EP2943227A4 - RADIOPHARMACEUTICAL PRODUCTS BASED ON TRIAZINE AND RADIOIMAGING AGENTS - Google Patents

RADIOPHARMACEUTICAL PRODUCTS BASED ON TRIAZINE AND RADIOIMAGING AGENTS

Info

Publication number
EP2943227A4
EP2943227A4 EP14738117.2A EP14738117A EP2943227A4 EP 2943227 A4 EP2943227 A4 EP 2943227A4 EP 14738117 A EP14738117 A EP 14738117A EP 2943227 A4 EP2943227 A4 EP 2943227A4
Authority
EP
European Patent Office
Prior art keywords
triazine
products based
radiopharmaceutical products
radioimaging agents
radioimaging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP14738117.2A
Other languages
German (de)
French (fr)
Other versions
EP2943227B8 (en
EP2943227A1 (en
EP2943227B1 (en
Inventor
John W Babich
Craig Zimmerman
John Joyal
Genliang Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Insight Pharmaceuticals Inc
Original Assignee
Molecular Insight Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP21190931.2A priority Critical patent/EP3939972A1/en
Priority to EP19174044.8A priority patent/EP3545978B1/en
Priority to EP17187271.6A priority patent/EP3300746B1/en
Priority to PL17187271T priority patent/PL3300746T3/en
Priority to PL14738117T priority patent/PL2943227T3/en
Application filed by Molecular Insight Pharmaceuticals Inc filed Critical Molecular Insight Pharmaceuticals Inc
Publication of EP2943227A1 publication Critical patent/EP2943227A1/en
Publication of EP2943227A4 publication Critical patent/EP2943227A4/en
Application granted granted Critical
Publication of EP2943227B1 publication Critical patent/EP2943227B1/en
Publication of EP2943227B8 publication Critical patent/EP2943227B8/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/481—Diagnostic techniques involving the use of contrast agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP14738117.2A 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents Active EP2943227B8 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP19174044.8A EP3545978B1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents
EP17187271.6A EP3300746B1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents
PL17187271T PL3300746T3 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents
PL14738117T PL2943227T3 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents
EP21190931.2A EP3939972A1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361752350P 2013-01-14 2013-01-14
US201361785788P 2013-03-14 2013-03-14
PCT/US2014/011047 WO2014110372A1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents

Related Child Applications (4)

Application Number Title Priority Date Filing Date
EP19174044.8A Division EP3545978B1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents
EP17187271.6A Division-Into EP3300746B1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents
EP17187271.6A Division EP3300746B1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents
EP21190931.2A Division EP3939972A1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents

Publications (4)

Publication Number Publication Date
EP2943227A1 EP2943227A1 (en) 2015-11-18
EP2943227A4 true EP2943227A4 (en) 2016-05-25
EP2943227B1 EP2943227B1 (en) 2017-09-20
EP2943227B8 EP2943227B8 (en) 2017-11-22

Family

ID=51167394

Family Applications (4)

Application Number Title Priority Date Filing Date
EP21190931.2A Withdrawn EP3939972A1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents
EP19174044.8A Active EP3545978B1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents
EP14738117.2A Active EP2943227B8 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents
EP17187271.6A Active EP3300746B1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP21190931.2A Withdrawn EP3939972A1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents
EP19174044.8A Active EP3545978B1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP17187271.6A Active EP3300746B1 (en) 2013-01-14 2014-01-10 Triazine based radiopharmaceuticals and radioimaging agents

Country Status (14)

Country Link
US (5) US9447121B2 (en)
EP (4) EP3939972A1 (en)
JP (2) JP6468602B2 (en)
KR (1) KR102187940B1 (en)
CN (1) CN105025933B (en)
AU (1) AU2014205304B2 (en)
BR (1) BR112015016585B1 (en)
CA (1) CA2897437C (en)
ES (2) ES2648096T3 (en)
HU (2) HUE044552T2 (en)
MX (1) MX378439B (en)
PL (2) PL3300746T3 (en)
SG (1) SG11201505477TA (en)
WO (1) WO2014110372A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
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EP3939972A1 (en) * 2013-01-14 2022-01-19 Molecular Insight Pharmaceuticals, Inc. Triazine based radiopharmaceuticals and radioimaging agents
EP3456700A1 (en) 2013-10-18 2019-03-20 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
CN106660943B (en) * 2014-05-06 2020-03-17 约翰霍普金斯大学 Metal/radiometal labeled PSMA inhibitors for PSMA-targeted imaging and radiotherapy
JP2017530109A (en) * 2014-09-08 2017-10-12 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド Organ protection during radionuclide therapy targeting PSMA for prostate cancer
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
US10688200B2 (en) * 2015-12-31 2020-06-23 Five Eleven Pharma Inc. Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy
RS65188B1 (en) * 2016-03-22 2024-03-29 Univ Johns Hopkins Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
AU2017348111B2 (en) * 2016-10-27 2023-04-06 Progenics Pharmaceuticals, Inc. Network for medical image analysis, decision support system, and related graphical user interface (GUI) applications
ES2814555T3 (en) 2016-11-28 2021-03-29 Bayer Pharma AG Gadolinium chelate compounds with high relaxivity for use in magnetic resonance imaging
CN111032632B (en) * 2017-05-30 2024-04-12 约翰霍普金斯大学 High affinity agents for prostate specific membrane antigen targeting for intracavity radiation therapy of prostate cancer
DK3643707T3 (en) 2017-06-19 2022-05-09 Futurechem Co Ltd 18F MARKED CONNECTION FOR DIAGNOSIS OF PROSTATE CANCER AND ITS USE
WO2018236115A1 (en) * 2017-06-19 2018-12-27 (주)퓨쳐켐 18F-labeled compounds and their uses for the diagnosis of prostate cancer
HRP20230604T1 (en) 2018-03-30 2023-09-29 Futurechem Co., Ltd. Psma-targeted radiopharmaceutical for diagnosing and treating prostate cancer
KR102934987B1 (en) 2018-11-23 2026-03-09 바이엘 악티엔게젤샤프트 Formulation of contrast medium and method for producing same
CN114364405B (en) * 2019-04-26 2024-07-16 五一一制药股份有限公司 Prostate Specific Membrane Antigen (PSMA) inhibitors as diagnostic and radionuclide therapeutics
JP2024542539A (en) * 2021-11-24 2024-11-15 クラリティー・ファーマシューティカルズ・リミテッド Compounds and compositions thereof for the treatment of cancer - Patents.com
CN116199736B (en) * 2023-03-01 2025-03-18 西南医科大学附属医院 A DOTA-Te-PSMA compound and its application

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