EP3302450A4 - METHODS OF AMINE PEGYLATION FOR THE PREPARATION OF SPECIFIC PROTEIN CONJUGATES OF A SITE - Google Patents

METHODS OF AMINE PEGYLATION FOR THE PREPARATION OF SPECIFIC PROTEIN CONJUGATES OF A SITE Download PDF

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Publication number
EP3302450A4
EP3302450A4 EP16803982.4A EP16803982A EP3302450A4 EP 3302450 A4 EP3302450 A4 EP 3302450A4 EP 16803982 A EP16803982 A EP 16803982A EP 3302450 A4 EP3302450 A4 EP 3302450A4
Authority
EP
European Patent Office
Prior art keywords
site
preparation
methods
specific protein
protein conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16803982.4A
Other languages
German (de)
French (fr)
Other versions
EP3302450A1 (en
Inventor
Mary S. Rosendahl
Sankaram B. Mantripragada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rezolute Inc
Original Assignee
Antriabio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antriabio Inc filed Critical Antriabio Inc
Publication of EP3302450A1 publication Critical patent/EP3302450A1/en
Publication of EP3302450A4 publication Critical patent/EP3302450A4/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP16803982.4A 2015-06-04 2016-05-19 METHODS OF AMINE PEGYLATION FOR THE PREPARATION OF SPECIFIC PROTEIN CONJUGATES OF A SITE Withdrawn EP3302450A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562170933P 2015-06-04 2015-06-04
PCT/US2016/033190 WO2016196017A1 (en) 2015-06-04 2016-05-19 Amine pegylation methods for the preparation of site-specific protein conjugates

Publications (2)

Publication Number Publication Date
EP3302450A1 EP3302450A1 (en) 2018-04-11
EP3302450A4 true EP3302450A4 (en) 2019-01-16

Family

ID=57442063

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16803982.4A Withdrawn EP3302450A4 (en) 2015-06-04 2016-05-19 METHODS OF AMINE PEGYLATION FOR THE PREPARATION OF SPECIFIC PROTEIN CONJUGATES OF A SITE

Country Status (12)

Country Link
US (1) US10220075B2 (en)
EP (1) EP3302450A4 (en)
JP (1) JP2018516874A (en)
KR (1) KR20180015131A (en)
CN (1) CN107708679A (en)
AU (1) AU2016270302B2 (en)
BR (1) BR112017023145A2 (en)
CA (1) CA2981501A1 (en)
MX (1) MX2017014586A (en)
RU (1) RU2730848C2 (en)
WO (1) WO2016196017A1 (en)
ZA (1) ZA201708573B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115029204A (en) * 2022-07-15 2022-09-09 曾会明 Wine with SOD activity and preparation method thereof

Citations (2)

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US20070083006A1 (en) * 2003-04-11 2007-04-12 Pr Pharmaceuticals, Inc. Method for preparation of site-specific protein conjugates
US20110171312A1 (en) * 2008-09-19 2011-07-14 Nektar Therapeutics Modified therapeutic peptides, methods of their preparation and use

