EP3813687A4 - Pharmaceutical compositions and methods for the treatment of thrombosis and delivery by medical devices - Google Patents

Pharmaceutical compositions and methods for the treatment of thrombosis and delivery by medical devices Download PDF

Info

Publication number
EP3813687A4
EP3813687A4 EP19824845.2A EP19824845A EP3813687A4 EP 3813687 A4 EP3813687 A4 EP 3813687A4 EP 19824845 A EP19824845 A EP 19824845A EP 3813687 A4 EP3813687 A4 EP 3813687A4
Authority
EP
European Patent Office
Prior art keywords
thrombosis
delivery
treatment
methods
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19824845.2A
Other languages
German (de)
French (fr)
Other versions
EP3813687A1 (en
Inventor
Michael K. HANDLEY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Marizyme Inc
Original Assignee
Marizyme Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marizyme Biotech filed Critical Marizyme Biotech
Publication of EP3813687A1 publication Critical patent/EP3813687A1/en
Publication of EP3813687A4 publication Critical patent/EP3813687A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4806—Hydrolases (3) acting on peptide bonds (3.4) from animals other than mammals, e.g. snakes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21001—Chymotrypsin (3.4.21.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21004—Trypsin (3.4.21.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/12036—Type of occlusion partial occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/1204—Type of occlusion temporary occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12136—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1052—Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)
EP19824845.2A 2018-06-28 2019-06-28 Pharmaceutical compositions and methods for the treatment of thrombosis and delivery by medical devices Withdrawn EP3813687A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862691319P 2018-06-28 2018-06-28
PCT/US2019/039878 WO2020006444A1 (en) 2018-06-28 2019-06-28 Pharmaceutical compositions and methods for the treatment of thrombosis and delivery by medical devices

Publications (2)

Publication Number Publication Date
EP3813687A1 EP3813687A1 (en) 2021-05-05
EP3813687A4 true EP3813687A4 (en) 2022-03-23

Family

ID=68985200

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19824845.2A Withdrawn EP3813687A4 (en) 2018-06-28 2019-06-28 Pharmaceutical compositions and methods for the treatment of thrombosis and delivery by medical devices

Country Status (10)

Country Link
EP (1) EP3813687A4 (en)
JP (1) JP2022525713A (en)
CN (1) CN112638289A (en)
AU (1) AU2019292557A1 (en)
BR (1) BR112021004809A2 (en)
CA (1) CA3110779A1 (en)
CR (1) CR20210059A (en)
EA (1) EA202190494A1 (en)
PE (1) PE20241469A1 (en)
WO (1) WO2020006444A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170115A1 (en) * 1984-07-20 1986-02-05 Kao Corporation Thrombus dissolvent
WO2007080515A1 (en) * 2006-01-13 2007-07-19 Aker Biomarine Asa Thrombosis preventing krill extract

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7278094A (en) * 1994-06-07 1996-01-04 M D Serv Europe S.A. Intravasal thrombolysis
US6022309A (en) * 1996-04-24 2000-02-08 The Regents Of The University Of California Opto-acoustic thrombolysis
FR2797768B1 (en) * 1999-09-01 2003-06-13 Ifremer USE OF A LOW MOLECULAR WEIGHT SULPHATE POLYSACCHARIDE FOR THE PRODUCTION OF A MEDICAMENT ACTIVE AGAINST VASCULAR THROMBOSIS
CN102319266B (en) * 2001-06-18 2014-12-17 海王星技术&生物资源有限公司 Krill and/or seafood extracts for the prevention and/or treatment of cardiovascular disease, arthritis, skin cancer, diabetes, PMS and transdermal delivery
PT1438065E (en) * 2001-10-01 2013-01-24 Matrizyme Pharma Corp Use of collagenase to facilitate guide wire crossing in chronic arterial occlusions
CN1210036C (en) * 2002-06-18 2005-07-13 蚌埠丰原医药科技发展有限公司 New application of aspirin-lysine
SE0303588D0 (en) * 2003-12-30 2003-12-30 Bioactive Polymers Ab C O Lund Surface protection of exposed biological tissues
JP4677557B2 (en) * 2005-05-11 2011-04-27 国立大学法人東北大学 Ultrasonic probe, catheter using the same, and manufacturing method thereof
EP1726301A1 (en) * 2005-05-24 2006-11-29 Flamel Technologies Oral pharmaceutical composition for treating a COX-2 mediated condition
DE102005042338B4 (en) * 2005-09-06 2007-07-05 Siemens Ag catheter device
WO2012095702A1 (en) * 2011-01-13 2012-07-19 Medestea Internazionale S.P.A. A composition for the regeneration of atrophic tissues
US10687832B2 (en) * 2013-11-18 2020-06-23 Koninklijke Philips N.V. Methods and devices for thrombus dispersal
DE202015002060U1 (en) * 2015-03-17 2015-11-25 Gerhard-Friedrich Horak Infusion and aspiration catheter (IAC) (catheter for removal of thrombi and application of drugs)
IL305537B2 (en) * 2016-08-12 2025-02-01 Clearside Biomedical Inc Devices and methods for adjusting the insertion depth of a needle for medicament delivery
US20180161552A1 (en) * 2016-12-13 2018-06-14 Boston Scientific Scimed, Inc. Thrombolysis catheter system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170115A1 (en) * 1984-07-20 1986-02-05 Kao Corporation Thrombus dissolvent
WO2007080515A1 (en) * 2006-01-13 2007-07-19 Aker Biomarine Asa Thrombosis preventing krill extract

