EP3733713A4 - BISPECIFIC ANTIBODIES AND ITS APPLICATIONS - Google Patents

BISPECIFIC ANTIBODIES AND ITS APPLICATIONS Download PDF

Info

Publication number: EP3733713A4
Authority: EP; European Patent Office
Prior art keywords: applications; bispecific antibodies; bispecific; antibodies
Prior art date: 2018-03-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP19776671.0A

Other languages

German (de)

French (fr)

Other versions

EP3733713A1 (en

Inventor

Wenjun Zhang

Cuijuan CHEN

Xuemei WEI

Tonghui LUO

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Excelmab Inc

Original Assignee

Excelmab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-03-27

Filing date

2019-01-07

Publication date

2021-05-26

2019-01-07 Application filed by Excelmab Inc filed Critical Excelmab Inc

2020-11-04 Publication of EP3733713A1 publication Critical patent/EP3733713A1/en

2021-05-26 Publication of EP3733713A4 publication Critical patent/EP3733713A4/en

Status Pending legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Oncology (AREA)
Epidemiology (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Mycology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

EP19776671.0A 2018-03-27 2019-01-07 BISPECIFIC ANTIBODIES AND ITS APPLICATIONS Pending EP3733713A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CN201810263832.0A CN110305217B (en)	2018-03-27	2018-03-27	Bispecific antibodies and their applications
PCT/CN2019/070655 WO2019184549A1 (en)	2018-03-27	2019-01-07	Bispecific antibody and uses thereof

Publications (2)

Publication Number	Publication Date
EP3733713A1 EP3733713A1 (en)	2020-11-04
EP3733713A4 true EP3733713A4 (en)	2021-05-26

Family

ID=68062214

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19776671.0A Pending EP3733713A4 (en)	2018-03-27	2019-01-07	BISPECIFIC ANTIBODIES AND ITS APPLICATIONS

Country Status (7)

Country	Link
US (1)	US11718671B2 (en)
EP (1)	EP3733713A4 (en)
JP (1)	JP7066953B2 (en)
CN (1)	CN110305217B (en)
AU (1)	AU2019240974B2 (en)
CA (1)	CA3089254C (en)
WO (1)	WO2019184549A1 (en)

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CN110551221B (en) *	2019-07-02	2021-03-05	广州爱思迈生物医药科技有限公司	A kind of bispecific antibody and its preparation method and application
US20220372070A1 (en) *	2019-11-07	2022-11-24	Amgen Inc.	High salt load conditioning during cation exchange chromatography to remove product-related impurities
JP2022554283A (en) *	2019-11-07	2022-12-28	アムジエン・インコーポレーテツド	High-salt wash during cation-exchange chromatography to remove product-related impurities
CN111748040B (en) *	2020-07-31	2021-09-28	杭州皓阳生物技术有限公司	Multivalent antibodies and methods of making same
CN117120477A (en) *	2020-11-10	2023-11-24	上海齐鲁制药研究中心有限公司	Bispecific antibodies against claudin 18A2 and CD3 and their applications
CN113527493B (en) *	2021-07-20	2023-10-27	广州爱思迈生物医药科技有限公司	A B7-H3 antibody and its application
KR20240040097A (en) *	2021-08-04	2024-03-27	에이비프로 코퍼레이션	CD3 targeting antibodies and uses thereof
CN115109164A (en) *	2022-06-07	2022-09-27	博际生物医药科技(杭州)有限公司	Bispecific antibodies targeting EPCAM and CD3
US12649790B2 (en) *	2023-07-03	2026-06-09	Medicovestor, Inc.	Proteins that bind SP17 including fully-human anti-SP17 antibodies
US12624097B2 (en)	2023-07-03	2026-05-12	Medicovestor, Inc.	Nucleic acids, vectors, and cells that encode anti-Sp17 antibodies and other Sp17 binding proteins
TW202532440A (en)	2023-10-19	2025-08-16	美商建南德克公司	Combinations of il15/il15r alpha heterodimeric fc-fusion proteins and her2xcd3 bispecific antibodies for the treatment of her2-positive cancers
US12121587B1 (en)	2023-12-26	2024-10-22	Medicovestor, Inc.	Dimeric antibodies
US12673991B2 (en)	2023-12-26	2026-07-07	Medicovestor, Inc.	Methods of crosslinking IgG

