EP3316898A4 - HUMANIZED SKELETAL MUSCLE - Google Patents

HUMANIZED SKELETAL MUSCLE Download PDF

Info

Publication number: EP3316898A4
Authority: EP; European Patent Office
Prior art keywords: skeletal muscle; humanized skeletal; humanized; muscle; skeletal
Prior art date: 2015-06-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP16818785.4A

Other languages

German (de)

French (fr)

Other versions

EP3316898A1 (en

Inventor

Daniel J. GARRY

Mary G. GARRY

Naoko KOYANO-NAKAGAWA

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Minnesota Twin Cities

University of Minnesota System

Original Assignee

University of Minnesota Twin Cities

University of Minnesota System

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-06-30

Filing date

2016-06-30

Publication date

2019-02-27

2016-06-30 Application filed by University of Minnesota Twin Cities, University of Minnesota System filed Critical University of Minnesota Twin Cities

2018-05-09 Publication of EP3316898A1 publication Critical patent/EP3316898A1/en

2019-02-27 Publication of EP3316898A4 publication Critical patent/EP3316898A4/en

Status Pending legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0604—Whole embryos; Culture medium therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Environmental Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Cell Biology (AREA)
Biodiversity & Conservation Biology (AREA)
Animal Husbandry (AREA)
Animal Behavior & Ethology (AREA)
Rheumatology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Developmental Biology & Embryology (AREA)
Veterinary Medicine (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

EP16818785.4A 2015-06-30 2016-06-30 HUMANIZED SKELETAL MUSCLE Pending EP3316898A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201562187027P	2015-06-30	2015-06-30
PCT/US2016/040378 WO2017004367A1 (en)	2015-06-30	2016-06-30	Humanized skeletal muscle

Publications (2)

Publication Number	Publication Date
EP3316898A1 EP3316898A1 (en)	2018-05-09
EP3316898A4 true EP3316898A4 (en)	2019-02-27

Family

ID=57609173

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP16818785.4A Pending EP3316898A4 (en)	2015-06-30	2016-06-30	HUMANIZED SKELETAL MUSCLE

Country Status (10)

Country	Link
US (2)	US10874092B2 (en)
EP (1)	EP3316898A4 (en)
JP (1)	JP2018522553A (en)
CN (1)	CN108135943A (en)
AU (1)	AU2016288196A1 (en)
BR (1)	BR112017028619A2 (en)
CA (1)	CA2991053A1 (en)
MX (1)	MX2018000273A (en)
RU (1)	RU2018103093A (en)
WO (1)	WO2017004367A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR102684690B1 (en)	2015-03-03	2024-07-15	리젠츠 오브 더 유니버시티 오브 미네소타	ETV2 and its uses
WO2017004388A1 (en)	2015-06-30	2017-01-05	Regents Of The University Of Minnesota	Humanized heart muscle
RU2018103093A (en)	2015-06-30	2019-07-31	Реджентс Оф Зэ Юниверсити Оф Миннесота	HUMANIZED skeletal muscle
CN111808820A (en) *	2020-06-01	2020-10-23	贵州省种畜禽种质测定中心	Method for constructing MyoD1 gene knockout MDBK cell line based on CRISPRCAS9 technology

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060008451A1 (en) *	2004-07-06	2006-01-12	Michigan State University	In vivo methods for effecting tissue specific differentiation of embryonic stem cells
GB2475656A (en) *	2008-08-22	2011-05-25	Univ Tokyo	Organ regeneration method utilizing iPS cell and blastocyst complementation
US20140115728A1 (en) *	2012-10-24	2014-04-24	A. Joseph Tector	Double knockout (gt/cmah-ko) pigs, organs and tissues
WO2015168125A1 (en) *	2014-04-28	2015-11-05	Recombinetics, Inc.	Multiplex gene editing in swine
WO2017075276A2 (en) *	2015-10-27	2017-05-04	Regents Of The University Of Minnesota	Compositions and methods for chimeric embryo-assisted organ production

