EP2510361A4 - Nachweis von oxidierten polypeptiden - Google Patents

Nachweis von oxidierten polypeptiden

Info

Publication number
EP2510361A4
EP2510361A4 EP10836736.8A EP10836736A EP2510361A4 EP 2510361 A4 EP2510361 A4 EP 2510361A4 EP 10836736 A EP10836736 A EP 10836736A EP 2510361 A4 EP2510361 A4 EP 2510361A4
Authority
EP
European Patent Office
Prior art keywords
detection
polypeptides
oxidized
oxidized polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10836736.8A
Other languages
English (en)
French (fr)
Other versions
EP2510361A2 (de
Inventor
Ashraf G Madian
Fred E Regnier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of EP2510361A2 publication Critical patent/EP2510361A2/de
Publication of EP2510361A4 publication Critical patent/EP2510361A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP10836736.8A 2009-12-11 2010-12-10 Nachweis von oxidierten polypeptiden Withdrawn EP2510361A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28583009P 2009-12-11 2009-12-11
PCT/US2010/059828 WO2011072197A2 (en) 2009-12-11 2010-12-10 Detection of oxidized polypeptides

Publications (2)

Publication Number Publication Date
EP2510361A2 EP2510361A2 (de) 2012-10-17
EP2510361A4 true EP2510361A4 (de) 2013-07-17

Family

ID=44146194

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10836736.8A Withdrawn EP2510361A4 (de) 2009-12-11 2010-12-10 Nachweis von oxidierten polypeptiden

Country Status (3)

