EP3601311A4 - METHODS, DEVICES AND KITS FOR IMPROVING THE REDUCTION OR MARKING OF CARBON HYDRATES - Google Patents

METHODS, DEVICES AND KITS FOR IMPROVING THE REDUCTION OR MARKING OF CARBON HYDRATES Download PDF

Info

Publication number
EP3601311A4
EP3601311A4 EP18771481.1A EP18771481A EP3601311A4 EP 3601311 A4 EP3601311 A4 EP 3601311A4 EP 18771481 A EP18771481 A EP 18771481A EP 3601311 A4 EP3601311 A4 EP 3601311A4
Authority
EP
European Patent Office
Prior art keywords
kits
marking
improving
reduction
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18771481.1A
Other languages
German (de)
French (fr)
Other versions
EP3601311A1 (en
Inventor
Andres GUERRERO NAVARRO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
Original Assignee
Agilent Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agilent Technologies Inc filed Critical Agilent Technologies Inc
Publication of EP3601311A1 publication Critical patent/EP3601311A1/en
Publication of EP3601311A4 publication Critical patent/EP3601311A4/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N21/643—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" non-biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0845—Filaments, strings, fibres, i.e. not hollow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34—Purifying; Cleaning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G01N2001/4088—Concentrating samples by other techniques involving separation of suspended solids filtration

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Materials Engineering (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Optics & Photonics (AREA)
  • Polymers & Plastics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP18771481.1A 2017-03-23 2018-03-22 METHODS, DEVICES AND KITS FOR IMPROVING THE REDUCTION OR MARKING OF CARBON HYDRATES Pending EP3601311A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762475815P 2017-03-23 2017-03-23
US201862636815P 2018-02-28 2018-02-28
US201862644460P 2018-03-17 2018-03-17
PCT/US2018/023875 WO2018175800A1 (en) 2017-03-23 2018-03-22 Methods, devices, and kits to improve reduction or labeling of carbohydrates

Publications (2)

Publication Number Publication Date
EP3601311A1 EP3601311A1 (en) 2020-02-05
EP3601311A4 true EP3601311A4 (en) 2021-01-13

Family

ID=63586210

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18771481.1A Pending EP3601311A4 (en) 2017-03-23 2018-03-22 METHODS, DEVICES AND KITS FOR IMPROVING THE REDUCTION OR MARKING OF CARBON HYDRATES

Country Status (4)

Country Link
US (2) US11543414B2 (en)
EP (1) EP3601311A4 (en)
CN (2) CN117101743A (en)
WO (1) WO2018175800A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2599034B (en) * 2019-05-03 2024-02-28 Agilent Technologies Inc Methods to improve detection of glycosylamines

