EP2477594A4 - ISOKETAL TRAPS AND REDUCTION OF DISORDERS INVOLVING OXIDATIVE INJURY - Google Patents

ISOKETAL TRAPS AND REDUCTION OF DISORDERS INVOLVING OXIDATIVE INJURY

Info

Publication number
EP2477594A4
EP2477594A4 EP09847430A EP09847430A EP2477594A4 EP 2477594 A4 EP2477594 A4 EP 2477594A4 EP 09847430 A EP09847430 A EP 09847430A EP 09847430 A EP09847430 A EP 09847430A EP 2477594 A4 EP2477594 A4 EP 2477594A4
Authority
EP
European Patent Office
Prior art keywords
isoketal
traps
reduction
disorders involving
oxidative injury
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09847430A
Other languages
German (de)
French (fr)
Other versions
EP2477594A1 (en
Inventor
Jackson L Roberts
Jeffrey R Balser
Sean S Davies
Venkataraman Amarnath
Prakash Viswanathan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbilt University filed Critical Vanderbilt University
Publication of EP2477594A1 publication Critical patent/EP2477594A1/en
Publication of EP2477594A4 publication Critical patent/EP2477594A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/606—Salicylic acid; Derivatives thereof having amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP09847430A 2009-07-15 2009-07-15 ISOKETAL TRAPS AND REDUCTION OF DISORDERS INVOLVING OXIDATIVE INJURY Withdrawn EP2477594A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2009/050644 WO2011008202A1 (en) 2009-07-15 2009-07-15 Isoketal scavengers and mitigation of disorders involving oxidative injury

Publications (2)

Publication Number Publication Date
EP2477594A1 EP2477594A1 (en) 2012-07-25
EP2477594A4 true EP2477594A4 (en) 2013-03-13

Family

ID=43449619

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09847430A Withdrawn EP2477594A4 (en) 2009-07-15 2009-07-15 ISOKETAL TRAPS AND REDUCTION OF DISORDERS INVOLVING OXIDATIVE INJURY

Country Status (2)

Country Link
EP (1) EP2477594A4 (en)
WO (1) WO2011008202A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006249866B2 (en) 2005-05-26 2011-10-13 Aldeyra Therapeutics, Inc. Compositions and methods of treating retinal disease
CA2782015C (en) 2009-12-11 2020-08-25 Neuron Systems, Inc. Topical ophthalmic compositions and methods for the treatment of macular degeneration
US10975033B2 (en) * 2011-07-12 2021-04-13 Vanderbilt University Methods for treating inflammation and hypertension with γ-ketoaldehyde skavengers
KR20150118106A (en) 2012-12-20 2015-10-21 알데이라 테라퓨틱스, 아이엔씨. Peri-carbinols
CN111135171B (en) 2013-01-23 2023-09-08 奥尔德拉医疗公司 Diseases and treatments associated with toxic aldehydes
AU2014209585A1 (en) 2013-01-25 2015-07-23 Aldeyra Therapeutics, Inc. Novel traps in the treatment of macular degeneration
CN118724806A (en) 2015-08-21 2024-10-01 奥尔德拉医疗公司 Deuterated compounds and uses thereof
CN109152774A (en) 2016-05-09 2019-01-04 奥尔德拉医疗公司 Combination therapy for ocular inflammatory conditions and diseases
PL3481505T3 (en) * 2016-07-07 2026-01-26 Vanderbilt University Prevention and treatment of atrial fibrillation/flutter with gamma-ketoaldehyde scavengers
WO2018170476A1 (en) 2017-03-16 2018-09-20 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
HUE066390T2 (en) * 2017-04-27 2024-07-28 Univ Vanderbilt Gamma-ketoaldehyde scavengers for treating atherosclerosis
CN111356451A (en) 2017-10-10 2020-06-30 奥尔德拉医疗公司 Treatment of Inflammatory Conditions
CN112714762A (en) 2018-08-06 2021-04-27 奥尔德拉医疗公司 Polymorphic compounds and uses thereof
CN113056353B (en) 2018-09-25 2022-11-01 奥尔德拉医疗公司 Formulation for treating dry eye
US11786518B2 (en) 2019-03-26 2023-10-17 Aldeyra Therapeutics, Inc. Ophthalmic formulations and uses thereof
US12098132B2 (en) 2019-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
CN113784954A (en) 2019-05-02 2021-12-10 奥尔德拉医疗公司 Polymorphic compounds and their uses
WO2021231792A1 (en) 2020-05-13 2021-11-18 Aldeyra Therapeutics, Inc. Pharmaceutical formulations and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000021516A2 (en) * 1998-10-14 2000-04-20 Kansas University Medical Center Research Institute, Inc. Methods for inhibiting diabetic complications
WO2005072295A2 (en) * 2004-01-23 2005-08-11 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
US20080227776A1 (en) * 2005-06-15 2008-09-18 Oates John A Inhibitors of hemeprotein-catalyzed lipid peroxidation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277826B1 (en) * 1996-08-27 2001-08-21 Praecis Pharmaceuticals, Inc. Modulators of β-amyloid peptide aggregation comprising D-amino acids
US20050031651A1 (en) * 2002-12-24 2005-02-10 Francine Gervais Therapeutic formulations for the treatment of beta-amyloid related diseases
JP2009517411A (en) * 2005-11-28 2009-04-30 メディキュア インターナショナル インコーポレーテッド Formulations for the treatment of cardiovascular and related medical conditions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000021516A2 (en) * 1998-10-14 2000-04-20 Kansas University Medical Center Research Institute, Inc. Methods for inhibiting diabetic complications
WO2005072295A2 (en) * 2004-01-23 2005-08-11 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
US20080227776A1 (en) * 2005-06-15 2008-09-18 Oates John A Inhibitors of hemeprotein-catalyzed lipid peroxidation

