EP2709447A4 - Compositions, methods & systems for respiratory delivery of two or more active agents - Google Patents

Compositions, methods & systems for respiratory delivery of two or more active agents

Info

Publication number: EP2709447A4
Authority: EP; European Patent Office
Prior art keywords: compositions; systems; methods; active agents; respiratory delivery
Prior art date: 2011-05-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP11865780.8A

Other languages

German (de)

French (fr)

Other versions

EP2709447A1 (en

Inventor

Reinhard Vehring

Michael Steven Hartman

David Lechuga-Ballesteros

Adrian Edward Smith

Vidya B Joshi

Sarvajna Kumar Dwivedi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pearl Therapeutics Inc

Original Assignee

Pearl Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-05-17

Filing date

2011-05-17

Publication date

2014-10-22

2011-05-17 Application filed by Pearl Therapeutics Inc filed Critical Pearl Therapeutics Inc

2014-03-26 Publication of EP2709447A1 publication Critical patent/EP2709447A1/en

2014-10-22 Publication of EP2709447A4 publication Critical patent/EP2709447A4/en

Status Withdrawn legal-status Critical Current

Links

239000013543 active substance Substances 0.000 title 1
239000000203 mixture Substances 0.000 title 1
230000000241 respiratory effect Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
- A61L9/02—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air by heating or combustion
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Dispersion Chemistry (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Otolaryngology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP11865780.8A 2011-05-17 2011-05-17 Compositions, methods & systems for respiratory delivery of two or more active agents Withdrawn EP2709447A4 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2011/036868 WO2012158166A1 (en)	2011-05-17	2011-05-17	Compositions, methods & systems for respiratory delivery of two or more active agents

Publications (2)

Publication Number	Publication Date
EP2709447A1 EP2709447A1 (en)	2014-03-26
EP2709447A4 true EP2709447A4 (en)	2014-10-22

Family

ID=47177229

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP11865780.8A Withdrawn EP2709447A4 (en)	2011-05-17	2011-05-17	Compositions, methods & systems for respiratory delivery of two or more active agents

Country Status (14)

Country	Link
EP (1)	EP2709447A4 (en)
JP (1)	JP2014518871A (en)
KR (1)	KR20140032404A (en)
CN (1)	CN103687483A (en)
AU (1)	AU2011368334A1 (en)
BR (1)	BR112013029507A2 (en)
CA (1)	CA2835927A1 (en)
EA (1)	EA201490991A1 (en)
IL (1)	IL229260A0 (en)
MX (1)	MX2013013440A (en)
PH (1)	PH12013502270A1 (en)
RU (1)	RU2013155903A (en)
SG (1)	SG194896A1 (en)
WO (1)	WO2012158166A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8815258B2 (en)	2009-05-29	2014-08-26	Pearl Therapeutics, Inc.	Compositions, methods and systems for respiratory delivery of two or more active agents
PL3111927T3 (en)	2009-05-29	2020-06-29	Pearl Therapeutics, Inc.	Compositions for respiratory delivery of active agents and associated methods and systems
US9682038B2 (en)	2013-01-31	2017-06-20	Prosonix Limited	Pharmaceutical compositions comprising multi-component crystalline particles suitable for use in inhalation therapy
SG11201507286QA (en)	2013-03-15	2015-10-29	Pearl Therapeutics Inc	Methods and systems for conditioning of particulate crystalline materials
US20150150787A1 (en) *	2013-05-22	2015-06-04	Pearl Therapeutics, Inc.	Compositions, methods & systems for respiratory delivery of three or more active agents
GEAP201814192A (en) *	2013-12-30	2018-02-26	Chiesi Farm Spa	Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination
RS57687B1 (en)	2013-12-30	2018-11-30	Chiesi Farm Spa	Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination
DK3689332T3 (en)	2014-09-09	2026-03-23	Vectura Ltd	FORMULATION COMPRISING GLYCOPYRROLATE, METHOD AND APPARATUS
US20160310410A1 (en)	2015-04-24	2016-10-27	Glenmark Specialty S.A.	Pharmaceutical compositions comprising arformoterol and glycopyrronium
JP6940416B2 (en) *	2015-05-01	2021-09-29	ボードオブリージェンツ, ザユニバーシティオブテキサスシステムBoard Of Regents, The University Of Texas System	Multi-agent brittle matrix composition
CN105125542A (en) *	2015-08-23	2015-12-09	杭州紫金医药科技有限公司	Medicine composition with tiotropium bromide and formoterol, application of medicine composition and preparation
CN106880636A (en) *	2015-12-15	2017-06-23	天津金耀集团有限公司	A kind of ciclesonide folk prescription and compound dry powder inhalation composition
CN106880637B (en) *	2015-12-15	2021-01-29	天津金耀集团有限公司	Ciclesonide formoterol and tiotropium bromide compound dry powder inhalant composition
CN106943350A (en) *	2017-03-14	2017-07-14	上海现代药物制剂工程研究中心有限公司	Aerosol and preparation method containing muscarinic receptor antagonist and β 2 receptor agonist
US20210393598A1 (en) *	2018-11-12	2021-12-23	Kindeva Drug Delivery L.P.	Umeclidinium and vilanterol formulation and inhaler
WO2021071967A1 (en) *	2019-10-09	2021-04-15	Island Breeze Systems Ca, Llc	Compositions for pulmonary delivery of cannabinoids and associated methods and systems
CN111467498A (en) *	2020-05-14	2020-07-31	王兆霖	Pharmaceutical composition preparation
TW202241410A (en) *	2021-01-08	2022-11-01	大陸商江蘇恒瑞醫藥股份有限公司	Pharmaceutical composition delivered by metered dose inhaler
CA3226557A1 (en) *	2021-07-09	2023-01-12	Astrazeneca Pharmaceuticals Lp	Compositions, methods and systems for aerosol drug delivery
CN116785239A (en) *	2022-03-17	2023-09-22	上海惠永药物研究有限公司	Method for preparing microspheres by spray freeze drying

