EP3455337A4 - SYSTEMS AND METHODS FOR ENRICHMENT OF A SAMPLE IN TARGET CELLS - Google Patents

SYSTEMS AND METHODS FOR ENRICHMENT OF A SAMPLE IN TARGET CELLS Download PDF

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Publication number
EP3455337A4
EP3455337A4 EP16901116.0A EP16901116A EP3455337A4 EP 3455337 A4 EP3455337 A4 EP 3455337A4 EP 16901116 A EP16901116 A EP 16901116A EP 3455337 A4 EP3455337 A4 EP 3455337A4
Authority
EP
European Patent Office
Prior art keywords
enrichment
sample
systems
methods
target cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16901116.0A
Other languages
German (de)
French (fr)
Other versions
EP3455337A1 (en
Inventor
Ali Asgar S. Bhagat
Andrew En-Tzu WU
Junquan Huang
Guofeng Guan
Shuzhe CHAO
Yau Luong KOH
Yifang LEE
Man Chun LEONG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biolidics Ltd
Original Assignee
Biolidics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolidics Ltd filed Critical Biolidics Ltd
Publication of EP3455337A1 publication Critical patent/EP3455337A1/en
Publication of EP3455337A4 publication Critical patent/EP3455337A4/en
Withdrawn legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/567—Valves, taps or stop-cocks
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/088—Channel loops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G01N2001/4083—Concentrating samples by other techniques involving separation of suspended solids sedimentation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Fluid Mechanics (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
EP16901116.0A 2016-05-04 2016-05-04 SYSTEMS AND METHODS FOR ENRICHMENT OF A SAMPLE IN TARGET CELLS Withdrawn EP3455337A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SG2016/050205 WO2017192098A1 (en) 2016-05-04 2016-05-04 Systems and methods for enriching target cells in a sample

Publications (2)

Publication Number Publication Date
EP3455337A1 EP3455337A1 (en) 2019-03-20
EP3455337A4 true EP3455337A4 (en) 2020-01-01

Family

ID=60203155

Family Applications (1)

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EP16901116.0A Withdrawn EP3455337A4 (en) 2016-05-04 2016-05-04 SYSTEMS AND METHODS FOR ENRICHMENT OF A SAMPLE IN TARGET CELLS

Country Status (7)

Country Link
US (1) US11059042B2 (en)
EP (1) EP3455337A4 (en)
JP (1) JP6924210B2 (en)
CN (1) CN109072149B (en)
AU (1) AU2016405636B2 (en)
SG (1) SG11201809482TA (en)
WO (1) WO2017192098A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11059042B2 (en) * 2016-05-04 2021-07-13 Biolidics Limited Systems and methods for enriching target cells in a sample
CN110951579A (en) * 2019-08-09 2020-04-03 上海乘黄纳米抗体科技有限公司 Immunomagnetic bead sorting container, sorting device and sorting system
CN114901392B (en) * 2019-10-21 2024-10-29 南洋理工大学 Direct and expandable separation of circulating extracellular vesicles from whole blood using centrifugal force
US20210237064A1 (en) * 2020-01-31 2021-08-05 Astrin Biosciences, Inc. Biological Fluid Filtration System
CN112903411B (en) * 2021-01-25 2023-02-03 东南大学 A multi-mode biological particle concentrator
CN112958173B (en) * 2021-03-04 2023-01-10 深圳市美好创亿医疗科技股份有限公司 Microfluidic kit
CN114806803A (en) * 2022-04-18 2022-07-29 广州万孚生物技术股份有限公司 Cell sorting system and sorting method thereof
EP4591989A1 (en) * 2022-09-21 2025-07-30 Canon Kabushiki Kaisha Microchannel device, separation device, and separation method

