EP3844171A4 - NEUROLYSIN ACTIVITY AMPLIFIERS - Google Patents

NEUROLYSIN ACTIVITY AMPLIFIERS Download PDF

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Publication number
EP3844171A4
EP3844171A4 EP19854587.3A EP19854587A EP3844171A4 EP 3844171 A4 EP3844171 A4 EP 3844171A4 EP 19854587 A EP19854587 A EP 19854587A EP 3844171 A4 EP3844171 A4 EP 3844171A4
Authority
EP
European Patent Office
Prior art keywords
amplifiers
neurolysin
activity
neurolysin activity
activity amplifiers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19854587.3A
Other languages
German (de)
French (fr)
Other versions
EP3844171A1 (en
Inventor
Vardan T. KARAMYAN
Paul TRIPPIER
David A. Ostrov
Tom ABBRUSCATO
Srinidhi JAYARAMAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas Tech University TTU
University of Florida Research Foundation Inc
Original Assignee
University of Florida
Texas Tech University TTU
University of Florida Research Foundation Inc
Texas Tech University System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida, Texas Tech University TTU, University of Florida Research Foundation Inc, Texas Tech University System filed Critical University of Florida
Publication of EP3844171A1 publication Critical patent/EP3844171A1/en
Publication of EP3844171A4 publication Critical patent/EP3844171A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6416—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24016—Neurolysin (3.4.24.16)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
EP19854587.3A 2018-08-31 2019-08-29 NEUROLYSIN ACTIVITY AMPLIFIERS Withdrawn EP3844171A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862725444P 2018-08-31 2018-08-31
PCT/US2019/048702 WO2020047185A1 (en) 2018-08-31 2019-08-29 Enhancers of neurolysin activity

Publications (2)

Publication Number Publication Date
EP3844171A1 EP3844171A1 (en) 2021-07-07
EP3844171A4 true EP3844171A4 (en) 2022-08-10

Family

ID=69644644

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19854587.3A Withdrawn EP3844171A4 (en) 2018-08-31 2019-08-29 NEUROLYSIN ACTIVITY AMPLIFIERS

Country Status (3)

Country Link
US (1) US12331333B2 (en)
EP (1) EP3844171A4 (en)
WO (1) WO2020047185A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4015501A1 (en) * 2020-12-16 2022-06-22 Consejo Superior de Investigaciones Científicas (CSIC) N-benzyl-alpha-aminoamides as anaphase-promoting complex/cyclosome (apc/c) inhibitors
CN116768855B (en) * 2022-03-09 2026-03-27 中国药科大学 Aromatic amino acid compounds, their preparation methods, pharmaceutical compositions and applications
CN117603085B (en) * 2023-12-18 2026-02-06 武汉鼎粒生物科技有限公司 Peptidase neurolysin enhancer and preparation method and application thereof
CN117603084A (en) * 2023-12-18 2024-02-27 江苏瑞思坦生物科技有限公司 Peptidase neurolysin enhancer and its preparation method and application
WO2025233460A1 (en) 2024-05-09 2025-11-13 Jiangsu Re-Stem Biotechnology Co., Ltd. Treatment and prevention of alpha-synuclein-mediated disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020483A1 (en) * 2003-06-12 2005-01-27 Donna Oksenberg Sigma ligands for neuronal regeneration and functional recovery
US8933056B2 (en) * 2005-12-19 2015-01-13 Trustees Of Tufts College Soft protease inhibitors and pro-soft forms thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4611076A (en) * 1985-06-26 1986-09-09 Shell Oil Company Chiral cyanohydrination process
ITMI20030755A1 (en) * 2003-04-11 2004-10-12 Bottega Verde S R L PEPTIDES AND THEIR DERIVATIVES AS INHIBITORS OF DEGRADATIVE PHENOMENA AND COMPOSITIONS CONTAINING THE SAME.
US10272106B2 (en) * 2014-06-04 2019-04-30 Case Western Reserve University Compositions and methods of treating diabetic retinopathy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020483A1 (en) * 2003-06-12 2005-01-27 Donna Oksenberg Sigma ligands for neuronal regeneration and functional recovery
US8933056B2 (en) * 2005-12-19 2015-01-13 Trustees Of Tufts College Soft protease inhibitors and pro-soft forms thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
HART BRADLEY R. ET AL: "Molecular Imprinting for the Recognition of N-Terminal Histidine Peptides in Aqueous Solution", vol. 35, no. 16, 26 June 2002 (2002-06-26), US, pages 6192 - 6201, XP055931670, ISSN: 0024-9297, Retrieved from the Internet <URL:https://pubs.acs.org/doi/pdf/10.1021/ma020091f> DOI: 10.1021/ma020091f *
JAYARAMAN SRINIDHI ET AL: "Allosteric Potentiation of Peptidase Neurolysin by Small Molecules", BIOPHYSICAL JOURNAL, vol. 110, no. 3, 2016, XP029427042, ISSN: 0006-3495, DOI: 10.1016/J.BPJ.2015.11.2143 *
See also references of WO2020047185A1 *
SHEN WEILIN ET AL: "Current knowledge of intestinal absorption of bioactive peptides", vol. 8, no. 12, 25 October 2017 (2017-10-25), GB, pages 4306 - 4314, XP055931659, ISSN: 2042-6496, Retrieved from the Internet <URL:https://pubs.rsc.org/en/content/articlepdf/2017/fo/c7fo01185g> DOI: 10.1039/C7FO01185G *
SMITH$ MICHELE C ET AL: "THE JOURNAL OF BIOLOGICAL CHEMISTRY 8 1988 hy The American Society for Biochemistry and Molecular Biology, Inc. Chelating Peptide-immobilized Metal Ion Affinity Chromatography A NEW CONCEPT IN AFFINITY CHROMATOGRAPHY FOR RECOMBINANT PROTEINS*", 25 March 1988 (1988-03-25), pages 7211 - 7215, XP055931651, Retrieved from the Internet <URL:https://www.jbc.org/article/S0021-9258(18)68629-6/pdf> [retrieved on 20220615] *
TANAKA MITSURU ET AL: "Visualized absorption of anti-atherosclerotic dipeptide, Trp-His, in Sprague-Dawley rats by LC-MS and MALDI-MS imaging analyses", MOLECULAR NUTRITION & FOOD RESEARCH, vol. 59, no. 8, 30 April 2015 (2015-04-30), DE, pages 1541 - 1549, XP093281482, ISSN: 1613-4125, DOI: 10.1002/mnfr.201500075 *
VOGLER RAPHAEL ET AL: "FULL PAPER Dipeptides Made up Solely from Histidine: Solution Behaviour and Zinc Complexation []", EUR. J. INORG. CHEM, 1 January 2002 (2002-01-01), pages 761 - 766, XP055931624, Retrieved from the Internet <URL:https://doi.org/10.1002/1099-0682(200203)2002:3<761::AID-EJIC761>3.0.CO;2-V> [retrieved on 20220615] *

Also Published As

Publication number Publication date
EP3844171A1 (en) 2021-07-07
WO2020047185A1 (en) 2020-03-05
US20210198647A1 (en) 2021-07-01
WO2020047185A9 (en) 2020-09-17
US12331333B2 (en) 2025-06-17

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