EP3209128A4 - Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion - Google Patents

Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion Download PDF

Info

Publication number: EP3209128A4
Authority: EP; European Patent Office
Prior art keywords: reperfusion; solution; calcium ion; related method; novel composition
Prior art date: 2014-10-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP15853016.2A

Other languages

German (de)

French (fr)

Other versions

EP3209128A1 (en

Inventor

Christopher White

Darren FREED

Larry Hryshko

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Tevosol Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-10-24

Filing date

2015-10-23

Publication date

2018-04-11

2015-04-10 Priority claimed from PCT/CA2015/050297 external-priority patent/WO2015154193A1/en

2015-10-23 Application filed by Individual filed Critical Individual

2017-08-30 Publication of EP3209128A1 publication Critical patent/EP3209128A1/en

2018-04-11 Publication of EP3209128A4 publication Critical patent/EP3209128A4/en

Status Withdrawn legal-status Critical Current

Links

BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 title 1
229910001424 calcium ion Inorganic materials 0.000 title 1
230000010410 reperfusion Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Pain & Pain Management (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Dentistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP15853016.2A 2014-10-24 2015-10-23 Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion Withdrawn EP3209128A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201462068524P	2014-10-24	2014-10-24
PCT/CA2015/050297 WO2015154193A1 (en)	2014-04-10	2015-04-10	Modulation of calcium ion homeostasis in harvested transplantable hearts
PCT/CA2015/051084 WO2016061700A1 (en)	2014-10-24	2015-10-23	Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion

Publications (2)

Publication Number	Publication Date
EP3209128A1 EP3209128A1 (en)	2017-08-30
EP3209128A4 true EP3209128A4 (en)	2018-04-11

Family

ID=55760003

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP15853016.2A Withdrawn EP3209128A4 (en)	2014-10-24	2015-10-23	Novel composition and solution with controlled calcium ion level, and related method and use for reperfusion

Country Status (6)

Country	Link
EP (1)	EP3209128A4 (en)
CN (2)	CN107105640B (en)
AU (1)	AU2015336862B2 (en)
BR (1)	BR112017008076B1 (en)
CA (1)	CA2965400C (en)
WO (1)	WO2016061700A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US12010987B2 (en)	2004-10-07	2024-06-18	Transmedics, Inc.	Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US9814230B2 (en)	2008-01-31	2017-11-14	Transmedics, Inc.	Systems and methods for ex vivo lung care
IT201600120839A1 (en) *	2016-12-01	2018-06-01	Valentina Valenti	Cardioplegic solution with autophagy activators for the diastolic arrest of the heart during cardiac surgery
CN113303325B (en) *	2021-05-27	2025-04-25	南方医科大学南方医院	A perfusion fluid and a normothermic blood mechanical perfusion system suitable for rat donor hearts
CN114983667B (en) *	2021-10-25	2025-07-08	首都医科大学附属北京安贞医院	Method for determining control parameters in cardiac surgery and related equipment

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5407793A (en) *	1991-10-18	1995-04-18	University Of Pittsburgh Of The Commonwealth System Of Higher Education	An aqueous heart preservation and cardioplegia solution
WO2001001774A1 (en) *	1999-06-17	2001-01-11	Regents Of The University Of California	Continuous cardiac perfusion preservation with peg-hb for improved hypothermic storage
US20030124503A1 (en) *	2001-12-28	2003-07-03	Olivencia-Yurvati Albert H.	Pyruvate cardioplegia solutions for administration to the heart during cardiopulmonary surgery and methods of use thereof
US20050202394A1 (en) *	2002-06-21	2005-09-15	Global Cardiac Solutions Pty. Ltd.	Organ arrest, protection, preservation and recovery
WO2015154193A1 (en) *	2014-04-10	2015-10-15	University Of Manitoba	Modulation of calcium ion homeostasis in harvested transplantable hearts

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2785501B1 (en) *	1998-11-10	2001-01-05	Centre Nat Rech Scient	PERFUSION AND / OR PRESERVATION AND / OR REPERFUSION SOLUTION DURING ORGAN TRANSPLANTATION
FR2975869B1 (en) *	2011-05-31	2017-03-03	Hemarina	ORGAN PRESERVATION COMPOSITION AND USES
CN103893205B (en) *	2014-04-15	2016-03-09	青岛大学附属医院	A kind ofly comprise cardioplegic solution of lignocaine and adenosine and preparation method thereof

