EP3600319A4 - Novel alpha-hydroxy carboxylic acid and derivatives and other gras- based prodrugs of opioids and uses thereof - Google Patents

Novel alpha-hydroxy carboxylic acid and derivatives and other gras- based prodrugs of opioids and uses thereof Download PDF

Info

Publication number
EP3600319A4
EP3600319A4 EP18774382.8A EP18774382A EP3600319A4 EP 3600319 A4 EP3600319 A4 EP 3600319A4 EP 18774382 A EP18774382 A EP 18774382A EP 3600319 A4 EP3600319 A4 EP 3600319A4
Authority
EP
European Patent Office
Prior art keywords
gras
opioids
derivatives
carboxylic acid
hydroxy carboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18774382.8A
Other languages
German (de)
French (fr)
Other versions
EP3600319A1 (en
Inventor
John K. Thottathil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/472,758 external-priority patent/US10449190B2/en
Application filed by Individual filed Critical Individual
Publication of EP3600319A1 publication Critical patent/EP3600319A1/en
Publication of EP3600319A4 publication Critical patent/EP3600319A4/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Addiction (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP18774382.8A 2017-03-29 2018-03-27 Novel alpha-hydroxy carboxylic acid and derivatives and other gras- based prodrugs of opioids and uses thereof Withdrawn EP3600319A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/472,758 US10449190B2 (en) 2015-04-27 2017-03-29 Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof
PCT/US2018/024476 WO2018183264A1 (en) 2017-03-29 2018-03-27 Novel alpha-hydroxy carboxylic acid and derivatives and other gras- based prodrugs of opioids and uses thereof

Publications (2)

Publication Number Publication Date
EP3600319A1 EP3600319A1 (en) 2020-02-05
EP3600319A4 true EP3600319A4 (en) 2020-11-25

Family

ID=63676908

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18774382.8A Withdrawn EP3600319A4 (en) 2017-03-29 2018-03-27 Novel alpha-hydroxy carboxylic acid and derivatives and other gras- based prodrugs of opioids and uses thereof

Country Status (2)

Country Link
EP (1) EP3600319A4 (en)
WO (1) WO2018183264A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201704282UA (en) * 2014-12-01 2017-06-29 Cellix Bio Private Ltd Compositions and methods for the treatment of multiple sclerosis
US10226456B2 (en) 2015-04-27 2019-03-12 3St Research Llc Methods and compositions for preventing opioid abuse
EP4200275A2 (en) 2020-08-21 2023-06-28 Sitryx Therapeutics Limited Fumarate derivatives and their medical use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011002995A1 (en) * 2009-07-02 2011-01-06 Kempharm, Inc. Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof
US20160326182A1 (en) * 2015-04-27 2016-11-10 Waterville Valley Technologies, Inc. Methods and compositions for preventing opioid abuse

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
CN1263760C (en) * 2002-11-12 2006-07-12 财团法人奇美医院 Novel buprenorphine ester derivative and its preparation method, and long-acting analgesic pharmaceutical composition
SI2307420T1 (en) * 2008-04-24 2012-05-31 Janssen Pharmaceutica Nv Nalmefene di-ester prodrugs
EP2413937A1 (en) * 2009-04-02 2012-02-08 Shire LLC Novel dicarboxylic acid linked amino acid and peptide prodrugs of opioids and uses thereof
US10449190B2 (en) * 2015-04-27 2019-10-22 John K. Thottathil Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011002995A1 (en) * 2009-07-02 2011-01-06 Kempharm, Inc. Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof
US20160326182A1 (en) * 2015-04-27 2016-11-10 Waterville Valley Technologies, Inc. Methods and compositions for preventing opioid abuse

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2018183264A1 *
SZABOLCS BÉNI ET AL: "Preparation of benzoate esters of morphine and its derivatives", MONATSHEFTE FÜR CHEMIE - CHEMICAL MONTHLY ; AN INTERNATIONAL JOURNAL OF CHEMISTRY, SPRINGER-VERLAG, AU, vol. 143, no. 10, 26 June 2012 (2012-06-26), pages 1431 - 1440, XP035116687, ISSN: 1434-4475, DOI: 10.1007/S00706-012-0803-8 *

Also Published As

Publication number Publication date
EP3600319A1 (en) 2020-02-05
WO2018183264A1 (en) 2018-10-04

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