EP3411689A4 - ANALYTE SYSTEM AND METHOD FOR DETERMINING PARAMETERS OF HEMOGLOBIN IN TOTAL BLOOD - Google Patents

ANALYTE SYSTEM AND METHOD FOR DETERMINING PARAMETERS OF HEMOGLOBIN IN TOTAL BLOOD Download PDF

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Publication number
EP3411689A4
EP3411689A4 EP16889601.7A EP16889601A EP3411689A4 EP 3411689 A4 EP3411689 A4 EP 3411689A4 EP 16889601 A EP16889601 A EP 16889601A EP 3411689 A4 EP3411689 A4 EP 3411689A4
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EP
European Patent Office
Prior art keywords
hemoglobin
determining parameters
total blood
analyte system
analyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16889601.7A
Other languages
German (de)
French (fr)
Other versions
EP3411689B1 (en
EP3411689A1 (en
Inventor
Michael Cafferty
Scott P. Cionek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nova Biomedical Corp
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Nova Biomedical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nova Biomedical Corp filed Critical Nova Biomedical Corp
Priority to EP22174613.4A priority Critical patent/EP4067869B1/en
Priority to EP22174592.0A priority patent/EP4067867B1/en
Priority to EP22174620.9A priority patent/EP4071460B1/en
Priority to EP22174601.9A priority patent/EP4067868B1/en
Publication of EP3411689A1 publication Critical patent/EP3411689A1/en
Publication of EP3411689A4 publication Critical patent/EP3411689A4/en
Application granted granted Critical
Publication of EP3411689B1 publication Critical patent/EP3411689B1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14535—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring haematocrit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14557—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted to extracorporeal circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14558—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters by polarisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0202—Mechanical elements; Supports for optical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0208—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using focussing or collimating elements, e.g. lenses or mirrors; performing aberration correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0286—Constructional arrangements for compensating for fluctuations caused by temperature, humidity or pressure, or using cooling or temperature stabilization of parts of the device; Controlling the atmosphere inside a spectrometer, e.g. vacuum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0291—Housings; Spectrometer accessories; Spatial arrangement of elements, e.g. folded path arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J3/14—Generating the spectrum; Monochromators using refracting elements, e.g. prisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J3/18—Generating the spectrum; Monochromators using diffraction elements, e.g. grating
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/42—Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/492—Determining multiple analytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J5/00—Radiation pyrometry, e.g. infrared or optical thermometry
    • G01J5/02—Constructional details
    • G01J5/08—Optical arrangements
    • G01J5/0878—Diffusers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21—Polarisation-affecting properties
    • G01N2021/216—Polarisation-affecting properties using circular polarised light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0634—Diffuse illumination

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  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Ecology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optical Measuring Cells (AREA)
  • Spectrometry And Color Measurement (AREA)
EP16889601.7A 2016-02-04 2016-02-04 System and method for optical absorbance measurement of whole blood Active EP3411689B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP22174613.4A EP4067869B1 (en) 2016-02-04 2016-02-04 An optical component group for use in a spectrometer module
EP22174592.0A EP4067867B1 (en) 2016-02-04 2016-02-04 Light-emitting module
EP22174620.9A EP4071460B1 (en) 2016-02-04 2016-02-04 A replacable cuvette assembly
EP22174601.9A EP4067868B1 (en) 2016-02-04 2016-02-04 A calibrating-light module

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2016/016560 WO2017135952A1 (en) 2016-02-04 2016-02-04 Analyte system and method for determining hemoglobin parameters in whole blood

Related Child Applications (8)

Application Number Title Priority Date Filing Date
EP22174601.9A Division EP4067868B1 (en) 2016-02-04 2016-02-04 A calibrating-light module
EP22174601.9A Division-Into EP4067868B1 (en) 2016-02-04 2016-02-04 A calibrating-light module
EP22174620.9A Division EP4071460B1 (en) 2016-02-04 2016-02-04 A replacable cuvette assembly
EP22174620.9A Division-Into EP4071460B1 (en) 2016-02-04 2016-02-04 A replacable cuvette assembly
EP22174613.4A Division EP4067869B1 (en) 2016-02-04 2016-02-04 An optical component group for use in a spectrometer module
EP22174613.4A Division-Into EP4067869B1 (en) 2016-02-04 2016-02-04 An optical component group for use in a spectrometer module
EP22174592.0A Division-Into EP4067867B1 (en) 2016-02-04 2016-02-04 Light-emitting module
EP22174592.0A Division EP4067867B1 (en) 2016-02-04 2016-02-04 Light-emitting module

Publications (3)

Publication Number Publication Date
EP3411689A1 EP3411689A1 (en) 2018-12-12
EP3411689A4 true EP3411689A4 (en) 2020-01-22
EP3411689B1 EP3411689B1 (en) 2022-07-06

Family

ID=59499943

Family Applications (5)

Application Number Title Priority Date Filing Date
EP22174613.4A Active EP4067869B1 (en) 2016-02-04 2016-02-04 An optical component group for use in a spectrometer module
EP16889601.7A Active EP3411689B1 (en) 2016-02-04 2016-02-04 System and method for optical absorbance measurement of whole blood
EP22174601.9A Active EP4067868B1 (en) 2016-02-04 2016-02-04 A calibrating-light module
EP22174592.0A Active EP4067867B1 (en) 2016-02-04 2016-02-04 Light-emitting module
EP22174620.9A Active EP4071460B1 (en) 2016-02-04 2016-02-04 A replacable cuvette assembly

