EP2712368A4 - Glucose and insulin sensors and methods of use thereof - Google Patents
Glucose and insulin sensors and methods of use thereofInfo
- Publication number
- EP2712368A4 EP2712368A4 EP12774552.9A EP12774552A EP2712368A4 EP 2712368 A4 EP2712368 A4 EP 2712368A4 EP 12774552 A EP12774552 A EP 12774552A EP 2712368 A4 EP2712368 A4 EP 2712368A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- glucose
- methods
- insulin sensors
- insulin
- sensors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title 1
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 title 1
- 239000008103 glucose Substances 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478274P | 2011-04-22 | 2011-04-22 | |
| PCT/US2012/034170 WO2012145459A2 (en) | 2011-04-22 | 2012-04-19 | Glucose and insulin sensors and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2712368A2 EP2712368A2 (en) | 2014-04-02 |
| EP2712368A4 true EP2712368A4 (en) | 2015-04-29 |
Family
ID=47042149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP12774552.9A Withdrawn EP2712368A4 (en) | 2011-04-22 | 2012-04-19 | Glucose and insulin sensors and methods of use thereof |
Country Status (3)
| Country | Link |
|---|---|
| US (3) | US9683266B2 (en) |
| EP (1) | EP2712368A4 (en) |
| WO (1) | WO2012145459A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012145459A2 (en) * | 2011-04-22 | 2012-10-26 | International Park Of Creativity | Glucose and insulin sensors and methods of use thereof |
| WO2015017852A1 (en) * | 2013-08-02 | 2015-02-05 | International Park Of Creativity | Biological devices and methods of use thereof for the study and control of alzheimer's disease |
| WO2020117937A1 (en) * | 2018-12-06 | 2020-06-11 | Bio Capital Holdings, LLC | Glucose sensors and methods of use thereof |
| CN114957293B (en) * | 2022-05-30 | 2023-07-25 | 常州大学 | Guanine-based cyanine probe for specific recognition of insulin and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996040963A1 (en) * | 1995-06-07 | 1996-12-19 | Megabios Corporation | Cationic lipid:dna complexes for gene targeting |
| US20030148421A1 (en) * | 2001-02-20 | 2003-08-07 | Newgard Christopher B. | Gene products that regulate glucose response in cells |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6416959B1 (en) | 1997-02-27 | 2002-07-09 | Kenneth Giuliano | System for cell-based screening |
| US6537806B1 (en) | 1998-06-02 | 2003-03-25 | University Of Washington | Compositions and methods for treating diabetes |
| AU2003301883A1 (en) * | 2002-10-30 | 2004-06-07 | University Of Tennessee Research Foundation | Modified luciferase nucleic acids and methods of use |
| EP1580273A1 (en) * | 2004-03-26 | 2005-09-28 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Peptide-based method for monitoring gene expression in a host cell |
| FR2877011B1 (en) * | 2004-10-27 | 2010-08-27 | Centre Nat Rech Scient | GENETICALLY MODIFIED YEAST STRAIN HAVING EXTENDED PRODUCTION AND EXCRETION OF S-ADENOSYLMETHIONINE (SAM) |
| US20100015871A1 (en) | 2006-09-29 | 2010-01-21 | Hirotoshi Tanimoto | Molded article, process for producing the same, and crosslinked molded article and copper-clad laminate each obtained therefrom |
| EP2158323A4 (en) * | 2007-05-18 | 2011-06-22 | Microbia Prec Engineering Inc | Organic acid production by fungal cells |
| WO2009037279A1 (en) * | 2007-09-18 | 2009-03-26 | Basf Plant Science Gmbh | Plants with increased yield |
| EP2217067A4 (en) * | 2007-11-07 | 2011-01-19 | Burnham Inst Medical Research | METHOD AND COMPOUNDS FOR REGULATING INSULIN PRODUCTION |
| JP5670755B2 (en) * | 2008-03-12 | 2015-02-18 | ザ ロックフェラー ユニバーシティ | Methods and compositions for translation profiling and molecular phenotyping |
