EP2841444A4 - Process for preparation of 17-substituted steroids - Google Patents

Process for preparation of 17-substituted steroids

Info

Publication number
EP2841444A4
EP2841444A4 EP13780667.5A EP13780667A EP2841444A4 EP 2841444 A4 EP2841444 A4 EP 2841444A4 EP 13780667 A EP13780667 A EP 13780667A EP 2841444 A4 EP2841444 A4 EP 2841444A4
Authority
EP
European Patent Office
Prior art keywords
preparation
substituted steroids
steroids
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13780667.5A
Other languages
German (de)
French (fr)
Other versions
EP2841444A1 (en
Inventor
Craig E Dixon
Qingbo Lu
Boris Gorin
Erwin Schreiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alphora Research Inc
Original Assignee
Alphora Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alphora Research Inc filed Critical Alphora Research Inc
Publication of EP2841444A1 publication Critical patent/EP2841444A1/en
Publication of EP2841444A4 publication Critical patent/EP2841444A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
EP13780667.5A 2012-04-23 2013-04-22 Process for preparation of 17-substituted steroids Withdrawn EP2841444A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261637048P 2012-04-23 2012-04-23
US201261642253P 2012-05-03 2012-05-03
PCT/CA2013/050311 WO2013159225A1 (en) 2012-04-23 2013-04-22 Process for preparation of 17-substituted steroids

Publications (2)

Publication Number Publication Date
EP2841444A1 EP2841444A1 (en) 2015-03-04
EP2841444A4 true EP2841444A4 (en) 2015-11-04

Family

ID=49482082

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13780667.5A Withdrawn EP2841444A4 (en) 2012-04-23 2013-04-22 Process for preparation of 17-substituted steroids

Country Status (3)

Country Link
EP (1) EP2841444A4 (en)
CA (1) CA2871314A1 (en)
WO (1) WO2013159225A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014016830A1 (en) * 2012-07-25 2014-01-30 Mapi Pharma Ltd. Process and intermediates for the preparation of abiraterone acetate
US9937259B2 (en) * 2014-06-27 2018-04-10 Zhuhai Beihai Biotech Co., Ltd. Abiraterone derivatives and non-covalent complexes with albumin
US10722527B2 (en) 2015-04-10 2020-07-28 Capsugel Belgium Nv Abiraterone acetate lipid formulations
CN105503992A (en) * 2016-01-22 2016-04-20 江苏联环药业股份有限公司 Preparation method of abiraterone acetate
CN107722101A (en) * 2017-11-03 2018-02-23 郑州大学 Steroidal pyridine derivatives and its preparation method and application
US10792292B2 (en) 2019-03-06 2020-10-06 Propella Therapeutics, Inc. Abiraterone prodrugs
US11957696B2 (en) 2021-02-15 2024-04-16 Propella Therapeutics, Inc. Abiraterone prodrugs
CN117683073A (en) * 2023-12-15 2024-03-12 江苏希迪制药有限公司 Synthesis method of abiraterone acetate

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2938030A (en) * 1956-10-03 1960-05-24 Ciba Pharm Prod Inc New steroids substituted by a heterocyclic nitrogen-containing ring in 17-position
WO1993020097A1 (en) * 1992-03-31 1993-10-14 British Technology Group Ltd. 17-substituted steroids useful in cancer treatment
WO1995009178A1 (en) * 1993-09-30 1995-04-06 British Technology Group Limited Synthesis of 17-(3-pyridyl) steroids
CN101768199A (en) * 2009-12-24 2010-07-07 深圳万乐药业有限公司 Polymorphs of abiraterone acetate and preparation method thereof
CN102321142A (en) * 2011-09-29 2012-01-18 重庆医药工业研究院有限责任公司 Abiraterone acetate crystal form and preparation method thereof
WO2013030410A2 (en) * 2011-12-23 2013-03-07 Crystal Pharma, S.A.U. Synthesis of abiraterone and related compounds
WO2014016830A1 (en) * 2012-07-25 2014-01-30 Mapi Pharma Ltd. Process and intermediates for the preparation of abiraterone acetate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102898495B (en) * 2012-11-12 2014-11-26 浙江神洲药业有限公司 Method for preparing abiraterone acetate

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2938030A (en) * 1956-10-03 1960-05-24 Ciba Pharm Prod Inc New steroids substituted by a heterocyclic nitrogen-containing ring in 17-position
WO1993020097A1 (en) * 1992-03-31 1993-10-14 British Technology Group Ltd. 17-substituted steroids useful in cancer treatment
WO1995009178A1 (en) * 1993-09-30 1995-04-06 British Technology Group Limited Synthesis of 17-(3-pyridyl) steroids
CN101768199A (en) * 2009-12-24 2010-07-07 深圳万乐药业有限公司 Polymorphs of abiraterone acetate and preparation method thereof
CN102321142A (en) * 2011-09-29 2012-01-18 重庆医药工业研究院有限责任公司 Abiraterone acetate crystal form and preparation method thereof
WO2013030410A2 (en) * 2011-12-23 2013-03-07 Crystal Pharma, S.A.U. Synthesis of abiraterone and related compounds
WO2014016830A1 (en) * 2012-07-25 2014-01-30 Mapi Pharma Ltd. Process and intermediates for the preparation of abiraterone acetate

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A. V. KAMERNITSKII ET AL: "Transformed steroids. 114. Direction of opening oxide ring of 16,17?-epoxy-17?-phenylandrost-4-en-3-one", BULLETIN OF THE ACADEMY OF SCIENCES OF THE USSR; DIVISION OF CHEMICAL SCIENCES, vol. 29, no. 8, 1 August 1980 (1980-08-01), pages 1363 - 1366, XP055213844, ISSN: 0568-5230, DOI: 10.1007/BF00950590 *
DATABASE WPI Week 201058, Derwent World Patents Index; AN 2010-K12540, XP002744750 *
DATABASE WPI Week 201233, Derwent World Patents Index; AN 2012-B86835, XP002744749 *
J. HEER: "Über Pyridyl-Steroide. I. Über Steroide, 141. Mitteilung", HELVETICA CHIMICA ACTA, vol. 39, no. 6, 1 January 1956 (1956-01-01), pages 1804 - 1813, XP055214017, ISSN: 0018-019X, DOI: 10.1002/hlca.19560390640 *
See also references of WO2013159225A1 *

Also Published As

Publication number Publication date
EP2841444A1 (en) 2015-03-04
CA2871314A1 (en) 2013-10-31
WO2013159225A1 (en) 2013-10-31

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Legal Events

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DAX Request for extension of the european patent (deleted)
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Ipc: C07J 75/00 20060101ALI20150925BHEP

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Inventor name: SCHREINER, ERWIN

Inventor name: LU, QINGBO

Inventor name: GORIN, BORIS

Inventor name: DIXON, CRAIG E.

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