EP3512561A4 - Sulfatierte glykosaminoglykanbiomaterialien als proteoglykanmimetika - Google Patents

Sulfatierte glykosaminoglykanbiomaterialien als proteoglykanmimetika Download PDF

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Publication number
EP3512561A4
EP3512561A4 EP17851611.8A EP17851611A EP3512561A4 EP 3512561 A4 EP3512561 A4 EP 3512561A4 EP 17851611 A EP17851611 A EP 17851611A EP 3512561 A4 EP3512561 A4 EP 3512561A4
Authority
EP
European Patent Office
Prior art keywords
biomaterials
sulfated glycosaminoglycan
proteoglycan
mimics
proteoglycan mimics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP17851611.8A
Other languages
English (en)
French (fr)
Other versions
EP3512561A1 (de
Inventor
Thomas H. Jozefiak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycologix Inc
Original Assignee
Glycologix LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycologix LLC filed Critical Glycologix LLC
Publication of EP3512561A1 publication Critical patent/EP3512561A1/de
Publication of EP3512561A4 publication Critical patent/EP3512561A4/de
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
    • C07C317/08—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/005—Crosslinking of cellulose derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP17851611.8A 2016-09-16 2017-09-15 Sulfatierte glykosaminoglykanbiomaterialien als proteoglykanmimetika Pending EP3512561A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662395805P 2016-09-16 2016-09-16
PCT/US2017/051799 WO2018053276A1 (en) 2016-09-16 2017-09-15 Sulfated glycosaminoglycan biomaterials as proteoglycan mimics

Publications (2)

Publication Number Publication Date
EP3512561A1 EP3512561A1 (de) 2019-07-24
EP3512561A4 true EP3512561A4 (de) 2020-10-07

Family

ID=61619817

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17851611.8A Pending EP3512561A4 (de) 2016-09-16 2017-09-15 Sulfatierte glykosaminoglykanbiomaterialien als proteoglykanmimetika

Country Status (7)

Country Link
US (2) US11090327B2 (de)
EP (1) EP3512561A4 (de)
JP (2) JP7619759B2 (de)
AU (2) AU2017326009B2 (de)
CA (1) CA3035659C (de)
MA (1) MA46426A (de)
WO (1) WO2018053276A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022018535A2 (pt) * 2020-03-19 2022-11-29 Glycologix Inc Biomateriais de glicosaminoglicano sulfatado como miméticos de proteoglicanos
SE545148C2 (en) 2020-06-29 2023-04-18 Antaros Tracer Ab Novel compounds for use in diagnosis and/or monitoring of fibrosis
CN116874830B (zh) * 2023-05-31 2024-02-27 山东丰金美业科技有限公司 一种romp聚合反应交联的透明质酸材料及制备与应用

Citations (8)

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Publication number Priority date Publication date Assignee Title
US4863907A (en) * 1984-06-29 1989-09-05 Seikagaku Kogyo Co., Ltd. Crosslinked glycosaminoglycans and their use
EP0830416A1 (de) * 1995-06-06 1998-03-25 C.R. Bard, Inc. Verfahren zur herstellung von wässrigen dispersionen von wasserlöslichen polymerpartikel und die partikel
EP1607405A1 (de) * 2003-03-11 2005-12-21 Seikagaku Corporation Photovernetzte polysaccharidzusammensetzung und herstellungsverfahren dafür
WO2008070640A1 (en) * 2006-12-04 2008-06-12 Johns Hopkins University Imidated biopolymer adhesive and hydrogel
WO2015115609A1 (ja) * 2014-01-31 2015-08-06 生化学工業株式会社 ジアミン架橋剤、酸性多糖架橋体、及び医用材料
WO2015142721A1 (en) * 2014-03-16 2015-09-24 Drexel University Novel hydrogels and methods using same
EP3040117A1 (de) * 2014-12-29 2016-07-06 Galderma S.A. Ethervernetzte Chondroitinsulfathydrogele und deren Verwendung für Weichgewebeanwendungen
EP3187510A1 (de) * 2015-12-29 2017-07-05 Galderma S.A. Kohlenhydratvernetzer

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JPS61164558A (ja) * 1985-01-17 1986-07-25 生化学工業株式会社 医療用成形物の成形材料
US4582865A (en) * 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
DE68926051T2 (de) * 1988-12-20 1996-08-29 Jolla Cancer Res Found Polypeptid-polymer-konjugate mit wundheilender wirkung
US6281341B1 (en) * 1997-04-30 2001-08-28 Biomm, Inc. & University Of Miami Hetero-polysaccharide conjugate and methods of making and using the same
FI974321A0 (fi) * 1997-11-25 1997-11-25 Jenny Ja Antti Wihurin Rahasto Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa
US7504387B2 (en) * 2002-10-16 2009-03-17 Arthrodynamic Technologies, Animal Health Division, Inc. Glycosaminoglycan composition and method for treatment and prevention of interstitial cystitis
US20040161476A1 (en) * 2003-02-19 2004-08-19 Hahn Sungtack Samuel Cystitis treatment with high dose chondroitin sulfate
ITMI20061030A1 (it) * 2006-05-26 2007-11-27 Altergon Sa Nuova composizione comprendente glicosamminoglicani a viscosita' controllata e uso di tale composizione nella terapuia della cistite cronica
US8383156B2 (en) * 2007-04-30 2013-02-26 Cordis Corporation Coating for a medical device having an anti-thrombotic conjugate
US8912149B1 (en) * 2007-11-28 2014-12-16 California Institute Of Technology Glycosaminoglycan mimetics
US20150306237A1 (en) * 2012-12-19 2015-10-29 University Of Geneva Hyaluronic acid-antioxidant conjugates and their uses
US9200039B2 (en) * 2013-03-15 2015-12-01 Symic Ip, Llc Extracellular matrix-binding synthetic peptidoglycans
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Patent Citations (10)