2015
- 2015-10-23 CN CN201580070774.4A patent/CN107105640B/en active Active
- 2015-10-23 WO PCT/CA2015/051084 patent/WO2016061700A1/en not_active Ceased
- 2015-10-23 CN CN202111194944.3A patent/CN113841687A/en active Pending
- 2015-10-23 EP EP15853016.2A patent/EP3209128A4/en not_active Withdrawn
- 2015-10-23 BR BR112017008076-1A patent/BR112017008076B1/en active IP Right Grant
- 2015-10-23 AU AU2015336862A patent/AU2015336862B2/en active Active
- 2015-10-23 CA CA2965400A patent/CA2965400C/en active Active

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5407793A (en) *	1991-10-18	1995-04-18	University Of Pittsburgh Of The Commonwealth System Of Higher Education	An aqueous heart preservation and cardioplegia solution
WO2001001774A1 (en) *	1999-06-17	2001-01-11	Regents Of The University Of California	Continuous cardiac perfusion preservation with peg-hb for improved hypothermic storage
US20030124503A1 (en) *	2001-12-28	2003-07-03	Olivencia-Yurvati Albert H.	Pyruvate cardioplegia solutions for administration to the heart during cardiopulmonary surgery and methods of use thereof
US20050202394A1 (en) *	2002-06-21	2005-09-15	Global Cardiac Solutions Pty. Ltd.	Organ arrest, protection, preservation and recovery
WO2015154193A1 (en) *	2014-04-10	2015-10-15	University Of Manitoba	Modulation of calcium ion homeostasis in harvested transplantable hearts

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
D J HEARSE ET AL: "Protection of the myocardium during ischemic arrest. Dose response curves for procaine and lignocaine in cardioplegic solutions", MEDLINE, 1 June 1981 (1981-06-01), U.S.A., pages 1 - 2, XP055454788, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pubmed/7230856> [retrieved on 20180227] *
DOBSON G P ET AL: "Adenosine and lidocaine: a new concept in nondepolarizing surgical myocardial arrest, protection, and preservation", JOURNAL OF THORACIC AND CARDIOVASCULAR SURG, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 127, no. 3, 1 March 2004 (2004-03-01), pages 794 - 805, XP008092313, ISSN: 0022-5223, DOI: 10.1016/S0022-5223(03)01192-9 *
DONNA M RUDD ET AL: "Eight hours of cold static storage with adenosine and lidocaine (Adenocaine) heart preservation solutions: Toward therapeutic suspended animation", JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 142, no. 6, 5 May 2011 (2011-05-05), pages 1552 - 1561, XP028111611, ISSN: 0022-5223, [retrieved on 20110528], DOI: 10.1016/J.JTCVS.2011.05.023 *
N TAKEMOTO, H KURODA, T MORI: "THE RECIPROCAL PROTECTIVE EFFECTS OF MAGNESIUM AND CALCIUM IN HYPERKALEMIC CARDIOPLEGIC SOLUTIONS ON ISCHEMIC MYOCARDIUM", BASIC RESEARCH IN CARDIOLOGY, vol. 87, 1 September 1992 (1992-09-01), pages 559 - 569, XP009503749 *
See also references of WO2016061700A1 *
STACY B O BLENES ET AL: "Protecting the aged heart during cardiac surgery: The potential benefits of del Nido cardioplegia", JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 141, no. 3, 2 June 2010 (2010-06-02), pages 762 - 770, XP028144755, ISSN: 0022-5223, [retrieved on 20100607], DOI: 10.1016/J.JTCVS.2010.06.004 *

Also Published As

Publication number	Publication date
CA2965400A1 (en)	2016-04-28
CA2965400C (en)	2023-03-14
AU2015336862B2 (en)	2018-08-09
CN107105640B (en)	2021-10-12
AU2015336862A1 (en)	2017-06-01
WO2016061700A1 (en)	2016-04-28
CN107105640A (en)	2017-08-29
BR112017008076A2 (en)	2017-12-26
BR112017008076B1 (en)	2021-06-29
EP3209128A1 (en)	2017-08-30
CN113841687A (en)	2021-12-28

Legal Events

Date	Code	Title	Description
2017-07-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2017-08-30	17P	Request for examination filed	Effective date: 20170522
2017-08-30	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2017-08-30	AX	Request for extension of the european patent	Extension state: BA ME
2018-01-31	DAV	Request for validation of the european patent (deleted)
2018-01-31	DAX	Request for extension of the european patent (deleted)
2018-04-11	A4	Supplementary search report drawn up and despatched	Effective date: 20180309
2018-04-11	RIC1	Information provided on ipc code assigned before grant	Ipc: A01N 1/02 20060101AFI20180306BHEP
2018-12-26	17Q	First examination report despatched	Effective date: 20181127
2019-06-12	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: TEVOSOL, INC.
2020-06-26	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2020-07-29	18D	Application deemed to be withdrawn	Effective date: 20200109

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