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EP0901578A1 (en) * 1996-05-31 1999-03-17 University of Washington Valveless liquid microswitch
EP1593968A2 (en) * 2004-05-06 2005-11-09 Seiko Instruments Inc. Microchip for analysis, analysis system having the same, and analysis method
US20110207621A1 (en) * 2008-02-21 2011-08-25 Avantra Biosciences Corporation Assays Based on Liquid Flow over Arrays
WO2015002975A1 (en) * 2013-07-05 2015-01-08 University Of Washington Through Its Center For Commercialization Methods, compositions and systems for microfluidic assays
WO2015057159A1 (en) * 2013-10-16 2015-04-23 Clearbridge Biomedics Pte Ltd Microfluidics sorter for cell detection and isolation
US20150226657A1 (en) * 2014-02-13 2015-08-13 Owl biomedical, Inc. Microfluidic system with viscoelastic fluid
WO2016010861A1 (en) * 2014-07-14 2016-01-21 President And Fellows Of Harvard College Systems and methods for improved performance of fluidic and microfluidic systems

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JP5062658B2 (en) 2006-07-28 2012-10-31 東京エレクトロン株式会社 Standing wave measuring unit and standing wave measuring method in waveguide, electromagnetic wave utilizing apparatus, plasma processing apparatus, and plasma processing method
JP2010151777A (en) * 2008-11-19 2010-07-08 Sony Corp Microparticle analyzer, microchip, and method for analyzing microparticle
JP5834001B2 (en) * 2009-03-17 2015-12-16 シリコン・バイオシステムズ・ソシエタ・ペル・アチオニ Microfluidic device for separating cells
JP2010226978A (en) * 2009-03-26 2010-10-14 Mitsui Eng & Shipbuild Co Ltd Cell sorter
RU2583068C2 (en) 2010-01-24 2016-05-10 Институт Хеми Физичней Польской Академии Наук System and method for automated formation and handling of liquid mixtures
US20140087412A1 (en) 2011-04-20 2014-03-27 4Dx Pty Ltd Method and Device for Application of Fluid Forces to Cells
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US10502674B2 (en) * 2014-06-27 2019-12-10 The Regents Of The University Of California Apparatus and method for label-free analysis of rare cells from bodily fluids
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US11059042B2 (en) * 2016-05-04 2021-07-13 Biolidics Limited Systems and methods for enriching target cells in a sample

Patent Citations (8)

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Publication number Priority date Publication date Assignee Title
EP0901578A1 (en) * 1996-05-31 1999-03-17 University of Washington Valveless liquid microswitch
EP0901578B1 (en) * 1996-05-31 2002-01-02 University of Washington Valveless liquid microswitch and method
EP1593968A2 (en) * 2004-05-06 2005-11-09 Seiko Instruments Inc. Microchip for analysis, analysis system having the same, and analysis method
US20110207621A1 (en) * 2008-02-21 2011-08-25 Avantra Biosciences Corporation Assays Based on Liquid Flow over Arrays
WO2015002975A1 (en) * 2013-07-05 2015-01-08 University Of Washington Through Its Center For Commercialization Methods, compositions and systems for microfluidic assays
WO2015057159A1 (en) * 2013-10-16 2015-04-23 Clearbridge Biomedics Pte Ltd Microfluidics sorter for cell detection and isolation
US20150226657A1 (en) * 2014-02-13 2015-08-13 Owl biomedical, Inc. Microfluidic system with viscoelastic fluid
WO2016010861A1 (en) * 2014-07-14 2016-01-21 President And Fellows Of Harvard College Systems and methods for improved performance of fluidic and microfluidic systems

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Title
See also references of WO2017192098A1 *

Also Published As

Publication number Publication date
US11059042B2 (en) 2021-07-13
CN109072149B (en) 2022-02-18
AU2016405636A1 (en) 2018-11-15
CN109072149A (en) 2018-12-21
WO2017192098A1 (en) 2017-11-09
JP2019515678A (en) 2019-06-13
US20190151847A1 (en) 2019-05-23
JP6924210B2 (en) 2021-08-25
AU2016405636B2 (en) 2019-12-05
SG11201809482TA (en) 2018-11-29
EP3455337A1 (en) 2019-03-20

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