EP2971024A4 - Thioesterases and cells for production of tailored oils - Google Patents
Thioesterases and cells for production of tailored oilsInfo
- Publication number
- EP2971024A4 EP2971024A4 EP14769502.7A EP14769502A EP2971024A4 EP 2971024 A4 EP2971024 A4 EP 2971024A4 EP 14769502 A EP14769502 A EP 14769502A EP 2971024 A4 EP2971024 A4 EP 2971024A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- thioesterases
- cells
- production
- tailored oils
- tailored
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000005488 Thioesterase Human genes 0.000 title 1
- 239000003921 oil Substances 0.000 title 1
- 108020002982 thioesterase Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/02—Thioester hydrolases (3.1.2)
- C12Y301/02014—Oleoyl-[acyl-carrier-protein] hydrolase (3.1.2.14), i.e. ACP-thioesterase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Edible Oils And Fats (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791861P | 2013-03-15 | 2013-03-15 | |
| US13/837,996 US9290749B2 (en) | 2013-03-15 | 2013-03-15 | Thioesterases and cells for production of tailored oils |
| US201361917217P | 2013-12-17 | 2013-12-17 | |
| PCT/US2014/026644 WO2014151904A1 (en) | 2013-03-15 | 2014-03-13 | Thioesterases and cells for production of tailored oils |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2971024A1 EP2971024A1 (en) | 2016-01-20 |
| EP2971024A4 true EP2971024A4 (en) | 2016-11-16 |
Family
ID=51581068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP14769502.7A Withdrawn EP2971024A4 (en) | 2013-03-15 | 2014-03-13 | Thioesterases and cells for production of tailored oils |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2971024A4 (en) |
| JP (1) | JP2016518112A (en) |
| KR (1) | KR20150128770A (en) |
| CN (1) | CN105143458A (en) |
| AU (2) | AU2014236763B2 (en) |
| BR (1) | BR112015023192A8 (en) |
| CA (1) | CA2904395A1 (en) |
| MX (1) | MX2015011507A (en) |
| WO (1) | WO2014151904A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9816079B2 (en) | 2013-01-29 | 2017-11-14 | Terravia Holdings, Inc. | Variant thioesterases and methods of use |
| US9567615B2 (en) | 2013-01-29 | 2017-02-14 | Terravia Holdings, Inc. | Variant thioesterases and methods of use |
| US9290749B2 (en) | 2013-03-15 | 2016-03-22 | Solazyme, Inc. | Thioesterases and cells for production of tailored oils |
| US9783836B2 (en) | 2013-03-15 | 2017-10-10 | Terravia Holdings, Inc. | Thioesterases and cells for production of tailored oils |
| US9765368B2 (en) | 2014-07-24 | 2017-09-19 | Terravia Holdings, Inc. | Variant thioesterases and methods of use |
| US10125382B2 (en) | 2014-09-18 | 2018-11-13 | Corbion Biotech, Inc. | Acyl-ACP thioesterases and mutants thereof |
| US20180142218A1 (en) | 2016-10-05 | 2018-05-24 | Terravia Holdings, Inc. | Novel acyltransferases, variant thioesterases, and uses thereof |
| MY205555A (en) | 2017-04-03 | 2024-10-25 | Genomatica Inc | Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives |
| EP4090735A1 (en) | 2020-01-16 | 2022-11-23 | Corbion Biotech, Inc. | Beta-ketoacyl-acp synthase iv variants |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992020236A1 (en) * | 1991-05-21 | 1992-11-26 | Calgene, Inc. | Plant medium-chain thioesterases |
| CN102586350A (en) * | 2012-01-09 | 2012-07-18 | 北京化工大学 | Production method for C8:0/C10:0/C12:0/C14:0 medium-chain fatty acid and ethyl ester thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5344771A (en) | 1990-04-26 | 1994-09-06 | Calgene, Inc. | Plant thiosterases |
| US5298421A (en) | 1990-04-26 | 1994-03-29 | Calgene, Inc. | Plant medium-chain-preferring acyl-ACP thioesterases and related methods |
| US5639790A (en) | 1991-05-21 | 1997-06-17 | Calgene, Inc. | Plant medium-chain thioesterases |
| US5455167A (en) | 1991-05-21 | 1995-10-03 | Calgene Inc. | Medium-chain thioesterases in plants |
| US5850022A (en) | 1992-10-30 | 1998-12-15 | Calgene, Inc. | Production of myristate in plant cells |
| US5654495A (en) | 1992-10-30 | 1997-08-05 | Calgene, Inc. | Production of myristate in plant cells |
| WO1995006740A2 (en) * | 1993-09-03 | 1995-03-09 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Medium chain-specific thioesterases |
| WO1995013390A2 (en) | 1993-11-10 | 1995-05-18 | Calgene, Inc. | Plant acyl acp thioesterase sequences |
| US5807893A (en) | 1993-11-18 | 1998-09-15 | Voelker; Toni Alois | Plant thioesterases and use for modification of fatty acid composition in plant seed oils |