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2282209A1 (en) * 2008-04-30 2011-02-09 Sumitomo Bakelite Company Limited Method for labelling sugar chains
WO2012107572A1 (en) * 2011-02-10 2012-08-16 Leiden University Medical Center Method for the purification of a glycan and/or a glycoconjugate by chromatography using a stationary phase comprising cotton
US20160025606A1 (en) * 2014-07-25 2016-01-28 Orochem Technologies, Inc. Method and apparatus for the extraction of vitamin d metabolites from human plasma
WO2016100447A1 (en) * 2014-12-17 2016-06-23 Water Technologies Corporation Device for solid phase extraction and method for use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020051971A1 (en) * 1999-05-21 2002-05-02 John R. Stuelpnagel Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8182766B2 (en) * 2004-05-04 2012-05-22 Emd Millipore Corporation Universal filter plate
JP5139085B2 (en) * 2005-02-11 2013-02-06 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Solid-phase oligosaccharide tagging: manipulation techniques for immobilized carbohydrates
WO2008006373A1 (en) * 2006-07-12 2008-01-17 Merck Patent Gmbh Solid-phase detection of terminal monosaccharides cleaved from glycosylated substrates
EP2278334A1 (en) * 2009-07-22 2011-01-26 Etablissement Francais du Sang A membrane based microarray device for high-throughput multianalyte detection
EP2306199A1 (en) * 2009-09-29 2011-04-06 Academisch Ziekenhuis Leiden Acting Under The Name Leiden University Medical Center Reductive amination and analysis of carbohydrates using 2-picoline borane as reducing agent
WO2012037407A1 (en) 2010-09-17 2012-03-22 Prozyme, Inc. Isolation and deglycosylation of glycoproteins
DE102013212179A1 (en) 2012-07-31 2014-02-06 Agilent Technologies, Inc. Derivatization of PNGase F-released glycans on an HPLC chip
WO2016003795A1 (en) * 2014-07-02 2016-01-07 New England Biolabs, Inc. Universal n-glycan binding reagent
EP3304051B1 (en) 2015-05-29 2020-08-26 Agilent Technologies, Inc. Compounds for labeling amine-containing compounds, and their use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2282209A1 (en) * 2008-04-30 2011-02-09 Sumitomo Bakelite Company Limited Method for labelling sugar chains
WO2012107572A1 (en) * 2011-02-10 2012-08-16 Leiden University Medical Center Method for the purification of a glycan and/or a glycoconjugate by chromatography using a stationary phase comprising cotton
US20160025606A1 (en) * 2014-07-25 2016-01-28 Orochem Technologies, Inc. Method and apparatus for the extraction of vitamin d metabolites from human plasma
WO2016100447A1 (en) * 2014-12-17 2016-06-23 Water Technologies Corporation Device for solid phase extraction and method for use thereof

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "AdvanceBio N-Glycan Sample Preparation Kit User Guide (96 samples) p/n 5190-8005", 24 February 2015 (2015-02-24), XP055756514, Retrieved from the Internet <URL:https://www.agilent.com/cs/library/usermanuals/public/AdvanceBio%20N-Glycan-96-5991-9561.pdf> [retrieved on 20201204] *
ANONYMOUS: "Solid Phase Extraction Products Improve Sensitivity and Increase Throughput", 1 January 2015 (2015-01-01), XP055754609, Retrieved from the Internet <URL:https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Supelco/General_Information/t402150.pdf> [retrieved on 20201127] *
HEMSTR�M PETRUS ET AL: "Hydrophilic interaction chromatography", JOURNAL OF SEPARATION SCIENCE, vol. 29, no. 12, 1 August 2006 (2006-08-01), DE, pages 1784 - 1821, XP055821605, ISSN: 1615-9306, DOI: 10.1002/jssc.200600199 *
JANA SVACINOV� ET AL: "A new approach for cytokinin isolation from Arabidopsis tissues using miniaturized purification: pipette tip solid-phase extraction", PLANT METHODS, vol. 8, no. 1, 1 January 2012 (2012-01-01), GB, pages 17, XP055543147, ISSN: 1746-4811, DOI: 10.1186/1746-4811-8-17 *
KAHLE V ET AL: "Separation of saccharides and their anomers by high-performance liquid chromatography", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 191, 18 April 1980 (1980-04-18), pages 121 - 128, XP026476906, ISSN: 0021-9673, [retrieved on 19800418], DOI: 10.1016/S0021-9673(00)86371-2 *
KUAN JIANG ET AL: "Solid-phase reductive amination for glycomic analysis", ANALYTICA CHIMICA ACTA, vol. 962, 31 January 2017 (2017-01-31), AMSTERDAM, NL, pages 32 - 40, XP055752873, ISSN: 0003-2670, DOI: 10.1016/j.aca.2017.01.049 *
L. RENEE RUHAAK ET AL: "Hydrophilic Interaction Chromatography-Based High-Throughput Sample Preparation Method for N-Glycan Analysis from Total Human Plasma Glycoproteins", ANALYTICAL CHEMISTRY, vol. 80, no. 15, 1 August 2008 (2008-08-01), pages 6119 - 6126, XP055002922, ISSN: 0003-2700, DOI: 10.1021/ac800630x *
RUHAAK L R ET AL: "Glycan labeling strategies and their use in identification and quantification", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, SPRINGER, BERLIN, DE, vol. 397, no. 8, 12 March 2010 (2010-03-12), pages 3457 - 3481, XP019839132, ISSN: 1618-2650 *
See also references of WO2018175800A1 *
TOLSTIKOV VLADIMIR V. ET AL: "Analysis of Highly Polar Compounds of Plant Origin: Combination of Hydrophilic Interaction Chromatography and Electrospray Ion Trap Mass Spectrometry", ANALYTICAL BIOCHEMISTRY, vol. 301, no. 2, 1 February 2002 (2002-02-01), Amsterdam, NL, pages 298 - 307, XP093117772, ISSN: 0003-2697, DOI: 10.1006/abio.2001.5513 *

