EP3242671A4 - Ex vivo methods for minimizing risks and maximizing benefits of allogeneic blood and marrow transplantation - Google Patents

Ex vivo methods for minimizing risks and maximizing benefits of allogeneic blood and marrow transplantation Download PDF

Info

Publication number: EP3242671A4
Authority: EP; European Patent Office
Prior art keywords: marrow transplantation; vivo methods; allogeneic blood; minimizing risks; maximizing benefits
Prior art date: 2015-01-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP16735447.1A

Other languages

German (de)

French (fr)

Other versions

EP3242671A1 (en

Inventor

Jenny Zilberberg

Woo Lee

Robert Korngold

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Stevens Institute of Technology

Hackensack University Medical Center

Original Assignee

Hackensack University Medical Center

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-01-08

Filing date

2016-01-08

Publication date

2018-08-08

2016-01-08 Application filed by Hackensack University Medical Center filed Critical Hackensack University Medical Center

2017-11-15 Publication of EP3242671A1 publication Critical patent/EP3242671A1/en

2018-08-08 Publication of EP3242671A4 publication Critical patent/EP3242671A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/418—Antigens related to induction of tolerance to non-self
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
- G01N2800/245—Transplantation related diseases, e.g. graft versus host disease

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Epidemiology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Cell Biology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Chemical & Material Sciences (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Tropical Medicine & Parasitology (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)

EP16735447.1A 2015-01-08 2016-01-08 Ex vivo methods for minimizing risks and maximizing benefits of allogeneic blood and marrow transplantation Withdrawn EP3242671A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201562101181P	2015-01-08	2015-01-08
PCT/US2016/012573 WO2016112245A1 (en)	2015-01-08	2016-01-08	Ex vivo methods for minimizing risks and maximizing benefits of allogeneic blood and marrow transplantation

Publications (2)

Publication Number	Publication Date
EP3242671A1 EP3242671A1 (en)	2017-11-15
EP3242671A4 true EP3242671A4 (en)	2018-08-08

Family

ID=56356448

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP16735447.1A Withdrawn EP3242671A4 (en)	2015-01-08	2016-01-08	Ex vivo methods for minimizing risks and maximizing benefits of allogeneic blood and marrow transplantation

Country Status (3)

Country	Link
EP (1)	EP3242671A4 (en)
CA (1)	CA2972846A1 (en)
WO (1)	WO2016112245A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI794171B (en)	2016-05-11	2023-03-01	美商滬亞生物國際有限公司	Combination therapies of hdac inhibitors and pd-l1 inhibitors
TWI808055B (en)	2016-05-11	2023-07-11	美商滬亞生物國際有限公司	Combination therapies of hdac inhibitors and pd-1 inhibitors
KR102492455B1 (en) *	2016-11-24	2023-01-27	알베오릭스 테크놀러지스 아게	Cell culture systems and methods
CN109401971B (en) *	2018-12-28	2024-01-30	江苏省人民医院（南京医科大学第一附属医院）	Multifunctional automatic independent/combined co-culture device
WO2021055968A1 (en) *	2019-09-20	2021-03-25	Natera Inc.	Methods for assessing graft suitability for transplantation
CN116850177A (en) *	2023-08-04	2023-10-10	南方医科大学南方医院	Application of dihydroartemisinin in the preparation of drugs for preventing and treating chronic graft rejection

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5827642A (en) *	1994-08-31	1998-10-27	Fred Hutchinson Cancer Research Center	Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US20040259177A1 (en) *	2003-05-06	2004-12-23	Lowery Robert G.	Three dimensional cell cultures in a microscale fluid handling system
WO2008060449A2 (en) *	2006-11-09	2008-05-22	President And Fellows Of Harvard College	Microfluidic detector
US20110027804A1 (en) *	2008-01-10	2011-02-03	Hurel Corporation	Immune system modeling devices and methods
US20140038279A1 (en) *	2011-02-28	2014-02-06	President And Fellows Of Harvard College	Cell culture system

2016
- 2016-01-08 WO PCT/US2016/012573 patent/WO2016112245A1/en not_active Ceased
- 2016-01-08 CA CA2972846A patent/CA2972846A1/en active Pending
- 2016-01-08 EP EP16735447.1A patent/EP3242671A4/en not_active Withdrawn

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5827642A (en) *	1994-08-31	1998-10-27	Fred Hutchinson Cancer Research Center	Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US20040259177A1 (en) *	2003-05-06	2004-12-23	Lowery Robert G.	Three dimensional cell cultures in a microscale fluid handling system
WO2008060449A2 (en) *	2006-11-09	2008-05-22	President And Fellows Of Harvard College	Microfluidic detector
US20110027804A1 (en) *	2008-01-10	2011-02-03	Hurel Corporation	Immune system modeling devices and methods
US20140038279A1 (en) *	2011-02-28	2014-02-06	President And Fellows Of Harvard College	Cell culture system

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CARLENS STEFAN ET AL: "Ex vivo T lymphocyte expansion for retroviral transduction: Influence of serum-free media on variations in cell expansion rates and lymphocyte subset distribution", EXPERIMENTAL HEMATO, ELSEVIER INC, US, vol. 28, no. 10, 1 October 2000 (2000-10-01), pages 1137 - 1146, XP009165868, ISSN: 0301-472X, DOI: 10.1016/S0301-472X(00)00526-9 *
DMITRY SAMSONOV ET AL: "Differential activation of human T cells to allogeneic endothelial cells, epithelial cells and fibroblasts in vitro", TRANSPLANTATION RESEARCH, BIOMED CENTRAL LTD, LONDON, UK, vol. 1, no. 1, 24 April 2012 (2012-04-24), pages 4, XP021124468, ISSN: 2047-1440, DOI: 10.1186/2047-1440-1-4 *
See also references of WO2016112245A1 *
STYBAYEVA G ET AL: "Micropatterned co-cultures of T-lymphocytes and epithelial cells as a model of mucosal immune system", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 380, no. 3, 13 March 2009 (2009-03-13), pages 575 - 580, XP026422257, ISSN: 0006-291X, [retrieved on 20090131], DOI: 10.1016/J.BBRC.2009.01.164 *
VÉRONIQUE LECAULT ET AL: "Microfluidic cell culture arrays for clonal expansion and characterization of mammalian cells", 1 January 2012 (2012-01-01), XP055487736, Retrieved from the Internet <URL:http://dataaccess-p.internal.epo.org/dal/data/documents/nonpatent> *

Also Published As

Publication number	Publication date
EP3242671A1 (en)	2017-11-15
CA2972846A1 (en)	2016-07-14
WO2016112245A1 (en)	2016-07-14

Legal Events

Date	Code	Title	Description
2017-07-13	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2017-10-13	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2017-10-13	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2017-11-15	17P	Request for examination filed	Effective date: 20170712
2017-11-15	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2017-11-15	AX	Request for extension of the european patent	Extension state: BA ME
2018-04-11	DAV	Request for validation of the european patent (deleted)
2018-04-11	DAX	Request for extension of the european patent (deleted)
2018-08-08	A4	Supplementary search report drawn up and despatched	Effective date: 20180705
2018-08-08	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 35/17 20150101AFI20180629BHEP
2018-09-14	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1246665 Country of ref document: HK
2019-07-31	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: HACKENSACK UNIVERSITY MEDICAL CENTER Owner name: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOG
2020-05-25	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
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2023-05-10	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 35/17 20150101ALI20230404BHEP Ipc: G01N 33/50 20060101AFI20230404BHEP
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