| US20090004715A1 (en) | 2007-06-01 | 2009-01-01 | Solazyme, Inc. | Glycerol Feedstock Utilization for Oil-Based Fuel Manufacturing |
| CA2692687C (en) * | 2007-07-09 | 2021-10-26 | Bayer Bioscience N.V. | Brassica plant comprising mutant fatty acyl-acp thioesterase alleles |
| US7982035B2 (en) | 2007-08-27 | 2011-07-19 | Duquesne University Of The Holy Spirit | Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof |
| CN102066569A (en) * | 2008-06-20 | 2011-05-18 | 巴斯夫植物科学有限公司 | Plants having enhanced yield-related traits and a method for making the same |
| AU2009319722B2 (en) | 2008-11-28 | 2016-08-04 | Corbion Biotech, Inc. | Production of tailored oils in heterotrophic microorganisms |
| EP2417246A4 (en) * | 2009-04-10 | 2015-11-04 | Reg Life Sciences Llc | Production of fatty acid derivatives |
| US8592188B2 (en) | 2010-05-28 | 2013-11-26 | Solazyme, Inc. | Tailored oils produced from recombinant heterotrophic microorganisms |
| KR101964965B1 (en) | 2011-02-02 | 2019-04-03 | 테라비아 홀딩스 인코포레이티드 | Tailored oils produced from recombinant oleaginous microorganisms |
| US8951762B2 (en) * | 2011-07-27 | 2015-02-10 | Iowa State University Research Foundation, Inc. | Materials and methods for using an acyl—acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis |
| US8945908B2 (en) | 2012-04-18 | 2015-02-03 | Solazyme, Inc. | Tailored oils |
-
2014
- 2014-03-13 BR BR112015023192A patent/BR112015023192A8/en not_active Application Discontinuation
- 2014-03-13 CN CN201480020002.5A patent/CN105143458A/en active Pending
- 2014-03-13 KR KR1020157027058A patent/KR20150128770A/en not_active Withdrawn
- 2014-03-13 MX MX2015011507A patent/MX2015011507A/en unknown
- 2014-03-13 WO PCT/US2014/026644 patent/WO2014151904A1/en not_active Ceased
- 2014-03-13 JP JP2016502205A patent/JP2016518112A/en active Pending
- 2014-03-13 CA CA2904395A patent/CA2904395A1/en not_active Abandoned
- 2014-03-13 AU AU2014236763A patent/AU2014236763B2/en not_active Ceased
- 2014-03-13 EP EP14769502.7A patent/EP2971024A4/en not_active Withdrawn
-
2018
- 2018-11-21 AU AU2018267601A patent/AU2018267601A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992020236A1 (en) * | 1991-05-21 | 1992-11-26 | Calgene, Inc. | Plant medium-chain thioesterases |
| CN102586350A (en) * | 2012-01-09 | 2012-07-18 | 北京化工大学 | Production method for C8:0/C10:0/C12:0/C14:0 medium-chain fatty acid and ethyl ester thereof |
Non-Patent Citations (2)
| Title |
|---|
| See also references of WO2014151904A1 * |
| YUAN L ET AL: "MODIFICATION OF THE SUBSTRATE SPECIFICITY OF AN ACYL-ACYL CARRIER PROTEIN THIOESTERASE BY PROTEIN ENGINEERING", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 92, 1 November 1995 (1995-11-01), pages 10639 - 10643, XP002014019, ISSN: 0027-8424, DOI: 10.1073/PNAS.92.23.10639 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2015011507A (en) | 2016-04-07 |
| AU2014236763B2 (en) | 2018-08-23 |
| KR20150128770A (en) | 2015-11-18 |
| WO2014151904A1 (en) | 2014-09-25 |
| JP2016518112A (en) | 2016-06-23 |
| CN105143458A (en) | 2015-12-09 |
| AU2018267601A1 (en) | 2018-12-06 |
| EP2971024A1 (en) | 2016-01-20 |
| AU2014236763A1 (en) | 2015-10-01 |
| CA2904395A1 (en) | 2014-09-25 |
| BR112015023192A2 (en) | 2017-11-21 |
| BR112015023192A8 (en) | 2018-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20150921 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| AX | Request for extension of the european patent |
Extension state: BA ME |
|
| DAX | Request for extension of the european patent (deleted) | ||
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 9/00 20060101ALI20160630BHEP Ipc: C12N 5/02 20060101ALI20160630BHEP Ipc: C12P 7/64 20060101AFI20160630BHEP Ipc: C12N 5/00 20060101ALI20160630BHEP |
|
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: TERRAVIA HOLDINGS, INC. |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20161013 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 5/00 20060101ALI20161007BHEP Ipc: C12P 7/64 20060101AFI20161007BHEP Ipc: C12N 5/02 20060101ALI20161007BHEP Ipc: C12N 9/00 20060101ALI20161007BHEP |
|
| 17Q | First examination report despatched |
Effective date: 20170711 |
|
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: CORBION BIOTECH, INC. |
|
| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: CASOLARI, JASON Inventor name: FRANKLIN, SCOTT Inventor name: RUDENKO, GEORGE N. |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20200603 |