Also Published As

Publication number Publication date
US20200041522A1 (en) 2020-02-06
US20200346214A1 (en) 2020-11-05
US11371998B2 (en) 2022-06-28
WO2018175800A1 (en) 2018-09-27
EP3601311A1 (en) 2020-02-05
CN110662754A (en) 2020-01-07
US11543414B2 (en) 2023-01-03
CN110662754B (en) 2023-08-08
CN117101743A (en) 2023-11-24

Similar Documents

Publication Publication Date Title
KR102528285B9 (en) Carbon nanotube dispersion and its use
EP3451973A4 (en) ANNULOPLASTY PROCEDURES, DEVICES AND RELATED METHODS
PH12020550781A1 (en) Anti-jagged1 antibodies and methods of use
IL263274A (en) Covalently modified surfaces, kits, and methods of preparation and use
EP3746211A4 (en) SAMPLE CHARACTERIZATION DEVICES, METHODS AND KITS
PH12017500861A1 (en) Anti-interleukin-33 antibodies and uses thereof
EP3515337A4 (en) ARTHROSCOPY DEVICES AND METHODS
EP3672505A4 (en) ARTHROSCOPY DEVICES AND METHODS
PH12017500877A1 (en) ANTI-CD79b ANTIBODIES AND METHODS OF USE
BR112017008666A2 (en) anti-fgfr2 / 3 antibodies and methods of use
EP3468725C0 (en) DEVICE FOR COATING PIPES
MX2017016169A (en) Anti-her2 antibodies and methods of use.
EP3389481A4 (en) METHODS, COMPOSITIONS, KITS AND DEVICES FOR RAPID ANALYSIS OF BIOLOGICAL MARKERS
SG10201804931QA (en) Anti-cll-1 antibodies and immunoconjugates
MA40390A (en) Assay methods involving dissociable nanoparticles
AU2016263598A8 (en) Methods and kits for treating depression
EP3309204A4 (en) RUBBER COMPOSITION AND TIRE USING THE SAME
EP3439412A4 (en) PREAMBLE CONFIGURATION AND SENDING METHODS, AND DEVICES THEREOF
EP3456767A4 (en) RUBBER AND PNEUMATIC COMPOSITION USING THE SAME
EP4279762A3 (en) Eddy current brake configurations
EP3456770A4 (en) RUBBER AND PNEUMATIC COMPOSITION USING THE SAME
IL280728B1 (en) Microorganism mixtures, molecules derived therefrom, and methods of use thereof
IL262747A (en) Anti-kv1.3 antibodies, and methods of production and use thereof
FR3027604B1 (en) PREPARATION OF A MASTER MIXTURE BASED ON SULFUR AND CARBON NANOCHARGES, THE MIXTURE OBTAINED AND USES THEREOF
PL3414362T3 (en) Device and method for the electrochemical use of carbon dioxide

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20191022

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: AGILENT TECHNOLOGIES, INC.

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20201215

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 1/34 20060101ALI20201209BHEP

Ipc: C07H 3/02 20060101ALI20201209BHEP

Ipc: C07H 1/06 20060101AFI20201209BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20240115

P01 Opt-out of the competence of the unified patent court (upc) registered

Free format text: CASE NUMBER: UPC_APP_325344/2023

Effective date: 20230523