EP2714909A4 - PROCESS FOR PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT PROCESSES - Google Patents

PROCESS FOR PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT PROCESSES

Info

Publication number
EP2714909A4
EP2714909A4 EP12796718.0A EP12796718A EP2714909A4 EP 2714909 A4 EP2714909 A4 EP 2714909A4 EP 12796718 A EP12796718 A EP 12796718A EP 2714909 A4 EP2714909 A4 EP 2714909A4
Authority
EP
European Patent Office
Prior art keywords
factor viii
producing factor
recombinant processes
viii proteins
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12796718.0A
Other languages
German (de)
French (fr)
Other versions
EP2714909A1 (en
Inventor
Randal J Kaufman
Steven W Pipe
Michael Griffith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cangene Corp
University of Michigan System
Original Assignee
Cangene Corp
University of Michigan System
University of Michigan Ann Arbor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/153,040 external-priority patent/US20120028900A1/en
Application filed by Cangene Corp, University of Michigan System, University of Michigan Ann Arbor filed Critical Cangene Corp
Publication of EP2714909A1 publication Critical patent/EP2714909A1/en
Publication of EP2714909A4 publication Critical patent/EP2714909A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP12796718.0A 2011-06-03 2012-06-01 PROCESS FOR PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT PROCESSES Withdrawn EP2714909A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/153,040 US20120028900A1 (en) 2006-06-30 2011-06-03 Method of producing factor viii proteins by recombinant methods
PCT/US2012/040376 WO2012170289A1 (en) 2011-06-03 2012-06-01 Method of producing factor viii proteins by recombinant methods

Publications (2)

Publication Number Publication Date
EP2714909A1 EP2714909A1 (en) 2014-04-09
EP2714909A4 true EP2714909A4 (en) 2014-12-17

Family

ID=47296374

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12796718.0A Withdrawn EP2714909A4 (en) 2011-06-03 2012-06-01 PROCESS FOR PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT PROCESSES

Country Status (3)

Country Link
EP (1) EP2714909A4 (en)
CA (1) CA2837995A1 (en)
WO (1) WO2012170289A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014127215A1 (en) 2013-02-15 2014-08-21 Biogen Idec Ma Inc. Optimized factor viii gene
US11008561B2 (en) 2014-06-30 2021-05-18 Bioverativ Therapeutics Inc. Optimized factor IX gene
MX388739B (en) 2015-02-06 2025-03-20 Univ North Carolina Chapel Hill OPTIMIZED HUMAN COAGULATION FACTOR VIII GENE EXPRESSION CASSETTES AND THEIR USE.
JP2018524995A (en) * 2015-08-06 2018-09-06 グリコトープ ゲーエムベーハー Heteromers containing antibody domain fusion proteins
CA3012695A1 (en) 2016-02-01 2017-08-10 Bioverativ Therapeutics Inc. Optimized factor viii genes
US11299533B2 (en) 2017-06-23 2022-04-12 Takeda Pharmaceutical Company Limited Purification of factor VIII subspecies
JP7672334B2 (en) * 2018-10-23 2025-05-07 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア Compositions and methods for modulating factor VIII function
EP3785726A1 (en) * 2019-09-02 2021-03-03 Biotest AG Factor viii protein with increased half-life
EP4017521A1 (en) * 2019-09-02 2022-06-29 Biotest AG Factor viii protein with increased half-life
KR20220097891A (en) 2019-09-30 2022-07-08 바이오버라티브 테라퓨틱스 인크. Lentiviral vector formulation
MX2023000156A (en) 2020-06-24 2023-02-16 Bioverativ Therapeutics Inc METHODS FOR THE ELIMINATION OF FREE FACTOR VIII FROM PREPARATIONS OF LENTIVIRAL VECTORS MODIFIED TO EXPRESS SAID PROTEIN.
CN117192132B (en) * 2023-11-03 2024-02-02 庄亚(北京)生物科技有限公司 vWF fragment residue detection kit and method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008005847A2 (en) * 2006-06-30 2008-01-10 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008005847A2 (en) * 2006-06-30 2008-01-10 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KERRY L. DOORISS ET AL: "Comparison of Factor VIII Transgenes Bioengineered for Improved Expression in Gene Therapy of Hemophilia A", HUMAN GENE THERAPY, vol. 20, no. 5, 1 May 2009 (2009-05-01), pages 465 - 478, XP055136766, ISSN: 1043-0342, DOI: 10.1089/hum.2008.150 *
MIAO HONGZHI Z ET AL: "Bioengineering of coagulation factor VIII for improved secretion", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 103, no. 9, 1 May 2004 (2004-05-01), pages 3412 - 3419, XP002452857, ISSN: 0006-4971, DOI: 10.1182/BLOOD-2003-10-3591 *
N. J. WARD ET AL: "Codon optimization of human factor VIII cDNAs leads to high-level expression", BLOOD, vol. 117, no. 3, 20 January 2011 (2011-01-20), pages 798 - 807, XP055052195, ISSN: 0006-4971, DOI: 10.1182/blood-2010-05-282707 *
See also references of WO2012170289A1 *

Also Published As

Publication number Publication date
WO2012170289A1 (en) 2012-12-13
CA2837995A1 (en) 2012-12-13
EP2714909A1 (en) 2014-04-09

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20131216

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CANGENE CORPORATION

Owner name: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20141117

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 38/37 20060101ALI20141111BHEP

Ipc: C07K 14/755 20060101ALI20141111BHEP

Ipc: C12Q 1/68 20060101ALI20141111BHEP

Ipc: A61P 7/04 20060101ALI20141111BHEP

Ipc: C12N 15/12 20060101AFI20141111BHEP

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20150616