Country Link
US (1) US9134318B2 (de)
EP (1) EP2510361A4 (de)
WO (1) WO2011072197A2 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110242108A1 (en) * 2010-03-31 2011-10-06 Microsoft Corporation Visualization of complexly related data
CN103299192B (zh) 2010-09-21 2016-05-11 普罗蒂阿米克斯国际有限公司 与糖尿病前期、糖尿病以及糖尿病相关病症相关的生物标记
US9040903B2 (en) * 2011-04-04 2015-05-26 Wisconsin Alumni Research Foundation Precursor selection using an artificial intelligence algorithm increases proteomic sample coverage and reproducibility
EP2764350A4 (de) * 2011-09-22 2015-06-03 Expression Pathology Inc Srm / mrm-test für fettsäuresynthaseprotein
EP2841952A4 (de) * 2012-04-22 2015-12-02 Perfinity Biosciences Inc Automatisierte proteinverdauung, -rückgewinnung und -analyse
US20140194304A1 (en) * 2013-01-08 2014-07-10 Battelle Memorial Institute Process for ultra-sensitive quantification of target analytes in complex biological systems
ES2702183T3 (es) 2013-03-15 2019-02-27 Mayo Found Medical Education & Res Identificación y monitorización de inmunoglobulinas monoclonales por masa molecular
CN104931705A (zh) * 2014-03-19 2015-09-23 中国科学院大连化学物理研究所 一种细胞内纳米粒子表面蛋白质环冠的稳定同位素标记分析方法
CN103837625A (zh) * 2014-03-20 2014-06-04 北京工商大学 一种检测味精生产中焦谷氨酸的样品预处理及测定方法
WO2015154052A1 (en) 2014-04-04 2015-10-08 Mayo Foundation For Medical Education And Research Isotyping immunoglobulins using accurate molecular mass
CN106461630B (zh) * 2014-06-02 2018-09-28 Dh科技发展私人贸易有限公司 用于将质谱库转换成准确质谱库的方法
CN104391071B (zh) * 2014-12-13 2016-04-06 中国烟草总公司郑州烟草研究院 一种人体尿液中8-羟基脱氧鸟苷、8-羟基鸟苷和8-异构前列腺素F2α的分析方法
CN108026164A (zh) 2015-09-24 2018-05-11 梅约医学教育与研究基金会 通过质谱鉴定免疫球蛋白游离轻链
BR112018069072A2 (pt) * 2016-05-19 2019-01-22 Genentech, Inc. método para determinar o nível total de carbonilação e kit para levar a cabo o método
CN106066367A (zh) * 2016-05-24 2016-11-02 云南同创检测技术股份有限公司 同时检测糕点类食品中九种Amadori化合物浓度的方法
CN107573412B (zh) * 2016-07-04 2021-04-27 上海清流生物医药科技有限公司 一种新型天然蛋白及其应用
CN106353308B (zh) * 2016-08-24 2021-02-26 程玉慧 一种对羟基苯丙氨酸尿液检测试剂的制备方法
WO2018042454A2 (en) * 2016-09-01 2018-03-08 Translational Health Science And Technology Institute (Thsti) Method of hyperplexing in mass spectrometry to elucidate temporal dynamics of proteome
AU2017325022B2 (en) 2016-09-07 2022-10-13 Mayo Foundation For Medical Education And Research Identification and monitoring of cleaved immunoglobulins by molecular mass
CN108508125B (zh) * 2017-02-24 2021-06-11 中国科学院大连化学物理研究所 一种活性蛋白质与小分子相互作用的质谱检测方法
JP2020513846A (ja) * 2017-03-03 2020-05-21 ザ ユニヴァーシティー オブ ニューカッスル 組織の老化のマーカー及びその使用
EP3681907A4 (de) 2017-09-13 2021-07-07 Mayo Foundation for Medical Education and Research Identifizierung und überwachung von immunglobulin-j-ketten
WO2019055634A1 (en) 2017-09-13 2019-03-21 Mayo Foundation For Medical Education And Research IDENTIFICATION AND MONITORING OF A MACROPHAGE APOPTOSIS INHIBITOR
CN107894507A (zh) * 2017-11-22 2018-04-10 南宁科城汇信息科技有限公司 一种发现和鉴定肝癌血清差异表达蛋白和验证标志物蛋白方法
JP7165210B2 (ja) * 2018-05-24 2022-11-02 シグマ－アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー タンパク質の定量分析
CN109060989B (zh) * 2018-08-29 2021-07-30 重庆市肿瘤研究所 应用iTRAQ技术研究三阴性乳腺癌外泌体差异表达蛋白的方法
CN110882378A (zh) 2018-09-10 2020-03-17 上海清流生物医药科技有限公司 一种蛋白在制备预防和治疗动脉粥样硬化及并发症药物的应用
JP7256069B2 (ja) * 2019-05-10 2023-04-11 株式会社ファンケル 生体の酸化ストレスの評価方法
WO2021108237A1 (en) * 2019-11-26 2021-06-03 Merck Sharp & Dohme Corp. On-line ultra performance hydrophobic interaction chromatography for monitoring at least one product attribute
BR112022014901A2 (pt) * 2020-01-31 2022-09-20 Regeneron Pharma Identificação de composto de alta confiança por cromatografia líquida de espectrometria de massa
CN114525320A (zh) * 2020-11-23 2022-05-24 中国科学院大连化学物理研究所 一种甲基化肽段的富集方法
CN113138206B (zh) * 2021-03-04 2022-04-19 宁波大学 一种鉴别氨基酸的方法
WO2023047304A1 (en) * 2021-09-22 2023-03-30 Dh Technologies Development Pte. Ltd. Ms/ms-based identification of trisulfide bonds
CN115932131A (zh) * 2023-01-16 2023-04-07 南京农业大学 一种肌肉组织中羰基化蛋白质的富集和鉴定方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080299542A1 (en) * 2007-05-15 2008-12-04 Joseph Loscalzo Identification of oxidatively modified peptide sequences in the proteome (loscalzo)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE344456T1 (de) 2000-05-05 2006-11-15 Purdue Research Foundation Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen
CA2461587C (en) 2001-09-27 2011-04-26 Purdue Research Foundation Materials and methods for controlling isotope effects during fractionation of analytes
US20070087448A1 (en) * 2004-02-16 2007-04-19 Nelsestuen Gary L Biological profiles and methods of use
EP1797433A1 (de) 2004-09-29 2007-06-20 University Of Florida Research Foundation, Inc. Mit isotopen markierte dinitrophenylhydrazine und verwendungsverfahren dafür
JP4366507B2 (ja) 2006-03-20 2009-11-18 国立大学法人北陸先端科学技術大学院大学 酸化蛋白質の定量方法
WO2009134439A2 (en) 2008-05-02 2009-11-05 Purdue Research Foundation Group specific internal standard technology (gsist) for simultaneous identification and quantification of small molecules