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US6191105B1 (en) 1993-05-10 2001-02-20 Protein Delivery, Inc. Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin
US5359030A (en) 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US6620413B1 (en) 1995-12-27 2003-09-16 Genentech, Inc. OB protein-polymer chimeras
DK1411075T3 (en) 1998-03-12 2008-10-27 Nektar Therapeutics Al Corp Process for Preparation of Polymer Conjugates
US6323311B1 (en) * 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
US7053150B2 (en) 2000-12-18 2006-05-30 Nektar Therapeutics Al, Corporation Segmented polymers and their conjugates
TW593427B (en) 2000-12-18 2004-06-21 Nektar Therapeutics Al Corp Synthesis of high molecular weight non-peptidic polymer derivatives
WO2003084985A1 (en) 2002-04-11 2003-10-16 Mochida Pharmaceutical Co., Ltd. Peptide chemically modified with polyethylene glycol
JP2006501820A (en) 2002-09-06 2006-01-19 バイエル・フアーマシユーチカルズ・コーポレーシヨン Modified GLP-1 receptor agonists and their pharmacological uses
AU2003285286A1 (en) 2002-09-27 2004-04-19 F. Hoffmann-La Roche Ag Conjugates of insulin-like growth factor binding protein-4 and poly (ethylene glycol)
EP1581582B2 (en) 2003-01-06 2017-06-07 Nektar Therapeutics Thiol-selective water-soluble polmer derivatives
EP1605897B1 (en) 2003-03-19 2012-07-25 Eli Lilly And Company Polyethelene glycol link glp-1 compounds
KR101135244B1 (en) 2007-11-29 2012-04-24 한미사이언스 주식회사 A pharmaceutical composition for treating obesity-related disease comprising insulinotropic peptide conjugate
EP1710304A4 (en) 2003-12-24 2008-01-16 Shionogi & Co PROCESS FOR PRODUCING A PROTEIN POLYMER COMPOSITE
WO2005065239A2 (en) 2003-12-31 2005-07-21 Centocor, Inc. Novel recombinant proteins with n-terminal free thiol
KR20060029770A (en) 2004-10-04 2006-04-07 주식회사 펙스피어 Selective PET Bonder of JP-1 and its manufacturing method
PT1881850E (en) 2005-05-13 2010-11-26 Lilly Co Eli Glp-1 pegylated compounds
EP1893632B1 (en) 2005-06-17 2015-08-12 Novo Nordisk Health Care AG Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
GB0513852D0 (en) 2005-07-06 2005-08-10 Celltech R&D Ltd Biological products
EP2570133B1 (en) 2005-11-07 2016-03-23 Indiana University Research and Technology Corporation Glucagon analogs exhibiting physiological solubility and stability
RU2424246C2 (en) 2006-05-26 2011-07-20 Ипсен Фарма С.А.С. Method for site-specific pegylation
ES2542146T3 (en) 2006-07-31 2015-07-31 Novo Nordisk A/S PEGylated extended insulin.
US8617531B2 (en) 2006-12-14 2013-12-31 Bolder Biotechnology, Inc. Methods of making proteins and peptides containing a single free cysteine
JP2008156283A (en) * 2006-12-25 2008-07-10 Kyowa Hakko Kogyo Co Ltd Method for producing water-soluble polymer-modified polypeptide
EP2480578A4 (en) 2009-09-25 2013-04-17 Vybion Inc Polypeptide modification
GB0917072D0 (en) 2009-09-29 2009-11-11 Univ Ulster Peptide analogues of glucagon for diabetes therapy
WO2011163473A1 (en) 2010-06-25 2011-12-29 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility and stability in physiological ph buffers
WO2012054882A1 (en) 2010-10-21 2012-04-26 Kci Licensing, Inc. Debridement hand tool
WO2012054861A1 (en) 2010-10-22 2012-04-26 Nektar Therapeutics Glp-1 polymer conjugates having a releasable linkage
KR101746686B1 (en) 2010-10-26 2017-06-15 한미사이언스 주식회사 An GLP-2 conjugate using an immunoglobulin fragment
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EP3808378A1 (en) 2011-05-27 2021-04-21 Baxalta GmbH Therapeutic proteins with increased half-life and methods of preparing same
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Patent Citations (2)

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US20070083006A1 (en) * 2003-04-11 2007-04-12 Pr Pharmaceuticals, Inc. Method for preparation of site-specific protein conjugates
US20110171312A1 (en) * 2008-09-19 2011-07-14 Nektar Therapeutics Modified therapeutic peptides, methods of their preparation and use

Non-Patent Citations (1)

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Title
See also references of WO2016196017A1 *

Also Published As

Publication number Publication date
EP3302450A1 (en) 2018-04-11
CA2981501A1 (en) 2016-12-08
AU2016270302A1 (en) 2017-10-19
US20160354478A1 (en) 2016-12-08
KR20180015131A (en) 2018-02-12
ZA201708573B (en) 2019-08-28
RU2730848C2 (en) 2020-08-26
RU2017145825A3 (en) 2019-11-18
RU2017145825A (en) 2019-07-10
CN107708679A (en) 2018-02-16
MX2017014586A (en) 2018-03-09
US10220075B2 (en) 2019-03-05
BR112017023145A2 (en) 2018-07-10
WO2016196017A1 (en) 2016-12-08
AU2016270302B2 (en) 2020-09-17
JP2018516874A (en) 2018-06-28

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