| US20100021942A1 (en) * | 2008-07-25 | 2010-01-28 | Paul Freemont | Cell-free expression system for the detection of bacterial biofilms |
| WO2010077832A1 (en) * | 2008-12-15 | 2010-07-08 | Wisconsin Alumni Research Foundation | Methods and compositions for testing and breeding cattle for improved fertility and embryonic survival |
| WO2012145459A2 (en) * | 2011-04-22 | 2012-10-26 | International Park Of Creativity | Glucose and insulin sensors and methods of use thereof |
-
2012
- 2012-04-19 WO PCT/US2012/034170 patent/WO2012145459A2/en not_active Ceased
- 2012-04-19 EP EP12774552.9A patent/EP2712368A4/en not_active Withdrawn
- 2012-04-19 US US14/112,984 patent/US9683266B2/en active Active
-
2017
- 2017-04-27 US US15/498,630 patent/US9932644B2/en active Active
-
2018
- 2018-04-02 US US15/942,681 patent/US10501815B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996040963A1 (en) * | 1995-06-07 | 1996-12-19 | Megabios Corporation | Cationic lipid:dna complexes for gene targeting |
| US20030148421A1 (en) * | 2001-02-20 | 2003-08-07 | Newgard Christopher B. | Gene products that regulate glucose response in cells |
Non-Patent Citations (7)
| Title |
|---|
| FUKAZAWA ET AL: "Development of a novel beta-cell specific promoter system for the identification of insulin-producing cells in in vitro cell cultures", EXPERIMENTAL CELL RESEARCH, ACADEMIC PRESS, US, vol. 312, no. 17, 15 October 2006 (2006-10-15), pages 3404 - 3412, XP005653985, ISSN: 0014-4827, DOI: 10.1016/J.YEXCR.2006.07.015 * |
| GANZLIN MARKUS ET AL: "In-depth analysis of the Aspergillus niger glucoamylase (glaA) promoter performance using high-throughput screening and controlled bioreactor cultivation techniques.", JOURNAL OF BIOTECHNOLOGY 30 JUN 2008, vol. 135, no. 3, 30 June 2008 (2008-06-30), pages 266 - 271, XP002737229, ISSN: 0168-1656 * |
| KIM SUK KYOUNG ET AL: "A dual-reporter system for specific tracing of pancreatic ss-cell lines that non-invasively measures viable in vivo islet cells.", BIOTECHNOLOGY LETTERS JAN 2010, vol. 32, no. 1, January 2010 (2010-01-01), pages 53 - 57, XP002737228, ISSN: 1573-6776 * |
| OHTANI K ET AL: "Identification and characterization of a glucose-responsiveness region upstream of human insulin gene in transfected HIT-T 15 cells.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 14 JAN 1998, vol. 242, no. 2, 14 January 1998 (1998-01-14), pages 446 - 451, XP002737231, ISSN: 0006-291X * |
| PEDERSEN KIM B ET AL: "The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions.", AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM MAR 2007, vol. 292, no. 3, March 2007 (2007-03-01), pages E788 - E801, XP002737230, ISSN: 0193-1849 * |
| See also references of WO2012145459A2 * |
| SZABAT MARTA ET AL: "Maturation of adult beta-cells revealed using a Pdx1/insulin dual-reporter lentivirus.", ENDOCRINOLOGY APR 2009, vol. 150, no. 4, April 2009 (2009-04-01), pages 1627 - 1635, XP002737227, ISSN: 1945-7170 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20180223379A1 (en) | 2018-08-09 |
| US10501815B2 (en) | 2019-12-10 |
| EP2712368A2 (en) | 2014-04-02 |
| US20140287425A1 (en) | 2014-09-25 |
| US20170240979A1 (en) | 2017-08-24 |
| WO2012145459A2 (en) | 2012-10-26 |
| US9683266B2 (en) | 2017-06-20 |
| WO2012145459A3 (en) | 2014-05-01 |
| US9932644B2 (en) | 2018-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20140117 |
|
| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| R17D | Deferred search report published (corrected) |
Effective date: 20140501 |
|
| DAX | Request for extension of the european patent (deleted) | ||
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12Q 1/68 20060101AFI20150317BHEP |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20150326 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20150624 |