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP22174613.4A Active EP4067869B1 (en) 2016-02-04 2016-02-04 An optical component group for use in a spectrometer module

Family Applications After (3)

Application Number Title Priority Date Filing Date
EP22174601.9A Active EP4067868B1 (en) 2016-02-04 2016-02-04 A calibrating-light module
EP22174592.0A Active EP4067867B1 (en) 2016-02-04 2016-02-04 Light-emitting module
EP22174620.9A Active EP4071460B1 (en) 2016-02-04 2016-02-04 A replacable cuvette assembly

Country Status (10)

Country Link
EP (5) EP4067869B1 (en)
JP (8) JP6886473B2 (en)
KR (1) KR102477340B1 (en)
CN (1) CN108885166B (en)
BR (1) BR112018015948B1 (en)
CA (5) CA3220899A1 (en)
ES (5) ES2991726T3 (en)
MX (1) MX2018009526A (en)
RU (1) RU2730366C2 (en)
WO (1) WO2017135952A1 (en)

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CN107505266B (en) * 2017-08-14 2023-08-25 重庆电子工程职业学院 Semi-automatic optical detection analysis system
US10883925B2 (en) * 2018-09-24 2021-01-05 Hf Scientific, Inc. Spectrophotometer for use in explosive atmospheres
US11125738B2 (en) 2018-11-06 2021-09-21 Thermo Finnigan Llc Blood sample analysis systems and methods
KR102278503B1 (en) * 2019-10-31 2021-07-16 주식회사 엠젠 Spectro reflectometer apparatus
JP7602934B2 (en) * 2020-03-16 2024-12-19 旭化成エレクトロニクス株式会社 Gas detection equipment
CN113533219B (en) * 2020-04-17 2026-04-07 深圳迈瑞生物医疗电子股份有限公司 Measuring apparatus for sample testing and its installation method
CN111537409B (en) * 2020-05-06 2022-10-14 南京邮电大学 A high-precision erythrocyte sedimentation temperature compensation measurement method and device
CN111366533A (en) * 2020-05-11 2020-07-03 上海仪电物理光学仪器有限公司 Full-spectrum miniature optical fiber spectrometer
CN111781171A (en) * 2020-06-12 2020-10-16 迈克医疗电子有限公司 Method, device and equipment for measuring object parameters in-vitro detection sample
CN111707589A (en) * 2020-07-10 2020-09-25 基蛋生物科技股份有限公司 HCT measuring device and method and chemiluminescence instrument provided with same
WO2022032683A1 (en) * 2020-08-14 2022-02-17 深圳迈瑞生物医疗电子股份有限公司 Blood analyzer and hemoglobin measurement method
CN114755194B (en) * 2022-04-15 2023-06-06 苏州赛分医疗器械有限公司 Glycosylated hemoglobin detector and signal generation and processing method thereof
US12174071B2 (en) * 2022-05-13 2024-12-24 Verity Instruments, Inc. System, apparatus, and method for improved background correction and calibration of optical devices
CN115120249B (en) * 2022-05-19 2023-08-15 深圳未来脑律科技有限公司 Bimodal brain function imaging device
US12564326B2 (en) 2022-10-25 2026-03-03 GE Precision Healthcare LLC Non-invasive bilirubin detection using induced photoreaction
CN116359132B (en) * 2023-05-19 2023-08-15 无锡迅杰光远科技有限公司 Multifunctional on-line spectrum acquisition device
CN116746917B (en) * 2023-05-24 2024-02-23 深圳京柏医疗科技股份有限公司 Jaundice tester calibrating device
AT527038B1 (en) * 2023-06-29 2024-10-15 Christoph Rampetsreiter Method for determining hemolysis, jaundice and/or lipemia in a blood sample
KR102623539B1 (en) * 2023-08-21 2024-01-11 코리아스펙트랄프로덕츠(주) Component analysis device and analysis method of animal liquid manure
WO2025186076A1 (en) * 2024-03-08 2025-09-12 Radiometer Medical Aps A lightguide assembly for an apparatus for hemolyzing a blood sample

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US3569721A (en) * 1969-01-13 1971-03-09 American Optical Corp Measuring bilirubin in blood using light at two wavelengths
JPS5928642A (en) * 1982-08-11 1984-02-15 Hitachi Ltd scattering photometer
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US20050094127A1 (en) * 2003-10-29 2005-05-05 Chf Solutions Inc. Cuvette apparatus and system for measuring optical properties of a liquid such as blood
US20050259254A1 (en) * 2004-04-26 2005-11-24 Soller Babs R Spectrometer system for optical reflectance measurements
CN1268916C (en) * 2002-12-12 2006-08-09 上海交通大学 Sensor for detecting upward flow of duodenum and stomach
US20070060810A1 (en) * 2005-09-13 2007-03-15 Higgins Michael J Continuous spectroscopic measurement of total hemoglobin
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