EP3442991A4 - PIN BINDING PEPTIDES AND METHODS OF USE - Google Patents

PIN BINDING PEPTIDES AND METHODS OF USE Download PDF

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Publication number
EP3442991A4
EP3442991A4 EP17783273.0A EP17783273A EP3442991A4 EP 3442991 A4 EP3442991 A4 EP 3442991A4 EP 17783273 A EP17783273 A EP 17783273A EP 3442991 A4 EP3442991 A4 EP 3442991A4
Authority
EP
European Patent Office
Prior art keywords
methods
binding peptides
pin binding
pin
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17783273.0A
Other languages
German (de)
French (fr)
Other versions
EP3442991A1 (en
Inventor
Kristopher JOSEPHSON
Zhong MA
Yili SUN
Nathan Ezekiel Nims
Kathleen Seyb
Sylvia TOBE
Ping Ye
Douangsone D. VADYSIRISACK
Guo-Qing Tang
Douglas A. Treco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Inc
Original Assignee
Ra Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ra Pharmaceuticals Inc filed Critical Ra Pharmaceuticals Inc
Publication of EP3442991A1 publication Critical patent/EP3442991A1/en
Publication of EP3442991A4 publication Critical patent/EP3442991A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hospice & Palliative Care (AREA)
EP17783273.0A 2016-04-15 2017-04-14 PIN BINDING PEPTIDES AND METHODS OF USE Withdrawn EP3442991A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662323115P 2016-04-15 2016-04-15
PCT/US2017/027697 WO2017181061A1 (en) 2016-04-15 2017-04-14 Ras binding peptides and methods of use

Publications (2)

Publication Number Publication Date
EP3442991A1 EP3442991A1 (en) 2019-02-20
EP3442991A4 true EP3442991A4 (en) 2019-11-20

Family

ID=60042269

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17783273.0A Withdrawn EP3442991A4 (en) 2016-04-15 2017-04-14 PIN BINDING PEPTIDES AND METHODS OF USE

Country Status (3)

Country Link
US (1) US10954287B2 (en)
EP (1) EP3442991A4 (en)
WO (1) WO2017181061A1 (en)