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050175549A1 (en) *	2004-02-06	2005-08-11	Sofotec Gmbh & Co. Kg	Novel combination of anticholinergic and ss mimetics for the treatment of respiratory diseases
WO2010138862A2 (en) *	2009-05-29	2010-12-02	Pearl Therapeutics, Inc.	Compositions for respiratory delivery of active agents and associated methods and systems

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU756693B2 (en) *	1997-09-29	2003-01-23	Novartis Ag	Stabilized bioactive preparations and methods of use
US20060165606A1 (en) *	1997-09-29	2006-07-27	Nektar Therapeutics	Pulmonary delivery particles comprising water insoluble or crystalline active agents
GB9903759D0 (en) *	1999-02-18	1999-04-14	Novartis Ag	Organic compounds
SE527190C2 (en) *	2003-06-19	2006-01-17	Microdrug Ag	Administration of metered dry powder combined doses of finely divided dry medication powders involves selecting first and second medicaments for forming of pharmaceutical, combined doses
US8815258B2 (en) *	2009-05-29	2014-08-26	Pearl Therapeutics, Inc.	Compositions, methods and systems for respiratory delivery of two or more active agents

2011
- 2011-05-17 RU RU2013155903/15A patent/RU2013155903A/en not_active Application Discontinuation
- 2011-05-17 AU AU2011368334A patent/AU2011368334A1/en not_active Abandoned
- 2011-05-17 WO PCT/US2011/036868 patent/WO2012158166A1/en not_active Ceased
- 2011-05-17 SG SG2013083431A patent/SG194896A1/en unknown
- 2011-05-17 CN CN201180072341.4A patent/CN103687483A/en active Pending
- 2011-05-17 CA CA2835927A patent/CA2835927A1/en not_active Abandoned
- 2011-05-17 EP EP11865780.8A patent/EP2709447A4/en not_active Withdrawn
- 2011-05-17 BR BR112013029507A patent/BR112013029507A2/en not_active IP Right Cessation
- 2011-05-17 JP JP2014511329A patent/JP2014518871A/en active Pending
- 2011-05-17 EA EA201490991A patent/EA201490991A1/en unknown
- 2011-05-17 PH PH1/2013/502270A patent/PH12013502270A1/en unknown
- 2011-05-17 KR KR1020137030446A patent/KR20140032404A/en not_active Ceased
- 2011-05-17 MX MX2013013440A patent/MX2013013440A/en unknown
2013
- 2013-11-05 IL IL229260A patent/IL229260A0/en unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050175549A1 (en) *	2004-02-06	2005-08-11	Sofotec Gmbh & Co. Kg	Novel combination of anticholinergic and ss mimetics for the treatment of respiratory diseases
WO2010138862A2 (en) *	2009-05-29	2010-12-02	Pearl Therapeutics, Inc.	Compositions for respiratory delivery of active agents and associated methods and systems
WO2010138884A2 (en) *	2009-05-29	2010-12-02	Pearl Therapeutics, Inc.	Compositions, methods & systems for respiratory delivery of two or more active agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2012158166A1 *

Also Published As

Publication number	Publication date
AU2011368334A1 (en)	2013-11-21
MX2013013440A (en)	2014-06-05
CN103687483A (en)	2014-03-26
EA201490991A1 (en)	2014-09-30
IL229260A0 (en)	2014-01-30
WO2012158166A1 (en)	2012-11-22
EP2709447A1 (en)	2014-03-26
RU2013155903A (en)	2015-06-27
JP2014518871A (en)	2014-08-07
SG194896A1 (en)	2013-12-30
KR20140032404A (en)	2014-03-14
BR112013029507A2 (en)	2019-09-24
PH12013502270A1 (en)	2014-01-27
CA2835927A1 (en)	2012-11-22

Legal Events

Date	Code	Title	Description
2014-02-21	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2014-03-26	17P	Request for examination filed	Effective date: 20131213
2014-03-26	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2014-03-26	AX	Request for extension of the european patent	Extension state: BA ME
2014-10-22	A4	Supplementary search report drawn up and despatched	Effective date: 20140924
2014-10-22	RIC1	Information provided on ipc code assigned before grant	Ipc: A61P 11/08 20060101ALI20140918BHEP Ipc: A61K 9/72 20060101ALI20140918BHEP Ipc: A61K 31/167 20060101AFI20140918BHEP Ipc: A61P 11/00 20060101ALI20140918BHEP Ipc: A61K 31/40 20060101ALI20140918BHEP Ipc: A61K 9/10 20060101ALI20140918BHEP Ipc: A61K 9/12 20060101ALI20140918BHEP
2014-11-14	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1195450 Country of ref document: HK
2018-04-06	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2018-05-09	18D	Application deemed to be withdrawn	Effective date: 20171201
2020-12-31	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1195450 Country of ref document: HK

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