EP2566508A4 - Conjugaison de polysaccharide à une entérotoxine thermolabile (lt) d'e.coli détoxifiée, utilisée comme vaccin - Google Patents
Conjugaison de polysaccharide à une entérotoxine thermolabile (lt) d'e.coli détoxifiée, utilisée comme vaccinInfo
- Publication number
- EP2566508A4 EP2566508A4 EP11817824.3A EP11817824A EP2566508A4 EP 2566508 A4 EP2566508 A4 EP 2566508A4 EP 11817824 A EP11817824 A EP 11817824A EP 2566508 A4 EP2566508 A4 EP 2566508A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- enteroxin
- detoxified
- conjugation
- vaccine
- polysaccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33065010P | 2010-05-03 | 2010-05-03 | |
| PCT/IB2011/001429 WO2012023008A2 (fr) | 2010-05-03 | 2011-04-29 | Conjugaison de polysaccharide à une entérotoxine thermolabile (lt) d'e.coli détoxifiée, utilisée comme vaccin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP2566508A2 EP2566508A2 (fr) | 2013-03-13 |
| EP2566508A4 true EP2566508A4 (fr) | 2013-10-09 |
| EP2566508B1 EP2566508B1 (fr) | 2015-07-22 |
Family
ID=44902090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP11817824.3A Active EP2566508B1 (fr) | 2010-05-03 | 2011-04-29 | Conjugaison de polysaccharide à une entérotoxine thermolabile (lt) d'e.coli détoxifiée, utilisée comme vaccin |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10624962B2 (fr) |
| EP (1) | EP2566508B1 (fr) |
| JP (2) | JP5967585B2 (fr) |
| CN (2) | CN102858370A (fr) |
| ES (1) | ES2550853T3 (fr) |
| TW (2) | TWI451874B (fr) |
| WO (1) | WO2012023008A2 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113616783B (zh) * | 2020-05-08 | 2025-08-08 | 昱厚生技股份有限公司 | 使用免疫调节剂和包含所述免疫调节剂的疫苗组合物预防或治疗冠状病毒感染的方法 |
| CN113388008B (zh) * | 2021-06-25 | 2023-04-28 | 太原师范学院 | 一种细胞内质网靶向的自释放型蛋白运输载体lca2及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0172107A1 (fr) * | 1984-08-10 | 1986-02-19 | Praxis Biologics, Inc. | Conjugués immunogènes d'unité secondaire d'entérotoxine LT-B d'E. coli et polymères capsulaires |
| WO2009011707A1 (fr) * | 2007-07-18 | 2009-01-22 | Development Center For Biotechnology | Entérotoxine thermolabile d'e. coli ayant muté |
| US20090181054A1 (en) * | 2005-09-21 | 2009-07-16 | Ryall Robert P | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5920226A (ja) * | 1982-07-26 | 1984-02-01 | Kitasato Inst:The | 動物用ワクチンおよびその製造法 |
| CN1191357C (zh) | 1998-12-22 | 2005-03-02 | 博伊斯·汤普生植物研究所 | 口服的免疫原性细菌肠毒素在转基因植物中的表达 |
| DK1471936T3 (da) * | 2002-01-14 | 2010-04-26 | Novartis Vaccines & Diagnostic | HIV-Vaccine og fremgangsmåde til anvendelse |
| MXPA04011249A (es) * | 2002-05-14 | 2005-06-06 | Chiron Srl | Vacunas mucosales con adyuvante de quitosano y antigenos meningococicos. |
| CN1852733A (zh) * | 2003-05-07 | 2006-10-25 | 安万特巴斯德公司 | 多价脑膜炎球菌衍生的多糖－蛋白质缀合物及疫苗 |
| GB0408978D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Meningococcal fermentation for preparing conjugate vaccines |
| WO2008021076A2 (fr) * | 2006-08-07 | 2008-02-21 | President And Fellows Of Harvard College | Vaccins à base de matrice protéique et procédés de fabrication et d'administration de tels vaccins |