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997025412A1 (en)	1996-01-09	1997-07-17	The Regents Of The University Of California	Ungulate embryonic stem-like cells, methods of making and using the cells to produce transgenic ungulates
US5994619A (en)	1996-04-01	1999-11-30	University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus	Production of chimeric bovine or porcine animals using cultured inner cell mass cells
CN1241210A (en)	1996-10-11	2000-01-12	得克萨斯农业及机械体系综合大学	Method for generation of primordial germ cell and transgenic animal species
US20050039222A1 (en)	2001-10-24	2005-02-17	Kiyoshi Habu	Sgrf gene-modified non-human animals
US20040133931A1 (en)	2003-01-08	2004-07-08	Gavin William G.	Method and system for fusion and activation following nuclear transfer in reconstructed embryos
US20050125853A1 (en)	2002-03-22	2005-06-09	St. Jude Children's Resarch Hospital	Method for generating genetically modified animals
CA2488725A1 (en) *	2002-07-03	2004-01-15	Su Qian	Agouti-related protein deficient cells, non-human transgenic animals and methods of selecting compounds which regulate energy metabolism
GB2398784B (en) *	2003-02-26	2005-07-27	Babraham Inst	Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal
JP5425641B2 (en)	2007-01-11	2014-02-26	ユニバーシティーオブピッツバーグ − オブザコモンウェルスシステムオブハイヤーエデュケーション	Muscle-derived cells for the treatment of urinary tract conditions and methods of making and using the same
US20100107263A1 (en)	2007-01-20	2010-04-29	Boehringer Ingelheim International Gmbh & Co., Kg	C-reactive protein (crp) knockout mouse
JPWO2008102602A1 (en)	2007-02-22	2010-05-27	国立大学法人東京大学	Organ regeneration method using BLASTOCYSTCOMPLEMENTATION
JP5688788B2 (en)	2008-02-22	2015-03-25	国立大学法人東京大学	Production of founder animals for breeding animals with lethal phenotypes by genetic modification
WO2010108126A2 (en)	2009-03-19	2010-09-23	Fate Therapeutics, Inc.	Reprogramming compositions and methods of using the same
CA2762584A1 (en)	2009-05-20	2010-11-25	Cardio3 Biosciences S.A.	Pharmaceutical composition for the treatment of heart diseases
MX363013B (en) *	2011-02-25	2019-03-04	Recombinetics Inc	Genetically modified animals and methods for making the same.
AU2012249390B2 (en)	2011-04-27	2017-03-30	Amyris, Inc.	Methods for genomic modification
AU2012262139B2 (en) *	2011-06-02	2017-02-23	Children's Medical Center Corporation	Methods and uses for ex vivo tissue culture systems
US9862929B2 (en)	2011-11-18	2018-01-09	Kyoto University	Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells
IL221187A (en)	2012-07-30	2017-01-31	Adom Advanced Optical Tech Ltd	System for performing dual beam, two-dimensional optical coherence tomography (oct)
US11377639B2 (en)	2013-11-15	2022-07-05	Wisconsin Alumni Research Foundation	Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors
KR102684690B1 (en)	2015-03-03	2024-07-15	리젠츠 오브 더 유니버시티 오브 미네소타	ETV2 and its uses
WO2017004388A1 (en)	2015-06-30	2017-01-05	Regents Of The University Of Minnesota	Humanized heart muscle
RU2018103093A (en)	2015-06-30	2019-07-31	Реджентс Оф Зэ Юниверсити Оф Миннесота	HUMANIZED skeletal muscle
CN108125943A (en)	2018-01-17	2018-06-08	云南省第二人民医院	Application of Procuredol Angelica Lipid as Preparation of Anti-Atherosclerotic Drugs

2016
- 2016-06-30 RU RU2018103093A patent/RU2018103093A/en not_active Application Discontinuation
- 2016-06-30 JP JP2017568279A patent/JP2018522553A/en active Pending
- 2016-06-30 WO PCT/US2016/040378 patent/WO2017004367A1/en not_active Ceased
- 2016-06-30 CA CA2991053A patent/CA2991053A1/en not_active Abandoned
- 2016-06-30 AU AU2016288196A patent/AU2016288196A1/en not_active Abandoned
- 2016-06-30 EP EP16818785.4A patent/EP3316898A4/en active Pending
- 2016-06-30 MX MX2018000273A patent/MX2018000273A/en unknown
- 2016-06-30 BR BR112017028619A patent/BR112017028619A2/en not_active Application Discontinuation
- 2016-06-30 US US15/739,042 patent/US10874092B2/en active Active
- 2016-06-30 CN CN201680049673.3A patent/CN108135943A/en active Pending
2020
- 2020-11-19 US US16/952,807 patent/US12089574B2/en active Active

