EP2297325A4 - Methods of stratifying, prognosing and diagnosing schizophrenia, mutant nucleic acid molecules and polypeptides - Google Patents

Methods of stratifying, prognosing and diagnosing schizophrenia, mutant nucleic acid molecules and polypeptides

Info

Publication number
EP2297325A4
EP2297325A4 EP09753383A EP09753383A EP2297325A4 EP 2297325 A4 EP2297325 A4 EP 2297325A4 EP 09753383 A EP09753383 A EP 09753383A EP 09753383 A EP09753383 A EP 09753383A EP 2297325 A4 EP2297325 A4 EP 2297325A4
Authority
EP
European Patent Office
Prior art keywords
prognosing
stratifying
polypeptides
methods
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09753383A
Other languages
German (de)
French (fr)
Other versions
EP2297325A1 (en
Inventor
Guy A Rouleau
Pierre Drapeau
Julie Gauthier
Claude Marineau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHUM
Original Assignee
CHUM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHUM filed Critical CHUM
Publication of EP2297325A1 publication Critical patent/EP2297325A1/en
Publication of EP2297325A4 publication Critical patent/EP2297325A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/302—Schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP09753383A 2008-05-29 2009-05-29 Methods of stratifying, prognosing and diagnosing schizophrenia, mutant nucleic acid molecules and polypeptides Withdrawn EP2297325A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5689108P 2008-05-29 2008-05-29
PCT/CA2009/000735 WO2009143622A1 (en) 2008-05-29 2009-05-29 Methods of stratifying, prognosing and diagnosing schizophrenia, mutant nucleic acid molecules and polypeptides

Publications (2)

Publication Number Publication Date
EP2297325A1 EP2297325A1 (en) 2011-03-23
EP2297325A4 true EP2297325A4 (en) 2011-10-05

Family

ID=41376517

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09753383A Withdrawn EP2297325A4 (en) 2008-05-29 2009-05-29 Methods of stratifying, prognosing and diagnosing schizophrenia, mutant nucleic acid molecules and polypeptides

Country Status (2)

Country Link
EP (1) EP2297325A4 (en)
WO (1) WO2009143622A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2571515B1 (en) 2010-05-17 2016-11-30 Icahn School of Medicine at Mount Sinai Methods and assays for treating subjects with shank3 deletion, mutation or reduced expression
RU2506595C2 (en) * 2012-04-26 2014-02-10 Федеральное государственное бюджетное учреждение науки Институт биохимии и генетики Уфимского научного центра Российской академии наук (ИБГ УНЦ РАН) Method for prediction of risk of paranoid schizophrenia
JP2018110572A (en) * 2017-01-13 2018-07-19 国立大学法人千葉大学 DGKδ KNOCKOUT MOUSE AND METHOD USING THE SAME
CN108841931B (en) * 2018-07-05 2021-06-11 广州市达瑞生物技术股份有限公司 Primer group and detection kit for detecting STR locus of human chromosome 4 and application of primer group and detection kit
CN108913757B (en) * 2018-07-05 2021-06-11 广州市达瑞生物技术股份有限公司 Primer group and detection kit for chromosome aneuploid number abnormality and application thereof
CA3200980A1 (en) * 2020-11-06 2022-05-12 Flux Therapeutics, Inc. Cytosolic protein targeting engineered deubiquitinases and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070281896A1 (en) * 2003-09-30 2007-12-06 Morris David W Novel compositions and methods in cancer
WO2009008896A1 (en) * 2007-07-06 2009-01-15 University Of Louisville Research Foundation, Inc. Genetic markers of schizophrenia

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU772105B2 (en) * 1998-08-18 2004-04-08 Johns Hopkins University School Of Medicine, The Homer interacting proteins
WO2000078921A2 (en) * 1999-06-24 2000-12-28 The Johns Hopkins University School Of Medicine Shank proteins and methods of use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070281896A1 (en) * 2003-09-30 2007-12-06 Morris David W Novel compositions and methods in cancer
WO2009008896A1 (en) * 2007-07-06 2009-01-15 University Of Louisville Research Foundation, Inc. Genetic markers of schizophrenia

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE REFSEQ [online] XP002656892, retrieved from NCBI Database accession no. XP_589942 *
DATABASE REFSEQ [online] XP002656893, retrieved from NCBI Database accession no. XP_002688036 *
DUNHAM I ET AL: "THE DNA SEQUENCE OF HUMAN CHROMOSOME 22", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 402, no. 6761, 2 December 1999 (1999-12-02), pages 489 - 495, XP001180206, ISSN: 0028-0836, DOI: 10.1038/990031 *
HASHIMOTO ET AL: "SHANK proteins in the superior temporal cortex of patients with schizophrenia", SCHIZOPHRENIA RESEARCH, ELSEVIER, NETHERLANDS, vol. 60, no. 1, 15 March 2003 (2003-03-15), pages 63 - 64, XP005397336, ISSN: 0920-9964, DOI: 10.1016/S0920-9964(03)80574-1 *
See also references of WO2009143622A1 *

Also Published As

Publication number Publication date
EP2297325A1 (en) 2011-03-23
WO2009143622A1 (en) 2009-12-03

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RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/50 20060101ALI20110819BHEP

Ipc: G01N 33/68 20060101ALI20110819BHEP

Ipc: G01N 33/53 20060101ALI20110819BHEP

Ipc: C12Q 1/68 20060101ALI20110819BHEP

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A4 Supplementary search report drawn up and despatched

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Ipc: C12Q 1/68 20060101ALI20110829BHEP

Ipc: C07K 14/78 20060101ALI20110829BHEP

Ipc: C07K 14/47 20060101ALI20110829BHEP

Ipc: C12N 15/12 20060101AFI20110829BHEP

RIN1 Information on inventor provided before grant (corrected)

Inventor name: MARINEAU, CLAUDE

Inventor name: GAUTHIER, JULIE

Inventor name: DRAPEAU, PIERRE

Inventor name: ROULEAU, GUY, A.

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