| US8110197B2 (en) * | 2006-10-27 | 2012-02-07 | Development Center For Biotechnology | Mutated E. coli heat-labile enterotoxin |
| TWI304838B (en) * | 2006-10-27 | 2009-01-01 | Dev Center Biotechnology | Nucleotide acid sequence and amino acid sequence of e. coli heat-labile enterotoxin, and recombinant protein |
| CN102065868A (zh) * | 2008-06-16 | 2011-05-18 | 中央研究院 | 诱发对于Globo H及SSEA3的特异免疫反应的组合物以及其在癌症治疗中的用途 |
| EP3852230A4 (fr) | 2018-09-13 | 2022-05-18 | LS Electric Co., Ltd. | Dispositif d'alimentation électrique et système d'alimentation électrique |
-
2011
- 2011-04-29 CN CN2011800215281A patent/CN102858370A/zh active Pending
- 2011-04-29 CN CN201710238821.2A patent/CN107261129A/zh active Pending
- 2011-04-29 EP EP11817824.3A patent/EP2566508B1/fr active Active
- 2011-04-29 TW TW100115255A patent/TWI451874B/zh active
- 2011-04-29 ES ES11817824.3T patent/ES2550853T3/es active Active
- 2011-04-29 WO PCT/IB2011/001429 patent/WO2012023008A2/fr not_active Ceased
- 2011-04-29 TW TW102136855A patent/TW201406389A/zh unknown
- 2011-04-29 JP JP2013508580A patent/JP5967585B2/ja active Active
- 2011-04-29 US US13/097,218 patent/US10624962B2/en active Active
-
2014
- 2014-12-04 JP JP2014246147A patent/JP2015071630A/ja not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0172107A1 (fr) * | 1984-08-10 | 1986-02-19 | Praxis Biologics, Inc. | Conjugués immunogènes d'unité secondaire d'entérotoxine LT-B d'E. coli et polymères capsulaires |
| US20090181054A1 (en) * | 2005-09-21 | 2009-07-16 | Ryall Robert P | Multivalent meningococcal derivatized polysaccharide-protein conjugates and vaccine |
| WO2009011707A1 (fr) * | 2007-07-18 | 2009-01-22 | Development Center For Biotechnology | Entérotoxine thermolabile d'e. coli ayant muté |
Non-Patent Citations (3)
| Title |
|---|
| H. JAKOBSEN ET AL.: "Intranasal Immunization with Pneumococcal Polysaccharide Conjugate Vaccines with Nontoxic Mutants of Escherichia coli Heat-Labile Enterotoxins as Adjuvants Protects Mice against Invasive Pneumococcal Infections", INFECTION AND IMMUNITY, vol. 67, no. 11, November 1999 (1999-11-01), pages 5892 - 5897, XP002139940 * |
| See also references of WO2012023008A2 * |
| SHOUSUN C SZU ET AL: "Laboratory and Preliminary Clinical Characterization of Vi Capsular Polysaccharide-Protein Conjugate Vaccines", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MACROBIOLOGY, USA, vol. 62, no. 10, 1 October 1994 (1994-10-01), pages 4440 - 4444, XP007904999, ISSN: 0019-9567 * |
Also Published As
| Publication number | Publication date |
|---|---|
| TWI451874B (zh) | 2014-09-11 |
| US20110274717A1 (en) | 2011-11-10 |
| EP2566508B1 (fr) | 2015-07-22 |
| TW201406389A (zh) | 2014-02-16 |
| ES2550853T3 (es) | 2015-11-12 |
| WO2012023008A3 (fr) | 2012-05-24 |
| WO2012023008A2 (fr) | 2012-02-23 |
| JP2013525474A (ja) | 2013-06-20 |
| CN107261129A (zh) | 2017-10-20 |
| EP2566508A2 (fr) | 2013-03-13 |
| CN102858370A (zh) | 2013-01-02 |
| US10624962B2 (en) | 2020-04-21 |
| JP2015071630A (ja) | 2015-04-16 |
| JP5967585B2 (ja) | 2016-08-10 |
| TW201138814A (en) | 2011-11-16 |
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