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BERNOUD-HUBAC N ET AL: "Low concentrations of reactive gamma-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation", BIOCHIMICA AND BIOPHYSICA ACTA. MOLECULAR AND CELL BIOLOGY OF LIPIDS, ELSEVIER, AMSTERDAM, NL, vol. 1791, no. 4, 1 April 2009 (2009-04-01), pages 307 - 313, XP026011351, ISSN: 1388-1981, [retrieved on 20090221], DOI: 10.1016/J.BBALIP.2009.02.003 *
BOYDEN PENELOPE A ET AL: "Potential role of isoketals formed via the isoprostane pathway of lipid peroxidation in ischemic arrhythmias.", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY NOV 2007, vol. 50, no. 5, November 2007 (2007-11-01), pages 480 - 486, XP002691144, ISSN: 0160-2446 *
CIRCULATORY SHOCK 1981, vol. 8, no. 3, 1981, pages 273 - 282, ISSN: 0092-6213 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1990, MAEZAWA H ET AL: "THE EFFECT OF ONO-3144 ON LIMITING INFARCT SIZE IN A RAT MODEL OF MYOCARDIAL INFARCTION AND REPERFUSION", XP002691142, Database accession no. PREV199192008141 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 1981, LEFER A M ET AL: "Beneficial actions of a free radical scavenger in traumatic shock and myocardial ischemia.", XP002691143, Database accession no. NLM7249259 *
DAVIES SEAN S ET AL: "Treatment With Isoketal Scavenger, Salicylamine, Prevents Loss of Working Memory in Humanized Apoe4 Mice", FREE RADICAL BIOLOGY & MEDICINE, vol. 45, no. Suppl. 1, 2008, & 15TH ANNUAL MEETING OF THE SOCIETY-FOR-FREE-RADICAL-BIOLOGY-AND-MEDICINE; INDIANAPOLIS, IN, USA; NOVEMBER 19 -23, 2008, pages S103 - S104, XP002691141, ISSN: 0891-5849 *
DOKKYO JOURNAL OF MEDICAL SCIENCES, vol. 17, no. 2, 1990, pages 85 - 92, ISSN: 0385-5023 *
NEGRE-SALVAYRE A ET AL: "Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors.", BRITISH JOURNAL OF PHARMACOLOGY JAN 2008, vol. 153, no. 1, January 2008 (2008-01-01), pages 6 - 20, XP002691145, ISSN: 0007-1188 *
See also references of WO2011008202A1 *

Also Published As

Publication number Publication date
WO2011008202A1 (en) 2011-01-20
EP2477594A1 (en) 2012-07-25

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