EP3122333A4 - Cell free compositions for cellular restoration and methods of making and using same - Google Patents

Cell free compositions for cellular restoration and methods of making and using same Download PDF

Info

Publication number: EP3122333A4
Authority: EP; European Patent Office
Prior art keywords: making; methods; same; cell free; free compositions
Prior art date: 2014-03-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

EP15768892.0A

Other languages

German (de)

French (fr)

Other versions

EP3122333A1 (en

Inventor

Steve Greco

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Advanced Regen Medical Technologies LLC

Original Assignee

Advanced Regen Medical Technologies LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-03-24

Filing date

2015-03-24

Publication date

2017-11-29

2014-12-19 Priority claimed from PCT/US2014/071667 external-priority patent/WO2015095794A1/en

2015-03-24 Application filed by Advanced Regen Medical Technologies LLC filed Critical Advanced Regen Medical Technologies LLC

2015-03-24 Priority to EP24177086.6A priority Critical patent/EP4445915A3/en

2017-02-01 Publication of EP3122333A1 publication Critical patent/EP3122333A1/en

2017-11-29 Publication of EP3122333A4 publication Critical patent/EP3122333A4/en

Status Ceased legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Dermatology (AREA)
Virology (AREA)
Developmental Biology & Embryology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Epidemiology (AREA)
Cell Biology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

EP15768892.0A 2014-03-24 2015-03-24 Cell free compositions for cellular restoration and methods of making and using same Ceased EP3122333A4 (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
EP24177086.6A EP4445915A3 (en)	2014-03-24	2015-03-24	Cell free compositions for cellular restoration and methods of making and using same

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201461969694P	2014-03-24	2014-03-24
PCT/US2014/071667 WO2015095794A1 (en)	2013-12-20	2014-12-19	Compositions for cellular restoration and methods of making and using same
US14/577,978 US20150174166A1 (en)	2013-12-20	2014-12-19	Compositions for Cellular Restoration and Methods of Making and Using Same
PCT/US2015/022285 WO2015148534A1 (en)	2014-03-24	2015-03-24	Cell free compositions for cellular restoration and methods of making and using same

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
EP24177086.6A Division EP4445915A3 (en)	2014-03-24	2015-03-24	Cell free compositions for cellular restoration and methods of making and using same

Publications (2)

Publication Number	Publication Date
EP3122333A1 EP3122333A1 (en)	2017-02-01
EP3122333A4 true EP3122333A4 (en)	2017-11-29

Family

ID=54196315

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP24177086.6A Pending EP4445915A3 (en)	2014-03-24	2015-03-24	Cell free compositions for cellular restoration and methods of making and using same
EP15768892.0A Ceased EP3122333A4 (en)	2014-03-24	2015-03-24	Cell free compositions for cellular restoration and methods of making and using same

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
EP24177086.6A Pending EP4445915A3 (en)	2014-03-24	2015-03-24	Cell free compositions for cellular restoration and methods of making and using same

Country Status (4)

Country	Link
EP (2)	EP4445915A3 (en)
JP (2)	JP6471302B2 (en)
CR (1)	CR20160495A (en)
WO (1)	WO2015148534A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US11286463B2 (en)	2012-03-08	2022-03-29	Advanced ReGen Medical Technologies, LLC	Reprogramming of aged adult stem cells
US20150174166A1 (en)	2013-12-20	2015-06-25	Advanced ReGen Medical Technologies, LLC	Compositions for Cellular Restoration and Methods of Making and Using Same
US10772911B2 (en)	2013-12-20	2020-09-15	Advanced ReGen Medical Technologies, LLC	Cell free compositions for cellular restoration and methods of making and using same
US11203754B2 (en)	2016-04-29	2021-12-21	Advanced ReGen Medical Technologies, LLC	Microrna compositions and methods of making and using same
EP3740576A4 (en)	2018-01-18	2021-10-20	Advanced Regen Medical Technologies, LLC	Therapeutic compositions and methods of making and using the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2014028493A2 (en) *	2012-08-13	2014-02-20	Cedars-Sinai Medical Center	Exosomes and micro-ribonucleic acids for tissue regeneration

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2008501336A (en) *	2004-06-02	2008-01-24	ソースフアーム・インコーポレイテツド	Microvesicles containing RNA and methods therefor
US8693760B2 (en) *	2009-06-25	2014-04-08	Hitachi Medical Corporation	Medical imaging apparatus
EP2363136A1 (en) *	2010-03-02	2011-09-07	Fresenius Medical Care Deutschland GmbH	Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease
US20120093885A1 (en) *	2010-10-18	2012-04-19	Northwestern University	Therapeutic vesicles
US8747915B1 (en)	2011-09-14	2014-06-10	Vincent C. Giampapa	Dietary supplement system for multifunctional anti-aging management and method of use
WO2013066368A1 (en) *	2011-10-03	2013-05-10	The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services	Use of mirna 126 to produce hematopoietic stem cells
US9427450B2 (en) *	2012-01-31	2016-08-30	Xon Cells, Inc.	Therapeutic immune modulation by stem cell secreted exosomes
US9295696B2 (en) *	2012-06-08	2016-03-29	University of Pittsburgh—of the Commonwealth System of Higher Education	Compositions and methods for restoring or rejuvenating stem/progenitor cell function