Citations (4)

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WO2009055074A2 (en) *	2007-10-25	2009-04-30	Wyeth	Erbb2 binding proteins and use thereof
WO2012162067A2 (en) *	2011-05-21	2012-11-29	Macrogenics, Inc.	Cd3-binding molecules capable of binding to human and non-human cd3
WO2015016608A1 (en) *	2013-07-31	2015-02-05	삼성전자 주식회사	Composition for carrying nucleic acid, comprising antibody and nucleic acid-binding peptide
CN104829728A (en) *	2015-01-21	2015-08-12	武汉友芝友生物制药有限公司	Construction and application of bispecific antibody HER2*CD3

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US8012468B2 (en)	2004-06-11	2011-09-06	Catholic Universtiy Industry Academic Cooperation Foundation	Dendrite cells transduced with recombinant adenovirus AdVCEA which generate CEA-specific cytotoxic T lymphocytes, vaccine and pharmaceutical composition comprising the same
EP1748067A1 (en)	2005-07-29	2007-01-31	Institut Pasteur	Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes
US8236308B2 (en)	2005-10-11	2012-08-07	Micromet Ag	Composition comprising cross-species-specific antibodies and uses thereof
ES2356574T3 (en)	2006-02-24	2011-04-11	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	IMMUNOGENIC PEPTIDES AND METHODS OF USE.
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2018
- 2018-03-27 CN CN201810263832.0A patent/CN110305217B/en active Active
2019
- 2019-01-07 US US16/965,541 patent/US11718671B2/en active Active
- 2019-01-07 CA CA3089254A patent/CA3089254C/en active Active
- 2019-01-07 EP EP19776671.0A patent/EP3733713A4/en active Pending
- 2019-01-07 WO PCT/CN2019/070655 patent/WO2019184549A1/en not_active Ceased
- 2019-01-07 JP JP2020540284A patent/JP7066953B2/en active Active
- 2019-01-07 AU AU2019240974A patent/AU2019240974B2/en active Active

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WO2012162067A2 (en) *	2011-05-21	2012-11-29	Macrogenics, Inc.	Cd3-binding molecules capable of binding to human and non-human cd3
WO2015016608A1 (en) *	2013-07-31	2015-02-05	삼성전자 주식회사	Composition for carrying nucleic acid, comprising antibody and nucleic acid-binding peptide
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Also Published As

Publication number	Publication date
EP3733713A1 (en)	2020-11-04
AU2019240974A1 (en)	2020-08-13
JP7066953B2 (en)	2022-05-16
JP2021511052A (en)	2021-05-06
CN110305217A (en)	2019-10-08
US11718671B2 (en)	2023-08-08
AU2019240974B2 (en)	2022-12-01
US20210122823A1 (en)	2021-04-29
WO2019184549A1 (en)	2019-10-03
CN110305217B (en)	2022-03-29
CA3089254A1 (en)	2019-10-03
CA3089254C (en)	2025-06-10

Legal Events

Date	Code	Title	Description
2019-10-05	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2020-10-02	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2020-10-02	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2020-11-04	17P	Request for examination filed	Effective date: 20200728
2020-11-04	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2020-11-04	AX	Request for extension of the european patent	Extension state: BA ME
2021-05-26	A4	Supplementary search report drawn up and despatched	Effective date: 20210423
2021-05-26	RIC1	Information provided on ipc code assigned before grant	Ipc: C07K 16/30 20060101AFI20210419BHEP Ipc: C07K 16/28 20060101ALI20210419BHEP Ipc: C07K 16/46 20060101ALI20210419BHEP Ipc: C12N 15/85 20060101ALI20210419BHEP Ipc: A61K 39/395 20060101ALI20210419BHEP Ipc: A61K 47/68 20170101ALI20210419BHEP Ipc: A61P 35/00 20060101ALI20210419BHEP Ipc: C07K 16/32 20060101ALI20210419BHEP
2021-06-30	DAV	Request for validation of the european patent (deleted)
2021-06-30	DAX	Request for extension of the european patent (deleted)
2021-07-16	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2021-08-18	17Q	First examination report despatched	Effective date: 20210720

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