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SJODAHL JOHAN ET AL: "Characterization of proteinases from Antarctic krill (Euphausia superba)", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, vol. 26, no. 1, 1 October 2002 (2002-10-01), pages 153 - 161, XP002359070, ISSN: 1046-5928, DOI: 10.1016/S1046-5928(02)00519-3 *

Also Published As

Publication number Publication date
BR112021004809A2 (en) 2021-06-22
CN112638289A (en) 2021-04-09
CR20210059A (en) 2021-12-23
AU2019292557A1 (en) 2021-04-01
EA202190494A1 (en) 2021-12-09
WO2020006444A1 (en) 2020-01-02
EP3813687A1 (en) 2021-05-05
JP2022525713A (en) 2022-05-19
CA3110779A1 (en) 2020-01-02
PE20241469A1 (en) 2024-07-15

Similar Documents

Publication Publication Date Title
ZA202004025B (en) Novel compounds and pharmaceutical compositions thereof for the treatment of diseases
IL279397A (en) Novel compounds and pharmaceutical compositions thereof for the treatment of diseases
MX2016012262A (en) Cenicriviroc for the treatment of fibrosis.
IL271807A (en) Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis
EP3268007A4 (en) Compositions and therapeutic methods for the treatment of complement-associated diseases
MX2017010277A (en) Cenicriviroc for the treatment of fibrosis.
EP3716975A4 (en) Methods and pharmaceutical compositions for the treatment of non-alcoholic steatohepatitis
PL3743043T3 (en) Pharmaceutical compositions for the treatment of postoperative pain
HK40048989A (en) Pharmaceutical compositions and methods for the treatment of thrombosis and delivery by medical devices
EP3813687A4 (en) Pharmaceutical compositions and methods for the treatment of thrombosis and delivery by medical devices
EP3322435A4 (en) Pharmaceutical compositions useful for the treatment of tissue injury
EP3781194A4 (en) Compositions and methods for the selective delivery of therapeutic and imaging agents
HUE053866T2 (en) Pharmaceutical composition for the treatment of constipation
MX2019008847A (en) Cysteamine prodrugs.
HK40037090A (en) Novel compounds and pharmaceutical compositions thereof for the treatment of diseases
HK40050861A (en) Novel compounds and pharmaceutical compositions thereof for the treatment of diseases
GB202209022D0 (en) Pharmaceutical compositions and formulations for the treatment of retinoblastoma
HK40036525A (en) Compounds and pharmaceutical compositions thereof for use in the treatment of fibrotic diseases
HK40051042A (en) Compositions for drug delivery and methods of use thereof
HK40030474A (en) Compounds and pharmaceutical compositions thereof for use in the treatment of fibrotic diseases
GB201814764D0 (en) Pharmaceutical compositions for the treatment of proteinopathies
HK40047072A (en) Compositions and methods for the selective delivery of therapeutic and imaging agents
HK40033754A (en) Pharmaceutical compositions for the treatment of ophthalmic conditions
GB201817344D0 (en) Novel compounds and pharmaceutical compositions thereof for the treatment of diseases
GB201817343D0 (en) Novel compounds and pharmaceutical compositions thereof for the treatment of diseases

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20210128

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40048989

Country of ref document: HK

A4 Supplementary search report drawn up and despatched

Effective date: 20220223

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 38/48 20060101ALI20220217BHEP

Ipc: A61K 38/26 20060101ALI20220217BHEP

Ipc: A61K 31/616 20060101ALI20220217BHEP

Ipc: A61M 25/10 20130101ALI20220217BHEP

Ipc: A61K 38/43 20060101ALI20220217BHEP

Ipc: A61B 17/12 20060101AFI20220217BHEP

RAP3 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MARIZYME, INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20230822

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230907

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20240103