2015
- 2015-03-24 EP EP24177086.6A patent/EP4445915A3/en active Pending
- 2015-03-24 EP EP15768892.0A patent/EP3122333A4/en not_active Ceased
- 2015-03-24 CR CR20160495A patent/CR20160495A/en unknown
- 2015-03-24 JP JP2016558732A patent/JP6471302B2/en active Active
- 2015-03-24 WO PCT/US2015/022285 patent/WO2015148534A1/en not_active Ceased
2018
- 2018-12-18 JP JP2018236137A patent/JP6900358B2/en active Active

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2014028493A2 (en) *	2012-08-13	2014-02-20	Cedars-Sinai Medical Center	Exosomes and micro-ribonucleic acids for tissue regeneration

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BO YU ET AL: "Exosomes Derived from Mesenchymal Stem Cells", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 15, no. 3, 7 March 2014 (2014-03-07), pages 4142 - 4157, XP055407121, DOI: 10.3390/ijms15034142 *
D W BEELEN ET AL: "Transplantation of filgrastim-mobilized peripheral blood stem cells from HLA-identical sibling or alternative family donors in patients with hematologic malignancies: a prospective comparison on clinical outcome, immune reconstitution, and hematopoietic chimerism", BLOOD, 15 December 1997 (1997-12-15), United States, pages 4725, XP055519597, Retrieved from the Internet <URL:http://www.bloodjournal.org/content/bloodjournal/90/12/4725.full.pdf?sso-checked=true> *
DIANA M. IGLESIAS ET AL: "Stem Cell Microvesicles Transfer Cystinosin to Human Cystinotic Cells and Reduce Cystine Accumulation In Vitro", PLOS ONE, vol. 7, no. 8, 13 August 2012 (2012-08-13), pages e42840, XP055408200, DOI: 10.1371/journal.pone.0042840 *
F KROSCHINSKY ET AL: "Single-dose pegfilgrastim for the mobilization of allogeneic CD34+ peripheral blood progenitor cells in healthy family and unrelated donors", HAEMATOLOGICA, 1 December 2005 (2005-12-01), Italy, pages 1665, XP055519590, Retrieved from the Internet <URL:http://www.haematologica.org/content/haematol/90/12/1665.full.pdf> *
KONRAD HOETZENECKER ET AL: "Mononuclear cell secretome protects from experimental autoimmune myocarditis", EUROPEAN HEART JOURNAL, vol. 36, no. 11, 15 January 2013 (2013-01-15), GB, pages 676 - 685, XP055519658, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehs459 *
L KORDELAS ET AL: "MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease", LEUKEMIA., 21 January 2014 (2014-01-21), US, XP055406936, ISSN: 0887-6924, DOI: 10.1038/leu.2014.41 *
MICHAEL MILDNER ET AL: "Secretome of Peripheral Blood Mononuclear Cells Enhances Wound Healing", PLOS ONE, vol. 8, no. 3, 22 March 2013 (2013-03-22), pages e60103, XP055519612, DOI: 10.1371/journal.pone.0060103 *
See also references of WO2015148534A1 *
SERENA RUBINA BAGLIO ET AL: "Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy", FRONTIERS IN PHYSIOLOGY, vol. 3, 1 January 2012 (2012-01-01), XP055406899, DOI: 10.3389/fphys.2012.00359 *

Also Published As

Publication number	Publication date
EP4445915A3 (en)	2025-01-22
CR20160495A (en)	2017-05-29
EP3122333A1 (en)	2017-02-01
JP6900358B2 (en)	2021-07-07
WO2015148534A1 (en)	2015-10-01
EP4445915A2 (en)	2024-10-16
JP2017510582A (en)	2017-04-13
JP6471302B2 (en)	2019-02-20
JP2019052182A (en)	2019-04-04

Legal Events

Date	Code	Title	Description
2016-11-09	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2016-12-30	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2016-12-30	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2017-02-01	17P	Request for examination filed	Effective date: 20161004
2017-02-01	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2017-02-01	AX	Request for extension of the european patent	Extension state: BA ME
2017-06-28	DAV	Request for validation of the european patent (deleted)
2017-06-28	DAX	Request for extension of the european patent (deleted)
2017-11-29	A4	Supplementary search report drawn up and despatched	Effective date: 20171026
2017-11-29	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 35/12 20150101ALI20171020BHEP Ipc: A61K 38/00 20060101ALI20171020BHEP Ipc: A61P 17/00 20060101ALI20171020BHEP Ipc: A61K 45/06 20060101ALI20171020BHEP Ipc: A61K 31/7088 20060101ALI20171020BHEP Ipc: A61K 38/19 20060101ALI20171020BHEP Ipc: A61K 9/127 20060101AFI20171020BHEP
2018-01-12	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1232435 Country of ref document: HK
2018-11-02	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2018-12-05	17Q	First examination report despatched	Effective date: 20181106
2024-05-23	REG	Reference to a national code	Ref country code: DE Ref legal event code: R003
2024-10-03	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED
2024-11-06	18R	Application refused	Effective date: 20240523
2025-10-17	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1232435 Country of ref document: HK

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