EP3512552A4 - Anti-histone therapy in acute kidney injury - Google Patents

Anti-histone therapy in acute kidney injury Download PDF

Info

Publication number
EP3512552A4
EP3512552A4 EP17851497.2A EP17851497A EP3512552A4 EP 3512552 A4 EP3512552 A4 EP 3512552A4 EP 17851497 A EP17851497 A EP 17851497A EP 3512552 A4 EP3512552 A4 EP 3512552A4
Authority
EP
European Patent Office
Prior art keywords
histone
therapy
kidney injury
acute kidney
acute
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP17851497.2A
Other languages
German (de)
French (fr)
Other versions
EP3512552A1 (en
Inventor
Daigo NAKAZAWA
Hans-Joachim Anders
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunomedics Inc
Original Assignee
Immunomedics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/402,585 external-priority patent/US20170114126A1/en
Application filed by Immunomedics Inc filed Critical Immunomedics Inc
Publication of EP3512552A1 publication Critical patent/EP3512552A1/en
Publication of EP3512552A4 publication Critical patent/EP3512552A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP17851497.2A 2016-09-14 2017-09-14 Anti-histone therapy in acute kidney injury Withdrawn EP3512552A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662394529P 2016-09-14 2016-09-14
US15/402,585 US20170114126A1 (en) 2014-06-24 2017-01-10 Anti-histone therapy for vascular necrosis in severe glomerulonephritis
PCT/US2017/051485 WO2018053080A1 (en) 2016-09-14 2017-09-14 Anti-histone therapy in acute kidney injury

Publications (2)

Publication Number Publication Date
EP3512552A1 EP3512552A1 (en) 2019-07-24
EP3512552A4 true EP3512552A4 (en) 2020-05-06

Family

ID=61619282

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17851497.2A Withdrawn EP3512552A4 (en) 2016-09-14 2017-09-14 Anti-histone therapy in acute kidney injury

Country Status (3)

Country Link
EP (1) EP3512552A4 (en)
CA (1) CA3031540A1 (en)
WO (1) WO2018053080A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020172631A2 (en) 2019-02-21 2020-08-27 Xencor, Inc. Untargeted and targeted il-10 fc-fusion proteins
WO2020225549A1 (en) * 2019-05-06 2020-11-12 The Francis Crick Institute Limited Method for preventing inflammation
CN113122538A (en) * 2021-04-15 2021-07-16 遵义医科大学附属医院 shRNA expressed by targeted knockdown Rip3 gene, recombinant vector and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9642822B2 (en) * 2011-05-27 2017-05-09 Children's Medical Center Corporation Methods for treating and preventing neutrophil-derived net toxicity and thrombosis
EP3160504B1 (en) * 2014-06-24 2020-09-16 Immunomedics, Inc. Anti-histone therapy for vascular necrosis in severe glomerulonephritis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Extracellular histones cause vascular necrosis in severe glomerulonephritis", 2015, UNIVERSITY MÜNCHEN, article VANKAYALA RAMAIAH ET AL: "Extracellular histones cause vascular necrosis in severe glomerulonephritis", XP055678928, DOI: https://edoc.ub.uni-muenchen.de/18767/ *
KUMAR SANTHOSH V.R. ET AL: "Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 26, no. 10, 2 February 2015 (2015-02-02), US, pages 2399 - 2413, XP055926348, ISSN: 1046-6673, DOI: 10.1681/ASN.2014070673 *
See also references of WO2018053080A1 *

Also Published As

Publication number Publication date
EP3512552A1 (en) 2019-07-24
CA3031540A1 (en) 2018-03-22
WO2018053080A1 (en) 2018-03-22

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