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080299542A1 (en) * 2007-05-15 2008-12-04 Joseph Loscalzo Identification of oxidatively modified peptide sequences in the proteome (loscalzo)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CASTEGNA ALESSANDRA ET AL: "Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: Creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1", FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE, US, vol. 33, no. 4, 15 August 2002 (2002-08-15), pages 562 - 571, XP009169551, ISSN: 0891-5849 *
CASTEGNA ALESSANDRA ET AL: "Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: Dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71", JOURNAL OF NEUROCHEMISTRY, WILEY INTERSCIENCE, NEW YORK, NY, US, vol. 82, no. 6, 1 September 2002 (2002-09-01), pages 1524 - 1532, XP009169552, ISSN: 0022-3042, [retrieved on 20020919] *
MADIAN ASHRAF G ET AL: "Identification of Differentially Expressed Oxidized Proteins in the Plasma of Type II Diabetic Zucker Rats", FREE RADICAL BIOLOGY & MEDICINE, vol. 47, no. Suppl. 1, 2009, & 16TH ANNUAL MEETING OF THE SOCIETY-FOR-FREE-RADICAL-BIOLOGY-AND-MEDICINE; SAN FRANCISCO, CA, USA; NOVEMBER 18 -22, 2009, pages S182 - S183, XP009169608, ISSN: 0891-5849 *
MADIAN ASHRAF G ET AL: "Profiling Carbonylated Proteins in Human Plasma", JOURNAL OF PROTEOME RESEARCH, ACS, WASHINGTON, DC, US, vol. 9, no. 3, 5 March 2010 (2010-03-05), pages 1330 - 1343, XP009169555, ISSN: 1535-3893 *
MADIAN ASHRAF G ET AL: "Profiling of the Human Plasma Oxidized Proteome", FREE RADICAL BIOLOGY & MEDICINE, vol. 45, no. Suppl. 1, 2008, & 15TH ANNUAL MEETING OF THE SOCIETY-FOR-FREE-RADICAL-BIOLOGY-AND-MEDICINE; INDIANAPOLIS, IN, USA; NOVEMBER 19 -23, 2008, pages S122, XP009169607, ISSN: 0891-5849 *
MIRZAEI HAMID ET AL: "Identification of oxidized proteins in rat plasma using avidin chromatography and tandem mass spectrometry", PROTEOMICS, WILEY - VCH VERLAG, WEINHEIM, DE, vol. 8, no. 7, 1 April 2008 (2008-04-01), pages 1516 - 1527, XP009169547, ISSN: 1615-9853, [retrieved on 20080326] *

Also Published As

Publication number Publication date
WO2011072197A2 (en) 2011-06-16
US9134318B2 (en) 2015-09-15
US20120309040A1 (en) 2012-12-06
EP2510361A2 (de) 2012-10-17
WO2011072197A9 (en) 2011-10-13

Similar Documents

Publication Publication Date Title
EP2510361A4 (de) Nachweis von oxidierten polypeptiden
ZA201202816B (en) Detection of objects
ZA201201210B (en) Detection of aad-1 event das-40278-9
GB2468870B (en) Sensor
GB201017023D0 (en) ISFET switch
GB0912009D0 (en) Sensor
IL207866A0 (en) Proximity sensors
ZA201001878B (en) Improved detection of mage-a-expression
ZA201106546B (en) Zirconia powder
EP2433104A4 (de) Sensor
GB0915492D0 (en) Sensor
GB0903383D0 (en) Sensor
GB0914913D0 (en) Combined current sensor
GB0907785D0 (en) Detection of fungi
EP2478364A4 (de) Nachweis von antikörpern
ZA201007010B (en) Rapid detection of mycobateria
GB0917735D0 (en) Sensor
GB0913461D0 (en) Proximity sensor
GB2473067B (en) Proximity sensors
GB0908794D0 (en) Sensor
GB0920526D0 (en) Electrochemical detection
EP2450685A4 (de) Ladungserkennungssensor
GB0902939D0 (en) Orientation detection
GB0904218D0 (en) Detecting polypeptides
GB0904228D0 (en) Polypeptide detection

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20120711

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20130614

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/60 20060101ALI20130610BHEP

Ipc: G01N 33/68 20060101AFI20130610BHEP

Ipc: G01N 33/52 20060101ALI20130610BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20150701