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060008451A1 (en) *	2004-07-06	2006-01-12	Michigan State University	In vivo methods for effecting tissue specific differentiation of embryonic stem cells
GB2475656A (en) *	2008-08-22	2011-05-25	Univ Tokyo	Organ regeneration method utilizing iPS cell and blastocyst complementation
US20140115728A1 (en) *	2012-10-24	2014-04-24	A. Joseph Tector	Double knockout (gt/cmah-ko) pigs, organs and tissues
WO2015168125A1 (en) *	2014-04-28	2015-11-05	Recombinetics, Inc.	Multiplex gene editing in swine
WO2017075276A2 (en) *	2015-10-27	2017-05-04	Regents Of The University Of Minnesota	Compositions and methods for chimeric embryo-assisted organ production

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2017004367A1 *

Also Published As

Publication number	Publication date
US12089574B2 (en)	2024-09-17
CN108135943A (en)	2018-06-08
US20210161110A1 (en)	2021-06-03
WO2017004367A1 (en)	2017-01-05
US10874092B2 (en)	2020-12-29
CA2991053A1 (en)	2017-01-05
JP2018522553A (en)	2018-08-16
EP3316898A1 (en)	2018-05-09
US20180177166A1 (en)	2018-06-28
RU2018103093A (en)	2019-07-31
BR112017028619A2 (en)	2018-09-04
AU2016288196A1 (en)	2018-02-01
MX2018000273A (en)	2018-03-08

Legal Events

Date	Code	Title	Description
2017-01-06	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2018-04-06	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2018-04-06	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2018-05-09	17P	Request for examination filed	Effective date: 20180125
2018-05-09	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2018-05-09	AX	Request for extension of the european patent	Extension state: BA ME
2018-10-03	DAV	Request for validation of the european patent (deleted)
2018-10-03	DAX	Request for extension of the european patent (deleted)
2019-02-27	A4	Supplementary search report drawn up and despatched	Effective date: 20190124
2019-02-27	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 15/09 20060101ALI20190118BHEP Ipc: A01K 67/027 20060101AFI20190118BHEP Ipc: A61K 35/34 20150101ALI20190118BHEP Ipc: C12N 5/077 20100101ALI20190118BHEP Ipc: C12N 5/10 20060101ALI20190118BHEP Ipc: C12N 15/85 20060101ALI20190118BHEP
2020-08-21	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2020-09-23	17Q	First examination report despatched	Effective date: 20200820

Publication	Publication Date	Title
NL301348I2 (en)	2026-04-02	obecabtagene autoleucel
FIC20230006I1 (en)	2023-02-06	My vutrisiraani
DK3283625T3 (en)	2020-03-02	NUCLEASE-MEDIED GENOMEDITING
EP3286361A4 (en)	2019-05-08	KREBSNEOEPITOPE
DK3331528T3 (en)	2021-10-25	MUSCARINAGONISTS
DK3277719T3 (en)	2022-05-02	POLYPEPTIDER
EP3316375A4 (en)	2019-03-06	REDOXDURCHFLUSSZELLE
PT3298027T (en)	2022-01-26	ANTELMINTHIC DEPSYPEPTIDE COMPOUNDS
DK3360890T3 (en)	2020-11-02	GENTERAPHY
DK3305788T3 (en)	2020-09-28	JANUS-KINASE-HIMMER
DK3331529T3 (en)	2021-10-18	MUSCARINAGONISTS
EP3290364A4 (en)	2019-01-16	FÖRDERBANDVERSCHLEISSÜBERWACHUNGSSYSTEM
DK3310450T3 (en)	2019-08-05	OIL-WATER-SEPARATOR
DK3394281T3 (en)	2020-11-09	GÆRCELLLE
DK3270930T3 (en)	2021-10-04	PRE-CLAMPSY
EP3381654A4 (en)	2019-06-12	FLÜSSIGBLASFORMVERFAHREN
LT3362444T (en)	2021-06-25	COMPOUNDS
EP3363322A4 (en)	2019-06-19	HAARVERLÄNGERER
DK3597189T3 (en)	2022-06-27	CRYSTALLINIC COMPOUNDS
DK3292136T3 (en)	2021-03-22	PENICILLIN-G-ACYLASER
DK3274482T3 (en)	2020-01-06	STENBORSKNOP
DE112015006486A5 (en)	2018-01-04	Inkubationsrinne
HUE054584T2 (en)	2021-09-28	Maropitant preparation
EP3377179A4 (en)	2019-06-05	EPI-743 DEUTTERATED
DK3318308T3 (en)	2021-12-20	BATHMIN TONKETS