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Publication number Priority date Publication date Assignee Title
US4863907A (en) * 1984-06-29 1989-09-05 Seikagaku Kogyo Co., Ltd. Crosslinked glycosaminoglycans and their use
EP0830416A1 (de) * 1995-06-06 1998-03-25 C.R. Bard, Inc. Verfahren zur herstellung von wässrigen dispersionen von wasserlöslichen polymerpartikel und die partikel
EP0830416B1 (de) * 1995-06-06 2005-08-31 C.R. Bard, Inc. Verfahren zur herstellung von vernetzten wasserlöslichen polymerpartikel, die partikel und ihre verwendung
EP1607405A1 (de) * 2003-03-11 2005-12-21 Seikagaku Corporation Photovernetzte polysaccharidzusammensetzung und herstellungsverfahren dafür
WO2008070640A1 (en) * 2006-12-04 2008-06-12 Johns Hopkins University Imidated biopolymer adhesive and hydrogel
WO2015115609A1 (ja) * 2014-01-31 2015-08-06 生化学工業株式会社 ジアミン架橋剤、酸性多糖架橋体、及び医用材料
EP3101064A1 (de) * 2014-01-31 2016-12-07 Seikagaku Corporation Diaminvernetzungsmittel, saurer polysaccharid-vernetzter körper und medizinisches material
WO2015142721A1 (en) * 2014-03-16 2015-09-24 Drexel University Novel hydrogels and methods using same
EP3040117A1 (de) * 2014-12-29 2016-07-06 Galderma S.A. Ethervernetzte Chondroitinsulfathydrogele und deren Verwendung für Weichgewebeanwendungen
EP3187510A1 (de) * 2015-12-29 2017-07-05 Galderma S.A. Kohlenhydratvernetzer

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Title
CHANG K Y ET AL: "Fabrication and characterization of poly(@c-glutamic acid)-graft-chondroitin sulfate/polycaprolactone porous scaffolds for cartilage tissue engineering", ACTA BIOMATERIALIA, vol. 5, no. 6, 1 July 2009 (2009-07-01), pages 1937 - 1947, XP026161759, ISSN: 1742-7061, [retrieved on 20090211], DOI: 10.1016/J.ACTBIO.2009.02.002 *
LI Q ET AL: "PHOTOCROSSLINKABLE POLYSACCHARIDES BASED ON CHONDROITIN SULFATE", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 68, no. 1, 2004, pages 28 - 33, XP001181884, ISSN: 0021-9304, DOI: 10.1002/JBM.A.20007 *
LIU L-S ET AL: "LOCAL SUSTAINED RELEASE OF GROWTH FACTORS FROM AN IMPLANTABLE CHONDROITIN SULFATE SCAFFOLD FOR TISSUE REGENERATON", PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE BIOACTIVE MATERIALS, CONTROLLED RELEASE SOCIETY, INC, US; KR, vol. 24, 1997, pages 577 - 578, XP002906684, ISSN: 1022-0178 *
MING-FUNG TSAI ET AL: "Characterization of hydrogels prepared from copolymerization of the different degrees of methacrylate-grafted chondroitin sulfate macromers and acrylic acid", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, vol. 84A, no. 3, 1 March 2008 (2008-03-01), pages 727 - 739, XP055064618, ISSN: 1549-3296, DOI: 10.1002/jbm.a.31441 *
See also references of WO2018053276A1 *
SINTOV A ET AL: "Cross-linked chondroitin sulphate: characterization for drug delivery purposes", BIOMATERIALS, vol. 16, no. 6, 1995, pages 473 - 478, XP004032955, ISSN: 0142-9612, DOI: 10.1016/0142-9612(95)98820-5 *
WANG ET AL: "Characterization of chondroitin sulfate and its interpenetrating polymer network hydrogels for sustained-drug release", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 329, no. 1-2, 20 December 2006 (2006-12-20), pages 103 - 109, XP005809179, ISSN: 0378-5173, DOI: 10.1016/J.IJPHARM.2006.08.041 *

Also Published As

Publication number Publication date
AU2017326009B2 (en) 2020-11-12
JP2019529645A (ja) 2019-10-17
US11090327B2 (en) 2021-08-17
JP7619759B2 (ja) 2025-01-22
US20220000905A1 (en) 2022-01-06
WO2018053276A1 (en) 2018-03-22
MA46426A (fr) 2019-07-24
CA3035659C (en) 2022-09-06
US11975019B2 (en) 2024-05-07
CA3035659A1 (en) 2018-03-22
US20190262386A1 (en) 2019-08-29
AU2017326009A1 (en) 2019-03-28
JP2023123417A (ja) 2023-09-05
AU2021200256A1 (en) 2021-03-18
AU2021200256B2 (en) 2022-10-27
EP3512561A1 (de) 2019-07-24

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