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TWI640541B (en) 2011-12-28 2018-11-11 中外製藥股份有限公司 Peptide compound having an annular portion and pharmaceutical composition
US10815489B2 (en) 2015-03-13 2020-10-27 Chugai Seiyaku Kabushiki Kaisha Modified aminoacyl-tRNA synthetase and use thereof
WO2018085208A1 (en) 2016-11-02 2018-05-11 The Research Foundation For The State University Of New York Methods of inhibiting viruses using compositions targeting tsg101-ubiquitin interaction
US12391971B2 (en) 2017-01-31 2025-08-19 Chugai Seiyaku Kabushiki Kaisha Method for synthesizing peptides in cell-free translation system
KR20250007021A (en) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 Method for synthesizing peptide containing n-substituted amino acid
CN111479819B (en) 2017-12-15 2024-06-14 中外制药株式会社 Method for preparing peptide and method for treating base
EP3794014A4 (en) * 2018-05-15 2022-03-16 InterK Peptide Therapeutics Limited PEPTIDE ENHANCING AGENT
WO2019246286A1 (en) 2018-06-19 2019-12-26 Neon Therapeutics, Inc. Neoantigens and uses thereof
WO2019246386A1 (en) * 2018-06-21 2019-12-26 Ra Pharmaceuticals Inc. Cyclic polypeptides for pcsk9 inhibition
IL321719A (en) 2018-06-21 2025-08-01 Merck Sharp ַ& Dohme Llc PCSK9 antagonist compounds
US11530244B2 (en) 2018-06-21 2022-12-20 Merck Sharp & Dohme Llc Cyclic polypeptides for PCSK9 inhibition
EP3810177B1 (en) 2018-06-21 2024-12-04 Ra Pharmaceuticals, Inc. Cyclic polypeptides for pcsk9 inhibition
WO2019246352A1 (en) 2018-06-21 2019-12-26 Merck Sharp & Dohme Corp. Pcsk9 antagonist bicyclo-compounds
US11505575B2 (en) 2018-06-21 2022-11-22 Merck Sharp & Dohme Llc Cyclic polypeptides for PCSK9 inhibition
CN112533898A (en) 2018-07-31 2021-03-19 日商泛美克斯股份有限公司 Heterocyclic compounds
EP3878836B1 (en) 2018-11-07 2025-07-23 Chugai Seiyaku Kabushiki Kaisha O-substituted serine derivative production method
WO2020111238A1 (en) 2018-11-30 2020-06-04 中外製薬株式会社 Deprotection method and resin removal method in solid-phase reaction for peptide compound or amide compound, and method for producing peptide compound
CN113692401A (en) 2019-03-15 2021-11-23 中外制药株式会社 Process for producing aromatic amino acid derivative
US12577278B2 (en) 2019-06-07 2026-03-17 Emory University KRAS G12V mutant binds to JAK1, inhibitors, pharmaceutical compositions, and methods related thereto
US12565537B2 (en) 2019-06-18 2026-03-03 Musc Foundation For Research Development Compositions and methods targeting the nucleotide free state of RAS to block oncogenic signaling and transformation
WO2021041770A1 (en) 2019-08-30 2021-03-04 Merck Sharp & Dohme Corp. Pcsk9 antagonist compounds
CN114786777A (en) * 2019-11-04 2022-07-22 锐新医药公司 RAS inhibitors
EP4056580A4 (en) 2019-11-07 2023-12-06 Chugai Seiyaku Kabushiki Kaisha METHOD FOR MANUFACTURING A PEPTIDE COMPOUND CONTAINING A HIGHLY STERICALLY HINDERED AMINO ACID
JP6880352B1 (en) 2019-11-07 2021-06-02 中外製薬株式会社 Cyclic peptide compound with Kras inhibitory effect
CN111393519B (en) * 2019-11-21 2022-11-08 中国药科大学 Novel stapled peptides as KRASG12C/SOS1 inhibitors and uses thereof
US12577259B2 (en) 2019-12-20 2026-03-17 Merck Sharp & Dohme Llc PCSK9 antagonist compounds
WO2021142022A2 (en) * 2020-01-06 2021-07-15 Quanta Therapeutics, Inc. Compositions and methods for identification of modulators of ras protein complexes
WO2021217019A1 (en) * 2020-04-23 2021-10-28 The Regents Of The University Of California Ras inhibitors and uses thereof
US11932705B2 (en) 2020-12-18 2024-03-19 Merck Sharp & Dohme Llc Cyclic polypeptides for PCSK9 inhibition
AR125800A1 (en) 2021-05-07 2023-08-16 Chugai Pharmaceutical Co Ltd METHODS FOR PRODUCING CYCLIC COMPOUNDS COMPRISING N-SUBSTITUTED AMINO ACIDS RESIDUES
CN117279933A (en) 2021-05-07 2023-12-22 中外制药株式会社 Cyclic compounds with selective KRAS inhibition relative to HRAS and NRAS
EP4299069A4 (en) 2021-05-07 2025-03-05 Chugai Seiyaku Kabushiki Kaisha PREPARATION CONTAINING CYCLIC PEPTIDE COMPOUND AND PRODUCTION METHOD THEREOF
WO2022234639A1 (en) * 2021-05-07 2022-11-10 中外製薬株式会社 Bonding molecule exhibiting selective bonding to variant ras (g12d)
KR102666765B1 (en) 2021-05-07 2024-05-16 추가이 세이야쿠 가부시키가이샤 Medicinal uses of cyclic peptide compounds
KR20240133798A (en) * 2021-12-17 2024-09-04 쓰리비 파마슈티컬스 게엠베하 Carbonic anhydrase IX ligand
AU2023264918A1 (en) 2022-05-06 2025-01-09 Chugai Seiyaku Kabushiki Kaisha Cyclic compound having selective kras inhibitory effect on hras and nras
KR20240082196A (en) 2022-11-09 2024-06-10 추가이 세이야쿠 가부시키가이샤 Pharmaceutical composition comprising cyclic compound having selective inhibitory action on kras over hras and nras
TW202545946A (en) * 2024-01-08 2025-12-01 大陸商泰勵生物科技（上海）有限公司 Antibody-drug conjugates and uses thereof

Citations (3)

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US5910478A (en) * 1995-09-21 1999-06-08 Innapharma, Inc. Peptidomimetics inhibiting the oncogenic action of p21 ras
WO2012162628A2 (en) * 2011-05-25 2012-11-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lipopeptide inhibitors of ras oncoproteins
US20150239935A1 (en) * 2011-03-04 2015-08-27 New York University Hydrogen bond surrogate macrocycles as modulators of ras

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US5910478A (en) * 1995-09-21 1999-06-08 Innapharma, Inc. Peptidomimetics inhibiting the oncogenic action of p21 ras
US20150239935A1 (en) * 2011-03-04 2015-08-27 New York University Hydrogen bond surrogate macrocycles as modulators of ras
WO2012162628A2 (en) * 2011-05-25 2012-11-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lipopeptide inhibitors of ras oncoproteins

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THI B. TRINH ET AL: "Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides", ACS COMBINATORIAL SCIENCE, vol. 18, no. 1, 11 January 2016 (2016-01-11), US, pages 75 - 85, XP055431276, ISSN: 2156-8952, DOI: 10.1021/acscombsci.5b00164 *
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Also Published As

Publication number Publication date
US20190119358A1 (en) 2019-04-25
EP3442991A1 (en) 2019-02-20
US10954287B2 (en) 2021-03-23
WO2017181061A1 (en) 2017-10-19

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Inventor name: TRECO, DOUGLAS A.

Inventor name: NIMS, NATHAN EZEKIEL

Inventor name: SEYB, KATHLEEN

Inventor name: VADYSIRISACK, DOUANGSONE D.

Inventor name: TANG, GUO-QING

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