EP3976655A4 - ANTI-ADAM8 ANTIBODIES AND THEIR USE - Google Patents

ANTI-ADAM8 ANTIBODIES AND THEIR USE Download PDF

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Publication number
EP3976655A4
EP3976655A4 EP20813778.6A EP20813778A EP3976655A4 EP 3976655 A4 EP3976655 A4 EP 3976655A4 EP 20813778 A EP20813778 A EP 20813778A EP 3976655 A4 EP3976655 A4 EP 3976655A4
Authority
EP
European Patent Office
Prior art keywords
adam8
antibodies
adam8 antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20813778.6A
Other languages
German (de)
French (fr)
Other versions
EP3976655A1 (en
Inventor
Gail SONENSHEIN
Nora MINEVA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tufts University
Original Assignee
Tufts University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts University filed Critical Tufts University
Publication of EP3976655A1 publication Critical patent/EP3976655A1/en
Publication of EP3976655A4 publication Critical patent/EP3976655A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
EP20813778.6A 2019-05-31 2020-05-29 ANTI-ADAM8 ANTIBODIES AND THEIR USE Pending EP3976655A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962855575P 2019-05-31 2019-05-31
PCT/US2020/035280 WO2020243541A1 (en) 2019-05-31 2020-05-29 Anti-adam8 antibodies and uses of the same

Publications (2)

Publication Number Publication Date
EP3976655A1 EP3976655A1 (en) 2022-04-06
EP3976655A4 true EP3976655A4 (en) 2023-07-05

Family

ID=73552945

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20813778.6A Pending EP3976655A4 (en) 2019-05-31 2020-05-29 ANTI-ADAM8 ANTIBODIES AND THEIR USE

Country Status (5)

Country Link
US (1) US12540193B2 (en)
EP (1) EP3976655A4 (en)
AU (1) AU2020283906A1 (en)
CA (1) CA3142238A1 (en)
WO (1) WO2020243541A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014186364A2 (en) * 2013-05-13 2014-11-20 Tufts University Methods and compositions for prognosis, diagnosis and treatment of adam8-expressing cancer
US20170107258A1 (en) * 2007-10-12 2017-04-20 Cancer Research Technology Limited Protease inhibition

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5053394A (en) 1988-09-21 1991-10-01 American Cyanamid Company Targeted forms of methyltrithio antitumor agents
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
JP2003508028A (en) * 1999-07-28 2003-03-04 ジェネンテック・インコーポレーテッド Compositions and methods for treating tumors
WO2005090991A1 (en) * 2004-03-24 2005-09-29 Oncotherapy Science, Inc. Adam8 as tumor marker and therapeutic target for non-small cell lung cancer
EP2322665A1 (en) 2004-05-14 2011-05-18 Rosetta Genomics Ltd MicroRNAs and uses thereof
US20060275288A1 (en) 2005-01-20 2006-12-07 Grihalde Nelson D GLP-1 receptor agonist and allosteric modulator monoclonal antibodies and uses thereof
WO2012088105A2 (en) 2010-12-20 2012-06-28 Biozyme Inc. Methods and compositions for predicting disease status in cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170107258A1 (en) * 2007-10-12 2017-04-20 Cancer Research Technology Limited Protease inhibition
WO2014186364A2 (en) * 2013-05-13 2014-11-20 Tufts University Methods and compositions for prognosis, diagnosis and treatment of adam8-expressing cancer

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ISHIKAWA NOBUHISA ET AL: "ADAM8 as a novel serological and histochemical marker for lung cancer", CLINICAL CANCER RESEARCH, ASSOCIATION FOR CANCER RESEARCH, US, vol. 10, no. 24, 15 December 2004 (2004-12-15), pages 8363 - 8370, XP002349232, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-04-1436 *
PEREZ DE LA LASTRA ET AL: "Epitope mapping of 10 monoclonal antibodies against the pig analogue of human membrane cofactor protein (MCP)", CANCER RESEARCH, vol. 96, no. 4, 1 April 1999 (1999-04-01), GB, pages 663 - 670, XP055572134, ISSN: 0019-2805, DOI: 10.1046/j.1365-2567.1999.00732.x *
SCHLOMANN UWE ET AL: "ADAM8 as a drug target in pancreatic cancer", NATURE COMMUNICATIONS, vol. 6, no. 1, 28 January 2015 (2015-01-28), pages 1 - 16, XP093050410, Retrieved from the Internet <URL:https://www.nature.com/articles/ncomms7175> DOI: 10.1038/ncomms7175 *
SCHLOMANN UWE ET AL: "The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 277, no. 50, 13 December 2002 (2002-12-13), pages 48210 - 48219, XP002511876, ISSN: 0021-9258, DOI: 10.1074/JBC.M203355200 *
See also references of WO2020243541A1 *
SONIA G DAS ET AL: "Abstract 23: Antibody targeting of ADAM8 for treatment of triple-negative breast cancer", CANCER RESEARCH; AACR ANNUAL MEETING 2017, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US; WASHINGTON, DC, USA, vol. 77, no. 13 Supplement, 1 July 2017 (2017-07-01), pages 23, XP009524477, ISSN: 0008-5472, DOI: 10.1158/1538-7445.AM2017-23 *
VALERIE ZIELINSKI ET AL: "ADAM8 in squamous cell carcinoma of the head and neck: a retrospective study", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 12, no. 1, 27 February 2012 (2012-02-27), pages 76, XP021118139, ISSN: 1471-2407, DOI: 10.1186/1471-2407-12-76 *
ZHEHAI LI ET AL: "Upregulation of a Disintegrin and Metalloprotease 8 Influences Tumor Metastasis and Prognosis in Patients with Osteosarcoma", PATHOLOGY & ONCOLOGY RESEARCH ; OFFICIAL JOURNAL OF THE ARÃ NYI LAJOS FOUNDATION, SPRINGER NETHERLANDS, DORDRECHT, vol. 18, no. 3, 5 January 2012 (2012-01-05), pages 657 - 661, XP035050254, ISSN: 1532-2807, DOI: 10.1007/S12253-011-9491-7 *

Also Published As

Publication number Publication date
AU2020283906A1 (en) 2022-01-20
CA3142238A1 (en) 2020-12-03
EP3976655A1 (en) 2022-04-06
US12540193B2 (en) 2026-02-03
WO2020243541A1 (en) 2020-12-03
US20220227882A1 (en) 2022-07-21

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RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 39/00 20060101ALI20230601BHEP

Ipc: A61K 39/395 20060101ALI20230601BHEP

Ipc: A61K 38/00 20060101ALI20230601BHEP

Ipc: G01N 33/68 20060101ALI20230601BHEP

Ipc: G01N 33/574 20060101ALI20230601BHEP

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