure diol and dioxolane compounds - Google Patents

Processes for preparing enantiomerically pure diol and dioxolane compounds

Info

Publication number
EP2255009A4
EP2255009A4 EP09720379A EP09720379A EP2255009A4 EP 2255009 A4 EP2255009 A4 EP 2255009A4 EP 09720379 A EP09720379 A EP 09720379A EP 09720379 A EP09720379 A EP 09720379A EP 2255009 A4 EP2255009 A4 EP 2255009A4
Authority
EP
European Patent Office
Prior art keywords
processes
enantiomerically pure
preparing enantiomerically
pure diol
dioxolane compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09720379A
Other languages
German (de)
French (fr)
Other versions
EP2255009A2 (en
Inventor
Partha Barnerjee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stiefel Research Australia Pty Ltd
Stiefel Laboratories Inc
Original Assignee
Stiefel Research Australia Pty Ltd
Stiefel Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stiefel Research Australia Pty Ltd, Stiefel Laboratories Inc filed Critical Stiefel Research Australia Pty Ltd
Publication of EP2255009A2 publication Critical patent/EP2255009A2/en
Publication of EP2255009A4 publication Critical patent/EP2255009A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP09720379A 2008-03-03 2009-03-02 Processes for preparing enantiomerically pure diol and dioxolane compounds Withdrawn EP2255009A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3326608P 2008-03-03 2008-03-03
PCT/US2009/001315 WO2009114080A2 (en) 2008-03-03 2009-03-02 Processes for preparing enantiomerically pure diol and dioxolane compounds

Publications (2)

Publication Number Publication Date
EP2255009A2 EP2255009A2 (en) 2010-12-01
EP2255009A4 true EP2255009A4 (en) 2011-08-10

Family

ID=41065699

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09720379A Withdrawn EP2255009A4 (en) 2008-03-03 2009-03-02 Processes for preparing enantiomerically pure diol and dioxolane compounds

Country Status (7)

Country Link
EP (1) EP2255009A4 (en)
JP (1) JP2011513398A (en)
CN (1) CN102015582A (en)
AU (1) AU2009223833A1 (en)
CA (1) CA2718166A1 (en)
MX (1) MX2010009732A (en)
WO (1) WO2009114080A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102234267A (en) * 2010-04-21 2011-11-09 中国科学院上海药物研究所 Novel triazole antifungal compounds, and medicinal composition, preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661151A (en) * 1993-12-21 1997-08-26 Schering Corporation Tetrahydrofuran antifungals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW593312B (en) * 1997-07-11 2004-06-21 Janssen Pharmaceutica Nv 2,4,4-trisubstituted-1,3-dioxolane antifungals
MXPA05001451A (en) * 2002-08-06 2005-09-30 Pharmasset Ltd Processes for preparing 1,3-dioxolane nucleosides.
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661151A (en) * 1993-12-21 1997-08-26 Schering Corporation Tetrahydrofuran antifungals

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HOF R P ET AL: "LIPASE AKG MEDIATED RESOLUTIONS OF ALPHA,ALPHA-DISUBSTITUTED 1,2-DIOLS IN ORGANIC SOLVENTS; REMARKABLY HIGH REGIO-AND ENANTIO-SELECTIVITY", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY, LETCHWORTH; GB, 1 January 1996 (1996-01-01), pages 2051 - 2060, XP002935573, ISSN: 0300-922X, DOI: 10.1039/P19960002051 *
LOVEY ET AL: "PPL-catalyzed enzymic asymmetrization of a 2-substituted prochiral 1,3-diol with remote chiral functionality: improvements toward synthesis of the eutomers of SCH 45012", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 33, 15 August 1994 (1994-08-15), pages 6047 - 6050, XP002082288, ISSN: 0040-4039, DOI: 10.1016/0040-4039(94)88071-9 *
MEERPOEL L ET AL: "Synthesis and in Vitro and in Vivo Structure-Activity Relationships of Novel Antifungal Triazoles for Dermatology", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 48, no. 6, 1 January 2005 (2005-01-01), pages 2184 - 2193, XP002584860, ISSN: 0022-2623, DOI: 10.1021/JM0494772 *
YASOHARA Y ET AL: "A practical chemoenzymatic synthesis of a key intermediate of antifungal agents", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 42, no. 19, 7 May 2001 (2001-05-07), pages 3331 - 3333, XP004235302, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(01)00425-7 *

Also Published As

Publication number Publication date
AU2009223833A1 (en) 2009-09-17
WO2009114080A2 (en) 2009-09-17
EP2255009A2 (en) 2010-12-01
MX2010009732A (en) 2010-09-30
CA2718166A1 (en) 2009-09-17
WO2009114080A3 (en) 2010-03-04
CN102015582A (en) 2011-04-13
JP2011513398A (en) 2011-04-28

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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AX Request for extension of the european patent

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A4 Supplementary search report drawn up and despatched

Effective date: 20110711

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 317/00 20060101ALI20110705BHEP

Ipc: C12P 17/04 20060101AFI20110705BHEP

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Effective date: 20120208